The matricellular functions of small leucine-rich proteoglycans (SLRPs)

Journal of Cell Communication and Signaling

Volumn 3, Issue 3-4, 2009, Pages 323-335

  Merline, Rosetta ^a   Schaefer, Roland M ^b   Schaefer, Liliana ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Biglycan; Decorin; Fibrosis; Inflammation; Innate immunity; Lumican

Indexed keywords

BIGLYCAN; BONE MORPHOGENETIC PROTEIN; COLLAGEN; COMPLEMENT COMPONENT C1Q; DECORIN; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROMODULIN; GLYCOSAMINOGLYCAN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LUMICAN; PROTEOGLYCAN; SCATTER FACTOR RECEPTOR; SMALL LEUCINE RICH PROTEOGLYCAN DERIVATIVE; SOMATOMEDIN RECEPTOR; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WNT1 INDUCED SECRETED PROTEIN 1; WNT1 PROTEIN;

APOPTOSIS; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; EXTRACELLULAR MATRIX; FIBROGENESIS; FIBROSIS; INFLAMMATION; INNATE IMMUNITY; METASTASIS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TUMOR GROWTH;

EID: 72449146700     PISSN: 18739601     EISSN: 1873961X     Source Type: Journal    
DOI: 10.1007/s12079-009-0066-2     Document Type: Review

References (150)

1. N Abdel-Wahab SJ Wicks RM Mason A Chantry 2002 Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240 Biochem J 362 643 649 11879191
2. A Al Haj Zen G Caligiuri J Sainz M Lemitre C Demerens A Lafont 2006 Decorin overexpression reduces atherosclerosis development in apolipoprotein E-deficient mice Atherosclerosis 187 31 39 16183063
3. L Ameye D Aria K Jepsen A Oldberg T Xu MF Young 2002 Abnormal collagen fibrils in tendons of biglycan/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis FASEB J 16 673 680 11978731
4. A Babelova K Moreth W Tsalastra-Greul J Zeng-Brouwers O Eickelberg MF Young P Bruckner J Pfeilschifter RM Schaefer HJ Groene L Schaefer 2009 Biglycan: A danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors J Biol Chem 284 24035 24048 19605353
5. Y Bi CH Stuelten T Kilts S Wadhwa RV Iozzo PG Robey XD Chen MF Young 2005 Extracellular matrix proteoglycans control the fate of bone marrow stromal cells J Biol Chem 280 30481 30489 15964849
6. Y Bi D Ehirchiou TM Kilts CA Inkson MC Embree W Sonoyama L Li AI Leet BM Seo L Zhang S Shi MF Young 2007 Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche Nat Med 13 1219 1227 17828274
7. X Bi C Tong A Dockendorff L Bancroft L Gallagher G Guzman RV Iozzo LH Augenlicht W Yang 2008 Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation Carcinogenesis 29 1435 1440 18550571
8. DJ Bidanset C Guidry LC Rosenberg HU Choi R Timpl M Hook 1992 Binding of the proteoglycan decorin to collagen type VI J Biol Chem 267 5250 5256 1544908
9. WA Border NA Noble T Yamamoto JR Harper Y Yamaguchi MD Pierschbacher E Ruoslahti 1992 Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease Nature 360 361 364 1280332
10. E Brandan C Retamal C Cabello-Verrugio MP Marzolo 2006 The low density lipoprotein receptor-related protein functions as an endocytic receptor for decorin J Biol Chem 281 31562 31571 16936287
11. E Brandan C Cabello-Verrugio C Vial 2008 Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy Matrix Biol 27 700 708 18694824
12. S Brezillon L Venteo L Ramont MF D'Onofrio C Perreau M Pluot FX Maquart Y Wegrowski 2007 Expression of lumican, a small leucine-rich proteoglycan with antitumour activity, in human malignant melanoma Clin Exp Dermatol 32 405 416 17490399
13. EC Carlson M Lin CY Liu WW Kao VL Perez E Pearlman 2007 Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1 J Biol Chem 282 35502 35509 17911102
