The pharmacology of acute lung injury in sepsis

Advances in Pharmacological Sciences

Volumn 2011, Issue , 2011, Pages

  Varisco, Brian Michael ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; CARBON DIOXIDE; CORTICOSTEROID; FLUOROCARBON; FUROSEMIDE; LUNG SURFACTANT; METHYLPREDNISOLONE SODIUM SUCCINATE; NEUROMUSCULAR BLOCKING AGENT; NITRIC OXIDE; OMEGA 3 FATTY ACID; PHOSPHOLIPID; SALBUTAMOL; STEROID;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; CONSERVATIVE TREATMENT; DRUG MECHANISM; DRUG MEGADOSE; EXTRACORPOREAL OXYGENATION; HUMAN; LIQUID VENTILATION; LOADING DRUG DOSE; LUNG FIBROSIS; MESENCHYMAL STEM CELL TRANSPLANTATION; MYOPATHY; NONHUMAN; PATHOGEN CLEARANCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SECONDARY INFECTION; SEPSIS; SIDE EFFECT; WOUND HEALING IMPAIRMENT;

EID: 80052737757     PISSN: 16876334     EISSN: 16876342     Source Type: Journal    
DOI: 10.1155/2011/254619     Document Type: Review

References (95)

1. Phua J., Badia J. R., Adhikari N. K. J., Friedrich J. O., Fowler R. A., Singh J. M., Scales D. C., Stather D. R., Li A., Jones A., Gattas D. J., Hallett D., Tomlinson G., Stewart T. E., Ferguson N. D., Has mortality from acute respiratory distress syndrome decreased over time? A systematic review American Journal of Respiratory and Critical Care Medicine 2009 179 3 220 227
2. Erickson S. E., Martin G. S., Davis J. L., Matthay M. A., Eisner M. D., Recent trends in acute lung injury mortality: 19962005 Critical Care Medicine 2009 37 5 1574 1579
3. Randolph A. G., Management of acute lung injury and acute respiratory distress syndrome in children Critical Care Medicine 2009 37 8 2448 2454
4. Dahlem P., van Aalderen W. M. C., Bos A. P., Pediatric acute lung injury Paediatric Respiratory Reviews 2007 8 4 348 362 (Pubitemid 350102999)
5. Rossi C., Simini B., Brazzi L., Rossi G., Radrizzani D., Iapichino G., Bertolini G., Variable costs of ICU patients: a multicenter prospective study Intensive Care Medicine 2006 32 4 545 552
6. Bernard G. R., Artigas A., Brigham K. L., Carlet J., Falke K., Hudson L., Lamy M., LeGall J. R., Morris A., Spragg R., Cochin B., Lanken P. N., Leeper K. V., Marini J., Murray J. F., Oppenheimer L., Pesenti A., Reid L., Rinaldo J., Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination Intensive Care Medicine 1994 20 3 225 232 (Pubitemid 24088590)
7. Flori H. R., Glidden D. V., Rutherford G. W., Matthay M. A., Pediatric acute lung injury: prospective evaluation of risk factors associated with mortality American Journal of Respiratory and Critical Care Medicine 2005 171 9 995 1001 (Pubitemid 40616948)
8. Nash G., Foley F. D., Langlinais P. C., Pulmonary interstitial edema and hyaline membranes in adult burn patients. Electron microscopic observations Human Pathology 1974 5 2 149 160
9. Pratt P. C., Vollmer R. T., Shelburne J. D., Pulmonary morphology in a multihospital collaborative extracorporeal membrane oxygenation project. I. Light microscopy American Journal of Pathology 1979 95 1 191 214 (Pubitemid 9164962)
10. Marshall R., Bellingan G., Laurent G., The acute respiratory distress syndrome: fibrosis in the fast lane Thorax 1998 53 10 815 817 (Pubitemid 28459534)
11. Sarker M., Rose J., McDonald M., Morrow M. R., Booth V., Modifications to surfactant protein B structure and Lipid interactions under respiratory distress conditions: consequences of tryptophan oxidation Biochemistry 2011 50 1 25 36
12. Zasadzinski J. A., Stenger P. C., Shieh I., Dhar P., Overcoming rapid inactivation of lung surfactant: analogies between competitive adsorption and colloid stability Biochimica et Biophysica Acta 2010 1798 4 801 828
13. Markart P., Ruppert C., Wygrecka M., Colaris T., Dahal B., Walmrath D., Harbach H., Wilhelm J., Seeger W., Schmidt R., Guenther A., Patients with ARDS show improvement but not normalisation of alveolar surface activity with surfactant treatment: putative role of neutral lipids Thorax 2007 62 7 588 594 (Pubitemid 47056885)
