-
1
-
-
33645861910
-
Hypoxic pulmonary vasoconstriction: Mechanisms and controversies
-
Aaronson PI, Robertson TP, Knock GA, Becker S, Lewis TH, Snetkov V, Ward JP. Hypoxic pulmonary vasoconstriction: mechanisms and controversies. J Physiol 570: 53-58, 2006.
-
(2006)
J Physiol
, vol.570
, pp. 53-58
-
-
Aaronson, P.I.1
Robertson, T.P.2
Knock, G.A.3
Becker, S.4
Lewis, T.H.5
Snetkov, V.6
Ward, J.P.7
-
2
-
-
84856397577
-
Digoxin inhibits development of hypoxic pulmonary hypertension in mice
-
Abud EM, Maylor J, Undem C, Punjabi A, Zaiman AL, Myers AC, Sylvester JT, Semenza GL, Shimoda LA. Digoxin inhibits development of hypoxic pulmonary hypertension in mice. Proc Natl Acad Sci U SA 109: 1239-1244, 2012.
-
(2012)
Proc Natl Acad Sci U SA
, vol.109
, pp. 1239-1244
-
-
Abud, E.M.1
Maylor, J.2
Undem, C.3
Punjabi, A.4
Zaiman, A.L.5
Myers, A.C.6
Sylvester, J.T.7
Semenza, G.L.8
Shimoda, L.A.9
-
3
-
-
4644318828
-
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
-
Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 279: 38458-38465, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 38458-38465
-
-
Appelhoff, R.J.1
Tian, Y.M.2
Raval, R.R.3
Turley, H.4
Harris, A.L.5
Pugh, C.W.6
Ratcliffe, P.J.7
Gleadle, J.M.8
-
4
-
-
39149106144
-
Mitochondrial metabolism, redox signaling, and fusion: A mitochondria-ROS-HIF-1a-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer
-
Archer SL, Gomberg-Maitland M, Maitland ML, Rich S, Garcia JG, Weir EK. Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF- 1a-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer. Am J Physiol Heart Circ Physiol 294: H570-H578, 2008.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.294
-
-
Archer, S.L.1
Gomberg-Maitland, M.2
Maitland, M.L.3
Rich, S.4
Garcia, J.G.5
Weir, E.K.6
-
5
-
-
84894091541
-
Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle HIF-1a
-
In press
-
Ball MK, Waypa GB, Mungai PT, Nielsen JM, Czech L, Dudley VJ, Beussink L, Dettman RW, Berkelhamer SK, Steinhorn RH, Shah SJ, Schumacker PT. Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle HIF-1a. Am J Respir Crit Care Med. In press.
-
Am J Respir Crit Care Med
-
-
Ball, M.K.1
Waypa, G.B.2
Mungai, P.T.3
Nielsen, J.M.4
Czech, L.5
Dudley, V.J.6
Beussink, L.7
Dettman, R.W.8
Berkelhamer, S.K.9
Steinhorn, R.H.10
Shah, S.J.11
Schumacker, P.T.12
-
6
-
-
57649116076
-
Nuclear oxygen sensing: Induction of endogenous prolyl-hydroxylase 2 activity by hypoxia and nitric oxide
-
Berchner-Pfannschmidt U, Tug S, Trinidad B, Oehme F, Yamac H, Wotzlaw C, Flamme I, Fandrey J. Nuclear oxygen sensing: induction of endogenous prolyl-hydroxylase 2 activity by hypoxia and nitric oxide. J Biol Chem 283: 31745-31753, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 31745-31753
-
-
Berchner-Pfannschmidt, U.1
Tug, S.2
Trinidad, B.3
Oehme, F.4
Yamac, H.5
Wotzlaw, C.6
Flamme, I.7
Fandrey, J.8
-
7
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1a in normoxia
-
Berra E, Benizri E, Ginouves A, Volmat V, Roux D, Pouyssegur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1a in normoxia. EMBO J 22: 4082-4090, 2003.
-
(2003)
EMBO J
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
Pouyssegur, J.6
-
8
-
-
33745155785
-
An abnormal mitochondrial-hypoxia inducible factor-1a-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension
-
Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL. An abnormal mitochondrial-hypoxia inducible factor-1a-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation 113: 2630-2641, 2006.
-
(2006)
Circulation
, vol.113
, pp. 2630-2641
-
-
Bonnet, S.1
Michelakis, E.D.2
Porter, C.J.3
Andrade-Navarro, M.A.4
Thébaud, B.5
Bonnet, S.6
Haromy, A.7
Harry, G.8
Moudgil, R.9
McMurtry, M.S.10
Weir, E.K.11
Archer, S.L.12
-
9
-
-
85047691081
-
Heterozygous deficiency of hypoxia-inducible factor-2a protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
-
Brusselmans K, Compernolle V, Tjwa M, Wiesener MS, Maxwell PH, Collen D, Carmeliet P. Heterozygous deficiency of hypoxia-inducible factor-2a protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 111: 1519-1527, 2003.
-
(2003)
J Clin Invest
, vol.111
, pp. 1519-1527
-
-
Brusselmans, K.1
Compernolle, V.2
Tjwa, M.3
Wiesener, M.S.4
Maxwell, P.H.5
Collen, D.6
Carmeliet, P.7
-
10
-
-
67651238345
-
Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvi-ronment
-
Burke DL, Frid MG, Kunrath CL, Karoor V, Anwar A, Wagner BD, Strassheim D, Stenmark KR. Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvi-ronment. Am J Physiol Lung Cell Mol Physiol 297: L238-L250, 2009.
