메뉴 건너뛰기




Volumn 20, Issue 11, 2014, Pages 1831-1839

Novel therapeutic targets in neuropsychiatric disorders: The neuroepigenome

Author keywords

DNA methylation; Histone deacetylase; Neuroepigenome; Neuropsychiatric disorders

Indexed keywords

DNA; HISTONE; HISTONE DEACETYLASE INHIBITOR; PSYCHOTROPIC AGENT;

EID: 84900802721     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113199990535     Document Type: Review
Times cited : (7)

References (172)
  • 1
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • Berger SL. The complex language of chromatin regulation during transcription. Nature 2007; 447: 407-12.
    • (2007) Nature , vol.447 , pp. 407-412
    • Berger, S.L.1
  • 2
    • 84859233475 scopus 로고    scopus 로고
    • How epigenomics brings phenotype into being
    • Martín-Subero JI. How epigenomics brings phenotype into being. Pediatr Endocrinol Rev 2011; 9(Suppl.1): 506-10.
    • (2011) Pediatr Endocrinol Rev , vol.9 , Issue.SUPPL. 1 , pp. 506-510
    • Martín-Subero, J.I.1
  • 3
    • 3342989681 scopus 로고    scopus 로고
    • Epigenetic programming by maternal behavior
    • Weaver IC, Cervoni N, Champagne FA, et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004; 7: 847-54.
    • (2004) Nat Neurosci , vol.7 , pp. 847-854
    • Weaver, I.C.1    Cervoni, N.2    Champagne, F.A.3
  • 4
    • 34249700597 scopus 로고    scopus 로고
    • Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: Let's call the whole thing off
    • Weaver IC. Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: let's call the whole thing off. Epigenetics 2007; 2: 22-8.
    • (2007) Epigenetics , vol.2 , pp. 22-28
    • Weaver, I.C.1
  • 5
    • 34249275353 scopus 로고    scopus 로고
    • Phenotypic plasticity and the epigenetics of human disease
    • Feinberg AP. Phenotypic plasticity and the epigenetics of human disease. Nature 2007; 447: 433-40.
    • (2007) Nature , vol.447 , pp. 433-440
    • Feinberg, A.P.1
  • 6
    • 79957999588 scopus 로고    scopus 로고
    • Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity
    • Haggarty SJ, Tsai LH. Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiol Learn Mem 2011; 96: 41-52.
    • (2011) Neurobiol Learn Mem , vol.96 , pp. 41-52
    • Haggarty, S.J.1    Tsai, L.H.2
  • 7
    • 84863770814 scopus 로고    scopus 로고
    • Cancer genetics and epigenetics: Two sides of the same coin?
    • You JS, Jones PA. Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell 2012; 22: 9-20.
    • (2012) Cancer Cell , vol.22 , pp. 9-20
    • You, J.S.1    Jones, P.A.2
  • 8
    • 31944444233 scopus 로고    scopus 로고
    • The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases
    • Simonini MV, Camargo LM, Dong E, et al. The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases. Proc Natl Acad Sci USA 2006; 103: 1587-92.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1587-1592
    • Simonini, M.V.1    Camargo, L.M.2    Dong, E.3
  • 9
    • 0001065199 scopus 로고
    • On the propyl derivatives and decomposition products of ethylacetoacetate
    • Burton BS. On the propyl derivatives and decomposition products of ethylacetoacetate. Am Chem J. 1882; 3: 385-95.
    • (1882) Am Chem J , vol.3 , pp. 385-395
    • Burton, B.S.1
  • 10
    • 73649173245 scopus 로고
    • Propriétés pharmacodynamiques de l'Acide n-dipropylacetique
    • Meunier H, Carraz G, Meunier Y, Eymard P, Aimard M. Propriétés pharmacodynamiques de l'Acide n-dipropylacetique. Therapie 1963; 18: 435-38.
    • (1963) Therapie , vol.18 , pp. 435-438
    • Meunier, H.1    Carraz, G.2    Meunier, Y.3    Eymard, P.4    Aimard, M.5
  • 11
    • 0036401554 scopus 로고    scopus 로고
    • Pharmacological and therapeutic properties of valproate: A summary after 35 years of clinical experience
    • Perucca E. Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs 2002; 16: 695-714.
    • (2002) CNS Drugs , vol.16 , pp. 695-714
    • Perucca, E.1
  • 12
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 2001; 276: 36734-41.
    • (2001) J Biol Chem , vol.276 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5    Klein, P.S.6
  • 13
    • 0036402177 scopus 로고    scopus 로고
    • Basic pharmacology of valproate: A review after 35 years of clinical use for the treatment of epilepsy
    • Loscher W. Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy. CNS Drugs 2002; 16: 669-94.
    • (2002) CNS Drugs , vol.16 , pp. 669-694
    • Loscher, W.1
  • 14
    • 77957235135 scopus 로고    scopus 로고
    • Epigenetic modifications in valproic acidinduced teratogenesis
    • Tung EW, Winn LM. Epigenetic modifications in valproic acidinduced teratogenesis. Toxicol Appl Pharmacol 2010; 248: 201-9.
    • (2010) Toxicol Appl Pharmacol , vol.248 , pp. 201-209
    • Tung, E.W.1    Winn, L.M.2
  • 16
    • 17444379438 scopus 로고    scopus 로고
    • Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice
    • Tremolizzo L, Doueiri MS, Dong E, et al. Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biol Psychiatry 2005; 57: 500-9.
    • (2005) Biol Psychiatry , vol.57 , pp. 500-509
    • Tremolizzo, L.1    Doueiri, M.S.2    Dong, E.3
  • 17
    • 34547840258 scopus 로고    scopus 로고
    • Huntington's disease and HDACi: Would sulpiride and valproate be of therapeutic value?
    • Tremolizzo L, Rodriguez-Menendez V, DiFrancesco JC, et al. Huntington's disease and HDACi: would sulpiride and valproate be of therapeutic value? Med Hypotheses 2007; 69: 964-5.
    • (2007) Med Hypotheses , vol.69 , pp. 964-965
    • Tremolizzo, L.1    Rodriguez-Menendez, V.2    Difrancesco, J.C.3
  • 18
    • 0842325787 scopus 로고    scopus 로고
    • Histone deacetylase is a target of valproic acid-mediated cellular differentiation
    • Gurvich N, Tsygankova OM, Meinkoth JL, Klein PS. Histone deacetylase is a target of valproic acid-mediated cellular differentiation. Cancer Res 2004; 64: 1079-86.
    • (2004) Cancer Res , vol.64 , pp. 1079-1086
    • Gurvich, N.1    Tsygankova, O.M.2    Meinkoth, J.L.3    Klein, P.S.4
  • 21
    • 21744444434 scopus 로고    scopus 로고
    • Evolving anticancer drug valproic acid: Insights into the mechanism and clinical studies
    • Blaheta RA, Michaelis M, Driever PH, Cinatl Jr J. Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies. Med Res Rev 2005; 25: 383-97.
    • (2005) Med Res Rev , vol.25 , pp. 383-397
    • Blaheta, R.A.1    Michaelis, M.2    Driever, P.H.3    Cinatl, J.4
  • 22
    • 84861620928 scopus 로고    scopus 로고
    • Effect of valproic acid on the outcome of glioblastoma multiforme
    • Tsai HC, Wei KC, Tsai CN, et al. Effect of valproic acid on the outcome of glioblastoma multiforme. Br J Neurosurg 2012; 26: 347-54.
    • (2012) Br J Neurosurg , vol.26 , pp. 347-354
    • Tsai, H.C.1    Wei, K.C.2    Tsai, C.N.3
  • 23
    • 53249147679 scopus 로고    scopus 로고
    • Increase in antiepileptic efficacy during prolonged treatment with valproic acid: Role of inhibition of histone deacetylases?
    • Hoffmann K, Czapp M, Loscher W. Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases? Epilepsy Res 2008; 81: 107-13.
    • (2008) Epilepsy Res , vol.81 , pp. 107-113
    • Hoffmann, K.1    Czapp, M.2    Loscher, W.3
  • 24
    • 38049007956 scopus 로고    scopus 로고
    • Plasma and cerebrospinal fluid pharmacokinetics of valproic acid after oral administration in non-human primates
    • Stapleton SL, Thompson PA, Ou CN, et al. Plasma and cerebrospinal fluid pharmacokinetics of valproic acid after oral administration in non-human primates. Cancer Chemother Pharmacol 2008; 61: 647-52.