14. Zhou G., Dada L. A., Wu M., Kelly A., Trejo H., Zhou Q., Varga J., Sznajder J. I., Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1 American Journal of Physiology 2009 297 6 L1120 L1130
15. Kang D., Nakayama T., Togashi M., Yamamoto M., Takahashi M., Kunugi S., Ishizaki M., Fukuda Y., Two forms of diffuse alveolar damage in the lungs of patients with acute respiratory distress syndrome Human Pathology 2009 40 11 1618 1627
16. Synenki L., Chandel N. S., Budinger G. R. S., Donnelly H. K., Topin J., Eisenbart J., Jovanovic B., Jain M., Bronchoalveolar lavage fluid from patients with acute lung injury/acute respiratory distress syndrome induces myofibroblast differentiation Critical Care Medicine 2007 35 3 842 848 (Pubitemid 46407800)
17. Sanders Y. Y., Kumbla P., Hagood J. S., Enhanced myofibroblastic differentiation and survival in thy-1(-) lung fibroblasts American Journal of Respiratory Cell and Molecular Biology 2007 36 2 226 235 (Pubitemid 46233476)
18. Quesnel C., Nardelli L., Piednoir P., Leon V., Marchal-Somme J., Lasocki S., Bouadma L., Philip I., Soler P., Crestani B., Dehoux M., Alveolar fibroblasts in acute lung injury: biological behaviour and clinical relevance European Respiratory Journal 2010 35 6 1312 1321
19. Peters J. I., Bell R. C., Prihoda T. J., Harris G., Andrews C., Johanson W. G., Clinical determinants of abnormalities in pulmonary functions in survivors of the adult respiratory distress syndrome American Review of Respiratory Disease 1989 139 5 1163 1168 (Pubitemid 19139839)
20. American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS) American Journal of Respiratory and Critical Care Medicine 2000 161 2 646 664
21. Esan A., Hess D. R., Raoof S., George L., Sessler C. N., Severe hypoxemic respiratory failurepart 1ventilatory strategies Chest 2010 137 5 1203 1216
22. Brower R. G., Matthay M. A., Morris A., Schoenfeld D., Thompson B. T., Wheeler A., Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome New England Journal of Medicine 2000 342 18 1301 1308 (Pubitemid 30408714)
23. Brower R. G., Lanken P. N., MacIntyre N., Matthay M. A., Morris A., Ancukiewicz M., Schoenfeld D., Thompson B. T., Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome New England Journal of Medicine 2004 351 4 327 336
24. Derdak S., Mehta S., Stewart T. E., Smith T., Rogers M., Buchman T. G., Carlin B., Lowson S., Granton J., High-frequency oscillatory ventilation for acute respiratory distress syndrome in adults: a randomized, controlled trial American Journal of Respiratory and Critical Care Medicine 2002 166 6 801 808
25. Bollen C. W., van Well G. T., Sherry T., Beale R. J., Shah S., Findlay G., Monchi M., Chiche J. D., Weiler N., Uiterwaal C. S., van Vught A. J., High frequency oscillatory ventilation compared with conventional mechanical ventilation in adult respiratory distress syndrome: a randomized controlled trial [ISRCTN24242669] Critical Care 2005 9 4 R430 R439
26. Varpula T., Valta P., Niemi R., Takkunen O., Hynynen M., Pettil V., Airway pressure release ventilation as a primary ventilatory mode in acute respiratory distress syndrome Acta Anaesthesiologica Scandinavica 2004 48 6 722 731 (Pubitemid 38843392)
27. Verbrugghe W., Jorens P. G., Neurally adjusted ventilatory assist (NAVA): a new ventilatory tool or a ventilatory toy? Respiratory Care 2011 56 3 327 335
28. Meade M. O., Cook D. J., Guyatt G. H., Slutsky A. S., Arabi Y. M., Cooper D. J., Davies A. R., Hand L. E., Zhou Q., Thabane L., Austin P., Lapinsky S., Baxter A., Russell J., Skrobik Y., Ronco J. J., Stewart T. E., Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial Journal of the American Medical Association 2008 299 6 637 645 (Pubitemid 351252725)