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.297
-
-
Burke, D.L.1
Frid, M.G.2
Kunrath, C.L.3
Karoor, V.4
Anwar, A.5
Wagner, B.D.6
Strassheim, D.7
Stenmark, K.R.8
-
11
-
-
33745756977
-
Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia
-
Bushuev VI, Miasnikova GY, Sergueeva AI, Polyakova LA, Okhotin D, Gaskin PR, Debebe Z, Nekhai S, Castro OL, Prchal JT, Gordeuk VR. Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia. Haema-tologica 91: 744-749, 2006.
-
(2006)
Haema-tologica
, vol.91
, pp. 744-749
-
-
Bushuev, V.I.1
Miasnikova, G.Y.2
Sergueeva, A.I.3
Polyakova, L.A.4
Okhotin, D.5
Gaskin, P.R.6
Debebe, Z.7
Nekhai, S.8
Castro, O.L.9
Prchal, J.T.10
Gordeuk, V.R.11
-
12
-
-
84862594477
-
The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: Vasoconstrictor and structural mechanisms contribute equally
-
Cahill E, Rowan SC, Sands M, Banahan M, Ryan D, Howell K, McLoughlin P. The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally. Exp Physiol 97: 796-806, 2012.
-
(2012)
Exp Physiol
, vol.97
, pp. 796-806
-
-
Cahill, E.1
Rowan, S.C.2
Sands, M.3
Banahan, M.4
Ryan, D.5
Howell, K.6
McLoughlin, P.7
-
13
-
-
0345490692
-
Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1a
-
Compernolle V, Brusselmans K, Franco D, Moorman A, Dewerchin M, Collen D, Carmeliet P. Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1a. Cardiovasc Res 60: 569-579, 2003.
-
(2003)
Cardiovasc Res
, vol.60
, pp. 569-579
-
-
Compernolle, V.1
Brusselmans, K.2
Franco, D.3
Moorman, A.4
Dewerchin, M.5
Collen, D.6
Carmeliet, P.7
-
14
-
-
33846315497
-
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay
-
Ehrismann D, Flashman E, Genn DN, Mathioudakis N, Hewitson KS, Ratcliffe PJ, Schofield CJ. Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. Biochem J 401: 227-234, 2007.
-
(2007)
Biochem J
, vol.401
, pp. 227-234
-
-
Ehrismann, D.1
Flashman, E.2
Genn, D.N.3
Mathioudakis, N.4
Hewitson, K.S.5
Ratcliffe, P.J.6
Schofield, C.J.7
-
16
-
-
0031000736
-
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1a regulates the VEGF expression and is potentially involved in lung and vascular development
-
Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1a regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 94: 4273-4278, 1997.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4273-4278
-
-
Ema, M.1
Taya, S.2
Yokotani, N.3
Sogawa, K.4
Matsuda, Y.5
Fujii-Kuriyama, Y.6
-
17
-
-
17944375360
-
C. Elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107: 43-54, 2001.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
Tian, Y.M.11
Masson, N.12
Hamilton, D.L.13
Jaakkola, P.14
Barstead, R.15
Hodgkin, J.16
Maxwell, P.H.17
Pugh, C.W.18
Schofield, C.J.19
Ratcliffe, P.J.20
more..
-
18
-
-
33748187417
-
Regulating cellular oxygen sensing by hydroxylation
-
Fandrey J, Gorr TA, Gassmann M. Regulating cellular oxygen sensing by hydroxylation. Cardiovasc Res 71: 642-651, 2006.
-
(2006)
Cardiovasc Res
, vol.71
, pp. 642-651
-
-
Fandrey, J.1
Gorr, T.A.2
Gassmann, M.3
-
19
-
-
77749291806
-
Hypoxia inducible-factor1a regulates the metabolic shift of pulmonary hypertensive endothelial cells
-
Fijalkowska I, Xu W, Comhair SA, Janocha AJ, Mavrakis LA, Krishnamachary B, Zhen L, Mao T, Richter A, Erzurum SC, Tuder RM. Hypoxia inducible-factor1a regulates the metabolic shift of pulmonary hypertensive endothelial cells. Am J Pathol 176: 1130-1138, 2010.
-
(2010)
Am J Pathol
, vol.176
, pp. 1130-1138
-
-
Fijalkowska, I.1
Xu, W.2
Comhair, S.A.3
Janocha, A.J.4
Mavrakis, L.A.5
Krishnamachary, B.6
Zhen, L.7
Mao, T.8
Richter, A.9
Erzurum, S.C.10
Tuder, R.M.11
-
20
-
-
79957901942
-
Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: Von Hippel-Lindau disease and HIF-2a gain-of-function mutation
-
Formenti F, Beer PA, Croft QP, Dorrington KL, Gale DP, Lappin TR, Lucas GS, Maher ER, Maxwell PH, McMullin MF, O'Connor DF, Percy MJ, Pugh CW, Ratcliffe PJ, Smith TG, Talbot NP, Robbins PA. Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2a gain-of-function mutation. FASEB J 25: 2001-2011, 2011.
-
(2011)
FASEB J
, vol.25
, pp. 2001-2011
-
-
Formenti, F.1
Beer, P.A.2
Croft, Q.P.3
Dorrington, K.L.4
Gale, D.P.5
Lappin, T.R.6
Lucas, G.S.7
Maher, E.R.8
Maxwell, P.H.9
McMullin, M.F.10
O'Connor, D.F.11
Percy, M.J.12
Pugh, C.W.13
Ratcliffe, P.J.14
Smith, T.G.15
Talbot, N.P.16
Robbins, P.A.17
-
21
-
-
84874903225
-
Hypoxia-induced inflammation in the lung: A potential therapeutic target in acute lung injury?
