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Volumn 3, Issue 2, 2009, Pages 89-94

Connective tissue growth factor (CTGF, CCN2) gene regulation: A potent clinical bio-marker of fibroproliferative disease?

Author keywords

Biomarker; CCN2; CTGF; Fibrosis

Indexed keywords

ANGIOTENSIN II; BIOLOGICAL MARKER; CONNECTIVE TISSUE GROWTH FACTOR; ENDOTHELIN 1; GLUCOCORTICOID; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

EID: 73549104820     PISSN: 18739601     EISSN: 1873961X     Source Type: Journal    
DOI: 10.1007/s12079-009-0037-7     Document Type: Review
Times cited : (161)

References (57)
  • 1
    • 0034685936 scopus 로고    scopus 로고
    • Tumor necrosis factor α suppresses the induction of connective tissue growth factor by transforming growth factor-β in normal and scleroderma fibroblasts
    • DOI 10.1074/jbc.275.20.15220
    • DJ Abraham X Shiwen CM Black S Sa Y Xu A Leask 2000 Tumor necrosis factor α suppresses the induction of connective tissue growth factor by transforming growth factor-β in normal and scleroderma fibroblasts J Biol Chem 275 15220 15225 10809757 10.1074/jbc.275.20.15220 1:CAS:528: DC%2BD3cXjsFanu7g%3D (Pubitemid 30337246)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.20 , pp. 15220-15225
    • Abraham, D.J.1    Shiwen, X.2    Black, C.M.3    Sa, S.4    Xu, Y.5    Leask, A.6
  • 2
    • 0036775477 scopus 로고    scopus 로고
    • Gene regulation of connective tissue growth factor: New targets for antifibrotic therapy?
    • DOI 10.1016/S0945-053X(02)00055-0, PII S0945053X02000550
    • IE Blom R Goldschmeding A Leask 2002 Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol 21 473 482 12392758 10.1016/S0945-053X(02)00055-0 1:CAS:528:DC%2BD38XotVCntbo%3D (Pubitemid 35248272)
    • (2002) Matrix Biology , vol.21 , Issue.6 , pp. 473-482
    • Blom, I.E.1    Goldschmeding, R.2    Leask, A.3
  • 3
    • 0026055366 scopus 로고
    • Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early geneproduct CEF-10
    • 1654338 10.1083/jcb.114.6.1285 1:CAS:528:DyaK38Xhs1Knsb0%3D
    • DM Bradham A Igarashi RL Potter GR Grotendorst 1991 Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early geneproduct CEF-10 J Cell Biol 114 1285 1294 1654338 10.1083/jcb.114.6.1285 1:CAS:528:DyaK38Xhs1Knsb0%3D
    • (1991) J Cell Biol , vol.114 , pp. 1285-1294
    • Bradham, D.M.1    Igarashi, A.2    Potter, R.L.3    Grotendorst, G.R.4
  • 4
    • 0035890235 scopus 로고    scopus 로고
    • Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome
    • DOI 10.1006/excr.2001.5364
    • Y Chen P Segarini F Raoufi D Bradham A Leask 2001 Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome Exp Cell Res 271 109 117 11697887 10.1006/excr.2001.5364 1:CAS:528: DC%2BD3MXotVynsbk%3D (Pubitemid 33070998)
    • (2001) Experimental Cell Research , vol.271 , Issue.1 , pp. 109-117
    • Chen, Y.1    Segarini, P.2    Raoufi, F.3    Bradham, D.4    Leask, A.5
  • 5
    • 0036378148 scopus 로고    scopus 로고
    • CTGF expression in mesangial cells: Involvement of SMADs, MAP kinase, and PKC
    • 12234285 10.1111/j.1523-1755.2002.kid567.x 1:CAS:528:DC%2BD38XotVSntL0%3D
    • Y Chen IE Blom S Sa R Goldschmeding DJ Abraham A Leask 2002 CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC Kidney Int 62 1149 1159 12234285 10.1111/j.1523-1755.2002.kid567.x 1:CAS:528: DC%2BD38XotVSntL0%3D