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 647-652
    • Stapleton, S.L.1    Thompson, P.A.2    Ou, C.N.3
  • 25
  • 26
    • 75749138038 scopus 로고    scopus 로고
    • Valproate and amitriptyline exert common and divergent influences on global and gene promoter specific chromatin modifications in rat primary astrocytes
    • Perisic T, Zimmermann N, Kirmeier T, et al. Valproate and amitriptyline exert common and divergent influences on global and gene promoter specific chromatin modifications in rat primary astrocytes. Neuropsychopharmacology 2010; 35: 792-805.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 792-805
    • Perisic, T.1    Zimmermann, N.2    Kirmeier, T.3
  • 27
    • 0003103892 scopus 로고    scopus 로고
    • Reelin and schizophrenia: A disease at the interface of the genome and the epigenome
    • Costa E, Chen Y, Davis J, et al. Reelin and schizophrenia: a disease at the interface of the genome and the epigenome. Mol Interv 2002; 2: 47-57.
    • (2002) Mol Interv , vol.2 , pp. 47-57
    • Costa, E.1    Chen, Y.2    Davis, J.3
  • 28
    • 0037168650 scopus 로고    scopus 로고
    • An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability
    • Tremolizzo L, Carboni G, Ruzicka WB, et al. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc Natl Acad Sci USA 2002; 99: 17095-100.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 17095-17100
    • Tremolizzo, L.1    Carboni, G.2    Ruzicka, W.B.3
  • 29
    • 28044436691 scopus 로고    scopus 로고
    • Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: Altering epigenetic marking later in life
    • Weaver IC, Champagne FA, Brown SE, et al. Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J Neurosci 2005; 25: 11045-54.
    • (2005) J Neurosci , vol.25 , pp. 11045-11054
    • Weaver, I.C.1    Champagne, F.A.2    Brown, S.E.3
  • 30
    • 84455169456 scopus 로고    scopus 로고
    • How does the social environment 'get into the mind'? Epigenetics at the intersection of social and psychiatric epidemiology
    • Toyokawa S, Uddin M, Koenen KC, Galea S. How does the social environment 'get into the mind'? Epigenetics at the intersection of social and psychiatric epidemiology. Soc Sci Med 2012; 74: 67-74.
    • (2012) Soc Sci Med , vol.74 , pp. 67-74
    • Toyokawa, S.1    Uddin, M.2    Koenen, K.C.3    Galea, S.4
  • 32
    • 33947671401 scopus 로고    scopus 로고
    • Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection
    • Ruzicka WB, Zhubi A, Veldic M, Grayson DR, Costa E, Guidotti A. Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection. Mol Psychiatry 2007; 12: 385-97.
    • (2007) Mol Psychiatry , vol.12 , pp. 385-397
    • Ruzicka, W.B.1    Zhubi, A.2    Veldic, M.3    Grayson, D.R.4    Costa, E.5    Guidotti, A.6
  • 34
    • 34249667064 scopus 로고    scopus 로고
    • Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability
    • Costa E, Dong E, Grayson DR, Guidotti A, Ruzicka W, Veldic M. Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability. Epigenetics 2007; 2: 29-36.
    • (2007) Epigenetics , vol.2 , pp. 29-36
    • Costa, E.1    Dong, E.2    Grayson, D.R.3    Guidotti, A.4    Ruzicka, W.5    Veldic, M.6
  • 35
    • 0034177303 scopus 로고    scopus 로고
    • Actin and the agile spine: How and why do dendritic spines dance?
    • Halpain S. Actin and the agile spine: how and why do dendritic spines dance? Trends Neurosci 2000; 23: 141-6.
    • (2000) Trends Neurosci , vol.23 , pp. 141-146
    • Halpain, S.1
  • 36
    • 9744273944 scopus 로고    scopus 로고
    • A GABAergic cortical deficit dominates schizophrenia pathophysiology
    • Costa E, Davis JM, Dong E, et al. A GABAergic cortical deficit dominates schizophrenia pathophysiology. Crit Rev Neurobiol 2004; 16: 1-23.
    • (2004) Crit Rev Neurobiol , vol.16 , pp. 1-23
    • Costa, E.1    Davis, J.M.2    Dong, E.3
  • 37
    • 80052964607 scopus 로고    scopus 로고
    • A neurochemical basis for an epigenetic vision of psychiatric disorders (1994-2009)
    • Guidotti A, Grayson DR. A neurochemical basis for an epigenetic vision of psychiatric disorders (1994-2009). Pharmacol Res 2011; 64: 344-9.
    • (2011) Pharmacol Res , vol.64 , pp. 344-349
    • Guidotti, A.1    Grayson, D.R.2
  • 38
    • 0037627336 scopus 로고    scopus 로고
    • A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes
    • Dong E, Caruncho H, Liu WS, et al. A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes. Proc Natl Acad Sci USA 2003; 100: 5479-84.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5479-5484
    • Dong, E.1    Caruncho, H.2    Liu, W.S.3
  • 39
    • 65749318026 scopus 로고
    • 2 new mutants, trembler and reeler, with neurological actions in the house mouse (mus-musculus l)
    • Falconer DS. 2 new mutants, trembler and reeler, with neurological actions in the house mouse (mus-musculus l). J Genet 1951; 50: 192-201.
    • (1951) J Genet , vol.50 , pp. 192-201
    • Falconer, D.S.1
  • 40
    • 0028940096 scopus 로고
    • A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    • D'Arcangelo G, Miao GG, Chen SC, Soares HD, Morgan JI, Curran T. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature 1995; 374: 719-23.
    • (1995) Nature , vol.374 , pp. 719-723
    • D'Arcangelo, G.1    Miao, G.G.2    Chen, S.C.3    Soares, H.D.4    Morgan, J.I.5    Curran, T.6
  • 41
    • 0038823525 scopus 로고    scopus 로고
    • The endophenotype concept in psychiatry: Etymology and strategic intentions
    • Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160: 636-45.
    • (2003) Am J Psychiatry , vol.160 , pp. 636-645
    • Gottesman, I.I.1    Gould, T.D.2
  • 42
    • 0033606075 scopus 로고    scopus 로고
    • The phenotypic characteristics of heterozygous reeler mouse
    • Tueting P, Costa E, Dwivedi Y, et al. The phenotypic characteristics of heterozygous reeler mouse. Neuroreport 1999; 10: 1329-34.
    • (1999) Neuroreport , vol.10 , pp. 1329-1334
    • Tueting, P.1    Costa, E.2    Dwivedi, Y.3
  • 43
    • 0344197998 scopus 로고    scopus 로고
    • Immunocytochemical localization of reelin in the olfactory bulb of the heterozygous reeler mouse: An animal model for schizophrenia
    • Pappas GD, Kriho V, Liu WS, Tremolizzo L, Lugli G, Larson J. Immunocytochemical localization of reelin in the olfactory bulb of the heterozygous reeler mouse: an animal model for schizophrenia. Neurol Res 2003; 25: 819-30.
    • (2003) Neurol Res , vol.25 , pp. 819-830
    • Pappas, G.D.1    Kriho, V.2    Liu, W.S.3    Tremolizzo, L.4    Lugli, G.5    Larson, J.6
  • 44
    • 0036462448 scopus 로고    scopus 로고
    • The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics
    • Costa E, Davis J, Pesold C, Tueting P, Guidotti A. The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics. Curr Opin Pharmacol 2002; 2: 56-62.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 56-62
    • Costa, E.1    Davis, J.2    Pesold, C.3    Tueting, P.4    Guidotti, A.5
  • 45
    • 13044276244 scopus 로고    scopus 로고
    • A decrease of reelin expression as a putative vulnerability factor in schizophrenia
    • Impagnatiello F, Guidotti AR, Pesold C, et al. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proc Natl Acad Sci USA 1998; 95: 15718-23.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15718-15723
    • Impagnatiello, F.1    Guidotti, A.R.2    Pesold, C.3
  • 46
    • 21544433777 scopus 로고    scopus 로고
    • Reelin promoter hypermethylation in schizophrenia
    • Grayson DR, Jia X, Chen Y, et al. Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci USA 2005; 102: 9341-6.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9341-9346
    • Grayson, D.R.1    Jia, X.2    Chen, Y.3
  • 48
    • 78449250771 scopus 로고    scopus 로고
    • Valproate induces DNA demethylation in nuclear extracts from adult mouse brain
    • Dong E, Chen Y, Gavin DP, Grayson DR, Guidotti A. Valproate induces DNA demethylation in nuclear extracts from adult mouse brain. Epigenetics 2010; 5: 730-5.
