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Volumn 105, Issue 39, 2008, Pages 15046-15051

AP4 encodes a c-MYC-inducible repressor of p21

Author keywords

Colorectal cancer; DNA damage; p53; Progenitor cells; TGF beta

Indexed keywords

AP4 TRANSCRIPTION FACTOR; PROTEIN P21; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA BINDING PROTEIN; ENHANCER BINDING PROTEIN AP 4; ENHANCER-BINDING PROTEIN AP-4; MYC PROTEIN; MYC PROTEIN, HUMAN; REPRESSOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 54449095611     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801773105     Document Type: Article
Times cited : (136)

References (48)
  • 1
    • 23144464363 scopus 로고    scopus 로고
    • Transcriptional regulation and transformation by Myc proteins
    • Adhikary S, Eilers M (2005) Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol 6:635-645.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 635-645
    • Adhikary, S.1    Eilers, M.2
  • 2
    • 0028910316 scopus 로고
    • Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1
    • Alexandrow MG, Kawabata M, Aakre M, Moses HL (1995) Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1. Proc Natl Acad Sci USA 92:3239-3243.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3239-3243
    • Alexandrow, M.G.1    Kawabata, M.2    Aakre, M.3    Moses, H.L.4
  • 3
    • 33748169434 scopus 로고    scopus 로고
    • The Oscar-worthy role of Myc in apoptosis
    • Meyer N, Kim SS, Penn LZ (2006) The Oscar-worthy role of Myc in apoptosis. Semin Cancer Biol 16:275-287.
    • (2006) Semin Cancer Biol , vol.16 , pp. 275-287
    • Meyer, N.1    Kim, S.S.2    Penn, L.Z.3
  • 4
    • 33748171960 scopus 로고    scopus 로고
    • The c-Myc target gene network
    • Dang CV, et al. (2006) The c-Myc target gene network. Semin Cancer Biol 16:253-264.
    • (2006) Semin Cancer Biol , vol.16 , pp. 253-264
    • Dang, C.V.1
  • 5
    • 0034612593 scopus 로고    scopus 로고
    • A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts
    • Berns K, Hijmans EM, Koh E, Daley GQ, Bernards R (2000) A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts. Oncogene 19:3330-3334.
    • (2000) Oncogene , vol.19 , pp. 3330-3334
    • Berns, K.1    Hijmans, E.M.2    Koh, E.3    Daley, G.Q.4    Bernards, R.5
  • 6
    • 0025052367 scopus 로고
    • Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity
    • Hu YF, Luscher B, Admon A, Mermod N, Tjian R (1990) Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Genes Dev 4:1741-1752.
    • (1990) Genes Dev , vol.4 , pp. 1741-1752
    • Hu, Y.F.1    Luscher, B.2    Admon, A.3    Mermod, N.4    Tjian, R.5
  • 7
    • 0023888953 scopus 로고
    • Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro
    • Mermod N, Williams TJ, Tjian R (1988) Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature 332:557-561.
    • (1988) Nature , vol.332 , pp. 557-561
    • Mermod, N.1    Williams, T.J.2    Tjian, R.3
  • 8
    • 33744952170 scopus 로고    scopus 로고
    • Transcriptional repression of human immunodeficiency virus type 1 by AP-4
    • Imai K, Okamoto T (2006) Transcriptional repression of human immunodeficiency virus type 1 by AP-4. J Biol Chem 281:12495-12505.
    • (2006) J Biol Chem , vol.281 , pp. 12495-12505
    • Imai, K.1    Okamoto, T.2
  • 9
    • 33748350491 scopus 로고    scopus 로고
    • A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells
    • Kim MY, et al. (2006) A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. Proc Natl Acad Sci USA 103:13074-13079.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 13074-13079
    • Kim, M.Y.1
  • 10
    • 23044465261 scopus 로고    scopus 로고
    • Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis
    • Tsujimoto K, et al. (2005) Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis. J Biol Chem 280:27638-27644.
    • (2005) J Biol Chem , vol.280 , pp. 27638-27644
    • Tsujimoto, K.1
  • 11
    • 0036568506 scopus 로고    scopus 로고
    • C-myc gene expression alone is sufficient to confer resistance to antiestrogen in human breast cancer cells