14. S Chakravarti T Magnuson JH Lass KJ Jepsen C LaMantia H Carroll 1998 Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican J Cell Biol 141 1277 1286 9606218
15. S Chakravarti WM Petroll JR Hassell JV Jester JH Lass J Paul DE Birk 2000 Corneal opacity in lumican-null mice: defects in collagen fibril structure and packing in the posterior stroma Invest Ophthalmol Vis Sci 41 3365 3373 11006226
16. XD Chen S Shi T Xu PG Robey MF Young 2002 Age-related osteoporosis in biglycan-deficient mice is related to defects in bone marrow stromal cells J Bone Miner Res 17 331 340 11811564
17. XD Chen LW Fisher PG Robey MF Young 2004 The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiation FASEB J 18 948 958 15173106
18. M Comalada M Cardo J Xaus AF Valledor J Lloberas F Ventura A Celada 2003 Decorin reverses the repressive effect of autocrine-produced TGF-beta on mouse macrophage activation J Immunol 170 4450 4456 12707320
19. A Corsi T Xu XD Chen A Boyde J Liang M Mankani B Sommer RV Iozzo I Eichstetter PG Robey P Bianco MF Young 2002 Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues J Bone Miner Res 17 1180 1189 12102052
20. G Csordas M Santra CC Reed I Eichstetter DJ McQuillan D Gross MA Nugent G Hajnoczky RV Iozzo 2000 Sustained down-regulation of the epidermal growth factor receptor by decorin A mechanism for controlling tumor growth in vivo. J Biol Chem 275 32879 32887
21. KG Danielson H Baribault DF Holmes H Graham KE Kadler RV Iozzo 1997 Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility J Cell Biol 136 729 743 9024701
22. A De Luca M Santra A Baldi A Giordano RV Iozzo 1996 Decorin-induced growth suppression is associated with up-regulation of p21, an inhibitor of cyclin-dependent kinases J Biol Chem 271 18961 18965 8702560
23. L Desnoyers D Arnott D Pennica 2001 WISP-1 binds to decorin and biglycan J Biol Chem 276 47599 47607 11598131
24. T Douglas S Heinemann S Bierbaum D Scharnweber H Worch 2006 Fibrillogenesis of collagen types I, II, and III with small leucine-rich proteoglycans decorin and biglycan Biomacromolecules 7 2388 2393 16903686
25. T Ehnis W Dieterich M Bauer H Kresse D Schuppan 1997 Localization of a binding site for the proteoglycan decorin on collagen XIV (undulin) J Biol Chem 272 20414 20419 9252349
26. F Elefteriou JY Exposito R Garrone C Lethias 2001 Binding of tenascin-X to decorin FEBS Lett 495 44 47 11322944
27. Y Ezura S Chakravarti A Oldberg I Chervoneva DE Birk 2000 Differential expression of lumican and fibromodulin regulate collagen fibrillogenesis in developing mouse tendons J Cell Biol 151 779 788 11076963
28. LR Fiedler E Schonherr R Waddington S Niland DG Seidler D Aeschlimann JA Eble 2008 Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity J Biol Chem 283 17406 17415 18413316
29. JW Fischer MG Kinsella B Levkau AW Clowes TN Wight 2001 Retroviral overexpression of decorin differentially affects the response of arterial smooth muscle cells to growth factors Arterioscler Thromb Vasc Biol 21 777 784 11348874
30. B Font D Eichenberger D Goldschmidt MM Boutillon DJ Hulmes 1998 Structural requirements for fibromodulin binding to collagen and the control of type I collagen fibrillogenesis-critical roles for disulphide bonding and the C-terminal region Eur J Biochem 254 580 587 9688269
31. N Fukui A Fukuda K Kojima K Nakajima H Oda K Nakamura 2001 Suppression of fibrous adhesion by proteoglycan decorin J Orthop Res 19 456 462 11398860
32. JL Funderburgh RR Mitschler ML Funderburgh MR Roth SK Chapes GW Conrad 1997 Macrophage receptors for lumican. A corneal keratan sulfate proteoglycan Invest Ophthalmol Vis Sci 38 1159 1167 9152235
