Small leucine-rich proteoglycans in kidney disease

Journal of the American Society of Nephrology

Volumn 22, Issue 7, 2011, Pages 1200-1207

  Schaefer, Liliana ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIGLYCAN; COLLAGEN FIBRIL; COLLAGEN TYPE 1; CRYOPYRIN; DECORIN; FIBROMODULIN; INFLAMMASOME; LUMICAN; PROTEIN KINASE B; PROTEIN P21; PROTEOGLYCAN; SMALL LEUCINE RICH PROTEOGLYCAN; SOMATOMEDIN C RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; APOPTOSIS; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; DIFFUSION; ENDOCYTOSIS; ENDOTHELIUM CELL; ENZYME ACTIVATION; FIBROBLAST; GLOMERULUS; INNATE IMMUNITY; KIDNEY CELL; KIDNEY COLLECTING TUBULE; KIDNEY DISEASE; KIDNEY TUBULE; KIDNEY TUBULE ABSORPTION; LUPUS ERYTHEMATOSUS NEPHRITIS; MESANGIUM CELL; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS REGULATION; RECEPTOR BINDING; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 79960119978     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010050570     Document Type: Short Survey

References (76)

1. Schaefer L, Iozzo RV: Biological functions of the small leucine-rich proteoglycans: From genetics to signal transduction. J Biol Chem 283: 21305-21309, 2008
2. Schaefer L: Extracellular matrix molecules: Endogenous danger signals as new drug targets in kidney diseases. Curr Opin Pharmacol 10: 185-190, 2010
3. Brandan E, Cabello-Verrugio C, Vial C: Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy. Matrix Biol 27: 700-708, 2008
4. Merline R, Schaefer RM, Schaefer L: The matricellular functions of small leucine-rich proteoglycans (SLRPs). J Cell Commun Signal 3: 323-335, 2009
5. Schaefer L, Schaefer RM: Proteoglycans: From structural compounds to signaling molecules. Cell Tissue Res 339: 237-246, 2010
6. Kalamajski S, Oldberg A: The role of small leucine-rich proteoglycans in collagen fibrillogenesis. Matrix Biol 29: 248-253, 2010
7. Young MF, Bi Y, Ameye L, Xu T, Wadhwa S, Heegaard A, Kilts T, Chen XD: Small leucinerich proteoglycans in the aging skeleton. J Musculoskelet Neuronal Interact 6: 364-365, 2006 (Pubitemid 46099718)
8. Yamaguchi Y, Mann DM, Ruoslahti E: Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature 346: 281-284, 1990
9. Border WA, Noble NA, Yamamoto T, Harper JR, Yamaguchi Y, Pierschbacher MD, Ruoslahti E: Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature 360: 361-364, 1992 (Pubitemid 23000677)
10. Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E: Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J 302: 527-534, 1994 (Pubitemid 24280108)
11. Bianco P, Fisher LW, Young MF, Termine JD, Robey PG: Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J Histochem Cytochem 38: 1549-1563, 1990 (Pubitemid 20346965)
12. Schaefer L, Hausser H, Altenburger M, Ugorcakova J, August C, Fisher LW, Schaefer RM, Kresse H: Decorin, biglycan and their endocytosis receptor in rat renal cortex. Kidney Int 54: 1529-1541, 1998 (Pubitemid 28502895)
13. Schaefer L, Grone HJ, Raslik I, Robenek H, Ugorcakova J, Budny S, Schaefer RM, Kresse H: Small proteoglycans of normal adult human kidney: Distinct expression patterns of decorin, biglycan, fibromodulin, and lumican. Kidney Int 58: 1557-1568, 2000
14. Thomas GJ, Mason RM, Davies M: Characterization of proteoglycans synthesized by human adult glomerular mesangial cells in culture. Biochem J 277: 81-88, 1991