-
Frohlich S, Boylan J, McLoughlin P. Hypoxia-induced inflammation in the lung: a potential therapeutic target in acute lung injury? Am J Respir Cell Mol Biol 48: 271-279, 2013.
-
(2013)
Am J Respir Cell Mol Biol
, vol.48
, pp. 271-279
-
-
Frohlich, S.1
Boylan, J.2
McLoughlin, P.3
-
22
-
-
50949133897
-
Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation
-
Gale DP, Harten SK, Reid CDL, Tuddenham EGD, Maxwell PH. Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation. Blood 112: 919-921, 2008.
-
(2008)
Blood
, vol.112
, pp. 919-921
-
-
Gale, D.P.1
Harten, S.K.2
Reid, C.D.L.3
Tuddenham, E.G.D.4
Maxwell, P.H.5
-
23
-
-
0346492721
-
The endothelin system in pulmonary arterial hypertension
-
Galie N, Manes A, Branzi A. The endothelin system in pulmonary arterial hypertension. Cardiovasc Res 61: 227-237, 2004.
-
(2004)
Cardiovasc Res
, vol.61
, pp. 227-237
-
-
Galie, N.1
Manes, A.2
Branzi, A.3
-
24
-
-
84877121075
-
MTOR and vascular remodeling in lung diseases: Current challenges and therapeutic prospects
-
Goncharova EA. mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects. FASEB J 27: 1796-1807, 2013.
-
(2013)
FASEB J
, vol.27
, pp. 1796-1807
-
-
Goncharova, E.A.1
-
25
-
-
77949725833
-
The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
-
Hickey MM, Richardson T, Wang T, Mosqueira M, Arguiri E, Yu H, Yu QC, Solomides CC, Morrisey EE, Khurana TS, Christofidou-Solomidou M, Simon MC. The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. J Clin Invest 120: 827-839, 2010.
-
(2010)
J Clin Invest
, vol.120
, pp. 827-839
-
-
Hickey, M.M.1
Richardson, T.2
Wang, T.3
Mosqueira, M.4
Arguiri, E.5
Yu, H.6
Yu, Q.C.7
Solomides, C.C.8
Morrisey, E.E.9
Khurana, T.S.10
Christofidou-Solomidou, M.11
Simon, M.C.12
-
26
-
-
27544504817
-
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases
-
Hirota K, Semenza GL. Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. Biochem Biophys Res Commun 338: 610-616, 2005.
-
(2005)
Biochem Biophys Res Commun
, vol.338
, pp. 610-616
-
-
Hirota, K.1
Semenza, G.L.2
-
27
-
-
0035917313
-
HIFa targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr. HIFa targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292: 464-468, 2001.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin, Jr.W.G.10
-
28
-
-
15444342958
-
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1a
-
Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, Semenza GL. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1a. Genes Dev 12: 149-162, 1998.
-
(1998)
Genes Dev
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
29
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science 292: 468-472, 2001.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
30
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30: 393-402, 2008.
-
(2008)
Mol Cell
, vol.30
, pp. 393-402
-
-
Kaelin, Jr.W.G.1
Ratcliffe, P.J.2
-
31
-
-
68849102685
-
HIF2a cooperates with RAS to promote lung tumorigenesis in mice
-
Kim WY, Perera S, Zhou B, Carretero J, Yeh JJ, Heathcote SA, Jackson AL, Nikolinakos P, Ospina B, Naumov G, Brandstetter KA, Weigman VJ, Zaghlul S, Hayes DN, Padera RF, Heymach JV, Kung AL, Sharpless NE, Kaelin WG Jr, Wong KK. HIF2a cooperates with RAS to promote lung tumorigenesis in mice. J Clin Invest 119: 2160-2170, 2009.
-
(2009)
J Clin Invest
, vol.119
, pp. 2160-2170
-
-
Kim, W.Y.1
Perera, S.2
Zhou, B.3
Carretero, J.4
Yeh, J.J.5
Heathcote, S.A.6
Jackson, A.L.7
Nikolinakos, P.8
Ospina, B.9
Naumov, G.10
Brandstetter, K.A.11
Weigman, V.J.12
Zaghlul, S.13
Hayes, D.N.14
Padera, R.F.15
Heymach, J.V.16
Kung, A.L.17
Sharpless, N.E.18
Kaelin, Jr.W.G.19
Wong, K.K.20
more..
-
32
-
-
84877576147
-
Hypoxia inducible factor-1a in pulmonary artery smooth muscle cells lowers vascular tone by decreasing myosin light chain phosphorylation
-
Kim YM, Barnes EA, Alvira CM, Ying L, Reddy S, Cornfield DN. Hypoxia inducible factor-1a in pulmonary artery smooth muscle cells lowers vascular tone by decreasing myosin light chain phosphorylation. Circ Res 112: 1230-1233, 2013.
-
(2013)
Circ Res
, vol.112
, pp. 1230-1233
-
-
Kim, Y.M.1
Barnes, E.A.2
Alvira, C.M.3
Ying, L.4
Reddy, S.5
Cornfield, D.N.6
-
33
-
-
33749410367
-
The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases
-
Koivunen P, Hirsila M, Kivirikko KI, Myllyharju J. The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases. J Biol Chem 281: 28712-28720, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 28712-28720
-
-
Koivunen, P.1
Hirsila, M.2
Kivirikko, K.I.3
Myllyharju, J.4
-
34
-
-
0033562569
-
Defective vascularization of HIF-1a-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
-
Kotch LE, Iyer NV, Laughner E, Semenza GL. Defective vascularization of HIF-1a-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol 209: 254-267, 1999.