29. Curley M. A. Q., Hibberd P. L., Fineman L. D., Wypij D., Shih M. C., Thompson J. E., Grant M. J. C., Barr F. E., Cvijanovich N. Z., Sorce L., Luckett P. M., Matthay M. A., Arnold J. H., Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial Journal of the American Medical Association 2005 294 2 229 237 (Pubitemid 41043793)
30. Gattinoni L. G., Tognoni G., Pesenti A., Taccone P., Mascheroni D., Labarta V., Malacrida R., Di Giulio P., Fumagalli R., Pelosi P., Brazzi L., Latini R., Effect of prone positioning on the survival of patients with acute respiratory failure New England Journal of Medicine 2001 345 8 568 573 (Pubitemid 32772098)
31. Humphrey H., Hall J., Sznajder I., Silverstein M., Wood L., Improved survival in ARDS patients associated with a reduction in pulmonary capillary wedge pressure Chest 1990 97 5 1176 1180 (Pubitemid 20166812)
32. Wiedemann H. P., Wheeler A. P., Bernard G. R., Thompson B. T., Hayden D., DeBoisblanc B., Connors A. F., Hite R. D., Harabin A. L., Comparison of two fluid-management strategies in acute lung injury New England Journal of Medicine 2006 354 24 2564 2575 (Pubitemid 43882352)
33. Martin G. S., Moss M., Wheeler A. P., Mealer M., Morris J. A., Bernard G. R., A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury Critical Care Medicine 2005 33 8 1681 1687 (Pubitemid 41153690)
34. Martin G. S., Mangialardi R. J., Wheeler A. P., Dupont W. D., Morris J. A., Bernard G. R., Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury Critical Care Medicine 2002 30 10 2175 2182 (Pubitemid 35191564)
35. Matthay M. A., Idell S., Update on acute lung injury and critical care medicine 2009 American journal of respiratory and critical care medicine 2010 181 10 1027 1032
36. Zabrocki L. A., Brogan T. V., Statler K. D., Poss W. B., Rollins M. D., Bratton S. L., Extracorporeal membrane oxygenation for pediatric respiratory failure: survival and predictors of mortality Critical Care Medicine 2011 39 2 364 370
37. Zapol W. M., Snider M. T., Hill J. D., Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study Journal of the American Medical Association 1979 242 20 2193 2196 (Pubitemid 10195729)
38. Morris A. H., Wallace C. J., Menlove R. L., Clemmer T. P., Orme J. F., Weaver L. K., Dean N. C., Thomas F., East T. D., Pace N. L., Suchyta M. R., Beck E., Bombino M., Sittig D. F., Bhm S., Hoffmann B., Becks H., Butler S., Pearl J., Rasmusson B., Randomized clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for Adult Respiratory Distress Syndrome American Journal of Respiratory and Critical Care Medicine 1994 149 2 I 295 305 (Pubitemid 24068971)
39. Peek G. J., Mugford M., Tiruvoipati R., Wilson A., Allen E., Thalanany M. M., Hibbert C. L., Truesdale A., Clemens F., Cooper N., Firmin R. K., Elbourne D., Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial The Lancet 2009 374 9698 1351 1363
40. Norfolk S. G., Hollingsworth C. L., Wolfe C. R., Govert J. A., Que L. G., Cheifetz I. M., Hollingsworth J. W., Rescue therapy in adult and pediatric patients with pH1N1 influenza infection: a tertiary center intensive care unit experience from April to October 2009 Critical Care Medicine 2010 38 11 2103 2107
41. Floerchinger B., Philipp A., Foltan M., Rupprecht L., Klose A., Camboni D., Bruenger F., Schopka S., Arlt M., Hilker M., Schmid C., Switch from venoarterial extracorporeal membrane oxygenation to arteriovenous pumpless extracorporeal lung assist Annals of Thoracic Surgery 2010 89 1 125 131
42. Stirling S. L., Cordingley J. J., Hunter D. N., Griffiths M. J., Wort S. J., Evans T. W., Finney S. J., Extracorporeal carbon dioxide removal to protect the lung Thorax 2009 64 8 726 727
43. Confalonieri M., Urbino R., Potena A., Piattella M., Parigi P., Puccio G., Della Porta R., Giorgio C., Blasi F., Umberger R., Meduri G. U., Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study American Journal of Respiratory and Critical Care Medicine 2005 171 3 242 248