15. Couchman JR, Beavan LA, McCarthy KJ: Glomerular matrix: Synthesis, turnover and role in mesangial expansion. Kidney Int 45: 328-335, 1994
16. Schaefer L, Raslik I, Grone HJ, Schonherr E, Macakova K, Ugorcakova J, Budny S, Schaefer RM, Kresse H: Small proteoglycans in human diabetic nephropathy: Discrepancy between glomerular expression and protein accumulation of decorin, biglycan, lumican, and fibromodulin. FASEB J 15: 559-561, 2001
17. Stokes MB, Hudkins KL, Zaharia V, Taneda S, Alpers CE: Up-regulation of extracellular matrix proteoglycans and collagen type I in human crescentic glomerulonephritis. Kidney Int 59: 532-542, 2001 (Pubitemid 32157918)
18. Vleming LJ, Baelde JJ, Westendorp RG, Daha MR, van Es LA, Bruijn JA: Progression of chronic renal disease in humans is associated with the deposition of basement membrane components and decorin in the interstitial extracellular matrix. Clin Nephrol 44: 211-219, 1995
19. Mogyorosi A, Ziyadeh FN: What is the role of decorin in diabetic kidney disease? Nephrol Dial Transplant 14: 1078-1081, 1999 (Pubitemid 29209286)
20. De Heer E, Sijpkens YW, Verkade M, den Dulk M, Langers A, Schutrups J, Bruijn JA, van Es LA: Morphometry of interstitial fibrosis. Nephrol Dial Transplant 15[Suppl 6]: 72-73, 2000
21. Yamaguchi Y, Ruoslahti E: Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation. Nature 336: 244-246, 1988
22. Isaka Y, Brees DK, Ikegaya K, Kaneda Y, Imai E, Noble NA, Border WA: Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med 2: 418-423, 1996 (Pubitemid 26191913)
23. Huijun W, Long C, Zhigang Z, Feng J, Muyi G: Ex vivo transfer of the decorin gene into rat glomerulus via a mesangial cell vector suppressed extracellular matrix accumulation in experimental glomerulonephritis. Exp Mol Pathol 78: 17-24, 2005 (Pubitemid 41373312)
24. Wu F, Yao H, Bader A, Dong F, Zhu F, Wu N, Wang B, Li H, Brockmeyer NH, Altmeyer P: Decorin gene transfer inhibited the expression of TGFbeta1 and ECM in rat mesangial cells. Eur J Med Res 12: 360-368, 2007 (Pubitemid 47365154)
25. Kolb M, Margetts PJ, Sime PJ, Gauldie J: Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung. Am J Physiol Lung Cell Mol Physiol 280: L1327-L1334, 2001
26. Weis SM, Zimmerman SD, Shah M, Covell JW, Omens JH, Ross J Jr, Dalton N, Jones Y, Reed CC, Iozzo RV, McCulloch AD: A role for decorin in the remodeling of myocardial infarction. Matrix Biol 24: 313-324, 2005 (Pubitemid 40853880)
27. Shi YF, Zhang Q, Cheung PY, Shi L, Fong CC, Zhang Y, Tzang CH, Chan BP, Fong WF, Chun J, Kung HF, Yang M: Effects of rh-Decorin on TGF-beta1 induced human hepatic stellate cells LX-2 activation. Biochim Biophys Acta 1760: 1587-1595, 2006 (Pubitemid 44679805)
28. Al Haj Zen A, Caligiuri G, Sainz J, Lemitre M, Demerens C, Lafont A: Decorin overexpression reduces atherosclerosis development in apolipoprotein E-deficient mice. Atherosclerosis 187: 31-39, 2006 (Pubitemid 43816998)
29. Krishna P, Rosen CA, Branski RC, Wells A, Hebda PA: Primed fibroblasts and exogenous decorin: Potential treatments for subacute vocal fold scar. Otolaryngol Head Neck Surg 135: 937-945, 2006 (Pubitemid 44820628)