-
(1999)
Dev Biol
, vol.209
, pp. 254-267
-
-
Kotch, L.E.1
Iyer, N.V.2
Laughner, E.3
Semenza, G.L.4
-
35
-
-
70449580319
-
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
-
Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc Natl Acad Sci USA 106: 17910-17915, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 17910-17915
-
-
Lee, K.1
Zhang, H.2
Qian, D.Z.3
Rey, S.4
Liu, J.O.5
Semenza, G.L.6
-
36
-
-
84865137448
-
Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1
-
Leggett K, Maylor J, Undem C, Lai N, Lu W, Schweitzer KS, King LS, Myers AC, Sylvester JT, Sidhaye VK, Shimoda LA. Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1. Am J Physiol Lung Cell Mol Physiol 303: L343-L353, 2012.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.303
-
-
Leggett, K.1
Maylor, J.2
Undem, C.3
Lai, N.4
Lu, W.5
Schweitzer, K.S.6
King, L.S.7
Myers, A.C.8
Sylvester, J.T.9
Sidhaye, V.K.10
Shimoda, L.A.11
-
37
-
-
0028060499
-
Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia
-
Li H, Chen SJ, Chen YF, Meng QC, Durand J, Oparil S, Elton TS. Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia. J Appl Physiol 77: 1451-1459, 1994.
-
(1994)
J Appl Physiol
, vol.77
, pp. 1451-1459
-
-
Li, H.1
Chen, S.J.2
Chen, Y.F.3
Meng, Q.C.4
Durand, J.5
Oparil, S.6
Elton, T.S.7
-
38
-
-
84868155281
-
Endothelin-1 induces hypoxia inducible factor 1a expression in pulmonary artery smooth muscle cells
-
Li M, Liu Y, Jin F, Sun X, Li Z, Fang P, Shi H, Jiang X. Endothelin-1 induces hypoxia inducible factor 1a expression in pulmonary artery smooth muscle cells. FEBS Lett 586: 3888-3893, 2012.
-
(2012)
FEBS Lett
, vol.586
, pp. 3888-3893
-
-
Li, M.1
Liu, Y.2
Jin, F.3
Sun, X.4
Li, Z.5
Fang, P.6
Shi, H.7
Jiang, X.8
-
39
-
-
4444352981
-
2+ channels in pulmonary arterial smooth muscle cells: A novel mechanism of hypoxic pulmonary hypertension
-
2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension. Circ Res 95: 496-505, 2004.
-
(2004)
Circ Res
, vol.95
, pp. 496-505
-
-
Lin, M.J.1
Leung, G.P.2
Zhang, W.M.3
Yang, X.R.4
Yip, K.P.5
Tse, C.M.6
Sham, J.S.7
-
40
-
-
51449105857
-
Age-dependent impairment of HIF-1a expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells
-
Liu L, Marti GP, Wei X, Zhang X, Zhang H, Liu YV, Nastai M, Semenza GL, Harmon JW. Age-dependent impairment of HIF-1a expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. J Cell Physiol 217: 319-327, 2008.
-
(2008)
J Cell Physiol
, vol.217
, pp. 319-327
-
-
Liu, L.1
Marti, G.P.2
Wei, X.3
Zhang, X.4
Zhang, H.5
Liu, Y.V.6
Nastai, M.7
Semenza, G.L.8
Harmon, J.W.9
-
41
-
-
33846254999
-
RACK1 competes with HSP90 for binding to HIF-1a and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1a
-
Liu YV, Baek JH, Zhang H, Diez R, Cole RN, Semenza GL. RACK1 competes with HSP90 for binding to HIF-1a and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1a. Mol Cell 25: 207-217, 2007.
-
(2007)
Mol Cell
, vol.25
, pp. 207-217
-
-
Liu, Y.V.1
Baek, J.H.2
Zhang, H.3
Diez, R.4
Cole, R.N.5
Semenza, G.L.6
-
42
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1a and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K, Semenza GL. FIH-1: a novel protein that interacts with HIF-1a and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15: 2675-2686, 2001.
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
43
-
-
0030943461
-
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
-
Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, Simon MC. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386: 403-407, 1997.
-
(1997)
Nature
, vol.386
, pp. 403-407
-
-
Maltepe, E.1
Schmidt, J.V.2
Baunoch, D.3
Bradfield, C.A.4
Simon, M.C.5
-
44
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-A chains activated by prolyl hydroxylation
-
Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ. Independent function of two destruction domains in hypoxia-inducible factor-A chains activated by prolyl hydroxylation. EMBO J 20: 5197-5206, 2001.
-
(2001)
EMBO J
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
Willam, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
46
-
-
0037386143
-
Intracellular localisation of human HIF-1a hydroxylases: Implications for oxygen sensing
-
Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Burgel T, Jelkmann W, Acker H, Fandrey J. Intracellular localisation of human HIF-1a hydroxylases: implications for oxygen sensing. J Cell Sci 116: 1319-1326, 2003.
-
(2003)
J Cell Sci
, vol.116
, pp. 1319-1326
-
-
Metzen, E.1
Berchner-Pfannschmidt, U.2
Stengel, P.3
Marxsen, J.H.4
Stolze, I.5
Klinger, M.6
Huang, W.Q.7
Wotzlaw, C.8
Hellwig-Burgel, T.9
Jelkmann, W.10
Acker, H.11
Fandrey, J.12
-
47
-
-
0027441724
-
Stimulation of calcium entry is prerequisite for DNA synthesis induced by platelet-derived growth factor in vascular smooth muscle cells
-
Mogami H, Kojima I. Stimulation of calcium entry is prerequisite for DNA synthesis induced by platelet-derived growth factor in vascular smooth muscle cells. Biochem Biophys Res Commun 196: 650-658, 1993.