33. A Fust F LeBellego RV Iozzo PJ Roughley MS Ludwig 2005 Alterations in lung mechanics in decorin-deficient mice Am J Physiol Lung Cell Mol Physiol 288 L159 166 15447936
34. NS Gandhi RL Mancera 2008 The structure of glycosaminoglycans and their interactions with proteins Chem Biol Drug Des 72 455 482 19090915
35. Y Geng D McQuillan PJ Roughley 2006 SLRP interaction can protect collagen fibrils from cleavage by collagenases Matrix Biol 25 484 491 16979885
36. S Goldoni RV Iozzo 2008 Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs Int J Cancer 123 2473 2479 18798267
37. Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV (2009) Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol jcb.200901129
38. S Grisanti P Szurman M Warga R Kaczmarek F Ziemssen O Tatar KU Bartz-Schmidt 2005 Decorin modulates wound healing in experimental glaucoma filtration surgery: a pilot study Invest Ophthalmol Vis Sci 46 191 196 15623773
39. J Gu Y Wada 1996 Effect of exogenous decorin on cell morphology and attachment of decorin-deficient fibroblasts J Biochem 119 743 748 8743578
40. G Guidetti A Bertoni M Viola E Tira C Balduini M Torti 2002 The small proteoglycan decorin supports adhesion and activation of human platelets Blood 100 1707 1714 12176891
41. GF Guidetti B Bartolini B Bernardi ME Tira MC Berndt C Balduini M Torti 2004 Binding of von Willebrand factor to the small proteoglycan decorin FEBS Lett 574 95 100 15358546
42. H Hausser A Groning A Hasilik E Schonherr H Kresse 1994 Selective inactivity of TGF-beta/decorin complexes FEBS Lett 353 243 245 7957866
43. AM Heegaard A Corsi CC Danielsen KL Nielsen HL Jorgensen M Riminucci MF Young P Bianco 2007 Biglycan deficiency causes spontaneous aortic dissection and rupture in mice Circulation 115 2731 2738 17502576
44. Hewitson TD (2009) Renal Tubulointerstitial Fibrosis: Common but Never Simple. Am J Physiol Renal Physiol
45. A Hildebrand M Romaris LM Rasmussen D Heinegard DR Twardzik WA Border E Ruoslahti 1994 Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta Biochem J 302 Pt 2 527 534 8093006
46. AM Hocking T Shinomura DJ McQuillan 1998 Leucine-rich repeat glycoproteins of the extracellular matrix Matrix Biol 17 1 19 9628249
47. W Huijun C Long Z Zhigang J Feng G Muyi 2005 Ex vivo transfer of the decorin gene into rat glomerulus via a mesangial cell vector suppressed extracellular matrix accumulation in experimental glomerulonephritis Exp Mol Pathol 78 17 24 15596056
48. N Hunzelmann S Anders S Sollberg E Schonherr T Krieg 1996 Co-ordinate induction of collagen type I and biglycan expression in keloids Br J Dermatol 135 394 399 8949432
49. J Huxley-Jones DL Robertson RP Boot-Handford 2007 On the origins of the extracellular matrix in vertebrates Matrix Biol 26 2 11 17055232
50. JY Hwang PY Johnson KR Braun A Hinek JW Fischer KD O'Brien B Starcher AW Clowes MJ Merrilees TN Wight 2008 Retrovirally mediated overexpression of glycosaminoglycan-deficient biglycan in arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation in vitro and in neointimae after vascular injury Am J Pathol 173 1919 1928 18988796
51. D Iacob J Cai M Tsonis A Babwah C Chakraborty RN Bhattacharjee PK Lala 2008 Decorin-mediated inhibition of proliferation and migration of the human trophoblast via different tyrosine kinase receptors Endocrinology 149 6187 6197 18703624
52. S Ikegawa 2008 Expression, regulation and function of asporin, a susceptibility gene in common bone and joint diseases Curr Med Chem 15 724 728 18336287
53. CA Inkson M Ono Y Bi SA Kuznetsov LW Fisher MF Young 2009 The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells Cells Tissues Organs 189 153 157 18701807