    • (2002) Kidney Int , vol.62 , pp. 1149-1159
    • Chen, Y.1    Blom, I.E.2    Sa, S.3    Goldschmeding, R.4    Abraham, D.J.5    Leask, A.6
  • 6
    • 33646346588 scopus 로고    scopus 로고
    • Contribution of activin receptor-like kinase 5 (transforming growth factor β receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts
    • DOI 10.1002/art.21725
    • Y Chen X Shi-wen M Eastwood CM Black CP Denton A Leask DJ Abraham 2006 Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts Arthritis Rheum 54 1309 1316 16575856 10.1002/art.21725 1:CAS:528: DC%2BD28XksVyhtbg%3D (Pubitemid 43672944)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.4 , pp. 1309-1316
    • Chen, Y.1    Xu, S.-W.2    Eastwood, M.3    Black, C.M.4    Denton, C.P.5    Leask, A.6    Abraham, D.J.7
  • 7
    • 55849119491 scopus 로고    scopus 로고
    • The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts
    • 18600477 10.1007/s12079-007-0015-x
    • S Chen S McLean DE Carter A Leask 2007 The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts J Cell Commun Signal 1 175 183 18600477 10.1007/s12079-007-0015-x
    • (2007) J Cell Commun Signal , vol.1 , pp. 175-183
    • Chen, S.1    McLean, S.2    Carter, D.E.3    Leask, A.4
  • 9
    • 58149359860 scopus 로고    scopus 로고
    • Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing
    • 18563179 10.1038/jid.2008.171 1:CAS:528:DC%2BD1cXhsVymu7zF
    • CP Denton K Khan RK Hoyles X Shiwen P Leoni Y Chen M Eastwood DJ Abraham 2009 Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing J Invest Dermatol 129 194 204 18563179 10.1038/jid.2008.171 1:CAS:528:DC%2BD1cXhsVymu7zF
    • (2009) J Invest Dermatol , vol.129 , pp. 194-204
    • Denton, C.P.1    Khan, K.2    Hoyles, R.K.3    Shiwen, X.4    Leoni, P.5    Chen, Y.6    Eastwood, M.7    Abraham, D.J.8
  • 12
    • 0041322515 scopus 로고    scopus 로고
    • Urinary connective tissue growth factor excretion in patients with type 1 diabetes and nephropathy
    • DOI 10.2337/diacare.26.9.2632
    • RE Gilbert A Akdeniz S Weitz WR Usinger C Molineaux SE Jones RG Langham G Jerums 2003 Urinary connective tissue growth factor excretion in patients with type 1 diabetes and nephropathy Diabetes Care 26 2632 2636 12941731 10.2337/diacare.26.9.2632 1:CAS:528:DC%2BD3sXns1Gqu7k%3D (Pubitemid 37052112)
    • (2003) Diabetes Care , vol.26 , Issue.9 , pp. 2632-2636
    • Gilbert, R.E.1    Akdeniz, A.2    Weitz, S.3    Usinger, W.R.4    Molineaux, C.5    Jones, S.E.6    Langham, R.G.7    Jerums, G.8
  • 13
    • 33748308746 scopus 로고    scopus 로고
    • Connective tissue growth factor in serum as a new candidate test for assessment of hepatic fibrosis
    • DOI 10.1373/clinchem.2006.070466
    • AM Gressner E Yagmur B Lahme O Gressner S Stanzel 2006 Connective tissue growth factor in serum as a new candidate test for assessment of hepatic fibrosis Clin Chem 52 1815 1817 16858074 10.1373/clinchem.2006.070466 1:CAS:528:DC%2BD28Xpt1WitL8%3D (Pubitemid 44330719)
    • (2006) Clinical Chemistry , vol.52 , Issue.9 , pp. 1815-1817
    • Gressner, A.M.1    Yagmur, E.2    Lahme, B.3    Gressner, O.4    Stanzel, S.5
  • 14