-
(1993)
Biochem Biophys Res Commun
, vol.196
, pp. 650-658
-
-
Mogami, H.1
Kojima, I.2
-
48
-
-
4544244944
-
Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats
-
Nagaoka T, Morio Y, Casanova N, Bauer N, Gebb S, McMurtry I, Oka M. Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 287: L665-L672, 2004.
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.287
-
-
Nagaoka, T.1
Morio, Y.2
Casanova, N.3
Bauer, N.4
Gebb, S.5
McMurtry, I.6
Oka, M.7
-
49
-
-
34249062965
-
Hypoxia and the lung: Beyond hypoxic vasoconstriction
-
Nicolls MR, Voelkel NF. Hypoxia and the lung: beyond hypoxic vasoconstriction. Antioxid Redox Signal 9: 741-743, 2007.
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 741-743
-
-
Nicolls, M.R.1
Voelkel, N.F.2
-
50
-
-
0026758383
-
PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats
-
Ono S, Westcott JY, Voelkel NF. PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats. J Appl Physiol 73: 1084-1092, 1992.
-
(1992)
J Appl Physiol
, vol.73
, pp. 1084-1092
-
-
Ono, S.1
Westcott, J.Y.2
Voelkel, N.F.3
-
51
-
-
84878634927
-
Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1
-
Pisarcik S, Maylor J, Lu W, Yun X, Undem C, Sylvester JT, Semenza GL, Shimoda LA. Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. Am J Physiol Lung Cell Mol Physiol 304: L549-L561, 2013.
-
(2013)
Am J Physiol Lung Cell Mol Physiol
, vol.304
-
-
Pisarcik, S.1
Maylor, J.2
Lu, W.3
Yun, X.4
Undem, C.5
Sylvester, J.T.6
Semenza, G.L.7
Shimoda, L.A.8
-
52
-
-
70350379191
-
Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2
-
Prabhakar NR, Kumar GK, Nanduri J. Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2. Ann N Y Acad Sci 1177: 162-168, 2009.
-
(2009)
Ann N y Acad Sci
, vol.1177
, pp. 162-168
-
-
Prabhakar, N.R.1
Kumar, G.K.2
Nanduri, J.3
-
53
-
-
84864131464
-
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2
-
Prabhakar NR, Semenza GL. Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev 92: 967-1003, 2012.
-
(2012)
Physiol Rev
, vol.92
, pp. 967-1003
-
-
Prabhakar, N.R.1
Semenza, G.L.2
-
54
-
-
0030077602
-
+ exchange and growth factors in pulmonary artery smooth muscle cell proliferation
-
+ exchange and growth factors in pulmonary artery smooth muscle cell proliferation. Am J Respir Cell Mol Biol 14: 139-145, 1996.
-
(1996)
Am J Respir Cell Mol Biol
, vol.14
, pp. 139-145
-
-
Quinn, D.A.1
Dahlberg, C.G.2
Bonventre, J.P.3
Scheid, C.R.4
Honeyman, T.5
Joseph, P.M.6
Thompson, B.T.7
Hales, C.A.8
-
56
-
-
36749014049
-
Developmental regulation of hypoxia-inducible factor 1 and prolyl-hydroxylases in pulmonary vascular smooth muscle cells
-
Resnik ER, Herron JM, Lyu SC, Cornfield DN. Developmental regulation of hypoxia-inducible factor 1 and prolyl-hydroxylases in pulmonary vascular smooth muscle cells. Proc Natl Acad Sci USA 104: 18789-18794, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 18789-18794
-
-
Resnik, E.R.1
Herron, J.M.2
Lyu, S.C.3
Cornfield, D.N.4
-
57
-
-
0031719459
-
The short-term effects of digoxin in patients with right ventricular dysfunction from pulmonary hypertension
-
Rich S, Seidlitz M, Dodin E, Osimani D, Judd D, Genthner D, McLaughlin V, Francis G. The short-term effects of digoxin in patients with right ventricular dysfunction from pulmonary hypertension. Chest 114: 787-792, 1998.
-
(1998)
Chest
, vol.114
, pp. 787-792
-
-
Rich, S.1
Seidlitz, M.2
Dodin, E.3
Osimani, D.4
Judd, D.5
Genthner, D.6
McLaughlin, V.7
Francis, G.8
-
59
-
-
0032100732
-
HIF-1a is required for solid tumor formation and embryonic vascularization
-
Ryan HE, Lo J, Johnson RS. HIF-1a is required for solid tumor formation and embryonic vascularization. EMBOJ 17: 3005-3015, 1998.
-
(1998)
EMBOJ
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
60
-
-
84862991047
-
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
-
Sarkar K, Cai Z, Gupta R, Parajuli N, Fox-Talbot K, Darshan MS, Gonzalez FJ, Semenza GL. Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning. Proc Natl Acad Sci USA 109: 10504-10509, 2012.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 10504-10509
-
-
Sarkar, K.1
Cai, Z.2
Gupta, R.3
Parajuli, N.4
Fox-Talbot, K.5
Darshan, M.S.6
Gonzalez, F.J.7
Semenza, G.L.8
-
61
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29: 625-634, 2010.
-
(2010)
Oncogene
, vol.29
, pp. 625-634
-
-
Semenza, G.L.1
-
62
-
-
79957952535
-
Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning
-
Semenza GL. Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim Biophys Acta 1813: 1263-1268, 2011.