54. RV Iozzo 1997 The family of the small leucine-rich proteoglycans: key regulators of matrix assembly and cellular growth Crit Rev Biochem Mol Biol 32 141 174 9145286
55. RV Iozzo 1998 Matrix proteoglycans: from molecular design to cellular function Annu Rev Biochem 67 609 652 9759499
56. RV Iozzo 1999 The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins J Biol Chem 274 18843 18846 10383378
57. RV Iozzo DK Moscatello DJ McQuillan I Eichstetter 1999 Decorin is a biological ligand for the epidermal growth factor receptor J Biol Chem 274 4489 4492 9988678
58. Y Isaka DK Brees K Ikegaya Y Kaneda E Imai NA Noble WA Border 1996 Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney Nat Med 2 418 423 8597951
59. S Kalamajski A Oldberg 2009 Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding J Biol Chem 284 534 539 19008226
60. DR Keene JD San Antonio R Mayne DJ McQuillan G Sarris SA Santoro RV Iozzo 2000 Decorin binds near the C terminus of type I collagen J Biol Chem 275 21801 21804 10823816
61. CM Kielty SP Whittaker CA Shuttleworth 1996 Fibrillin: evidence that chondroitin sulphate proteoglycans are components of microfibrils and associate with newly synthesised monomers FEBS Lett 386 169 173 8647274
62. CM Kielty MJ Sherratt CA Shuttleworth 2002 Elastic fibres J Cell Sci 115 2817 2828 12082143
63. K Kitaya T Yasuo 2009 Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16(-) natural killer cells into human endometrium J Leukoc Biol 85 391 400 19088176
64. M Kolb PJ Margetts PJ Sime J Gauldie 2001 Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung Am J Physiol Lung Cell Mol Physiol 280 L1327 1334 11350814
65. J Koninger NA Giese M Bartel FF di Mola PO Berberat P di Sebastiano T Giese MW Buchler H Friess 2006 The ECM proteoglycan decorin links desmoplasia and inflammation in chronic pancreatitis J Clin Pathol 59 21 27 16394277
66. H Kresse E Schonherr 2001 Proteoglycans of the extracellular matrix and growth control J Cell Physiol 189 266 274 11748584
67. H Kresse H Hausser E Schonherr 1993 Small proteoglycans Experientia 49 403 416 8500596
68. H Kresse C Liszio E Schonherr LW Fisher 1997 Critical role of glutamate in a central leucine-rich repeat of decorin for interaction with type I collagen J Biol Chem 272 18404 18410 9218483
69. P Krishna CA Rosen RC Branski A Wells PA Hebda 2006 Primed fibroblasts and exogenous decorin: potential treatments for subacute vocal fold scar Otolaryngol Head Neck Surg 135 937 945 17141088
70. S Kuriyama G Lupo K Ohta S Ohnuma WA Harris H Tanaka 2006 Tsukushi controls ectodermal patterning and neural crest specification in Xenopus by direct regulation of BMP4 and X-delta-1 activity Development 133 75 88 16319115
71. Y Li T Aoki Y Mori M Ahmad H Miyamori T Takino H Sato 2004 Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar Cancer Res 64 7058 7064 15466200
72. X Li DC McFarland SG Velleman 2008 Extracellular matrix proteoglycan decorin-mediated myogenic satellite cell responsiveness to transforming growth factor-beta1 during cell proliferation and differentiation Decorin and transforming growth factor-beta1 in satellite cells Domest Anim Endocrinol 35 263 273 18650056
73. A Markmann H Hausser E Schonherr H Kresse 2000 Influence of decorin expression on transforming growth factor-beta-mediated collagen gel retraction and biglycan induction Matrix Biol 19 631 636 11102752
74. PA McEwan PG Scott PN Bishop J Bella 2006 Structural correlations in the family of small leucine-rich repeat proteins and proteoglycans J Struct Biol 155 294 305 16884925