44. Annane D., Sébille V., Bellissant E., Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome Critical Care Medicine 2006 34 1 22 30 (Pubitemid 43032376)
45. Meduri G. U., Golden E., Freire A. X., Taylor E., Zaman M., Carson S. J., Gibson M., Umberger R., Methylprednisolone infusion in early severe ards: results of a randomized controlled trial Chest 2007 131 4 954 963 (Pubitemid 46608692)
46. Meduri G. U., Headley A. S., Golden E., Carson S. J., Umberger R. A., Kelso T., Tolley E. A., Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial Journal of the American Medical Association 1998 280 2 159 165 (Pubitemid 28498389)
47. Steinberg K. P., Hudson L. D., Goodman R. B., Hough C. L., Lanken P. N., Hyzy R., Thompson B. T., Ancukiewicz M., Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome New England Journal of Medicine 2006 354 16 1671 1684
48. Meduri G. U., Marik P. E., Chrousos G. P., Pastores S. M., Arlt W., Beishuizen A., Bokhari F., Zaloga G., Annane D., Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature Intensive Care Medicine 2008 34 1 61 69
49. Sidhaye V., Hoffert J. D., King L. S., cAMP has distinct acute and chronic effects on aquaporin-5 in lung epithelial cells Journal of Biological Chemistry 2005 280 5 3590 3596 (Pubitemid 40223825)
50. Manocha S., Gordon A. C., Salehifar E., Groshaus H., Walley K. R., Russell J. A., Inhaled beta-2 agonist salbutamol and acute lung injury: an association with improvement in acute lung injury Critical Care 2006 10 1, article R12
51. Wang Y., Folkesson H. G., Jayr C., Ware L. B., Matthay M. A., Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and -agonist therapy Journal of Applied Physiology 1999 87 5 1852 1860
52. Sakuma T., Okaniwa G., Nakada T., Nishimura T., Fujimura S., Matthay M. A., Alveolar fluid clearance in the resected human lung American Journal of Respiratory and Critical Care Medicine 1994 150 2 305 310 (Pubitemid 24252335)
53. Mutlu G. M., Dumasius V., Burhop J., McShane P. J., Meng F. J., Welch L., Dumasius A., Mohebahmadi N., Thakuria G., Hardiman K., Matalon S., Hollenberg S., Factor P., Upregulation of alveolar epithelial active Na+ transport is dependent on -adrenergic receptor signaling Circulation Research 2004 94 8 1091 1100 (Pubitemid 38579704)
54. Perkins G. D., McAuley D. F., Thickett D. R., Gao F., The -agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial American Journal of Respiratory and Critical Care Medicine 2006 173 3 281 287 (Pubitemid 43209082)
55. Reising C. A., Chendrasekhar A., Wall P. L., Paradise N. F., Timberlake G. A., Moorman D. W., Continuous dose furosemide as a therapeutic approach to acute respiratory distress syndrome (ARDS) Journal of Surgical Research 1999 82 1 56 60 (Pubitemid 29394153)
56. Yuengsrigul A., Chin T. W., Nussbaum E., Immunosuppressive and cytotoxic effects of furosemide on human peripheral blood mononuclear cells Annals of Allergy, Asthma and Immunology 1999 83 6 I 559 566 (Pubitemid 30013516)
57. Deem S., Lee C. M., Curtis J. R., Acquired neuromuscular disorders in the intensive care unit American Journal of Respiratory and Critical Care Medicine 2003 168 7 735 739 (Pubitemid 37188296)
58. Papazian L., Forel J.-M., Gacouin A., Penot-Ragon C., Perrin G., Loundou A., Jaber S., Arnal J.-M., Perez D., Seghboyan J.-M., Constantin J.-M., Courant P., Lefrant J.-Y., Guérin C., Prat G., Morange S., Roch A., Neuromuscular blockers in early acute respiratory distress syndrome New England Journal of Medicine 2010 363 12 1107 1116
59. Soll R. F., Prophylactic natural surfactant extract for preventing morbidity and mortality in preterm infants Cochrane Database of Systematic Reviews 2000 2
60. Soll R. F., Prophylactic synthetic surfactant for preventing morbidity and mortality in preterm infants Cochrane Database of Systematic Reviews 2000 2
61. Wirbelauer J., Speer C. P., The role of surfactant treatment in preterm infants and term newborns with acute respiratory distress syndrome Journal of Perinatology 2009 29 2 S18 S22
