Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation

Journal of Biological Chemistry

Volumn 281, Issue 36, 2006, Pages 26408-26418

  Seidler, Daniela G ^a   Goldoni, Silvia ^a   Agnew, Christopher ^a   Cardi, Christopher ^a   Thakur, Mathew L ^a   Owens, Rick T ^b   McQuillan, David J ^b   Iozzo, Renato V ^a,c  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b LIFECELL CORPORATION   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH; EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR); SIGNALING MOLECULES; TYROSINE KINASE RECEPTORS;

CELL CULTURE; DEGRADATION; GROWTH KINETICS; METABOLISM; POSITRON EMISSION TOMOGRAPHY; TUMORS;

ENZYMES;

CASPASE 3; DECORIN PROTEIN CORE; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUORODEOXYGLUCOSE F 18; PROTEOGLYCAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOLOGY; CANCER GROWTH; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG UPTAKE; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; METABOLISM; MITOSIS INDEX; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; SQUAMOUS CELL CARCINOMA; TUMOR CELL; XENOGRAFT;

ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CASPASE 3; CELL LINE, TUMOR; DECORIN; DNA FRAGMENTATION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX PROTEINS; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS; PROTEOGLYCANS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSPLANTATION, HETEROLOGOUS;

ANIMALIA;

EID: 33748755116     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602853200     Document Type: Article

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