75. J Melrose ES Fuller PJ Roughley MM Smith B Kerr CE Hughes B Caterson CB Little 2008 Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues Arthritis Res Ther 10 R79 18620607
76. Merline R, Lazaroski S, Babelova A, Tsalastra-Greul W, Pfeilschifter J, Schlütter KD, Günther A, Iozzo RV, Schaefer RM, Schaefer L (2009) Decorin deficiency in diabetic mice: Aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration. J Physiol Pharmacol 60, Suppl 4
77. T Miura Y Kishioka J Wakamatsu A Hattori A Hennebry CJ Berry M Sharma R Kambadur T Nishimura 2006 Decorin binds myostatin and modulates its activity to muscle cells Biochem Biophys Res Commun 340 675 680 16380093
78. M Moreno R Munoz F Aroca M Labarca E Brandan J Larrain 2005 Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway EMBO J 24 1397 1405 15775969
79. SA Morris AD Almeida H Tanaka K Ohta S Ohnuma 2007 Tsukushi modulates Xnr2 FGF and BMP signaling: regulation of Xenopus germ layer formation. PLoS ONE 2 e1004
80. DK Moscatello M Santra DM Mann DJ McQuillan AJ Wong RV Iozzo 1998 Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor J Clin Invest 101 406 412 9435313
81. Z Naito 2005 Role of the small leucine-rich proteoglycan (SLRP) family in pathological lesions and cancer cell growth J Nippon Med Sch 72 137 145 16046829
82. M Nakajima H Kizawa M Saitoh I Kou K Miyazono S Ikegawa 2007 Mechanisms for asporin function and regulation in articular cartilage J Biol Chem 282 32185 32192 17827158
83. PJ Neame CJ Kay DJ McQuillan MP Beales JR Hassell 2000 Independent modulation of collagen fibrillogenesis by decorin and lumican Cell Mol Life Sci 57 859 863 10892350
84. D Nikitovic K Berdiaki G Chalkiadaki N Karamanos G Tzanakakis 2008 The role of SLRP-proteoglycans in osteosarcoma pathogenesis Connect Tissue Res 49 235 238 18661350
85. D Nikitovic P Katonis A Tsatsakis NK Karamanos GN Tzanakakis 2008 Lumican, a small leucine-rich proteoglycan IUBMB Life 60 818 823 18949819
86. N Nili AN Cheema FJ Giordano AW Barolet S Babaei R Hickey MR Eskandarian M Smeets J Butany G Pasterkamp BH Strauss 2003 Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: potential mechanism for inhibition of intimal hyperplasia after balloon angioplasty Am J Pathol 163 869 878 12937128
87. K Ohta S Kuriyama T Okafuji R Gejima S Ohnuma H Tanaka 2006 Tsukushi cooperates with VG1 to induce primitive streak and Hensen's node formation in the chick embryo Development 133 3777 3786 16943268
88. N Perrimon M Bernfield 2001 Cellular functions of proteoglycans-an overview Semin Cell Dev Biol 12 65 67 11292371
89. GA Pringle CM Dodd 1990 Immunoelectron microscopic localization of the core protein of decorin near the d and e bands of tendon collagen fibrils by use of monoclonal antibodies J Histochem Cytochem 38 1405 1411 1698203
90. M Raspanti M Viola A Forlino R Tenni C Gruppi ME Tira 2008 Glycosaminoglycans show a specific periodic interaction with type I collagen fibrils J Struct Biol 164 134 139 18664384
91. CC Reed RV Iozzo 2002 The role of decorin in collagen fibrillogenesis and skin homeostasis Glycoconj J 19 249 255 12975602
92. CC Reed J Gauldie RV Iozzo 2002 Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin Oncogene 21 3688 3695 12032837
93. B Reinboth E Hanssen EG Cleary MA Gibson 2002 Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1 J Biol Chem 277 3950 3957 11723132
94. B Reinboth J Thomas E Hanssen MA Gibson 2006 Beta ig-h3 interacts directly with biglycan and decorin, promotes collagen VI aggregation, and participates in ternary complexing with these macromolecules J Biol Chem 281 7816 7824 16434404
