Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice

Nature Genetics

Volumn 20, Issue 1, 1998, Pages 78-82

  Xu, Tianshun ^a   Bianco, Paolo ^b,c   Fisher, Larry W ^a   Longenecker, Glenn ^a   Smith, Erica ^d   Goldstein, Steven ^d   Bonadio, Jeffrey ^d   Boskey, Adele ^e   Heegaard, Anne Marie ^a   Sommer, Beatrice ^a   Satomura, Kazuhito ^a   Dominguez, Pedro ^a   Zhao, Chengyan ^a   Kulkarni, Ashok B ^a   Robey, Pamela Gehron ^a   Young, Marian F ^a,f  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e HOSPITAL FOR SPECIAL SURGERY   (United States)

^f MSC 4320 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIGLYCAN; COLLAGEN TYPE 1; PROTEOGLYCAN; TRANSFORMING GROWTH FACTOR BETA;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MASS; BONE MINERALIZATION; CELL SURVIVAL; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE TARGETING; MOUSE; NONHUMAN; OSTEOPOROSIS; PHENOTYPE; PRIORITY JOURNAL;

AGE FACTORS; ANIMALS; BONE AND BONES; BONE DENSITY; BONE DEVELOPMENT; EXTRACELLULAR MATRIX PROTEINS; FEMALE; FEMUR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOPOROSIS; PHENOTYPE; PROTEOGLYCANS; TIBIA;

EID: 17344364096     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/1746     Document Type: Article

References (33)

1. Fisher, L.W. et al. Proteoglycans of developing bone. J. Biol. Chem. 258, 6588-6594 (1983).
2. Bianco, P., Fisher, L.W., Young, M.F., Termine, J.D. & Robey, P.G. Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J. Histochem. Cytochem. 38, 1549-1563 (1990).
3. Fisher, L.W., Termine, J.D. & Young, M.F. Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. J. Biol. Chem. 264, 4571-4576 (1989).
4. Schönherr, E. et al. Interaction of biglycan with type I collagen. J. Biol. Chem. 270, 2776-2783 (1995).
5. Yamaguchi, Y., Mann, D.M. & Ruoslahti, E. Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature 346, 281-284 (1990).
6. Hildebrand, A. et al. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem. J. 302, 527-534 (1994).
7. Kappler, J. et al. Chondroitin/dermatan sulphate promotes the survival of neurons from rat embryonic neocortex. Eur. J. Neurosci. 9, 306-318 (1997).
8. Iozzo, R.V. & Murdoch, A.D. Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function. FASEB J. 10, 598-614 (1996).
9. Ruoslahti, E. Proteoglycans in cell regulation. J. Biol. Chem. 264, 13369-13372 (1989).
10. Ruoslahti, E. & Yamaguchi, Y. Proteoglycans as modulators of growth factor activities. Cell 64, 867-869 (1991).
11. Vetter, U.K. et al. in Basic and Clinical Approach to Turner Syndrome (eds Hibi, I. & Takano, K.) 143-146 (Elsevier, Amsterdam, 1993).
12. Parfitt, A.M. et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 2, 595-610 (1987).
13. Boskey, A.L., Pleshko, N., Doty, S. & Mendelsohn, R. Applications of Fourier Transform InfraRed (FT-IR) microscopy to the study of mineralization in bone and cartilage. Cells a Materials 2, 209-220 (1992).
14. Boskey, A.L., Spevak, L., Doty, S.B. & Rosenberg, L. Effects of bone CS-proteoglycans, DS-decorin, and DS-biglycan on hydroxyapatite formation in a gelatin gel. Calcif. Tissue Int. 61, 298-305 (1997).
15. Bonadio, J. et al. A murine skeletal adaptation that significantly increases cortical bone mechanical properties. Implications for human skeletal fragility. J. Clin. Invest. 92, 1697-1705 (1993).
16. Kuro-o, M. et al. Mutation of the mouse klotho gene leads to a syndrome resembling aging. Nature 390, 45-51 (1997).
17. Lewis, D.B. et al. Osteoporosis induced in mice by overproduction of interleukin 4. Proc. Natl Acad. Sci. USA 90, 11618-11622 (1993).
18. Erlebacher, A. & Derynck, R. Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J. Cell Biol. 132, 195-210 (1996).
19. Takahashi, T., Wada, T., Mori, M., Kokai, Y. & Ishii, S. Overexpression of the granulocyte colony-stimulating factor gene leads to osteoporosis in mice. Lab Invest. 74, 827-834 (1996).
20. rd. Involutional osteoporosis. W. Engl. J. Med. 314, 1676-1686 (1986).
21. Bucay, N. et al. osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev. 12, 1260-1268 (1998).
22. Prockop, D.J. & Kivirikko, K.I. Collagens: molecular biology, diseases, and potentials for therapy. Annu. Rev. Biochem. 64, 403-434 (1995).
23. Danielson, K.G. et al. Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J. Cell Biol. 136, 729-743 (1997).
24. Gilmour, D.T. et al. Mice deficient for the secreted glycoprotein 5PARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J. 17, 1860-1870 (1998).
25. Ducy, P. et al. Increased bone formation in osteocalcin-deficient mice. Nature 382, 448-452 (1996).
26. Tybulewicz, V.L., Crawford, C.E., Jackson, P.K., Bronson, R.T. & Mulligan, R.C. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65, 1153-1163 (1991).
27. Li, E., Bestor, T.H. & Janeisch, R. Targeted mutation of the DNA methyl transferase gene results in embryonic lethality. Cell 69, 915-926 (1992).
28. Love, P.E., Tremblay, M.L. & Westphal, H. Targeting of the T-cell receptor zetachain gene in embryonic stem cells: strategies for generating multiple mutations in a single gene. Proc. Natl Acad. Sci. USA 89, 9929-9933 (1992).
29. Bradley, A. in Teratocarcinomas and Embryonic Stem Cells (ed. Robinson, E.J.) 113-151 (IRL, Oxford, 1987).
30. Fisher, L.W., Stubbs, J.T. Jr. & Young, M.F. Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins. Acta Orthop. Scand. Suppl. 266, 61-65 (1995).
31. Vignery, A. & Baron, R. Dynamic histomorphometry of alveolar bone remodeling in the adult rat. Anat. Rec. 196, 191-200 (1980).
32. Boyce, B.F., Yoneda, T., Lowe, C., Soriano, P. & Mundy, G.R. Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice. J. Clin. Invest. 90, 1622-1627 (1992).
33. Andersson, G. & Ek-Rylander, B. The tartrate-resistant purple acid phosphatase of bone osteoclasts-a protein phosphatase with multivalent substrate specificity and regulation. Acta Orthop. Scand. Suppl. 266, 189-194 (1995).