    • 53249092406 scopus 로고    scopus 로고
    • Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways
    • epub
    • Gressner OA, Lahme B, Rehbein K, Siluschek M, Weiskirchen R, Gressner AM. (2008) Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. J Hepatol. epub
    • (2008) J Hepatol
    • Gressner, O.A.1    Lahme, B.2    Rehbein, K.3    Siluschek, M.4    Weiskirchen, R.5    Gressner, A.M.6
  • 15
    • 0031225015 scopus 로고    scopus 로고
    • Connective tissue growth factor: A mediator of TGf-β action on fibroblasts
    • DOI 10.1016/S1359-6101(97)00010-5, PII S1359610197000105
    • GR Grotendorst 1997 Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts Cytokine Growth Factor Rev 8 171 179 9462483 10.1016/S1359-6101(97)00010-5 1:CAS:528:DyaK1cXjsVWmsA%3D%3D (Pubitemid 28077925)
    • (1997) Cytokine and Growth Factor Reviews , vol.8 , Issue.3 , pp. 171-179
    • Grotendorst, G.R.1
  • 16
    • 0029808645 scopus 로고    scopus 로고
    • A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene
    • 9052988 1:CAS:528:DyaK28XitFegt7k%3D
    • GR Grotendorst H Okochi N Hayashi 1996 A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene Cell Growth Differ 7 469 480 9052988 1:CAS:528:DyaK28XitFegt7k%3D
    • (1996) Cell Growth Differ , vol.7 , pp. 469-480
    • Grotendorst, G.R.1    Okochi, H.2    Hayashi, N.3
  • 18
    • 0036330215 scopus 로고    scopus 로고
    • Novel growth factors involved in the pathogenesis of proliferative vitreoretinopathy
    • DOI 10.1038/sj.eye.6700190
    • DR Hinton S He ML Jin E Barron SJ Ryan 2002 Novel growth factors involved in the pathogenesis of proliferative vitreoretinopathy Eye 16 422 428 12101449 10.1038/sj.eye.6700190 1:STN:280:DC%2BD38vhtFKqtQ%3D%3D (Pubitemid 34845970)
    • (2002) Eye , vol.16 , Issue.4 , pp. 422-428
    • Hinton, D.R.1    He, S.2    Jin, M.L.3    Barron, E.4    Ryan, S.J.5
  • 19
    • 0035815683 scopus 로고    scopus 로고
    • CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling
    • DOI 10.1074/jbc.M010149200
    • A Holmes DJ Abraham S Sa X Shiwen CM Black A Leask 2001 CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling J Biol Chem 276 10594 10601 11152469 10.1074/jbc.M010149200 1:CAS:528: DC%2BD3MXjvFCqtrs%3D (Pubitemid 38089227)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.14 , pp. 10594-10601
    • Holmes, A.1    Abraham, D.J.2    Sa, S.3    Shiwen, X.4    Black, C.M.5    Leask, A.6
  • 20
    • 0142211305 scopus 로고    scopus 로고
    • Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1
    • DOI 10.1074/jbc.M305019200
    • A Holmes DJ Abraham Y Chen C Denton X Shi-wen CM Black A Leask 2003 Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1 J Biol Chem 278 41728 41733 12888575 10.1074/jbc.M305019200 1:CAS:528:DC%2BD3sXot1ams7c%3D (Pubitemid 37310431)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.43 , pp. 41728-41733
    • Holmes, A.1    Abraham, D.J.2    Chen, Y.3    Denton, C.4    Shi-Wen, X.5    Black, C.M.6    Leask, A.7
  • 21
    • 73549110023 scopus 로고    scopus 로고
    • The 5′ untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity
    • 18481207 10.1007/s12079-007-0003-1