95. PJ Roughley 2006 The structure and function of cartilage proteoglycans Eur Cell Mater 12 92 101 17136680
96. C Ruhland E Schonherr H Robenek U Hansen RV Iozzo P Bruckner DG Seidler 2007 The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis FEBS J 274 4246 4255 17651433
97. S San Martin TM Zorn 2003 The small proteoglycan biglycan is associated with thick collagen fibrils in the mouse decidua Cell Mol Biol (Noisy-le-grand) 49 673 678
98. M Santra CC Reed RV Iozzo 2002 Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope J Biol Chem 277 35671 35681 12105206
99. L Schaefer RV Iozzo 2008 Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction J Biol Chem 283 21305 21309 18463092
100. Schaefer L, Schaefer RM (2009) Proteoglycans: from structural compounds to signaling molecules. Cell Tissue Res Jun 10. [Epub ahead of print], PMID: 19513755
101. L Schaefer I Raslik HJ Grone E Schonherr K Macakova J Ugorcakova S Budny RM Schaefer H Kresse 2001 Small proteoglycans in human diabetic nephropathy: discrepancy between glomerular expression and protein accumulation of decorin, biglycan, lumican, and fibromodulin FASEB J 15 559 561 11259366
102. L Schaefer K Macakova I Raslik M Micegova HJ Grone E Schonherr H Robenek FG Echtermeyer S Grassel P Bruckner RM Schaefer RV Iozzo H Kresse 2002 Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction Am J Pathol 160 1181 1191 11891213
103. L Schaefer KF Beck I Raslik S Walpen D Mihalik M Micegova K Macakova E Schonherr DG Seidler G Varga RM Schaefer H Kresse J Pfeilschifter 2003 Biglycan, a nitric oxide-regulated gene, affects adhesion, growth, and survival of mesangial cells J Biol Chem 278 26227 26237 12719420
104. L Schaefer D Mihalik A Babelova M Krzyzankova HJ Grone RV Iozzo MF Young DG Seidler G Lin DP Reinhardt RM Schaefer 2004 Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury Am J Pathol 165 383 396 15277214
105. L Schaefer A Babelova E Kiss HJ Hausser M Baliova M Krzyzankova G Marsche MF Young D Mihalik M Gotte E Malle RM Schaefer HJ Grone 2005 The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages J Clin Invest 115 2223 2233 16025156
106. L Schaefer W Tsalastra A Babelova M Baliova J Minnerup L Sorokin HJ Grone DP Reinhardt J Pfeilschifter RV Iozzo RM Schaefer 2007 Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin Am J Pathol 170 301 315 17200203
107. E Schonherr H Hausser L Beavan H Kresse 1995 Decorin-type I collagen interaction. Presence of separate core protein-binding domains J Biol Chem 270 8877 8883 7721795
108. E Schonherr P Witsch-Prehm B Harrach H Robenek J Rauterberg H Kresse 1995 Interaction of biglycan with type I collagen J Biol Chem 270 2776 2783 7852349
109. E Schonherr M Broszat E Brandan P Bruckner H Kresse 1998 Decorin core protein fragment Leu155-Val260 interacts with TGF-beta but does not compete for decorin binding to type I collagen Arch Biochem Biophys 355 241 248 9675033
110. E Schonherr L Schaefer BC O'Connell H Kresse 2001 Matrix metalloproteinase expression by endothelial cells in collagen lattices changes during co-culture with fibroblasts and upon induction of decorin expression J Cell Physiol 187 37 47 11241347
111. E Schonherr C Sunderkotter L Schaefer S Thanos S Grassel A Oldberg RV Iozzo MF Young H Kresse 2004 Decorin deficiency leads to impaired angiogenesis in injured mouse cornea J Vasc Res 41 499 508 15528932
112. E Schonherr C Sunderkotter RV Iozzo L Schaefer 2005 Decorin, a novel player in the insulin-like growth factor system J Biol Chem 280 15767 15772 15701628