30. Grisanti S, Szurman P, Warga M, Kaczmarek R, Ziemssen F, Tatar O, Bartz-Schmidt KU: Decorin modulates wound healing in experimental glaucoma filtration surgery: A pilot study. Invest Ophthalmol Vis Sci 46: 191-196, 2005 (Pubitemid 40041197)
31. Schaefer L, Tsalastra W, Babelova A, Baliova M, Minnerup J, Sorokin L, Grone HJ, Reinhardt DP, Pfeilschifter J, Iozzo RV, Schaefer RM: Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin. Am J Pathol 170: 301-315, 2007 (Pubitemid 47339209)
32. Abdel-Wahab N, Wicks SJ, Mason RM, Chantry A: Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240. Biochem J 362: 643-649, 2002 (Pubitemid 34242315)
33. Zhu J, Li Y, Shen W, Qiao C, Ambrosio F, Lavasani M, Nozaki M, Branca MF, Huard J: Relationships between transforming growth factor-beta1, myostatin, and decorin: Implications for skeletal muscle fibrosis. J Biol Chem 282: 25852-25863, 2007 (Pubitemid 47372849)
34. Schonherr E, Broszat M, Brandan E, Bruckner P, Kresse H: Decorin core protein fragment Leu155-Val260 interacts with TGF-beta but does not compete for decorin binding to type I collagen. Arch Biochem Biophys 355: 241-248, 1998 (Pubitemid 28364375)
35. Kresse H, Schonherr E: Proteoglycans of the extracellular matrix and growth control. J Cell Physiol 189: 266-274, 2001 (Pubitemid 33063294)
36. Border WA: Transforming growth factor-beta and the pathogenesis of glomerular diseases. Curr Opin Nephrol Hypertens 3: 54-58, 1994
37. Danielson KG, Baribault H, Holmes DF, Graham H, Kadler KE, Iozzo RV: Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol 136: 729-743, 1997 (Pubitemid 27083772)
38. Schaefer L, Macakova K, Raslik I, Micegova M, Grone HJ, Schonherr E, Robenek H, Echtermeyer FG, Grassel S, Bruckner P, Schaefer RM, Iozzo RV, Kresse H: Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction. Am J Pathol 160: 1181-1191, 2002 (Pubitemid 34224603)
39. Merline R, Lazaroski S, Babelova A, Tsalastra-Greul W, Pfeilschifter J, Schluter KD, Gunther A, Iozzo RV, Schaefer RM, Schaefer L: Decorin deficiency in diabetic mice: Aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration. J Physiol Pharmacol 60[Suppl 4]: 5-13, 2009
40. Williams KJ, Qiu G, Usui HK, Dunn SR, McCue P, Bottinger E, Iozzo RV, Sharma K: Decorin deficiency enhances progressive nephropathy in diabetic mice. Am J Pathol 171: 1441-1450, 2007 (Pubitemid 350158306)
41. Brosius FC III, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T: Mouse models of diabetic nephropathy. J Am Soc Nephrol 20: 2503-2512, 2009
42. Schonherr E, Sunderkotter C, Iozzo RV, Schaefer L: Decorin, a novel player in the insulin-like growth factor system. J Biol Chem 280: 15767-15772, 2005 (Pubitemid 40616696)
43. Schonherr E, Levkau B, Schaefer L, Kresse H, Walsh K: Decorin affects endothelial cells by Akt-dependent and -independent pathways. Ann N Y Acad Sci 973: 149-152, 2002 (Pubitemid 36124996)
44. Lieberthal W, Levine JS: The role of the mammalian target of rapamycin (mTOR) in renal disease. J Am Soc Nephrol 20: 2493-2502, 2009
45. Wu H, Wang S, Xue A, Liu Y, Wang H, Chen Q, Guo M, Zhang Z: Overexpression of decorin induces apoptosis and cell growth arrest in cultured rat mesangial cells in vitro. Nephrology (Carlton) 13: 607-615, 2008
46. Geng Y, McQuillan D, Roughley PJ: SLRP interaction can protect collagen fibrils from cleavage by collagenases. Matrix Biol 25: 484-491, 2006 (Pubitemid 44751452)