-
(2011)
Biochim Biophys Acta
, vol.1813
, pp. 1263-1268
-
-
Semenza, G.L.1
-
63
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell 148: 399-408, 2012.
-
(2012)
Cell
, vol.148
, pp. 399-408
-
-
Semenza, G.L.1
-
64
-
-
70349237414
-
Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis
-
Semenza GL. Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis. Blood 114: 2015-2019, 2009.
-
(2009)
Blood
, vol.114
, pp. 2015-2019
-
-
Semenza, G.L.1
-
65
-
-
85047682984
-
Regulation of oxygen homeostasis by hypoxia-inducible factor 1
-
Semenza GL. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda) 24: 97-106, 2009.
-
(2009)
Physiology (Bethesda)
, vol.24
, pp. 97-106
-
-
Semenza, G.L.1
-
66
-
-
0033803047
-
Surviving ischemia: Adaptive responses mediated by hypoxia-inducible factor 1
-
Semenza GL. Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1. J Clin Invest 106: 809-812, 2000.
-
(2000)
J Clin Invest
, vol.106
, pp. 809-812
-
-
Semenza, G.L.1
-
67
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12: 5447-5454, 1992.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
68
-
-
84875741389
-
55th Bowditch Lecture: Effects of chronic hypoxia on the pulmonary circulation: Role of HIF-1
-
Shimoda LA. 55th Bowditch Lecture: Effects of chronic hypoxia on the pulmonary circulation: role of HIF-1. J Appl Physiol 113: 1343-1352, 2012.
-
(2012)
J Appl Physiol
, vol.113
, pp. 1343-1352
-
-
Shimoda, L.A.1
-
69
-
-
33751117499
-
HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes
-
Shimoda LA, Fallon M, Pisarcik S, Wang J, Semenza GL. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol 291: L941-L949, 2006.
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.291
-
-
Shimoda, L.A.1
Fallon, M.2
Pisarcik, S.3
Wang, J.4
Semenza, G.L.5
-
70
-
-
84875708891
-
Vascular remodeling in pulmonary hypertension
-
Shimoda LA, Laurie SS. Vascular remodeling in pulmonary hypertension. J Mol Med 91: 297-309, 2013.
-
(2013)
J Mol Med
, vol.91
, pp. 297-309
-
-
Shimoda, L.A.1
Laurie, S.S.2
-
71
-
-
0034815688
-
Partial HIF-1a deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia
-
Shimoda LA, Manalo DJ, Sham JS, Semenza GL, Sylvester JT. Partial HIF-1a deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. Am J Physiol Lung Cell Mol Physiol 281: L202-L208, 2001.
-
(2001)
Am J Physiol Lung Cell Mol Physiol
, vol.281
-
-
Shimoda, L.A.1
Manalo, D.J.2
Sham, J.S.3
Semenza, G.L.4
Sylvester, J.T.5
-
72
-
-
0037158630
-
Acute and chronic hypoxic pulmonary vasoconstriction: A central role for endothelin-1?
-
Shimoda LA, Sham JS, Liu Q, Sylvester JT. Acute and chronic hypoxic pulmonary vasoconstriction: a central role for endothelin-1? Respir Physiol Neurobiol 132: 93-106, 2002.
-
(2002)
Respir Physiol Neurobiol
, vol.132
, pp. 93-106
-
-
Shimoda, L.A.1
Sham, J.S.2
Liu, Q.3
Sylvester, J.T.4
-
74
-
-
67649579669
-
Updated clinical classification of pulmonary hypertension
-
Simonneau G, Robbins IM, Beghetti M, Channick RN, Delcroix M, Denton CP, Elliott CG, Gaine SP, Gladwin MT, Jing ZC, Krowka MJ, Langleben D, Nakanishi N, Souza R. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 54, Suppl 1: S43-S54, 2009.
-
(2009)
J Am Coll Cardiol
, vol.54
, Issue.SUPPL. 1
-
-
Simonneau, G.1
Robbins, I.M.2
Beghetti, M.3
Channick, R.N.4
Delcroix, M.5
Denton, C.P.6
Elliott, C.G.7
Gaine, S.P.8
Gladwin, M.T.9
Jing, Z.C.10
Krowka, M.J.11
Langleben, D.12
Nakanishi, N.13
Souza, R.14
-
75
-
-
67651098992
-
Endothelial deletion of hypoxia-inducible fac-tor-2a alters vascular function and tumor angiogenesis
-
Skuli N, Liu L, Runge A, Wang T, Yuan L, Patel S, Iruela-Arispe L, Simon MC, Keith B. Endothelial deletion of hypoxia-inducible fac-tor-2a alters vascular function and tumor angiogenesis. Blood 114: 469-477, 2009.
-
(2009)
Blood
, vol.114
, pp. 469-477
-
-
Skuli, N.1
Liu, L.2
Runge, A.3
Wang, T.4
Yuan, L.5
Patel, S.6
Iruela-Arispe, L.7
Simon, M.C.8
Keith, B.9
-
76
-
-
84860832553
-
Reversal of pulmonary vascular remodeling in pulmonary hypertensive rats
-
Sluiter I, van Heijst A, Haasdijk R, Kempen MB, Boerema-de Munck A, Reiss I, Tibboel D, Rottier RJ. Reversal of pulmonary vascular remodeling in pulmonary hypertensive rats. Exp Mol Pathol 93: 66-73, 2012.