    • (2010) Epigenetics , vol.5 , pp. 730-735
    • Dong, E.1    Chen, Y.2    Gavin, D.P.3    Grayson, D.R.4    Guidotti, A.5
  • 49
    • 51649127761 scopus 로고    scopus 로고
    • Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation
    • Dong E, Nelson M, Grayson DR, Costa E, Guidotti A. Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation. Proc Natl Acad Sci USA 2008; 105: 13614-9.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13614-13619
    • Dong, E.1    Nelson, M.2    Grayson, D.R.3    Costa, E.4    Guidotti, A.5
  • 50
    • 59349098142 scopus 로고    scopus 로고
    • Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling
    • Guidotti A, Dong E, Kundakovic M, Satta R, Grayson DR, Costa E. Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. Trends Pharmacol Sci 2009; 30: 55-60.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 55-60
    • Guidotti, A.1    Dong, E.2    Kundakovic, M.3    Satta, R.4    Grayson, D.R.5    Costa, E.6
  • 52
    • 79954601665 scopus 로고    scopus 로고
    • Analysis of the GAD1 promoter: Trans-acting factors and DNA methylation converge on the 5' untranslated region
    • Chen Y, Dong E, Grayson DR. Analysis of the GAD1 promoter: trans-acting factors and DNA methylation converge on the 5' untranslated region. Neuropharmacology 2011; 60: 1075-87.
    • (2011) Neuropharmacology , vol.60 , pp. 1075-1087
    • Chen, Y.1    Dong, E.2    Grayson, D.R.3
  • 53
    • 0031734725 scopus 로고    scopus 로고
    • Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism
    • Woods BT. Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. Am J Psychiatry 1998; 155: 1661-70.
    • (1998) Am J Psychiatry , vol.155 , pp. 1661-1670
    • Woods, B.T.1
  • 54
    • 81255174189 scopus 로고    scopus 로고
    • The HDAC Inhibitor Phenylbutyrate Reverses Effects of Neonatal Ventral Hippocampal Lesion in Rats
    • Sandner G, Host L, Angst MJ, Guiberteau T, Guignard B, Zwiller J. The HDAC Inhibitor Phenylbutyrate Reverses Effects of Neonatal Ventral Hippocampal Lesion in Rats. Front Psychiatry 2011; 1: 153.
    • (2011) Front Psychiatry , vol.1 , pp. 153
    • Sandner, G.1    Host, L.2    Angst, M.J.3    Guiberteau, T.4    Guignard, B.5    Zwiller, J.6
  • 55
    • 84865313397 scopus 로고    scopus 로고
    • Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome
    • Jul 15. [Epub ahead of print]
    • Connor CM, Dincer A, Straubhaar J, Galler JR, Houston IB, Akbarian S. Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome. Schizophr Res 2012 Jul 15. [Epub ahead of print].
    • (2012) Schizophr Res
    • Connor, C.M.1    Dincer, A.2    Straubhaar, J.3    Galler, J.R.4    Houston, I.B.5    Akbarian, S.6
  • 56
    • 77956689355 scopus 로고    scopus 로고
    • Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus
    • Zhang TY, Hellstrom IC, Bagot RC, Wen X, Diorio J, Meaney MJ. Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus. J Neurosci 2010; 30: 13130-7.
    • (2010) J Neurosci , vol.30 , pp. 13130-13137
    • Zhang, T.Y.1    Hellstrom, I.C.2    Bagot, R.C.3    Wen, X.4    Diorio, J.5    Meaney, M.J.6
  • 57
    • 84859499394 scopus 로고    scopus 로고
    • Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease
    • Gavin DP, Akbarian S. Epigenetic and post-transcriptional dysregulation of gene expression in schizophrenia and related disease. Neurobiol Dis 2012; 46: 255-62.
    • (2012) Neurobiol Dis , vol.46 , pp. 255-262
    • Gavin, D.P.1    Akbarian, S.2
  • 59
    • 0342424180 scopus 로고    scopus 로고
    • Valproate as an adjunct to neuroleptic medication for the treatment of acute episodes of mania: A prospective, randomized, double-blind, placebo-controlled, multicenter study. European Valproate Mania Study Group
    • Müller-Oerlinghausen B, Retzow A, Henn FA, Giedke H, Walden J. Valproate as an adjunct to neuroleptic medication for the treatment of acute episodes of mania: a prospective, randomized, double-blind, placebo-controlled, multicenter study. European Valproate Mania Study Group. J Clin Psychopharmacol 2000; 20: 195-203.
    • (2000) J Clin Psychopharmacol , vol.20 , pp. 195-203
    • Müller-Oerlinghausen, B.1    Retzow, A.2    Henn, F.A.3    Giedke, H.4    Walden, J.5
  • 60
    • 74549200467 scopus 로고    scopus 로고
    • Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders?
    • Grayson DR, Kundakovic M, Sharma RP. Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders? Mol Pharmacol 2010; 77: 126-35.
    • (2010) Mol Pharmacol , vol.77 , pp. 126-135
    • Grayson, D.R.1    Kundakovic, M.2    Sharma, R.P.3
  • 61
    • 77949470143 scopus 로고    scopus 로고
    • Increased soluble APPalpha, Abeta 1-42, and anti-Abeta 1-42 antibodies in plasma from down syndrome patients
    • Conti E, Galimberti G, Piazza F, Raggi ME, Ferrarese C. Increased soluble APPalpha, Abeta 1-42, and anti-Abeta 1-42 antibodies in plasma from down syndrome patients. Alzheimer Dis Assoc Disord 2010; 24: 96-100.
    • (2010) Alzheimer Dis Assoc Disord , vol.24 , pp. 96-100
    • Conti, E.1    Galimberti, G.2    Piazza, F.3    Raggi, M.E.4    Ferrarese, C.5
  • 62
    • 77950866465 scopus 로고    scopus 로고
    • Epigenetic regulation in the pathophysiology of Alzheimer's disease
    • Chouliaras L, Rutten BP, Kenis G, et al. Epigenetic regulation in the pathophysiology of Alzheimer's disease. Prog Neurobiol 2010; 90: 498-510.
    • (2010) Prog Neurobiol , vol.90 , pp. 498-510
    • Chouliaras, L.1    Rutten, B.P.2    Kenis, G.3
  • 64
    • 69449086451 scopus 로고    scopus 로고
    • DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain
    • Barrachina M, Ferrer I. DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. J Neuropathol Exp Neurol 2009; 68: 880-91.
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 880-891
    • Barrachina, M.1    Ferrer, I.2
  • 65
    • 0442307849 scopus 로고    scopus 로고
    • 4-Hydroxynonenal oxidatively modifies histones: Implications for Alzheimer's disease
    • Drake J, Petroze R, Castegna A, et al. 4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease. Neurosci Lett 2004; 356: 155-8.
    • (2004) Neurosci Lett , vol.356 , pp. 155-158
    • Drake, J.1    Petroze, R.2    Castegna, A.3
  • 66
    • 77954680640 scopus 로고    scopus 로고
    • Epigenetics. A role for epigenetics in cognition
    • Miller G. Epigenetics. A role for epigenetics in cognition. Science 2010; 329: 27.
    • (2010) Science , vol.329 , pp. 27
    • Miller, G.1
  • 67
    • 84861145950 scopus 로고    scopus 로고
    • Do epigenetic pathways initiate late onset alzheimer disease (LOAD): Towards a new paradigm
    • Bihaqi SW, Schumacher A, Maloney B, Lahiri DK, Zawia NH. Do epigenetic pathways initiate late onset alzheimer disease (LOAD): towards a new paradigm. Curr Alzheimer Res 2012; 9: 574-88.
    • (2012) Curr Alzheimer Res , vol.9 , pp. 574-588
    • Bihaqi, S.W.1    Schumacher, A.2    Maloney, B.3    Lahiri, D.K.4    Zawia, N.H.5
  • 68
    • 84862777943 scopus 로고    scopus 로고
    • An epigenetic blockade of cognitive functions in the neurodegenerating brain
    • Gräff J, Rei D, Guan JS, et al. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 2012; 483: 222-6.