62. Spragg R. G., Lewis J. F., Walmrath H. D., Johannigman J., Bellingan G., Laterre P. F., Witte M. C., Richards G. A., Rippin G., Rathgeb F., Hfner D., Taut F. J. H., Seeger W., Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome New England Journal of Medicine 2004 351 9 884 947
63. Gregory T. J., Steinberg K. P., Spragg R., Gadek J. E., Hyers T. M., Longmore W. J., Moxley M. A., Cai G. Z., Hite R. D., Smith R. M., Hudson L. D., Crim C., Newton P., Mitchell B. R., Gold A. J., Bovine surfactant therapy for patients with acute respiratory distress syndrome American Journal of Respiratory and Critical Care Medicine 1997 155 4 1309 1315 (Pubitemid 27172776)
64. Anzueto A., Baughman R. P., Guntupalli K. K., Weg J. G., Wiedemann H. P., Ravents A. A., Lemaire F., Long W., Zaccardelli D. S., Pattishall E. N., Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome New England Journal of Medicine 1996 334 22 1417 1421 (Pubitemid 26157436)
65. Kesecioglu J., Beale R., Stewart T. E., Findlay G. P., Rouby J. J., Holzapfel L., Bruins P., Steenken E. J., Jeppesen O. K., Lachmann B., Exogenous natural surfactant for treatment of acute lung injury and the acute respiratory distress syndrome American Journal of Respiratory and Critical Care Medicine 2009 180 10 989 994
66. Carnielli V. P., Zimmermann L. J. I., Hamvas A., Cogo P. E., Pulmonary surfactant kinetics of the newborn infant: novel insights from studies with stable isotopes Journal of Perinatology 2009 29 2, supplement S29 S37
67. Verlato G., Cogo P. E., Balzani M., Gucciardi A., Burattini I., De Benedictis F., Martiri G., Carnielli V. P., Surfactant status in preterm neonates recovering from respiratory distress syndrome Pediatrics 2008 122 1 102 108
68. Baraldi E., Filippone M., Chronic lung disease after premature birth New England Journal of Medicine 2007 357 19 1946 1955 (Pubitemid 350074689)
69. Balinotti J. E., Tiller C. J., Llapur C. J., Jones M. H., Kimmel R. N., Coates C. E., Katz B. P., Nguyen J. T., Tepper R. S., Growth of the lung parenchyma early in life American Journal of Respiratory and Critical Care Medicine 2009 179 2 134 137
70. West J. B., Respiratory Physiology: The Essentials 2005 7th Baltimore, Md, USA Lippincott Williams Wilkins
71. Willson D. F., Jiao J. H., Bauman L. A., Zaritsky A., Craft H., Dockery K., Conrad D., Dalton H., Calf's lung surfactant extract in acute hypoxemic respiratory failure in children Critical Care Medicine 1996 24 8 1316 1322 (Pubitemid 26262404)
72. Willson D. F., Thomas N. J., Markovitz B. P., Bauman L. A., DiCarlo J. V., Pon S., Jacobs B. R., Jefferson L. S., Conaway M. R., Egan E. A., Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: a randomized controlled trial Journal of the American Medical Association 2005 293 4 470 476
73. Curstedt T., Johansson J., Different effects of surfactant proteins B and Cimplications for development of synthetic surfactants Neonatology 2010 97 4 367 372
74. Halliday H. L., Surfactants: past, present and future Journal of Perinatology 2008 28 1, supplement S47 S56 (Pubitemid 351622251)
75. Willson D. F., Thomas N. J., Surfactant composition and biophysical properties are important in clinical studies American Journal of Respiratory and Critical Care Medicine 2010 181 7 762
76. Abman S. H., Pulmonary hypertension in children: a historical overview Pediatric Critical Care Medicine 2010 11 2, supplement S4 S9
77. Afshari A., Brok J., Mller A. M., Wetterslev J., Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults Cochrane Database of Systematic Reviews 2010 7
78. Singer P., Theilla M., Fisher H., Gibstein L., Grozovski E., Cohen J., Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury Critical Care Medicine 2006 34 4 1033 1038