    • BL Huang LM Dornbach KM Lyons 2007 The 5′ untranslated regions (UTRs) of CCN1, CCN2, and CCN4 exhibit cryptic promoter activity J Cell Commun Signal 1 17 32 18481207 10.1007/s12079-007-0003-1
    • (2007) J Cell Commun Signal , vol.1 , pp. 17-32
    • Huang, B.L.1    Dornbach, L.M.2    Lyons, K.M.3
  • 22
    • 0027229995 scopus 로고
    • Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair
    • 8374172 1:CAS:528:DyaK3sXmtVWjtrY%3D
    • A Igarashi H Okochi DM Bradham GR Grotendorst 1993 Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair Mol Biol Cell 4 637 645 8374172 1:CAS:528:DyaK3sXmtVWjtrY%3D
    • (1993) Mol Biol Cell , vol.4 , pp. 637-645
    • Igarashi, A.1    Okochi, H.2    Bradham, D.M.3    Grotendorst, G.R.4
  • 23
    • 0031959237 scopus 로고    scopus 로고
    • Expression of connective tissue growth factor in human renal fibrosis
    • DOI 10.1111/j.1523-1755.1998.00820.x
    • Y Ito J Aten RJ Bende BS Oemar TJ Rabelink JJ Weening R Goldschmeding 1998 Expression of connective tissue growth factor in human renal fibrosis Kidney Int 53 853 861 9551391 10.1111/j.1523-1755.1998.00820.x 1:CAS:528:DyaK1cXisVKmsbs%3D (Pubitemid 28155657)
    • (1998) Kidney International , vol.53 , Issue.4 , pp. 853-861
    • Ito, Y.1    Aten, J.2    Bende, R.J.3    Oemar, B.S.4    Rabelink, T.J.5    Weening, J.J.6    Goldschmeding, R.7
  • 24
    • 0035127214 scopus 로고    scopus 로고
    • Kinetics of connective tissue growth factor expression during experimental proliferative glomerulonephritis
    • 11181795 1:CAS:528:DC%2BD3MXitV2ksbY%3D
    • Y Ito R Goldschmeding R Bende N Claessen M Chand L Kleij T Rabelink J Weening J Aten 2001 Kinetics of connective tissue growth factor expression during experimental proliferative glomerulonephritis J Am Soc Nephrol 12 472 484 11181795 1:CAS:528:DC%2BD3MXitV2ksbY%3D
    • (2001) J Am Soc Nephrol , vol.12 , pp. 472-484
    • Ito, Y.1    Goldschmeding, R.2    Bende, R.3    Claessen, N.4    Chand, M.5    Kleij, L.6    Rabelink, T.7    Weening, J.8    Aten, J.9
  • 30
    • 33244456090 scopus 로고    scopus 로고
    • Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3′-untranslated region interacting with a cellular protein in human chondrosarcoma cells
    • DOI 10.1038/sj.onc.1209129, PII 1209129
    • S Kondo S Kubota Y Mukudai N Moritani T Nishida H Matsushita S Matsumoto T Sugahara M Takigawa 2006 Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3′ -untranslated region interacting with a cellular protein in human chondrosarcoma cells Oncogene 16 1099 1110 10.1038/sj.onc.1209129 (Pubitemid 43277017)
    • (2006) Oncogene , vol.25 , Issue.7 , pp. 1099-1110
    • Kondo, S.1    Kubota, S.2    Mukudai, Y.3    Moritani, N.4    Nishida, T.5    Matsushita, H.6    Matsumoto, S.7    Sugahara, T.8    Takigawa, M.9
  • 31
    • 0034726967 scopus 로고    scopus 로고
    • Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/ hypertrophic chondrocyte specific 24 (ctgf/hcs24)gene: Similarities to retroviral RNA-protein interactions
    • 11032028 10.1038/sj.onc.1203835 1:CAS:528:DC%2BD3cXns1ehs7s%3D
    • S Kubota S Kondo T Eguchi T Hattori T Nakanishi RJ Pomerantz M Takigawa 2000 Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/ hypertrophic chondrocyte specific 24 (ctgf/hcs24)gene: similarities to retroviral RNA-protein interactions Oncogene 19 4773 4786 11032028 10.1038/sj.onc.1203835 1:CAS:528: DC%2BD3cXns1ehs7s%3D