-
(2012)
Exp Mol Pathol
, vol.93
, pp. 66-73
-
-
Sluiter, I.1
Van Heijst, A.2
Haasdijk, R.3
Kempen, M.B.4
Boerema-De Munck, A.5
Reiss, I.6
Tibboel, D.7
Rottier, R.J.8
-
78
-
-
57649234937
-
The increase in pulmonary arterial pressure caused by hypoxia depends on iron status
-
Smith TG, Balanos GM, Croft QP, Talbot NP, Dorrington KL, Ratcliffe PJ, Robbins PA. The increase in pulmonary arterial pressure caused by hypoxia depends on iron status. J Physiol 586: 5999-6005, 2008.
-
(2008)
J Physiol
, vol.586
, pp. 5999-6005
-
-
Smith, T.G.1
Balanos, G.M.2
Croft, Q.P.3
Talbot, N.P.4
Dorrington, K.L.5
Ratcliffe, P.J.6
Robbins, P.A.7
-
79
-
-
33746398489
-
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology.
-
Smith TG, Brooks JT, Balanos GM, Lappin TR, Layton DM, Leedham DL, Liu C, Maxwell PH, McMullin MF, McNamara CJ, Percy MJ, Pugh CW, Ratcliffe PJ, Talbot NP, Treacy M, Robbins PA. Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med 3: e290, 2006.
-
(2006)
PLoS Med
, vol.3
-
-
Smith, T.G.1
Brooks, J.T.2
Balanos, G.M.3
Lappin, T.R.4
Layton, D.M.5
Leedham, D.L.6
Liu, C.7
Maxwell, P.H.8
McMullin, M.F.9
McNamara, C.J.10
Percy, M.J.11
Pugh, C.W.12
Ratcliffe, P.J.13
Talbot, N.P.14
Treacy, M.15
Robbins, P.A.16
-
80
-
-
70349909823
-
Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: Two randomized controlled trials
-
Smith TG, Talbot NP, Privat C, Rivera-Ch M, Nickol AH, Ratcliffe PJ, Dorrington KL, Leon-Velarde F, Robbins PA. Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. JAMA 302: 1444-1450, 2009.
-
(2009)
JAMA
, vol.302
, pp. 1444-1450
-
-
Smith, T.G.1
Talbot, N.P.2
Privat, C.3
Rivera-Ch, M.4
Nickol, A.H.5
Ratcliffe, P.J.6
Dorrington, K.L.7
Leon-Velarde, F.8
Robbins, P.A.9
-
81
-
-
12344302527
-
Hypoxia, leukocytes, and the pulmonary circulation
-
Stenmark KR, Davie NJ, Reeves JT, Frid MG. Hypoxia, leukocytes, and the pulmonary circulation. J Appl Physiol 98: 715-721, 2005.
-
(2005)
J Appl Physiol
, vol.98
, pp. 715-721
-
-
Stenmark, K.R.1
Davie, N.J.2
Reeves, J.T.3
Frid, M.G.4
-
82
-
-
71949129187
-
Animal models of pulmonary arterial hypertension: The hope for etiological discovery and pharmacological cure
-
Stenmark KR, Meyrick B, Galie N, Mooi WJ, McMurtry IF. Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. Am J Physiol Lung Cell Mol Physiol 297: L1013-L1032, 2009.
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.297
-
-
Stenmark, K.R.1
Meyrick, B.2
Galie, N.3
Mooi, W.J.4
McMurtry, I.F.5
-
83
-
-
0020135694
-
Membrane properties of smooth muscle cells in pulmonary hypertensive rats
-
Suzuki H, Twarog BM. Membrane properties of smooth muscle cells in pulmonary hypertensive rats. Am J Physiol Heart Circ Physiol 242: H907-H915, 1982.
-
(1982)
Am J Physiol Heart Circ Physiol
, vol.242
-
-
Suzuki, H.1
Twarog, B.M.2
-
84
-
-
84856991347
-
Hypoxic pulmonary vasoconstriction
-
Sylvester JT, Shimoda LA, Aaronson PI, Ward JP. Hypoxic pulmonary vasoconstriction. Physiol Rev 92: 367-520, 2012.
-
(2012)
Physiol Rev
, vol.92
, pp. 367-520
-
-
Sylvester, J.T.1
Shimoda, L.A.2
Aaronson, P.I.3
Ward, J.P.4
-
85
-
-
33750976389
-
Placental but not heart defects are associated with elevated hypoxia-inducible factor a levels in mice lacking prolyl hydroxylase domain protein 2
-
Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH. Placental but not heart defects are associated with elevated hypoxia-inducible factor a levels in mice lacking prolyl hydroxylase domain protein 2. Mol Cell Biol 26: 8336-8346, 2006.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 8336-8346
-
-
Takeda, K.1
Ho, V.C.2
Takeda, H.3
Duan, L.J.4
Nagy, A.5
Fong, G.H.6
-
86
-
-
84879037862
-
Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation
-
Tan Q, Kerestes H, Percy MJ, Pietrofesa R, Chen L, Khurana TS, Christofidou-Solomidou M, Lappin TR, Lee FS. Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation. J Biol Chem 288: 17134-17144, 2013.
-
(2013)
J Biol Chem
, vol.288
, pp. 17134-17144
-
-
Tan, Q.1
Kerestes, H.2
Percy, M.J.3
Pietrofesa, R.4
Chen, L.5
Khurana, T.S.6
Christofidou-Solomidou, M.7
Lappin, T.R.8
Lee, F.S.9
-
87
-
-
0031020884
-
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
-
Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 11: 72-82, 1997.
-
(1997)
Genes Dev
, vol.11
, pp. 72-82
-
-
Tian, H.1
McKnight, S.L.2
Russell, D.W.3
-
88
-
-
79959908260
-
Hypoxia: Adapting to high altitude by mutating EPAS-1, the gene encoding HIF-2a
-
Tissot van Patot MC, Gassmann M. Hypoxia: adapting to high altitude by mutating EPAS-1, the gene encoding HIF-2a. High Alt Med Biol 12: 157-167, 2011.