79. Pontes-Arruda A., DeMichele S., Seth A., Singer P., The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of outcome data Journal of Parenteral and Enteral Nutrition 2008 32 6 596 605
80. Wolfson M. R., Shaffer T. H., Pulmonary applications of perfluorochemical liquids: ventilation and beyond Paediatric Respiratory Reviews 2005 6 2 117 127 (Pubitemid 40692049)
81. Leach C. L., Greenspan J. S., Rubenstein S. D., Shaffer T. H., Wolfson M. R., Jackson J. C., Delemos R., Fuhrman B. P., Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome New England Journal of Medicine 1996 335 11 761 767 (Pubitemid 26296535)
82. Gauger P. G., Pranikoff T., Schreiner R. J., Moler F. W., Hirschl R. B., Initial experience with partial liquid ventilation in pediatric patients with the acute respiratory distress syndrome Critical Care Medicine 1996 24 1 16 22
83. Greenspan J. S., Wolfson M. R., Rubenstein S. D., Shaffer T. H., Liquid ventilation of human preterm neonates Journal of Pediatrics 1990 117 1 I 106 111 (Pubitemid 20217507)
84. Greenspan J. S., Wolfson M. R., Rubenstein S. D., Shaffer T. H., Liquid ventilation of preterm baby Lancet 1989 2 8671 1095 (Pubitemid 19264089)
85. Davies M. W., Dunster K. R., Wilson K., Colditz P. B., Perfluorocarbon dosing when starting partial liquid ventilation: haemodynamics and cerebral blood flow in preterm lambs Neonatology 2010 97 2 144 153
86. Shorr A. F., Bernard G. R., Dhainaut J. F., Russell J. R., Macias W. L., Nelson D. R., Sundin D. P., Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome Critical Care 2006 10 3, article R92
87. Bernard G. R., Vincent J. L., Laterre P. F., LaRosa S. P., Dhainaut J. F., Lopez-Rodriguez A., Steingrub J. S., Garber G. E., Helterbrand J. D., Ely E. W., Fisher C. J., Efficacy and safety of recombinant human activated protein C for severe sepsis New England Journal of Medicine 2001 344 10 699 709 (Pubitemid 32204987)
88. Maniatis N. A., Letsiou E., Orfanos S. E., Kardara M., Dimopoulou I., Nakos G., Lekka M. E., Roussos C., Armaganidis A., Kotanidou A., Inhaled activated protein C protects mice from ventilator-induced lung injury Critical Care 2010 14, article R70
89. Hare J. M., Traverse J. H., Henry T. D., Dib N., Strumpf R. K., Schulman S. P., Gerstenblith G., DeMaria A. N., Denktas A. E., Gammon R. S., Hermiller J. B., Reisman M. A., Schaer G. L., Sherman W., A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (Prochymal) after acute myocardial infarction Journal of the American College of Cardiology 2009 54 24 2277 2286
90. Mei S. H. J., Haitsma J. J., Dos Santos C. C., Deng Y., Lai P. F.H., Slutsky A. S., Liles W. C., Stewart D. J., Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis American Journal of Respiratory and Critical Care Medicine 2010 182 8 1047 1057
91. Bruno S., Bussolati B., Grange C., Collino F., Di Cantogno L. V., Herrera M. B., Biancone L., Tetta C., Segoloni G., Camussi G., Isolation and characterization of resident mesenchymal stem cells in human glomeruli Stem Cells and Development 2009 18 6 867 879
92. Rojas M., Xu J., Woods C. R., Mora A. L., Spears W., Roman J., Brigham K. L., Bone marrow-derived mesenchymal stem cells in repair of the injured lung American Journal of Respiratory Cell and Molecular Biology 2005 33 2 145 152 (Pubitemid 41473051)
93. Ortiz L. A., Gambelli F., McBride C., Gaupp D., Baddoo M., Kaminski N., Phinney D. G., Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects Proceedings of the National Academy of Sciences of the United States of America 2003 100 14 8407 8411 (Pubitemid 36842558)
94. Gupta N., Su X., Popov B., Jae W. L., Serikov V., Matthay M. A., Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice Journal of Immunology 2007 179 3 1855 1863
95. Krause D. S., Theise N. D., Collector M. I., Henegariu O., Hwang S., Gardner R., Neutzel S., Sharkis S. J., Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell Cell 2001 105 3 369 377 (Pubitemid 32455343)