    • (2012) Nature , vol.483 , pp. 222-226
    • Gräff, J.1    Rei, D.2    Guan, J.S.3
  • 69
    • 0346786306 scopus 로고    scopus 로고
    • The emerging role of epigenetics in cellular and organismal aging
    • Bandyopadhyay D, Medrano EE. The emerging role of epigenetics in cellular and organismal aging. Exp Gerontol 2003; 38: 1299-307.
    • (2003) Exp Gerontol , vol.38 , pp. 1299-1307
    • Bandyopadhyay, D.1    Medrano, E.E.2
  • 70
    • 34447625911 scopus 로고    scopus 로고
    • Epigenetics and aging: The targets and the marks
    • Fraga MF, Esteller M. Epigenetics and aging: the targets and the marks. Trends Genet 2007; 23: 413-8.
    • (2007) Trends Genet , vol.23 , pp. 413-418
    • Fraga, M.F.1    Esteller, M.2
  • 72
    • 34247473478 scopus 로고    scopus 로고
    • The epigenetic basis of twin discordance in age-related diseases
    • Poulsen P, Esteller M, Vaag A, Fraga MF. The epigenetic basis of twin discordance in age-related diseases. Pediatr Res 2007; 61: R38-42.
    • (2007) Pediatr Res , vol.61
    • Poulsen, P.1    Esteller, M.2    Vaag, A.3    Fraga, M.F.4
  • 73
    • 0020638422 scopus 로고
    • DNA methylation decreases in aging but not in immortal cells
    • Wilson VL, Jones PA. DNA methylation decreases in aging but not in immortal cells. Science 1983; 220: 1055-7.
    • (1983) Science , vol.220 , pp. 1055-1057
    • Wilson, V.L.1    Jones, P.A.2
  • 75
    • 0029926820 scopus 로고    scopus 로고
    • S-Adenosylmethionine and methylation
    • Chiang PK, Gordon RK, Tal J, et al. S-Adenosylmethionine and methylation. FASEB J 1996; 10: 471-80.
    • (1996) FASEB J , vol.10 , pp. 471-480
    • Chiang, P.K.1    Gordon, R.K.2    Tal, J.3
  • 76
    • 0033026734 scopus 로고    scopus 로고
    • Homocysteine and hypomethylation. A novel link to vascular disease
    • Lee ME, Wang H. Homocysteine and hypomethylation. A novel link to vascular disease, Trends Cardiovasc Med 1999; 9: 49-54.
    • (1999) Trends Cardiovasc Med , vol.9 , pp. 49-54
    • Lee, M.E.1    Wang, H.2
  • 77
    • 79958766232 scopus 로고    scopus 로고
    • One-carbon metabolism and Alzheimer's disease: Is it all a methylation matter?
    • Fuso A, Scarpa S. One-carbon metabolism and Alzheimer's disease: is it all a methylation matter? Neurobiol Aging 2011; 32: 1192-5.
    • (2011) Neurobiol Aging , vol.32 , pp. 1192-1195
    • Fuso, A.1    Scarpa, S.2
  • 78
    • 84867339786 scopus 로고    scopus 로고
    • Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease
    • doi: 10.1001/archneurol.2012.1282. [Epub ahead of print] Jul
    • Doecke JD, Laws SM, Faux NG, et al. Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease. Arch Neurol 2012 Jul 16: 1-8. doi: 10.1001/archneurol.2012.1282. [Epub ahead of print].
    • (2012) Arch Neurol , vol.16 , pp. 1-8
    • Doecke, J.D.1    Laws, S.M.2    Faux, N.G.3
  • 79
    • 44949107160 scopus 로고    scopus 로고
    • Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients?
    • Galimberti G, Conti E, Zini M, et al. Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients? Clin Biochem 2008; 41: 914-6.
    • (2008) Clin Biochem , vol.41 , pp. 914-916
    • Galimberti, G.1    Conti, E.2    Zini, M.3
  • 80
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 2011; 12: 723-38.
    • (2011) Nat Rev Neurosci , vol.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 81
    • 0037464488 scopus 로고    scopus 로고
    • Presenilin 1 gene silencing by S-adenosylmethionine: A treatment for Alzheimer disease?
    • Scarpa S, Fuso A, D'Anselmi F, Cavallaro RA. Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease? FEBS Lett 2003; 541: 145-8.
    • (2003) FEBS Lett , vol.541 , pp. 145-148
    • Scarpa, S.1    Fuso, A.2    D'Anselmi, F.3    Cavallaro, R.A.4
  • 82
    • 10644237168 scopus 로고    scopus 로고
    • Sadenosylmethionine/ homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production
    • Fuso A, Seminara L, Cavallaro RA, D'Anselmi F, Scarpa S. Sadenosylmethionine/ homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol Cell Neurosci 2005; 28: 195-204.
    • (2005) Mol Cell Neurosci , vol.28 , pp. 195-204
    • Fuso, A.1    Seminara, L.2    Cavallaro, R.A.3    D'Anselmi, F.4    Scarpa, S.5
  • 83
    • 79951677959 scopus 로고    scopus 로고
    • DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models
    • Fuso A, Nicolia V, Cavallaro RA, Scarpa S. DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models. J Nutr Biochem 2011; 22: 242-51.
    • (2011) J Nutr Biochem , vol.22 , pp. 242-251
    • Fuso, A.1    Nicolia, V.2    Cavallaro, R.A.3    Scarpa, S.4
  • 84
    • 34447642134 scopus 로고    scopus 로고
    • Gamma-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells
    • Fuso A, Cavallaro RA, Zampelli A, et al. Gamma-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells. J Alzheimers Dis 2007; 11: 275-90.
    • (2007) J Alzheimers Dis , vol.11 , pp. 275-290
    • Fuso, A.1    Cavallaro, R.A.2    Zampelli, A.3
  • 85
    • 41249098662 scopus 로고    scopus 로고
    • B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice
    • Fuso A, Nicolia V, Cavallaro RA, et al. B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice. Mol Cell Neurosci 2008; 37: 731-46.
    • (2008) Mol Cell Neurosci , vol.37 , pp. 731-746
    • Fuso, A.1    Nicolia, V.2    Cavallaro, R.A.3
  • 86
    • 84860368886 scopus 로고    scopus 로고
    • S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice
    • Fuso A, Nicolia V, Ricceri L, et al. S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice. Neurobiol Aging 2012; 33: 1482.e1-16.
    • (2012) Neurobiol Aging , vol.33 , Issue.1482
    • Fuso, A.1    Nicolia, V.2    Ricceri, L.3
  • 87
    • 33747449599 scopus 로고    scopus 로고
    • Gene silencing through methylation: An epigenetic intervention on Alzheimer disease
    • Scarpa S, Cavallaro RA, D'Anselmi F, Fuso A. Gene silencing through methylation: an epigenetic intervention on Alzheimer disease. J Alzheimers Dis 2006; 9: 407-14.
    • (2006) J Alzheimers Dis , vol.9 , pp. 407-414
    • Scarpa, S.1    Cavallaro, R.A.2    D'Anselmi, F.3    Fuso, A.4
  • 88
    • 84863012028 scopus 로고    scopus 로고
    • Dietary supplementation with S-adenosyl methionine delayed amyloid-_ and tau pathology in 3xTg-AD mice
    • Lee S, Lemere CA, Frost JL, Shea TB. Dietary supplementation with S-adenosyl methionine delayed amyloid-_ and tau pathology in 3xTg-AD mice. J Alzheimers Dis 2012; 28: 423-31.
    • (2012) J Alzheimers Dis , vol.28 , pp. 423-431
    • Lee, S.1    Lemere, C.A.2    Frost, J.L.3    Shea, T.B.4
  • 89
    • 78149313102 scopus 로고    scopus 로고
    • S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease
    • Linnebank M, Popp J, Smulders Y, et al. S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease. Neurodegener Dis 2010; 7: 373-8.