113. DG Seidler S Goldoni C Agnew C Cardi ML Thakur RT Owens DJ McQuillan RV Iozzo 2006 Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation J Biol Chem 281 26408 26418 16835231
114. YF Shi Q Zhang PY Cheung L Shi CC Fong Y Zhang CH Tzang BP Chan WF Fong J Chun HF Kung M Yang 2006 Effects of rhDecorin on TGF-beta1 induced human hepatic stellate cells LX-2 activation Biochim Biophys Acta 1760 1587 1595 17067743
115. R Shimizu-Hirota H Sasamura M Kuroda E Kobayashi M Hayashi T Saruta 2004 Extracellular matrix glycoprotein biglycan enhances vascular smooth muscle cell proliferation and migration Circ Res 94 1067 1074 15031262
116. M Sifaki M Assouti D Nikitovic K Krasagakis NK Karamanos GN Tzanakakis 2006 Lumican, a small leucine-rich proteoglycan substituted with keratan sulfate chains is expressed and secreted by human melanoma cells and not normal melanocytes IUBMB Life 58 606 610 17050378
117. AP Sjoberg GA Manderson M Morgelin AJ Day D Heinegard AM Blom 2009 Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation Mol Immunol 46 830 839 18962898
118. L Svensson D Heinegard A Oldberg 1995 Decorin-binding sites for collagen type I are mainly located in leucine-rich repeats 4-5 J Biol Chem 270 20712 20716 7657652
119. L Svensson A Aszodi FP Reinholt R Fassler D Heinegard A Oldberg 1999 Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon J Biol Chem 274 9636 9647 10092650
120. Y Takeuchi Y Kodama T Matsumoto 1994 Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity J Biol Chem 269 32634 32638 7798269
121. JG Tralhao L Schaefer M Micegova C Evaristo E Schonherr S Kayal H Veiga-Fernandes C Danel RV Iozzo H Kresse P Lemarchand 2003 In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer FASEB J 17 464 466 12631584
122. BC Trask TM Trask T Broekelmann RP Mecham 2000 The microfibrillar proteins MAGP-1 and fibrillin-1 form a ternary complex with the chondroitin sulfate proteoglycan decorin Mol Biol Cell 11 1499 1507 10793130
123. E Tufvesson G Westergren-Thorsson 2002 Tumour necrosis factor-alpha interacts with biglycan and decorin FEBS Lett 530 124 128 12387878
124. E Tufvesson G Westergren-Thorsson 2003 Biglycan and decorin induce morphological and cytoskeletal changes involving signalling by the small GTPases RhoA and Rac1 resulting in lung fibroblast migration J Cell Sci 116 4857 4864 14600270
125. N Vij L Roberts S Joyce S Chakravarti 2004 Lumican suppresses cell proliferation and aids Fas-Fas ligand mediated apoptosis: implications in the cornea Exp Eye Res 78 957 971 15051477
126. N Vij L Roberts S Joyce S Chakravarti 2005 Lumican regulates corneal inflammatory responses by modulating Fas-Fas ligand signaling Invest Ophthalmol Vis Sci 46 88 95 15623759
127. M Viola B Bartolini M Sonaggere C Giudici R Tenni ME Tira 2007 Fibromodulin interactions with type I and II collagens Connect Tissue Res 48 141 148 17522997
128. B Vuillermoz A Khoruzhenko MF D'Onofrio L Ramont L Venteo C Perreau F Antonicelli FX Maquart Y Wegrowski 2004 The small leucine-rich proteoglycan lumican inhibits melanoma progression Exp Cell Res 296 294 306 15149859
129. RJ Waddington HC Roberts RV Sugars E Schonherr 2003 Differential roles for small leucine-rich proteoglycans in bone formation Eur Cell Mater 6 12 21 14562268 discussion 21
130. IT Weber RW Harrison RV Iozzo 1996 Model structure of decorin and implications for collagen fibrillogenesis J Biol Chem 271 31767 31770 8943211
131. CK Weber G Sommer P Michl H Fensterer M Weimer F Gansauge G Leder G Adler TM Gress 2001 Biglycan is overexpressed in pancreatic cancer and induces G1-arrest in pancreatic cancer cell lines Gastroenterology 121 657 667 11522750 (Pubitemid 32822581)
