Lumican inhibits angiogenesis by interfering with α2β1 receptor activity and downregulating MMP-14 expression

Thrombosis Research

Volumn 128, Issue 5, 2011, Pages 452-457

  Niewiarowska, Jolanta ^a   Brézillon, Stéphane ^b   Sacewicz Hofman, Izabela ^a   Bednarek, Radoslaw ^a   Maquart, François Xavier ^b   Malinowski, Mariusz ^c   Wiktorska, Magdalena ^a   Wegrowski, Yanusz ^b   Cierniewski, Czeslaw S ^a,c  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^c INSTITUTE OF MEDICAL BIOLOGY   (Poland)

Author keywords

Angiogenesis; Integrins; Lumican; Metalloproteinases; Metastasis

Indexed keywords

ALPHA2BETA1 INTEGRIN RECEPTOR; BETA1 INTEGRIN; FIBRIN; GELATIN; INTEGRIN RECEPTOR; LUMICAN; MATRIGEL; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ZYMOGRAPHY;

ANIMALS; ANTIGENS, CD29; CHONDROITIN SULFATE PROTEOGLYCANS; DOWN-REGULATION; ENDOTHELIAL CELLS; INTEGRIN ALPHA2BETA1; KERATAN SULFATE; MATRIX METALLOPROTEINASE 14; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; RNA, SMALL INTERFERING;

EID: 80055093482     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.06.011     Document Type: Article

References (27)