    • (2000) Oncogene , vol.19 , pp. 4773-4786
    • Kubota, S.1    Kondo, S.2    Eguchi, T.3    Hattori, T.4    Nakanishi, T.5    Pomerantz, R.J.6    Takigawa, M.7
  • 33
    • 47549110604 scopus 로고    scopus 로고
    • The Starbuck stops here: It's a Smad world
    • epub
    • Leask A (2008) The Starbuck stops here: it's a Smad world. J Cell Commun Signal. epub
    • (2008) J Cell Commun Signal
    • Leask, A.1
  • 34
    • 33845906843 scopus 로고    scopus 로고
    • All in the CCN family: Essential matricellular signaling modulators emerge from the bunker
    • DOI 10.1242/jcs.03270
    • A Leask DJ Abraham 2006 All in the CCN family: essential matricellular signaling modulators emerge from the bunker J Cell Sci 119 4803 4810 17130294 10.1242/jcs.03270 1:CAS:528:DC%2BD2sXivFejsw%3D%3D (Pubitemid 46017793)
    • (2006) Journal of Cell Science , vol.119 , Issue.23 , pp. 4803-4810
    • Leask, A.1    Abraham, D.J.2
  • 36
    • 0038644847 scopus 로고    scopus 로고
    • Connective tissue growth factor gene regulation: Requirements for its induction by transforming growth factor-β2 in fibroblasts
    • DOI 10.1074/jbc.M210366200
    • A Leask A Holmes CM Black DJ Abraham 2003 Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts J Biol Chem 278 13008 13015 12571253 10.1074/jbc.M210366200 1:CAS:528:DC%2BD3sXislGrt7k%3D (Pubitemid 36800068)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.15 , pp. 13008-13015
    • Leask, A.1    Holmes, A.2    Black, C.M.3    Abraham, D.J.4
  • 37
    • 1642452822 scopus 로고    scopus 로고
    • Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma
    • DOI 10.1046/j.0022-202X.2003.22133.x
    • A Leask CP Denton DJ Abraham 2004 Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma J Invest Dermatol 122 1 6 14962082 10.1046/j.0022-202X.2003.22133.x 1:CAS:528:DC%2BD2cXmsFCmtg%3D%3D (Pubitemid 38114631)
    • (2004) Journal of Investigative Dermatology , vol.122 , Issue.1 , pp. 1-6
    • Leask, A.1    Denton, C.P.2    Abraham, D.J.3
  • 38
    • 54949124162 scopus 로고    scopus 로고
    • Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells
    • epub
    • Leask, A., Chen, S., Pala D, Brigstock, DR. (2008) Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells. J Cell Commun Signal, epub
    • (2008) J Cell Commun Signal
    • Leask, A.1    Chen, S.2    Pala, D.3    Brigstock, D.R.4
  • 39
    • 19944427451 scopus 로고    scopus 로고
    • Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells
    • DOI 10.1074/jbc.M407810200
    • Q Luo Q Kang W Si W Jiang JK Park Y Peng X Li HH Luu J Luo AG Montag RC Haydon TC He 2004 Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells J Biol Chem 279 55958 55968 15496414 10.1074/jbc. M407810200 1:CAS:528:DC%2BD2cXhtFeisL%2FJ (Pubitemid 40066603)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.53 , pp. 55958-55968
    • Luo, Q.1    Kang, Q.2    Si, W.3    Jiang, W.4    Park, J.K.5    Peng, Y.6    Li, X.7    Luu, H.H.8    Luo, J.9    Montag, A.G.10    Haydon, R.C.11    He, T.-C.12
  • 40
    • 33644875787 scopus 로고    scopus 로고
    • Urinary connective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathy
