Extracellular matrix lumican promotes bacterial phagocytosis, and Lum -/- mice show increased Pseudomonas aeruginosa lung infection severity

Journal of Biological Chemistry

Volumn 287, Issue 43, 2012, Pages 35860-35872

  Shao, HanJuan ^a   Lee, Seakwoo ^a   Gae Scott, Sherri ^a   Nakata, Chiaki ^a   Chen, Shoujun ^b   Hamad, Abdel R ^a   Chakravarti, Shukti ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AERUGINOSA; BACTERIAL INFECTIONS; CONNECTIVE TISSUES; EXTRACELLULAR MATRICES; IN-VITRO; LEUCINE-RICH REPEATS; LUMICAN; LUNG INFECTION; NOVEL FUNCTIONS; P.AERUGINOSA; PERITONEAL MACROPHAGE; PROTEOGLYCANS; PSEUDOMONAS AERUGINOSA; SPECIFIC BINDING;

AMINO ACIDS; BACTERIA; COLLAGEN; ESCHERICHIA COLI; MAMMALS; MUSCULOSKELETAL SYSTEM; RESTORATION; TISSUE;

ANTIGEN-ANTIBODY REACTIONS;

ALANINE; CD14 ANTIGEN; CD18 ANTIGEN; LUMICAN; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; CELL SURFACE; CONTROLLED STUDY; DISEASE SEVERITY; ENDOSOME; ESCHERICHIA COLI; IN VITRO STUDY; MORTALITY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PSEUDOMONAS INFECTION; SURFACE PLASMON RESONANCE;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, CD14; ANTIGENS, CD18; CHONDROITIN SULFATE PROTEOGLYCANS; KERATAN SULFATE; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; MUTATION, MISSENSE; PHAGOCYTOSIS; PNEUMONIA, BACTERIAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 84867809497     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.380550     Document Type: Article

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