-
(2011)
High Alt Med Biol
, vol.12
, pp. 157-167
-
-
Tissot Van Patot, M.C.1
Gassmann, M.2
-
90
-
-
84980110245
-
Observations on the pulmonary arterial blood pressure in the cat
-
von Euler U, Liljestrand G. Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 12: 301-320, 1946.
-
(1946)
Acta Physiol Scand
, vol.12
, pp. 301-320
-
-
Von Euler, U.1
Liljestrand, G.2
-
92
-
-
1642288514
-
Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle
-
Wang J, Shimoda LA, Sylvester JT. Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle. Am J Physiol Lung Cell Mol Physiol 286: L848-L858, 2004.
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.286
-
-
Wang, J.1
Shimoda, L.A.2
Sylvester, J.T.3
-
94
-
-
39149127581
-
+ channel expression in pulmonary arterial myocytes
-
+ channel expression in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol 294: L309-L318, 2008.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.294
-
-
Whitman, E.M.1
Pisarcik, S.2
Luke, T.3
Fallon, M.4
Wang, J.5
Sylvester, J.T.6
Semenza, G.L.7
Shimoda, L.A.8
-
95
-
-
0030583293
-
In vivo expression of mRNAs encoding hypoxia-inducible factor 1
-
Wiener CM, Booth G, Semenza GL. In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochem Biophys Res Commun 225: 485-488, 1996.
-
(1996)
Biochem Biophys Res Commun
, vol.225
, pp. 485-488
-
-
Wiener, C.M.1
Booth, G.2
Semenza, G.L.3
-
96
-
-
84865149277
-
Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis
-
Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi ME, Semenza GL. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. J Mol Med 90: 803-815, 2012.
-
(2012)
J Mol Med
, vol.90
, pp. 803-815
-
-
Wong, C.C.1
Zhang, H.2
Gilkes, D.M.3
Chen, J.4
Wei, H.5
Chaturvedi, P.6
Hubbi, M.E.7
Semenza, G.L.8
-
98
-
-
77953515701
-
Digoxin inhibits retinal ischemia-induced HIF-1a expression and ocular neovascularization
-
Yoshida T, Zhang H, Iwase T, Shen J, Semenza GL, Campochiaro PA. Digoxin inhibits retinal ischemia-induced HIF-1a expression and ocular neovascularization. FASEB J 24: 1759-1767, 2010.
-
(2010)
FASEB J
, vol.24
, pp. 1759-1767
-
-
Yoshida, T.1
Zhang, H.2
Iwase, T.3
Shen, J.4
Semenza, G.L.5
Campochiaro, P.A.6
-
99
-
-
0031753986
-
Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung
-
Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. Am J Physiol Lung Cell Mol Physiol 275: L818-L826, 1998.
-
(1998)
Am J Physiol Lung Cell Mol Physiol
, vol.275
-
-
Yu, A.Y.1
Frid, M.G.2
Shimoda, L.A.3
Wiener, C.M.4
Stenmark, K.5
Semenza, G.L.6
-
100
-
-
0033104847
-
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1a
-
Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun X, McWilliams R, Beaty T, Sham JS, Wiener CM, Sylvester JT, Semenza GL. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1a. J Clin Invest 103: 691-696, 1999.
-
(1999)
J Clin Invest
, vol.103
, pp. 691-696
-
-
Yu, A.Y.1
Shimoda, L.A.2
Iyer, N.V.3
Huso, D.L.4
Sun, X.5
McWilliams, R.6
Beaty, T.7
Sham, J.S.8
Wiener, C.M.9
Sylvester, J.T.10
Semenza, G.L.11
-
101
-
-
0035859692
-
HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
-
Yu F, White SB, Zhao Q, Lee FS. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA 98: 9630-9635, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9630-9635
-
-
Yu, F.1
White, S.B.2
Zhao, Q.3
Lee, F.S.4
-
102
-
-
80555143052
-
Silencing of NHE1 attenuates PASMC proliferation, hypertrophy and migration via E2F1
-
Yu L, Hales CA. Silencing of NHE1 attenuates PASMC proliferation, hypertrophy and migration via E2F1. Am J Respir Cell Mol Biol 45: 923-930, 2011.
-
(2011)
Am J Respir Cell Mol Biol
, vol.45
, pp. 923-930
-
-
Yu, L.1
Hales, C.A.2
-
103
-
-
44449095608
-
Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling
-
Yu L, Quinn DA, Garg HG, Hales CA. Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling. Am J Respir Crit Care Med 177: 1276-1284, 2008.
-
(2008)
Am J Respir Crit Care Med
, vol.177
, pp. 1276-1284
-
-
Yu, L.1
Quinn, D.A.2
Garg, H.G.3
Hales, C.A.4
-
104
-
-
58149374576
-
Digoxin and other cardiac glycosides inhibit HIF-1a synthesis and block tumor growth
-
Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, Rey S, Hammers H, Chang D, Pili R, Dang CV, Liu JO, Semenza GL. Digoxin and other cardiac glycosides inhibit HIF-1a synthesis and block tumor growth. Proc Natl Acad Sci USA 105: 19579-19586, 2008.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19579-19586
-
-
Zhang, H.1
Qian, D.Z.2
Tan, Y.S.3
Lee, K.4
Gao, P.5
Ren, Y.R.6
Rey, S.7
Hammers, H.8
Chang, D.9
Pili, R.10
Dang, C.V.11
Liu, J.O.12
Semenza, G.L.13
|