Multiple sclerosis: Could it be an epigenetic disease?

Medical Hypotheses

Volumn 71, Issue 6, 2008, Pages 945-947

  Kürtüncü, Murat ^a   Tüzün, Erdem ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CAUSAL ATTRIBUTION; CPG ISLAND; DISEASE COURSE; DISEASE SEVERITY; DNA METHYLATION; DNA SEQUENCE; EPIGENETICS; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; MULTIPLE SCLEROSIS; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

DNA; EPIGENESIS, GENETIC; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HUMANS; MULTIPLE SCLEROSIS; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC;

EID: 53949095861     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2008.06.034     Document Type: Article

References (25)

1. Oksenberg J.R., and Hauser S.L. Genetics of multiple sclerosis. Neurol Clin 23 (2005) 1-75
2. Hauser S.L., and Oksenberg J.R. The neurobiology of MS genes inflammation and neurodegeneration. Neuron 52 (2006) 61-76
3. Sawcer S. A new era in the genetic analysis of multiple sclerosis. Curr Opin Neurol 19 (2006) 237-241
4. Ebers G.C. Environmental factors and multiple sclerosis. Lancet Neurol 7 (2008) 268-277
5. Esteller M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene 21 (2002) 5427-5440
6. Jiang Y.H., Bressler J., and Beaudet A.L. Epigenetics and human disease. Annu Rev Genom Hum G 5 (2004) 479-510
7. Razin A. CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J 17 17 (1998) 4905-4908
8. Momparler R.L. Cancer epigenetics. Oncogene 2 (2003) 6479-6483
9. Bruniquel D., and Schwartz R.H. Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process. Nat Immunol 4 3 (2003) 235-240
10. Richardson B., Scheinbart L., Strahler J., et al. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 33 (1990) 1665-1673
11. Scheinbart L.S.M.A., Johnson L.A., Gross S.R., et al. Procainamide inhibits DNA methyltransferase in a human T cell line. J Rheumatol 18 (1991) 530-534
12. Ebers G.C., Bulman D.E., Sadovnick A.D., et al. A population-based study of multiple sclerosis in twins. N Engl J Med 315 26 (1986) 1638-1642
13. Moscarello M.A., Wood D.D., Ackerley C., et al. Myelin in multiple sclerosis is developmentally immature. J Clin Invest 94 (1994) 146-154
14. Mastronardi F.G., Wood D.D., Mei J., et al. Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase translocation. J Neurosci 26 44 (2006) 11387-11396
15. Tao Q., and Robertson K.D. Stealth technology: how Epstein-Barr virus utilizes DNA methylation to cloak itself from immune detection. Clin Immunol 10 (2003) 53-63
16. Makar K.W., and Wilson C.B. DNA methylation is a nonredundant repressor of the Th2 effector program. J Immunol 173 (2004) 4402-4406
17. Wilson C.B., Makar K.W.B., Shnyreva, et al. DNA methylation and the expanding epigenetics of T cell lineage commitment. Semin Immunol 17 (2005) 105-119
18. Young H.A., Dray J.F., and Farrar W.L. Expression of transfected human interferon-gamma DNA: evidence for cell-specific regulation. J Immunol 136 12 (1986) 4700-4703
19. Young H.A., Ghosh P., Ye J., et al. Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene. J Immunol 153 8 (1994) 3603-3610
20. Melvin A.J., McGurn M.E., Bort S.J., Gibson C., and Lewis D.B. Hypomethylation of the interferon-gamma gene correlates with its expression by primary T-lineage cells. Eur J Immunol 25 2 (1995) 426-430
21. Mikovits J.A., Young H.A., Vertino P., et al. Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production. Mol Cell Biol 18 9 (1998) 5166-5177
22. Agarwal S., and Rao A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9 6 (1998) 765-775
23. Camelo S., Iglesias A.H., Hwang D., et al. Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. J Neuroimmunol 164 1-2 (2005) 10-21
24. Grogan J.L., Mohrs M., Harmon B., et al. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14 3 (2001) 205-215
25. Mullen A.C., Hutchins A.S., Villarino A.V., et al. Cell cycle controlling the silencing and functioning of mammalian activators. Curr Biol 11 21 (2001) 1695-1699