    • Venditti M, Iwasiow B, Orr FW, Shiu RP (2002) C-myc gene expression alone is sufficient to confer resistance to antiestrogen in human breast cancer cells. Int J Cancer 99:35-42.
    • (2002) Int J Cancer , vol.99 , pp. 35-42
    • Venditti, M.1    Iwasiow, B.2    Orr, F.W.3    Shiu, R.P.4
  • 12
    • 13544271667 scopus 로고    scopus 로고
    • ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line
    • Varshochi R, et al. (2005) ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. J Biol Chem 280:3185-3196.
    • (2005) J Biol Chem , vol.280 , pp. 3185-3196
    • Varshochi, R.1
  • 13
    • 0037461931 scopus 로고    scopus 로고
    • Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter
    • Wu S, et al. (2003) Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene 22:351-360.
    • (2003) Oncogene , vol.22 , pp. 351-360
    • Wu, S.1
  • 14
    • 0029097759 scopus 로고
    • Radiation-induced cell cycle arrest compromised by p21 deficiency
    • Brugarolas J, et al. (1995) Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377:552-557.
    • (1995) Nature , vol.377 , pp. 552-557
    • Brugarolas, J.1
  • 15
    • 0028978183 scopus 로고
    • Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • Deng C, Zhang P, Harper JW, Elledge SJ, Leder P (1995) Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82:675-684.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 16
    • 0030011128 scopus 로고    scopus 로고
    • Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
    • Waldman T, Lengauer C, Kinzler KW, Vogelstein B (1996) Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381:713-716.
    • (1996) Nature , vol.381 , pp. 713-716
    • Waldman, T.1    Lengauer, C.2    Kinzler, K.W.3    Vogelstein, B.4
  • 17
    • 20144379460 scopus 로고    scopus 로고
    • Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(WAF1/Cip1)
    • Pardali K, Kowanetz M, Heldin CH, Moustakas A (2005) Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(WAF1/Cip1). J Cell Physiol 204:260-272.
    • (2005) J Cell Physiol , vol.204 , pp. 260-272
    • Pardali, K.1    Kowanetz, M.2    Heldin, C.H.3    Moustakas, A.4
  • 18
    • 0023986586 scopus 로고
    • Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-myc oncogene
    • Larsson LG, et al. (1988) Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-myc oncogene. Proc Natl Acad Sci USA 85:2638-2642.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 2638-2642
    • Larsson, L.G.1
  • 19
    • 0023551951 scopus 로고
    • Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter
    • Andersen RD, et al. (1987) Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter. Mol Cell Biol 7:3574-3581.
    • (1987) Mol Cell Biol , vol.7 , pp. 3574-3581
    • Andersen, R.D.1
  • 20
    • 2942668475 scopus 로고    scopus 로고
    • Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
    • Sansom OJ, et al. (2004) Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev 18:1385-1390.
    • (2004) Genes Dev , vol.18 , pp. 1385-1390
    • Sansom, O.J.1
  • 21
    • 18644373146 scopus 로고    scopus 로고
    • The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • van de Wetering M, et al. (2002) The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111:241-250.
    • (2002) Cell , vol.111 , pp. 241-250
    • van de Wetering, M.1
  • 22
    • 0030057835 scopus 로고    scopus 로고
    • Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia
    • Polyak K, Hamilton SR, Vogelstein B, Kinzler KW (1996) Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia. Am J Pathol 149:381-387.
    • (1996) Am J Pathol , vol.149 , pp. 381-387
    • Polyak, K.1    Hamilton, S.R.2    Vogelstein, B.3    Kinzler, K.W.4
  • 23
    • 0029791681 scopus 로고    scopus 로고
    • p21/WAF1/CIP1 expression in normal mucosa and in adenomas and adenocarcinomas of the colon: Its relationship with differentiation
    • Doglioni C, et al. (1996) p21/WAF1/CIP1 expression in normal mucosa and in adenomas and adenocarcinomas of the colon: Its relationship with differentiation. J Pathol 179:248-253.
    • (1996) J Pathol , vol.179 , pp. 248-253
    • Doglioni, C.1
  • 24