    • (2010) Neurodegener Dis , vol.7 , pp. 373-378
    • Linnebank, M.1    Popp, J.2    Smulders, Y.3
  • 90
    • 65549120331 scopus 로고    scopus 로고
    • Possible role of Sadenosylmethionine, S-adenosylhomocysteine, and polyunsaturated fatty acids in predementia syndromes and Alzheimer's disease
    • Panza F, Frisardi V, Capurso C, et al. Possible role of Sadenosylmethionine, S-adenosylhomocysteine, and polyunsaturated fatty acids in predementia syndromes and Alzheimer's disease. J Alzheimers Dis 2009; 16: 467-70.
    • (2009) J Alzheimers Dis , vol.16 , pp. 467-470
    • Panza, F.1    Frisardi, V.2    Capurso, C.3
  • 91
    • 40549097476 scopus 로고    scopus 로고
    • S-adenosyl methionine: A natural therapeutic agent effective against multiple hallmarks and risk factors associated with Alzheimer's disease
    • Shea TB, Chan A. S-adenosyl methionine: a natural therapeutic agent effective against multiple hallmarks and risk factors associated with Alzheimer's disease. J Alzheimers Dis 2008; 13: 67-70.
    • (2008) J Alzheimers Dis , vol.13 , pp. 67-70
    • Shea, T.B.1    Chan, A.2
  • 92
    • 84856147847 scopus 로고    scopus 로고
    • Epigenetics in nucleotide repeat expansion disorders
    • He F, Todd PK. Epigenetics in nucleotide repeat expansion disorders. Semin Neurol 2011; 31: 470-83.
    • (2011) Semin Neurol , vol.31 , pp. 470-483
    • He, F.1    Todd, P.K.2
  • 93
    • 0030575839 scopus 로고    scopus 로고
    • Long CCG triplet repeat blocks exclude nucleosomes: A possible mechanism for the nature of fragile sites in chromosomes
    • Wang YH, Gellibolian R, Shimizu M, Wells RD, Griffith J. Long CCG triplet repeat blocks exclude nucleosomes: a possible mechanism for the nature of fragile sites in chromosomes. J Mol Biol 1996; 263: 511-6.
    • (1996) J Mol Biol , vol.263 , pp. 511-516
    • Wang, Y.H.1    Gellibolian, R.2    Shimizu, M.3    Wells, R.D.4    Griffith, J.5
  • 95
    • 0035937523 scopus 로고    scopus 로고
    • Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
    • Nucifora FC Jr, Sasaki M, Peters MF, et al. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science 2001; 291: 2423-8.
    • (2001) Science , vol.291 , pp. 2423-2428
    • Nucifora Jr., F.C.1    Sasaki, M.2    Peters, M.F.3
  • 96
    • 0028060029 scopus 로고
    • Nuclear protein CBP is a coactivator for the transcription factor CREB
    • Kwok RP, Lundblad JR, Chrivia JC, et al. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 1994; 370: 223-6.
    • (1994) Nature , vol.370 , pp. 223-226
    • Kwok, R.P.1    Lundblad, J.R.2    Chrivia, J.C.3
  • 97
    • 33748928786 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors as therapeutics for polyglutamine disorders
    • Butler R, Bates GP. Histone deacetylase inhibitors as therapeutics for polyglutamine disorders. Nat Rev Neurosci 2006; 7: 784-96.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 784-796
    • Butler, R.1    Bates, G.P.2
  • 98
    • 0141642242 scopus 로고    scopus 로고
    • Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein
    • Hoshino M, Tagawa K, Okuda T, et al. Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein. J Neurochem 2003; 87: 257-67.
    • (2003) J Neurochem , vol.87 , pp. 257-267
    • Hoshino, M.1    Tagawa, K.2    Okuda, T.3
  • 99
    • 0035909330 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
    • Steffan JS, Bodai L, Pallos J, et al. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 2001; 413: 739-43.
    • (2001) Nature , vol.413 , pp. 739-743
    • Steffan, J.S.1    Bodai, L.2    Pallos, J.3
  • 100
    • 77955709610 scopus 로고    scopus 로고
    • HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAFdependent p53 acetylation
    • Gaub P, Tedeschi A, Puttagunta R, Nguyen T, Schmandke A, Di Giovanni S. HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAFdependent p53 acetylation. Cell Death Differ 2010; 17: 1392-408.
    • (2010) Cell Death Differ , vol.17 , pp. 1392-1408
    • Gaub, P.1    Tedeschi, A.2    Puttagunta, R.3    Nguyen, T.4    Schmandke, A.5    Di Giovanni, S.6
  • 101
    • 53249114029 scopus 로고    scopus 로고
    • Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease
    • Pallos J, Bodai L, Lukacsovich T, et al. Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Hum Mol Genet 2008; 17: 3767-75.
    • (2008) Hum Mol Genet , vol.17 , pp. 3767-3775
    • Pallos, J.1    Bodai, L.2    Lukacsovich, T.3
  • 102
    • 33644830913 scopus 로고    scopus 로고
    • Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity
    • Bates EA, Victor M, Jones AK, Shi Y, Hart AC. Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. J Neurosci 2006; 26: 2830-8.
    • (2006) J Neurosci , vol.26 , pp. 2830-2838
    • Bates, E.A.1    Victor, M.2    Jones, A.K.3    Shi, Y.4    Hart, A.C.5
  • 103
    • 0037452775 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
    • Hockly E, Richon VM, Woodman B, et al. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease. Proc Natl Acad Sci USA 2003; 100: 2041-6.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2041-2046
    • Hockly, E.1    Richon, V.M.2    Woodman, B.3
  • 104
    • 79551532277 scopus 로고    scopus 로고
    • Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism
    • Ma C, D'Mello SR. Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism. J Biol Chem 2011; 286: 4819-28.
    • (2011) J Biol Chem , vol.286 , pp. 4819-4828
    • Ma, C.1    D'Mello, S.R.2
  • 105
    • 66749119970 scopus 로고    scopus 로고
    • Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease
    • Benn CL, Butler R, Mariner L, et al. Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease. PLoS One 2009; 4: e5747.
    • (2009) PLoS One , vol.4
    • Benn, C.L.1    Butler, R.2    Mariner, L.3
  • 106
    • 82155182012 scopus 로고    scopus 로고
    • SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease
    • Mielcarek M, Benn CL, Franklin SA, et al. SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease. PLoS One 2011; 6: e27746.
    • (2011) PLoS One , vol.6
    • Mielcarek, M.1    Benn, C.L.2    Franklin, S.A.3
  • 107
    • 55749103407 scopus 로고    scopus 로고
    • The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
    • Thomas EA, Coppola G, Desplats PA, et al. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proc Natl Acad Sci USA 2008; 105: 15564-9.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15564-15569
    • Thomas, E.A.1    Coppola, G.2    Desplats, P.A.3
  • 108
    • 78349291479 scopus 로고    scopus 로고
    • Nicotinamide improves motor deficits and upregulates PGC-1_ and BDNF gene expression in a mouse model of Huntington's disease
    • Hathorn T, Snyder-Keller A, Messer A. Nicotinamide improves motor deficits and upregulates PGC-1_ and BDNF gene expression in a mouse model of Huntington's disease. Neurobiol Dis 2011; 41: 43-50.
    • (2011) Neurobiol Dis , vol.41 , pp. 43-50
    • Hathorn, T.1    Snyder-Keller, A.2    Messer, A.3
  • 109
    • 0142157600 scopus 로고    scopus 로고
    • Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice
    • Ferrante RJ, Kubilus JK, Lee J, et al. Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J Neurosci 2003; 23: 9418-27.
    • (2003) J Neurosci , vol.23 , pp. 9418-9427
    • Ferrante, R.J.1    Kubilus, J.K.2    Lee, J.3
  • 110
    • 77049120123 scopus 로고    scopus 로고
    • Identification of phenylbutyrate-generated metabolites in Huntington disease patients using parallel liquid chromatography/electrochemical array/mass spectrometry and off-line tandem mass spectrometry
    • Ebbel EN, Leymarie N, Schiavo S, et al. Identification of phenylbutyrate-generated metabolites in Huntington disease patients using parallel liquid chromatography/electrochemical array/mass spectrometry and off-line tandem mass spectrometry. Anal Biochem 2010; 399: 152-61.
    • (2010) Anal Biochem , vol.399 , pp. 152-161
    • Ebbel, E.N.1    Leymarie, N.2    Schiavo, S.3
  • 111
    • 33748450288 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: A novel therapeutic approach to Huntington's disease (complex mechanism of neuronal death)
    • Sadri-Vakili G, Cha JH. Histone deacetylase inhibitors: a novel therapeutic approach to Huntington's disease (complex mechanism of neuronal death). Curr Alzheimer Res 2006; 3: 403-8.