47. Hartner A, Schaefer L, Porst M, Cordasic N, Gabriel A, Klanke B, Reinhardt DP, Hilgers KF: Role of fibrillin-1 in hypertensive and diabetic glomerular disease. Am J Physiol Renal Physiol 290: F1329-F1336, 2006 (Pubitemid 43830757)
48. Bjornson Granqvist A, Ebefors K, Saleem MA, Mathieson PW, Haraldsson B, Nystrom JS: Podocyte proteoglycan synthesis is involved in the development of nephrotic syndrome. Am J Physiol Renal Physiol 291: F722-F730, 2006 (Pubitemid 44506968)
49. Schonherr E, Schaefer L, O'Connell BC, Kresse H: Matrix metalloproteinase expression by endothelial cells in collagen lattices changes during co-culture with fibroblasts and upon induction of decorin expression. J Cell Physiol 187: 37-47, 2001 (Pubitemid 32195243)
50. Dong FQ, Li H, Wu F, Yao HP: [Effects of overexpression of decorin on matrix metalloproteinases 2 and 9 in rat mesangial and tubular cells]. Zhonghua Yi Xue Za Zhi 88: 3444-3447, 2008
51. Mozes MM, Bottinger EP, Jacot TA, Kopp JB: Renal expression of fibrotic matrix proteins and of transforming growth factor-beta (TGF-beta) isoforms in TGF-beta transgenic mice. J Am Soc Nephrol 10: 271-280, 1999 (Pubitemid 29068066)
52. Stokes MB, Holler S, Cui Y, Hudkins KL, Eitner F, Fogo A, Alpers CE: Expression of decorin, biglycan, and collagen type I in human renal fibrosing disease. Kidney Int 57: 487-498, 2000 (Pubitemid 30430640)
53. Border WA, Okuda S, Languino LR, Ruoslahti E: Transforming growth factor-beta regulates production of proteoglycans by mesangial cells. Kidney Int 37: 689-695, 1990 (Pubitemid 20056841)
54. Schonherr E, Witsch-Prehm P, Harrach B, Robenek H, Rauterberg J, Kresse H: Interaction of biglycan with type I collagen. J Biol Chem 270: 2776-2783, 1995
55. Wiberg C, Heinegard D, Wenglen C, Timpl R, Morgelin M: Biglycan organizes collagen VI into hexagonal-like networks resembling tissue structures. J Biol Chem 277: 49120-49126, 2002 (Pubitemid 36014340)
56. Schaefer L, Mihalik D, Babelova A, Krzyzankova M, Grone HJ, Iozzo RV, Young MF, Seidler DG, Lin G, Reinhardt DP, Schaefer RM: Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury. Am J Pathol 165: 383-396, 2004 (Pubitemid 38971370)
57. Westermann D, Mersmann J, Melchior A, Freudenberger T, Petrik C, Schaefer L, Lullmann-Rauch R, Lettau O, Jacoby C, Schrader J, Brand-Herrmann SM, Young MF, Schultheiss HP, Levkau B, Baba HA, Unger T, Zacharowski K, Tschope C, Fischer JW: Biglycan is required for adaptive remodeling after myocardial infarction. Circulation 117: 1269-1276, 2008 (Pubitemid 351365659)
58. Schaefer L, Babelova A, Kiss E, Hausser HJ, Baliova M, Krzyzankova M, Marsche G, Young MF, Mihalik D, Gotte M, Malle E, Schaefer RM, Grone HJ: The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest 115: 2223-2233, 2005 (Pubitemid 41134165)
59. Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Grone HJ, Schaefer L: Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem 284: 24035-24048, 2009
60. Schaefer L, Beck KF, Raslik I, Walpen S, Mihalik D, Micegova M, Macakova K, Schonherr E, Seidler DG, Varga G, Schaefer RM, Kresse H, Pfeilschifter J: Biglycan, a nitric oxide-regulated gene, affects adhesion, growth, and survival of mesangial cells. J Biol Chem 278: 26227-26237, 2003 (Pubitemid 36835392)
