Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation

Journal of Biological Chemistry

Volumn 288, Issue 24, 2013, Pages 17134-17144

  Tan, Qiulin ^a   Kerestes, Heddy ^a   Percy, Melanie J ^c   Pietrofesa, Ralph ^a   Chen, Li ^b   Khurana, Tejvir S ^a   Christofidou Solomidou, Melpo ^a   Lappin, Terence R J ^d   Lee, Frank S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c BELFAST CITY HOSPITAL   (United Kingdom)

^d QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION;

DOSE-DEPENDENT MANNER; ERYTHROPOIETIN (EPO); GAIN-OF FUNCTION; GENETICALLY MODIFIED; HYPOXIA-INDUCIBLE FACTORS; POINT MUTATIONS; PROLYL HYDROXYLASE DOMAINS; PULMONARY HYPERTENSION;

MAMMALS;

HYPOXIA INDUCIBLE FACTOR 2ALPHA;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ERYTHROCYTOSIS; FEMALE; GAIN OF FUNCTION MUTATION; GENE LOCUS; GENETIC ASSOCIATION; HEART RIGHT VENTRICLE HYPERTROPHY; HETEROZYGOSITY; HOMOZYGOSITY; HYPOXIA INDUCIBLE FACTOR 2ALPHA GENE; MALE; MISSENSE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION;

MUS;

EID: 84879037862     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.444059     Document Type: Article

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