    • (2006) Curr Alzheimer Res , vol.3 , pp. 403-408
    • Sadri-Vakili, G.1    Cha, J.H.2
  • 112
    • 34447317536 scopus 로고    scopus 로고
    • Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models
    • Sadri-Vakili G, Bouzou B, Benn CL, et al. Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models. Hum Mol Genet 2007; 16: 1293-306.
    • (2007) Hum Mol Genet , vol.16 , pp. 1293-1306
    • Sadri-Vakili, G.1    Bouzou, B.2    Benn, C.L.3
  • 113
    • 33751106144 scopus 로고    scopus 로고
    • Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: Effect of histone deacetylase inhibitors
    • Oct 25
    • Oliveira JM, Chen S, Almeida S, et al. Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors. J Neurosci 2006 Oct 25; 26(43): 11174-86.
    • (2006) J Neurosci , vol.26 , Issue.43 , pp. 11174-11186
    • Oliveira, J.M.1    Chen, S.2    Almeida, S.3
  • 114
    • 34047175919 scopus 로고    scopus 로고
    • Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation
    • Dompierre JP, Godin JD, Charrin BC, et al. Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. J Neurosci 2007; 27: 3571-83.
    • (2007) J Neurosci , vol.27 , pp. 3571-3583
    • Dompierre, J.P.1    Godin, J.D.2    Charrin, B.C.3
  • 115
    • 79958064073 scopus 로고    scopus 로고
    • Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease
    • Bobrowska A, Paganetti P, Matthias P, Bates GP. Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease. PLoS One 2011; 6: e20696.
    • (2011) PLoS One , vol.6
    • Bobrowska, A.1    Paganetti, P.2    Matthias, P.3    Bates, G.P.4
  • 116
    • 77956949459 scopus 로고    scopus 로고
    • Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease
    • McConoughey SJ, Basso M, Niatsetskaya ZV, et al. Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease. EMBO Mol Med 2010; 2: 349-70.
    • (2010) EMBO Mol Med , vol.2 , pp. 349-370
    • McConoughey, S.J.1    Basso, M.2    Niatsetskaya, Z.V.3
  • 117
    • 2942733520 scopus 로고    scopus 로고
    • Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy
    • Minamiyama M, Katsuno M, Adachi H, et al. Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Hum Mol Genet 2004; 13: 1183-92.
    • (2004) Hum Mol Genet , vol.13 , pp. 1183-1192
    • Minamiyama, M.1    Katsuno, M.2    Adachi, H.3
  • 119
    • 0038274087 scopus 로고    scopus 로고
    • Structural biasing elements for in-cell histone deacetylase paralog selectivity
    • Wong JC, Hong R, Schreiber SL. Structural biasing elements for in-cell histone deacetylase paralog selectivity. J Am Chem Soc 2003; 125: 5586-7.
    • (2003) J Am Chem Soc , vol.125 , pp. 5586-5587
    • Wong, J.C.1    Hong, R.2    Schreiber, S.L.3
  • 120
    • 44349114629 scopus 로고    scopus 로고
    • HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model
    • Rai M, Soragni E, Jenssen K, et al. HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. PLoS One 2008; 3: e1958.
    • (2008) PLoS One , vol.3
    • Rai, M.1    Soragni, E.2    Jenssen, K.3
  • 121
    • 77952530173 scopus 로고    scopus 로고
    • Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model
    • Rai M, Soragni E, Chou CJ, et al. Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model. PLoS One 2010; 5: e8825.
    • (2010) PLoS One , vol.5
    • Rai, M.1    Soragni, E.2    Chou, C.J.3
  • 122
    • 79954628287 scopus 로고    scopus 로고
    • Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model
    • Sandi C, Pinto RM, Al-Mahdawi S, et al. Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model. Neurobiol Dis 2011; 42: 496-505.
    • (2011) Neurobiol Dis , vol.42 , pp. 496-505
    • Sandi, C.1    Pinto, R.M.2    Al-Mahdawi, S.3
  • 123
    • 78650693402 scopus 로고    scopus 로고
    • Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome
    • Todd PK, Oh SY, Krans A, et al. Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome. PLoS Genet 2010; 6: e1001240.
    • (2010) PLoS Genet , vol.6
    • Todd, P.K.1    Oh, S.Y.2    Krans, A.3
  • 124
    • 78650223113 scopus 로고    scopus 로고
    • Monozygotic twins with neurofibromatosis type 1 (NF1) display differences in methylation of NF1 gene promoter elements, 5' untranslated region, exon and intron 1
    • Harder A, Titze S, Herbst L, et al. Monozygotic twins with neurofibromatosis type 1 (NF1) display differences in methylation of NF1 gene promoter elements, 5' untranslated region, exon and intron 1. Twin Res Hum Genet 2010; 13: 582-94.
    • (2010) Twin Res Hum Genet , vol.13 , pp. 582-594
    • Harder, A.1    Titze, S.2    Herbst, L.3
  • 125
    • 79953296221 scopus 로고    scopus 로고
    • Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors
    • Feber A, Wilson GA, Zhang L, et al. Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors. Genome Res 2011; 21: 515-24.
    • (2011) Genome Res , vol.21 , pp. 515-524
    • Feber, A.1    Wilson, G.A.2    Zhang, L.3
  • 126
    • 77950632304 scopus 로고    scopus 로고
    • Epigenetic gene silencing underlies Cfiber dysfunctions in neuropathic pain
    • Uchida H, Ma L, Ueda H. Epigenetic gene silencing underlies Cfiber dysfunctions in neuropathic pain. J Neurosci 2010; 30: 4806-14.
    • (2010) J Neurosci , vol.30 , pp. 4806-4814
    • Uchida, H.1    Ma, L.2    Ueda, H.3
  • 127
    • 50249154276 scopus 로고    scopus 로고
    • Epigenetic control of myelin repair
    • Popko B. Epigenetic control of myelin repair. Nat Neurosci 2008; 11: 987-8.
    • (2008) Nat Neurosci , vol.11 , pp. 987-988
    • Popko, B.1
  • 128
    • 85027933467 scopus 로고    scopus 로고
    • How histone deacetylases control myelination
    • Jacob C, Lebrun-Julien F, Suter U. How histone deacetylases control myelination. Mol Neurobiol 2011; 44: 303-12.
    • (2011) Mol Neurobiol , vol.44 , pp. 303-312
    • Jacob, C.1    Lebrun-Julien, F.2    Suter, U.3
  • 129
    • 84856430034 scopus 로고    scopus 로고
    • Molecular mechanisms regulating myelination in the peripheral nervous system
    • Pereira JA, Lebrun-Julien F, Suter U. Molecular mechanisms regulating myelination in the peripheral nervous system. Trends Neurosci 2012; 35: 123-34.
    • (2012) Trends Neurosci , vol.35 , pp. 123-134
    • Pereira, J.A.1    Lebrun-Julien, F.2    Suter, U.3
  • 130
    • 80053447073 scopus 로고    scopus 로고
    • Epigenetic regulation of sensory neurogenesis in the dorsal root ganglion cell line ND7 by folic acid
    • Boshnjaku V, Ichi S, Shen YW, et al. Epigenetic regulation of sensory neurogenesis in the dorsal root ganglion cell line ND7 by folic acid. Epigenetics 2011; 6: 1207-16.
    • (2011) Epigenetics , vol.6 , pp. 1207-1216
    • Boshnjaku, V.1    Ichi, S.2    Shen, Y.W.3
  • 131
    • 45849101673 scopus 로고    scopus 로고
    • Targeting cancer and neuropathy with histone deacetylase inhibitors: Two birds with one stone?
    • Rodriguez-Menendez V, Tremolizzo L, Cavaletti G. Targeting cancer and neuropathy with histone deacetylase inhibitors: two birds with one stone? Curr Cancer Drug Targets 2008; 8: 266-74.
    • (2008) Curr Cancer Drug Targets , vol.8 , pp. 266-274
    • Rodriguez-Menendez, V.1    Tremolizzo, L.2    Cavaletti, G.3
  • 132
    • 84860915669 scopus 로고    scopus 로고
    • L.HDAC6 at the Intersection of Neuroprotection and Neurodegeneration
    • d'Ydewalle C, Bogaert E, Van Den Bosch L.HDAC6 at the Intersection of Neuroprotection and Neurodegeneration. Traffic 2012; 13: 771-9.