61. Wang Y, Harris, D: Macrophages in renal disease. J Am Soc Nephrol 22: 21-27, 2011
62. Sanz AB, Sanchez-Nino MD, Ramos AM, Moreno JA, Santamaria B, Ruiz-Ortega M, Egido J, Ortiz A: NF-kappaB in renal inflammation. J Am Soc Nephrol 21: 1254-1262, 2010
63. Anders HJ, Muruve, D: The inflammasome in kidney disease. J Am Soc Nephrol 2011 [Epub ahead of print]
64. Bedke J, Kiss E, Schaefer L, Behnes CL, Bonrouhi M, Gretz N, Horuk R, Diedrichs-Moehring M, Wildner G, Nelson PJ, Grone HJ: Beneficial effects of CCR1 blockade on the progression of chronic renal allograft damage. Am J Transplant 7: 527-537, 2007 (Pubitemid 46376438)
65. Wang S, Schmaderer C, Kiss E, Schmidt C, Bonrouhi M, Porubsky S, Gretz N, Schaefer L, Kirschning CJ, Popovic ZV, Grone HJ: Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88-and TRIF-dependent signaling. Dis Model Mech 3: 92-103, 2010
66. Kiss E, Popovic ZV, Bedke J, Adams J, Bonrouhi M, Babelova A, Schmidt C, Edenhofer F, Zschiedrich I, Domhan S, Abdollahi A, Schafer L, Gretz N, Porubsky S, Grone HJ: Peroxisome proliferator-activated receptor (PPAR)gamma can inhibit chronic renal allograft damage. Am J Pathol 176: 2150-2162, 2010
67. Wu H, Chen G, Wyburn KR, Yin J, Bertolino P, Eris JM, Alexander SI, Sharland AF, Chadban SJ: TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest 117: 2847-2859, 2007 (Pubitemid 47529615)
68. Leemans JC, Butter LM, Pulskens WP, Teske GJ, Claessen N, van der Poll T, Florquin S: The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury. PLoS One 4: e5704, 2009
69. Moreth K, Brodbeck R, Babelova A, Gretz N, Spieker T, Zeng-Brouwers J, Pfeilschifter J, Young MF, Schaefer RM, Schaefer L: The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis. J Clin Invest 120: 4251-4272, 2010
70. Ying S, Shiraishi A, Kao CW, Converse RL, Funderburgh JL, Swiergiel J, Roth MR, Conrad GW, Kao WW: Characterization and expression of the mouse lumican gene. J Biol Chem 272: 30306-30313, 1997 (Pubitemid 27512236)
71. Silverstein DM, Travis BR, Thornhill BA, Schurr JS, Kolls JK, Leung JC, Chevalier RL: Altered expression of immune modulator and structural genes in neonatal unilateral ureteral obstruction. Kidney Int 64: 25-35, 2003 (Pubitemid 36714154)
72. Vuillermoz B, Khoruzhenko A, D'Onofrio MF, Ramont L, Venteo L, Perreau C, Antonicelli F, Maquart FX, Wegrowski Y: The small leucine-rich proteoglycan lumican inhibits melanoma progression. Exp Cell Res 296: 294-306, 2004 (Pubitemid 38624650)
73. Vij N, Roberts L, Joyce S, Chakravarti S: Lumican suppresses cell proliferation and aids Fas-Fas ligand mediated apoptosis: Implications in the cornea. Exp Eye Res 78: 957-971, 2004 (Pubitemid 38402204)
74. Funderburgh JL, Mitschler RR, Funderburgh ML, Roth MR, Chapes SK, Conrad GW: Macrophage receptors for lumican. A corneal keratan sulfate proteoglycan. Invest Ophthalmol Vis Sci 38: 1159-1167, 1997 (Pubitemid 27227045)
75. Vij N, Roberts L, Joyce S, Chakravarti S: Lumican regulates corneal inflammatory responses by modulating Fas-Fas ligand signaling. Invest Ophthalmol Vis Sci 46: 88-95, 2005 (Pubitemid 40041183)
76. Carlson EC, Lin M, Liu CY, Kao WW, Perez VL, Pearlman E: Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1. J Biol Chem 282: 35502-35509, 2007