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • He TC, et al. (1998) Identification of c-MYC as a target of the APC pathway. Science 281:1509-1512.
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1
  • 25
    • 34247187543 scopus 로고    scopus 로고
    • Myc deletion rescues Apc deficiency in the small intestine
    • Sansom OJ, et al. (2007) Myc deletion rescues Apc deficiency in the small intestine. Nature 446:676-679.
    • (2007) Nature , vol.446 , pp. 676-679
    • Sansom, O.J.1
  • 26
    • 0036606633 scopus 로고    scopus 로고
    • Mechanisms of growth arrest by c-myc antisense oligonucleotides in MCF-7 breast cancer cells: Implications for the antiproliferative effects of antiestrogens
    • Carroll JS, Swarbrick A, Musgrove EA, Sutherland RL (2002) Mechanisms of growth arrest by c-myc antisense oligonucleotides in MCF-7 breast cancer cells: implications for the antiproliferative effects of antiestrogens. Cancer Res 62:3126-3131.
    • (2002) Cancer Res , vol.62 , pp. 3126-3131
    • Carroll, J.S.1    Swarbrick, A.2    Musgrove, E.A.3    Sutherland, R.L.4
  • 27
    • 24044525270 scopus 로고    scopus 로고
    • c-Myc suppresses p21WAF1/CIP1 expression during estrogen signaling and antiestrogen resistance in human breast cancer cells
    • Mukherjee S, Conrad SE (2005) c-Myc suppresses p21WAF1/CIP1 expression during estrogen signaling and antiestrogen resistance in human breast cancer cells. J Biol Chem 280:17617-17625.
    • (2005) J Biol Chem , vol.280 , pp. 17617-17625
    • Mukherjee, S.1    Conrad, S.E.2
  • 28
    • 0028053873 scopus 로고
    • Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function
    • Ou SH, Garcia-Martinez LF, Paulssen EJ, Gaynor RB (1994) Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. J Virol 68:7188-7199.
    • (1994) J Virol , vol.68 , pp. 7188-7199
    • Ou, S.H.1    Garcia-Martinez, L.F.2    Paulssen, E.J.3    Gaynor, R.B.4
  • 29
    • 20144384882 scopus 로고    scopus 로고
    • Lost in transcription: P21 repression, mechanisms, and consequences
    • Gartel AL, Radhakrishnan SK (2005) Lost in transcription: p21 repression, mechanisms, and consequences. Cancer Res 65:3980-3985.
    • (2005) Cancer Res , vol.65 , pp. 3980-3985
    • Gartel, A.L.1    Radhakrishnan, S.K.2
  • 30
    • 18644371442 scopus 로고    scopus 로고
    • Negative regulation of the mammalian UV response by Myc through association with Miz-1
    • Herold S, et al. (2002) Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol Cell 10:509-521.
    • (2002) Mol Cell , vol.10 , pp. 509-521
    • Herold, S.1
  • 31
    • 0035836706 scopus 로고    scopus 로고
    • Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3
    • Gartel AL, et al. (2001) Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci USA 98:4510-4515.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4510-4515
    • Gartel, A.L.1
  • 32
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • Siegel PM, Massague J (2003) Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 3:807-821.
    • (2003) Nat Rev Cancer , vol.3 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2
  • 34
    • 0030978315 scopus 로고    scopus 로고
    • Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15
    • Iavarone A, Massague J (1997) Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15. Nature 387:417-422.
    • (1997) Nature , vol.387 , pp. 417-422
    • Iavarone, A.1    Massague, J.2
  • 35
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • Massague J, Blain SW, Lo RS (2000) TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103:295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 36
    • 33846833986 scopus 로고    scopus 로고
    • The morphogenetic code and colon cancer development
    • van den Brink GR, Offerhaus GJ (2007) The morphogenetic code and colon cancer development. Cancer Cell 11:109-117.
    • (2007) Cancer Cell , vol.11 , pp. 109-117
    • van den Brink, G.R.1    Offerhaus, G.J.2
  • 37
    • 0023819693 scopus 로고
    • Enforced expression of the c-myc oncogene inhibits cell differentiation by precluding entry into a distinct predifferentiation state in G0/G1