    • (2012) Traffic , vol.13 , pp. 771-779
    • D'Ydewalle, C.1    Bogaert, E.2    van den, B.3
  • 133
    • 40549115641 scopus 로고    scopus 로고
    • Valproate protective effects on cisplatin-induced peripheral neuropathy: An in vitro and in vivo study
    • Rodriguez-Menendez V, Gilardini A, Bossi M, et al. Valproate protective effects on cisplatin-induced peripheral neuropathy: an in vitro and in vivo study. Anticancer Res 2008; 28: 335-42.
    • (2008) Anticancer Res , vol.28 , pp. 335-342
    • Rodriguez-Menendez, V.1    Gilardini, A.2    Bossi, M.3
  • 134
    • 78149466515 scopus 로고    scopus 로고
    • Schwann cell autophagy induced by SAHA, 17-AAG, or clonazepam can reduce bortezomib-induced peripheral neuropathy
    • Watanabe T, Nagase K, Chosa M, Tobinai K. Schwann cell autophagy induced by SAHA, 17-AAG, or clonazepam can reduce bortezomib-induced peripheral neuropathy. Br J Cancer 2010; 103: 1580-7.
    • (2010) Br J Cancer , vol.103 , pp. 1580-1587
    • Watanabe, T.1    Nagase, K.2    Chosa, M.3    Tobinai, K.4
  • 135
    • 8844232619 scopus 로고    scopus 로고
    • Chemotherapy-induced peripheral neurotoxicity
    • Cavaletti G, Marmiroli P. Chemotherapy-induced peripheral neurotoxicity. Expert Opin Drug Saf 2004; 3: 535-46.
    • (2004) Expert Opin Drug Saf , vol.3 , pp. 535-546
    • Cavaletti, G.1    Marmiroli, P.2
  • 136
    • 79957500607 scopus 로고    scopus 로고
    • Evidence-based guideline: Treatment of painful diabetic neuropathy: Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation
    • Bril V, England J, Franklin GM, et al. Evidence-based guideline: Treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology 2011; 76: 1758-65.
    • (2011) Neurology , vol.76 , pp. 1758-1765
    • Bril, V.1    England, J.2    Franklin, G.M.3
  • 137
    • 66049148780 scopus 로고    scopus 로고
    • Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain
    • Chiechio S, Zammataro M, Morales ME, et al. Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain. Mol Pharmacol 2009; 75: 1014-20.
    • (2009) Mol Pharmacol , vol.75 , pp. 1014-1020
    • Chiechio, S.1    Zammataro, M.2    Morales, M.E.3
  • 138
    • 84857315556 scopus 로고    scopus 로고
    • Epigenetic augmentation of the macrophage inflammatory protein 2/C-X-C chemokine receptor type 2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain
    • Kiguchi N, Kobayashi Y, Maeda T, et al. Epigenetic augmentation of the macrophage inflammatory protein 2/C-X-C chemokine receptor type 2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain. J Pharmacol Exp Ther 2012; 340: 577-87.
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 577-587
    • Kiguchi, N.1    Kobayashi, Y.2    Maeda, T.3
  • 139
    • 74449093596 scopus 로고    scopus 로고
    • Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury
    • Uchida H, Sasaki K, Ma L, Ueda H. Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury. Neuroscience 2010; 166: 1-4.
    • (2010) Neuroscience , vol.166 , pp. 1-4
    • Uchida, H.1    Sasaki, K.2    Ma, L.3    Ueda, H.4
  • 140
    • 0037965156 scopus 로고    scopus 로고
    • Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term randomized, doubleblind, placebo-controlled study
    • De Grandis D, Minardi C. Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term randomized, doubleblind, placebo-controlled study. Drugs R.D 2002; 3: 223-31.
    • (2002) Drugs R.D , vol.3 , pp. 223-231
    • de Grandis, D.1    Minardi, C.2
  • 141
    • 35348863733 scopus 로고    scopus 로고
    • Acetyl-L-carnitine in diabetic polyneuropathy: Experimental and clinical data
    • Sima AA. Acetyl-L-carnitine in diabetic polyneuropathy: experimental and clinical data. CNS Drugs 2007; 21: 13-23.
    • (2007) CNS Drugs , vol.21 , pp. 13-23
    • Sima, A.A.1
  • 142
    • 11844273799 scopus 로고    scopus 로고
    • Acetyl-L-Carnitine Study Group. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: An analysis of two randomized placebo-controlled trials
    • Sima AA, Calvani M, Mehra M, Amato A. Acetyl-L-Carnitine Study Group. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials. Diabetes Care 2005; 28: 89-94.
    • (2005) Diabetes Care , vol.28 , pp. 89-94
    • Sima, A.A.1    Calvani, M.2    Mehra, M.3    Amato, A.4
  • 143
    • 34247873189 scopus 로고    scopus 로고
    • A double-blind, parallelgroup, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection
    • ALCAR Study Group
    • Youle M, Osio M, ALCAR Study Group. A double-blind, parallelgroup, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. HIV Med 2007; 8: 241-50.
    • (2007) HIV Med , vol.8 , pp. 241-250
    • Youle, M.1    Osio, M.2
  • 144
    • 18944404875 scopus 로고    scopus 로고
    • A pilot study on the effect of acetyl-L-carnitine in paclitaxel-and cisplatin-induced peripheral neuropathy
    • Maestri, A, De Pasquale Ceratti A, Cundari S, Zanna C, Cortesi E, Crino L. A pilot study on the effect of acetyl-L-carnitine in paclitaxel-and cisplatin-induced peripheral neuropathy. Tumori 2005; 91: 135-8.
    • (2005) Tumori , vol.91 , pp. 135-138
    • Maestri, A.1    De Pasquale, C.A.2    Cundari, S.3    Zanna, C.4    Cortesi, E.5    Crino, L.6
  • 146
    • 0345060438 scopus 로고    scopus 로고
    • Paclitaxel and Cisplatininduced neurotoxicity: A protective role of acetyl-L-carnitine
    • Pisano C, Pratesi G, Laccabue D, et al. Paclitaxel and Cisplatininduced neurotoxicity: a protective role of acetyl-L-carnitine. Clin Cancer Res 2003; 9: 5756-67.
    • (2003) Clin Cancer Res , vol.9 , pp. 5756-5767
    • Pisano, C.1    Pratesi, G.2    Laccabue, D.3
  • 147
    • 18844398832 scopus 로고    scopus 로고
    • Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments
    • Tabolacci E, Pietrobono R, Moscato U, Oostra BA, Chiurazzi P, Neri G. Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments. Eur J Hum Genet 2005; 13: 641-8.
    • (2005) Eur J Hum Genet , vol.13 , pp. 641-648
    • Tabolacci, E.1    Pietrobono, R.2    Moscato, U.3    Oostra, B.A.4    Chiurazzi, P.5    Neri, G.6
  • 148
    • 80053385022 scopus 로고    scopus 로고
    • Intrathecal 5-azacytidine inhibits global DNA methylation and methyl-CpG-binding protein 2 expression and alleviates neuropathic pain in rats following chronic constriction injury
    • Wang Y, Liu C, Guo QL, et al. Intrathecal 5-azacytidine inhibits global DNA methylation and methyl-CpG-binding protein 2 expression and alleviates neuropathic pain in rats following chronic constriction injury. Brain Res 2011; 1418: 64-9.
    • (2011) Brain Res , vol.1418 , pp. 64-69
    • Wang, Y.1    Liu, C.2    Guo, Q.L.3
  • 151
    • 20144385858 scopus 로고    scopus 로고
    • Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice
    • Ryu H, Smith K, Camelo SI, et al. Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice. J Neurochem 2005; 93: 1087-98.
    • (2005) J Neurochem , vol.93 , pp. 1087-1098
    • Ryu, H.1    Smith, K.2    Camelo, S.I.3
  • 152
    • 79961028733 scopus 로고    scopus 로고
    • Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis
    • Yoo YE, Ko CP. Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis. Exp Neurol 2011; 231: 147-59.