    • 16373901 10.2337/diacare.29.01.06.dc05-1670 1:CAS:528: DC%2BD28Xps1Wqtg%3D%3D
    • TQ Nguyen L Tarnow S Andersen P Hovind HH Parving R Goldschmeding FA vanNieuwenhoven 2006 Urinary connective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathy Diabetes Care 29 83 88 16373901 10.2337/diacare.29.01.06.dc05-1670 1:CAS:528:DC%2BD28Xps1Wqtg%3D%3D
    • (2006) Diabetes Care , vol.29 , pp. 83-88
    • Nguyen, T.Q.1    Tarnow, L.2    Andersen, S.3    Hovind, P.4    Parving, H.H.5    Goldschmeding, R.6    Vannieuwenhoven, F.A.7
  • 42
    • 21344470149 scopus 로고    scopus 로고
    • TGF-β1-induced connective tissue growth factor (CCN2) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signalling
    • DOI 10.1159/000085445
    • MK Phanish NA Wahab BM Hendry ME Dockrell 2005 TGF-beta1-induced connective tissue growth factor (CCN2) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signalling Nephron, Exp Nephrol 100 e156 e165 10.1159/000085445 (Pubitemid 40910994)
    • (2005) Nephron - Experimental Nephrology , vol.100 , Issue.4
    • Phanish, M.K.1    Wahab, N.A.2    Hendry, B.M.3    Dockrell, M.E.C.4
  • 43
    • 54949125004 scopus 로고    scopus 로고
    • Analysis of CCN2 promoter activity in PANC-1 cells: Regulation by ras/MEK/ERK
    • 18481199 10.1007/s12079-007-0008-9
    • M Pickles A Leask 2007 Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK J Cell Commun Signal 1 2 85 90 18481199 10.1007/s12079-007-0008-9
    • (2007) J Cell Commun Signal , vol.1 , Issue.2 , pp. 85-90
    • Pickles, M.1    Leask, A.2
  • 44
    • 34248203088 scopus 로고    scopus 로고
    • The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1
    • DOI 10.1111/j.1440-1797.2007.00788.x
    • W Qi X Chen S Twigg Y Zhang RE Gilbert DJ Kelly CA Pollock 2007 The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1 Nephrology 12 267 274 17498122 10.1111/j.1440-1797.2007.00788.x 1:CAS:528:DC%2BD2sXntVynu78%3D (Pubitemid 46718206)
    • (2007) Nephrology , vol.12 , Issue.3 , pp. 267-274
    • Qi, W.1    Chen, X.2    Twigg, S.3    Zhang, Y.4    Gilbert, R.E.5    Kelly, D.J.6    Pollock, C.A.7
  • 45
    • 0033387824 scopus 로고    scopus 로고
    • Regulation of connective tissue growth factor expression by prostaglandin E(2)
    • 10600887 1:CAS:528:DC%2BD3cXhs1yntQ%3D%3D
    • DA Ricupero DC Rishikof PP Kuang CF Poliks RH Goldstein 1999 Regulation of connective tissue growth factor expression by prostaglandin E(2) Am J Physiol 277 L1165 L1171 10600887 1:CAS:528:DC%2BD3cXhs1yntQ%3D%3D
    • (1999) Am J Physiol , vol.277
    • Ricupero, D.A.1    Rishikof, D.C.2    Kuang, P.P.3    Poliks, C.F.4    Goldstein, R.H.5
  • 47
    • 0033978653 scopus 로고    scopus 로고
    • Serum levels of connective tissue growth factor are elevated in patients withsystemic sclerosis: Association with extent of skin sclerosis and severity of pulmonary fibrosis
    • S Sato T Nagaoka M Hasegawa T Tamatani T Nakanishi M Takigawa K Takehara 2000 Serum levels of connective tissue growth factor are elevated in patients withsystemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis J Rheumatol 7 149 154
    • (2000) J Rheumatol , vol.7 , pp. 149-154
    • Sato, S.1    Nagaoka, T.2    Hasegawa, M.3    Tamatani, T.4    Nakanishi, T.5    Takigawa, M.6    Takehara, K.7