132. SM Weis SD Zimmerman M Shah JW Covell JH Omens J Ross Jr N Dalton Y Jones CC Reed RV Iozzo AD McCulloch 2005 A role for decorin in the remodeling of myocardial infarction Matrix Biol 24 313 324 15949932
133. D Westermann J Mersmann A Melchior T Freudenberger C Petrik L Schaefer R Lullmann-Rauch O Lettau C Jacoby J Schrader SM Brand-Herrmann MF Young HP Schultheiss B Levkau HA Baba T Unger K Zacharowski C Tschope JW Fischer 2008 Biglycan is required for adaptive remodeling after myocardial infarction Circulation 117 1269 1276 18299507
134. C Wiberg D Heinegard C Wenglen R Timpl M Morgelin 2002 Biglycan organizes collagen VI into hexagonal-like networks resembling tissue structures J Biol Chem 277 49120 49126 12354766
135. KJ Williams G Qiu HK Usui SR Dunn P McCue E Bottinger RV Iozzo K Sharma 2007 Decorin deficiency enhances progressive nephropathy in diabetic mice Am J Pathol 171 1441 1450 17884968
136. M Winnemoller G Schmidt H Kresse 1991 Influence of decorin on fibroblast adhesion to fibronectin Eur J Cell Biol 54 10 17 1827765
137. M Winnemoller P Schon P Vischer H Kresse 1992 Interactions between thrombospondin and the small proteoglycan decorin: interference with cell attachment Eur J Cell Biol 59 47 55 1468447
138. S Wojtowicz-Praga 2003 Reversal of tumor-induced immunosuppression by TGF-beta inhibitors Invest New Drugs 21 21 32 12795527
139. F Wu N Vij L Roberts S Lopez-Briones S Joyce S Chakravarti 2007 A novel role of the lumican core protein in bacterial lipopolysaccharide-induced innate immune response J Biol Chem 282 26409 26417 17616530
140. J Xaus M Comalada M Cardo AF Valledor A Celada 2001 Decorin inhibits macrophage colony-stimulating factor proliferation of macrophages and enhances cell survival through induction of p27(Kip1) and p21(Waf1) Blood 98 2124 2133 11567999
141. T Xu P Bianco LW Fisher G Longenecker E Smith S Goldstein J Bonadio A Boskey AM Heegaard B Sommer K Satomura P Dominguez C Zhao AB Kulkarni PG Robey MF Young 1998 Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice Nat Genet 20 78 82 9731537
142. Y Yamaguchi E Ruoslahti 1988 Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation Nature 336 244 246 3194009
143. Y Yamaguchi DM Mann E Ruoslahti 1990 Negative regulation of transforming growth factor-beta by the proteoglycan decorin Nature 346 281 284 2374594
144. MF Young Y Bi L Ameye XD Chen 2002 Biglycan knockout mice: new models for musculoskeletal diseases Glycoconj J 19 257 262 12975603
145. G Zhang Y Ezura I Chervoneva PS Robinson DP Beason ET Carine LJ Soslowsky RV Iozzo DE Birk 2006 Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development J Cell Biochem 98 1436 1449 16518859
146. Z Zhang XJ Li Y Liu X Zhang YY Li WS Xu 2007 Recombinant human decorin inhibits cell proliferation and downregulates TGF-beta1 production in hypertrophic scar fibroblasts Burns 33 634 641 17374457
147. G Zhang S Chen S Goldoni BW Calder HC Simpson RT Owens DJ McQuillan MF Young RV Iozzo DE Birk 2009 Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan J Biol Chem 284 8888 8897 19136671
148. JX Zhu S Goldoni G Bix RT Owens DJ McQuillan CC Reed RV Iozzo 2005 Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis J Biol Chem 280 32468 32479 15994311
149. J Zhu Y Li W Shen C Qiao F Ambrosio M Lavasani M Nozaki MF Branca J Huard 2007 Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis J Biol Chem 282 25852 25863 17597062
150. JJ Zoeller W Pimtong H Corby S Goldoni AE Iozzo RT Owens SY Ho RV Iozzo 2009 A central role for decorin during vertebrate convergent extension J Biol Chem 284 11728 11737 19211552