    • (2011) Exp Neurol , vol.231 , pp. 147-159
    • Yoo, Y.E.1    Ko, C.P.2
  • 153
    • 10844284615 scopus 로고    scopus 로고
    • Benefit of valproic acid in suppressing disease progression of ALS model mice
    • Sugai F, Yamamoto Y, Miyaguchi K, et al. Benefit of valproic acid in suppressing disease progression of ALS model mice. Eur J Neurosci 2004; 20: 3179-83.
    • (2004) Eur J Neurosci , vol.20 , pp. 3179-3183
    • Sugai, F.1    Yamamoto, Y.2    Miyaguchi, K.3
  • 154
    • 34250612194 scopus 로고    scopus 로고
    • Sodium valproate exerts neuroprotective effects in vivo through CREB-binding proteindependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model
    • Rouaux C, Panteleeva I, René F, et al. Sodium valproate exerts neuroprotective effects in vivo through CREB-binding proteindependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model. J Neurosci 2007; 27: 5535-45.
    • (2007) J Neurosci , vol.27 , pp. 5535-5545
    • Rouaux, C.1    Panteleeva, I.2    René, F.3
  • 155
    • 49249136687 scopus 로고    scopus 로고
    • Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model
    • Feng HL, Leng Y, Ma CH, Zhang J, Ren M, Chuang DM. Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model. Neuroscience 2008; 155: 567-72.
    • (2008) Neuroscience , vol.155 , pp. 567-572
    • Feng, H.L.1    Leng, Y.2    Ma, C.H.3    Zhang, J.4    Ren, M.5    Chuang, D.M.6
  • 156
    • 70149086057 scopus 로고    scopus 로고
    • Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis
    • Piepers S, Veldink JH, de Jong SW, et al. Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis. Ann Neurol 2009; 66: 227-34.
    • (2009) Ann Neurol , vol.66 , pp. 227-234
    • Piepers, S.1    Veldink, J.H.2    de Jong, S.W.3
  • 157
    • 84055192382 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: From research to therapeutic attempts and therapeutic perspectives
    • Contestabile A. Amyotrophic lateral sclerosis: from research to therapeutic attempts and therapeutic perspectives. Curr Med Chem 2011; 18: 5655-65.
    • (2011) Curr Med Chem , vol.18 , pp. 5655-5665
    • Contestabile, A.1
  • 158
    • 80053640690 scopus 로고    scopus 로고
    • Helper T-cell differentiation and plasticity: Insights from epigenetics
    • Hirahara K, Vahedi G, Ghoreschi K, et al. Helper T-cell differentiation and plasticity: insights from epigenetics. Immunology 2011; 134: 235-45.
    • (2011) Immunology , vol.134 , pp. 235-245
    • Hirahara, K.1    Vahedi, G.2    Ghoreschi, K.3
  • 159
    • 33749059726 scopus 로고    scopus 로고
    • The neurobiology of multiple sclerosis: Genes, inflammation, and neurodegeneration
    • Hauser SL, Oksenberg JR. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron 2006; 52: 61-76.
    • (2006) Neuron , vol.52 , pp. 61-76
    • Hauser, S.L.1    Oksenberg, J.R.2
  • 160
    • 53949095861 scopus 로고    scopus 로고
    • Multiple sclerosis: Could it be an epigenetic disease?
    • Kurtuncu M. Multiple sclerosis: Could it be an epigenetic disease? Med Hypotheses 2008; 71: 945-7.
    • (2008) Med Hypotheses , vol.71 , pp. 945-947
    • Kurtuncu, M.1
  • 161
    • 84862620252 scopus 로고    scopus 로고
    • Exploring the role of the epigenome in multiple sclerosis: A window onto cell-specific transcriptional potential
    • Kaliszewska A, De Jager PL. Exploring the role of the epigenome in multiple sclerosis: A window onto cell-specific transcriptional potential. J Neuroimmunol 2012; 248: 2-9.
    • (2012) J Neuroimmunol , vol.248 , pp. 2-9
    • Kaliszewska, A.1    De Jager, P.L.2
  • 162
    • 0037340215 scopus 로고    scopus 로고
    • Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process
    • Bruniquel D, Schwartz RH. Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process. Nat Immunol 2003; 4: 235-40.
    • (2003) Nat Immunol , vol.4 , pp. 235-240
    • Bruniquel, D.1    Schwartz, R.H.2
  • 163
    • 57049160500 scopus 로고    scopus 로고
    • Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: A contribution to the current debate on disease pathogenesis
    • Casaccia-Bonnefil P, Pandozy G, Mastronardi F. Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis. Prog Neurobiol 2008; 86: 368-78.
    • (2008) Prog Neurobiol , vol.86 , pp. 368-378
    • Casaccia-Bonnefil, P.1    Pandozy, G.2    Mastronardi, F.3
  • 164
    • 34447334574 scopus 로고    scopus 로고
    • Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylated
    • Mastronardi FG, Noor A, Wood DD, Paton T, Moscarello MA. Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylated. J Neurosci Res 2007; 85: 2006-16.
    • (2007) J Neurosci Res , vol.85 , pp. 2006-2016
    • Mastronardi, F.G.1    Noor, A.2    Wood, D.D.3    Paton, T.4    Moscarello, M.A.5
  • 165
    • 77950867183 scopus 로고    scopus 로고
    • Epigenetic regulation of oligodendrocyte identity
    • Liu J, Casaccia P. Epigenetic regulation of oligodendrocyte identity. Trends Neurosci 2010; 33: 193-201.
    • (2010) Trends Neurosci , vol.33 , pp. 193-201
    • Liu, J.1    Casaccia, P.2
  • 166
    • 38449092452 scopus 로고    scopus 로고
    • Rationale for the use of histone deacetylase inhibitors as a dual therapeutic modality in multiple sclerosis
    • Gray SG, Dangond F. Rationale for the use of histone deacetylase inhibitors as a dual therapeutic modality in multiple sclerosis. Epigenetics 2006; 1: 67-75.
    • (2006) Epigenetics , vol.1 , pp. 67-75
    • Gray, S.G.1    Dangond, F.2
  • 167
    • 79957954734 scopus 로고    scopus 로고
    • The therapeutic potential of HDAC inhibitors in the treatment of multiple sclerosis
    • Faraco G, Cavone L, Chiarugi A. The therapeutic potential of HDAC inhibitors in the treatment of multiple sclerosis. Mol Med 2011; 17: 442-7.
    • (2011) Mol Med , vol.17 , pp. 442-447
    • Faraco, G.1    Cavone, L.2    Chiarugi, A.3
  • 168
    • 77957033927 scopus 로고    scopus 로고
    • Histone Deacetylase inhibitors: New promise in the treatment of immune and inflammatory diseases
    • Shuttleworth SJ, Bailey SG, Townsend PA. Histone Deacetylase inhibitors: new promise in the treatment of immune and inflammatory diseases. Curr Drug Targets 2010; 11: 1430-8.
    • (2010) Curr Drug Targets , vol.11 , pp. 1430-1438
    • Shuttleworth, S.J.1    Bailey, S.G.2    Townsend, P.A.3
  • 169
    • 20444446595 scopus 로고    scopus 로고
    • Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis
    • Camelo S, Iglesias AH, Hwang D, et al. Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. J Neuroimmunol 2005; 164: 10-21.
    • (2005) J Neuroimmunol , vol.164 , pp. 10-21
    • Camelo, S.1    Iglesias, A.H.2    Hwang, D.3
  • 170
    • 78149491805 scopus 로고    scopus 로고
    • Emerging role of epigenetics in stroke: Part 1: DNA methylation and chromatin modifications
    • Qureshi IA, Mehler MF. Emerging role of epigenetics in stroke: part 1: DNA methylation and chromatin modifications. Arch Neurol 2010; 67: 1316-22.
    • (2010) Arch Neurol , vol.67 , pp. 1316-1322
    • Qureshi, I.A.1    Mehler, M.F.2
  • 171
    • 79952596383 scopus 로고    scopus 로고
    • The emerging role of epigenetics in stroke: III. Neural stem cell biology and regenerative medicine
    • Qureshi IA, Mehler MF. The emerging role of epigenetics in stroke: III. Neural stem cell biology and regenerative medicine. Arch Neurol 2011; 68: 294-302.
    • (2011) Arch Neurol , vol.68 , pp. 294-302
    • Qureshi, I.A.1    Mehler, M.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.