    • Freytag SO (1988) Enforced expression of the c-myc oncogene inhibits cell differentiation by precluding entry into a distinct predifferentiation state in G0/G1. Mol Cell Biol 8:1614-1624.
    • (1988) Mol Cell Biol , vol.8 , pp. 1614-1624
    • Freytag, S.O.1
  • 38
    • 0024586879 scopus 로고
    • Dynamic expression pattern of the myc protooncogene in midgestation mouse embryos
    • Schmid P, Schulz WA, Hameister H (1989) Dynamic expression pattern of the myc protooncogene in midgestation mouse embryos. Science 243:226-229.
    • (1989) Science , vol.243 , pp. 226-229
    • Schmid, P.1    Schulz, W.A.2    Hameister, H.3
  • 39
    • 0031788329 scopus 로고    scopus 로고
    • p21Cip1/WAF1 is important for differentiation and survival of U937 cells
    • Asada M, Yamada T, Fukumuro K, Mizutani S (1998) p21Cip1/WAF1 is important for differentiation and survival of U937 cells. Leukemia 12:1944-1950.
    • (1998) Leukemia , vol.12 , pp. 1944-1950
    • Asada, M.1    Yamada, T.2    Fukumuro, K.3    Mizutani, S.4
  • 40
    • 0033104495 scopus 로고    scopus 로고
    • Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation
    • Asada M, et al. (1999) Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J 18:1223-1234.
    • (1999) EMBO J , vol.18 , pp. 1223-1234
    • Asada, M.1
  • 41
    • 0029094329 scopus 로고
    • Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes
    • Steiner P, et al. (1995) Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J 14:4814-4826.
    • (1995) EMBO J , vol.14 , pp. 4814-4826
    • Steiner, P.1
  • 42
    • 0028866121 scopus 로고
    • Abrogation of p53-induced cell cycle arrest by c-Myc: Evidence for an inhibitor of p21WAF1/CIP1/SDI1
    • Hermeking H, Funk JO, Reichert M, Ellwart JW, Eick D (1995) Abrogation of p53-induced cell cycle arrest by c-Myc: Evidence for an inhibitor of p21WAF1/CIP1/SDI1. Oncogene 11:1409-1415.
    • (1995) Oncogene , vol.11 , pp. 1409-1415
    • Hermeking, H.1    Funk, J.O.2    Reichert, M.3    Ellwart, J.W.4    Eick, D.5
  • 43
    • 0029822745 scopus 로고    scopus 로고
    • Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc
    • Vlach J, Hennecke S, Alevizopoulos K, Conti D, Amati B (1996) Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO J 15:6595-6604.
    • (1996) EMBO J , vol.15 , pp. 6595-6604
    • Vlach, J.1    Hennecke, S.2    Alevizopoulos, K.3    Conti, D.4    Amati, B.5
  • 44
    • 0037126303 scopus 로고    scopus 로고
    • Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
    • Seoane J, Le HV, Massague J (2002) Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419:729-734.
    • (2002) Nature , vol.419 , pp. 729-734
    • Seoane, J.1    Le, H.V.2    Massague, J.3
  • 45
    • 34547462456 scopus 로고    scopus 로고
    • Induction of cullin 7 by DNA damage attenuates p53 function
    • Jung P, et al. (2007) Induction of cullin 7 by DNA damage attenuates p53 function. Proc Natl Acad Sci USA 104:11388-11393.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 11388-11393
    • Jung, P.1
  • 46
    • 34250868124 scopus 로고    scopus 로고
    • Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: MiR-34a is a p53 target that induces apoptosis and G1-arrest
    • Tarasov V, et al. (2007) Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 6:1586-1593.
    • (2007) Cell Cycle , vol.6 , pp. 1586-1593
    • Tarasov, V.1
  • 47
    • 33847013757 scopus 로고    scopus 로고
    • c-MYC Delays Prometaphase by Direct Transactivation of MAD2 and BubR1: Identification of Mechanisms Underlying c-MYC-Induced DNA Damage and Chromosomal Instability
    • Menssen A, et al. (2007) c-MYC Delays Prometaphase by Direct Transactivation of MAD2 and BubR1: Identification of Mechanisms Underlying c-MYC-Induced DNA Damage and Chromosomal Instability. Cell Cycle 6:339-352.
    • (2007) Cell Cycle , vol.6 , pp. 339-352
    • Menssen, A.1
  • 48
    • 12944281162 scopus 로고    scopus 로고
    • Identification of CDK4 as a target of c-MYC
    • Hermeking H, et al. (2000) Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci USA 97:2229-2234.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2229-2234
    • Hermeking, H.1


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