1. K.J. Jepsen, F. Wu, J.H. Peragallo, J. Paul, L. Roberts, and Y. Ezura A syndrome of joint laxity and impaired tendon integrity in lumican- and fibromodulin deficient mice J Biol Chem 277 38 2002 35532 35540
2. S. Chakravarti, J. Paul, L. Roberts, I. Chervoneva, A. Oldberg, and D.E. Birk Ocular and scleral alterations in gene-targeted lumican-fibromodulin double-null mice Invest Ophthalmol Vis Sci 44 6 2003 2422 2432 (Pubitemid 36618397)
3. E. Leygue, L. Snell, H. Dotzlaw, K. Hole, T. Hiller-Hitchcock, and P.J. Roughley Expression of lumican in human breast carcinoma Cancer Res 58 7 1998 1348 1352 (Pubitemid 28193587)
4. E. Leygue, L. Snell, H. Dotzlaw, S. Troup, T. Hiller-Hitchcock, and L.C. Murphy Lumican and decorin are differentially expressed in human breast carcinoma J Pathol 192 3 2000 313 320
5. Y.P. Lu, T. Ishiwata, K. Kawahara, M. Watanabe, Z. Naito, and Y. Moriyama Expression of lumican in human colorectal cancer cells Pathol Int 52 8 2002 519 526 (Pubitemid 35279081)
6. Y. Ping Lu, T. Ishiwata, and G. Asano Lumican expression in alpha cells of islets in pancreas and pancreatic cancer cells J Pathol 196 3 2002 324 330 (Pubitemid 34189422)
7. J. Koninger, T. Giese, F.F. di Mola, M.N. Wente, I. Esposito, and M.G. Bachem Pancreatic tumor cells influence the composition of the extracellular matrix Biochem Biophys Res Commun 322 3 2004 943 949 (Pubitemid 39164444)
8. M. Sifaki, M. Assouti, D. Nikitovic, K. Krasagakis, N.K. Karamanos, and G.N. Tzanakakis Lumican, a small leucine-rich proteoglycan substituted with keratan sulfate chains is expressed and secreted by human melanoma cells and not normal melanocytes IUBMB Life 58 10 2006 606 610 (Pubitemid 44527225)
9. S. Brézillon, L. Venteo, L. Ramont, M.F. D'Onofrio, C. Perreau, and M. Pluot Expression of lumican, a small leucine-rich proteoglycan with antitumour activity, in human malignant melanoma Clin Exp Dermatol 32 4 2007 405 416 (Pubitemid 46828334)
10. S. Shinji, T. Tajiri, T. Ishiwata, T. Seya, N. Tanaka, and Z. Naito Different expression levels of lumican in human carcinoid tumor and neuroendocrine cell carcinoma Int J Oncol 26 4 2005 873 880
11. D. Nikitovic, A. Berdiaki, A. Zafiropoulos, P. Katonis, A. Tsatsakis, and N.K. Karamanos Lumican expression is positively correlated with the differentiation and negatively with the growth of human osteosarcoma cells FEBS J 275 2 2008 350 361
12. S. Troup, C. Njue, E.V. Kliewer, M. Parisien, C. Roskelley, and S. Chakravarti Reduced expression of the small leucine-rich proteoglycans, lumican, and decorin is associated with poor outcome in node-negative invasive breast cancer Clin Cancer Res 9 1 2003 207 214 (Pubitemid 36109735)
13. H. Baba, T. Ishiwata, E. Takashi, G. Xu, and G. Asano Expression and localization of lumican in the ischemic and reperfused rat heart Jpn Circ J 65 5 2001 445 450
14. B. Vuillermoz, A. Khoruzhenko, M.F. D'Onofrio, L. Ramont, L. Venteo, and C. Perreau The small leucine-rich proteoglycan lumican inhibits melanoma progression Exp Cell Res 296 2 2004 294 306 (Pubitemid 38624650)
15. C. Zeltz, S. Brézillon, J. Käpylä, J.A. Eble, H. Bobichon, and C. Terryn Lumican inhibits cell migration through α2β1 integrin Exp Cell Res 316 17 2010 2922 2931
16. C.M. Stoscheck Quantitation of protein Meth Enzymol 182 1990 50 69
17. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 5259 1970 680 685
18. J. Niewiarowska, I. Sacewicz, M. Wiktorska, T. Wysocki, O. Stasikowska, and M. Wagrowska-Danilewicz DNAzymes to mouse β1 integrin mRNA in vivo: targeting the tumor vasculature and retarding cancer growth Cancer Gene Ther 16 9 2009 713 722
19. B.G. Galvez, S. MatIas-Roman, M. Yanez-Mo, F. Sanchez-Madrid, and A.G. Arroyo ECM regulates MT1-MMP localization with beta1 or alphavbeta3 integrins at distinct cell compartments modulating its internalization and activity on human endothelial cells J Cell Biol 159 3 2002 509 521 (Pubitemid 35332837)
20. M.A. Moses The regulation of neovascularization of matrix metalloproteinases and their inhibitors Stem Cells 15 3 1997 180 189 (Pubitemid 27225283)
21. B. Schmalfeldt, D. Prechtel, K. Haerting, K. Spaethe, S. Rutke, and E. Konik Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer Clin Cancer Res 7 8 2001 2396 2404 (Pubitemid 32751641)
22. A.R. Nelson, B. Fingleton, M.L. Rothenberg, and L.M. Matrisian Matrix metalloproteinases: biologic activity and clinical implications J Clin Oncol 18 5 2000 1135 1149 (Pubitemid 30123793)
23. Q. Yu, and I. Stamenkovic Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGFbeta and promotes tumor invasion and angiogenesis Genes Dev 14 2 2000 163 176 (Pubitemid 30070982)
24. H.G. Munshi, and M.S. Stack Reciprocal interactions between adhesion receptor signaling and MMP regulation Cancer Metastasis Rev 25 1 2006 45 56 (Pubitemid 43723981)
25. R. Fridman, M. Toth, I. Chvyrkova, S.O. Meroueh, and S. Mobashery Cell surface association of matrix metalloproteinase-9 (gelatinase B) Cancer Metastasis Rev 22 2-3 2003 153 166 (Pubitemid 36561055)
26. K. Brew, D. Dinakarpandian, and H. Nagase Tissue inhibitors of metalloproteinases: evolution, structure and function Biochim Biophys Acta 1477 1-2 2000 267 283 (Pubitemid 30119906)
27. K. Kessenbrock, V. Plaks, and Z. Werb Matrix metalloproteinases: regulators of the tumor microenvironment Cell 141 1 2010 52 67