  • 52
    • 0036883881 scopus 로고    scopus 로고
    • Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway
    • 12368229 1:CAS:528:DC%2BD38Xps1KqurY%3D
    • R Stratton V Rajkumar M Ponticos B Nichols X Shiwen CM Black DJ Abraham A Leask 2002 Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway FASEB J 16 1949 1951 12368229 1:CAS:528:DC%2BD38Xps1KqurY%3D
    • (2002) FASEB J , vol.16 , pp. 1949-1951
    • Stratton, R.1    Rajkumar, V.2    Ponticos, M.3    Nichols, B.4    Shiwen, X.5    Black, C.M.6    Abraham, D.J.7    Leask, A.8
  • 53
    • 0034953832 scopus 로고    scopus 로고
    • Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients
    • 11457877 1:CAS:528:DC%2BD3MXlt1Kltr4%3D
    • R Stratton X Shiwen G Martini A Holmes A Leask T Haberberger GR Martin CM Black D Abraham 2001 Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients J Clin Invest 108 241 250 11457877 1:CAS:528:DC%2BD3MXlt1Kltr4%3D
    • (2001) J Clin Invest , vol.108 , pp. 241-250
    • Stratton, R.1    Shiwen, X.2    Martini, G.3    Holmes, A.4    Leask, A.5    Haberberger, T.6    Martin, G.R.7    Black, C.M.8    Abraham, D.9
  • 54
    • 0032578774 scopus 로고    scopus 로고
    • Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia
    • DOI 10.1006/bbrc.1998.9543
    • T Tamatani H Kobayashi K Tezuka S Sakamoto K Suzuki T Nakanishi M Takigawa T Miyano 1998 Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia Biochem Biophys Res Commun 251 748 752 9790981 10.1006/bbrc.1998.9543 1:CAS:528:DyaK1cXntlaisb4%3D (Pubitemid 28512782)
    • (1998) Biochemical and Biophysical Research Communications , vol.251 , Issue.3 , pp. 748-752
    • Tamatani, T.1    Kobayashi, H.2    Tezuka, K.3    Sakamoto, S.4    Suzuki, K.5    Nakanishi, T.6    Takigawa, M.7    Miyano, T.8
  • 55
    • 45849122111 scopus 로고    scopus 로고
    • Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: Possible predictive marker for incipient diabetic nephropathy
    • DOI 10.1016/j.jdiacomp.2007.07.001, PII S1056872707000906
    • SE Thomson SV McLennan PD Kirwan SJ Heffernan A Hennessy DK Yue SM Twigg 2008 Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy J Diabetes Complications 22 284 294 18413184 10.1016/j.jdiacomp.2007.07.001 (Pubitemid 351885491)
    • (2008) Journal of Diabetes and its Complications , vol.22 , Issue.4 , pp. 284-294
    • Thomson, S.E.1    McLennan, S.V.2    Kirwan, P.D.3    Heffernan, S.J.4    Hennessy, A.5    Yue, D.K.6    Twigg, S.M.7
  • 57
    • 45149109688 scopus 로고    scopus 로고
    • 2 production in scleroderma fibroblasts
    • DOI 10.1111/j.1365-2230.2008.02727.x
    • R Xiao T Kanekura N Yoshida Y Higashi KL Yan T Fukushige T Kanzaki 2008 9-Cis-retinoic acid exhibits antifibrotic activity via the induction of cyclooxygenase-2 expression and prostaglandin E2 production in scleroderma fibroblasts Clin Exp Dermatol 33 484 490 18462443 10.1111/j.1365-2230.2008. 02727.x 1:STN:280:DC%2BD1cvht1Wjuw%3D%3D (Pubitemid 351832143)
    • (2008) Clinical and Experimental Dermatology , vol.33 , Issue.4 , pp. 484-490
    • Xiao, R.1    Kanekura, T.2    Yoshida, N.3    Higashi, Y.4    Yan, K.-L.5    Fukushige, T.6    Kanzaki, T.7


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