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Volumn 8, Issue 4, 2008, Pages 266-274

Targeting cancer and neuropathy with histone deacetylase inhibitors: Two birds with one stone?

Author keywords

Cancer; Cisplatin; Histones; Neuropathy; Neuroprotection; Valproate

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTINEOPLASTIC AGENT; AZACITIDINE; CISPLATIN; HISTONE DEACETYLASE INHIBITOR; LEVACECARNINE; PACLITAXEL; PLATINUM DERIVATIVE; VALPROIC ACID; VORINOSTAT;

EID: 45849101673     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/156800908784533508     Document Type: Review
Times cited : (12)

References (133)
  • 1
    • 0035890986 scopus 로고    scopus 로고
    • Code of silence
    • Rice, J. C.; Allis, C. D. Code of silence. Nature 2001, 414, 258-261.
    • (2001) Nature , vol.414 , pp. 258-261
    • Rice, J.C.1    Allis, C.D.2
  • 2
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein, T.; Allis, C. D. Translating the histone code. Science 2001, 293, 1074-1080.
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 3
    • 0037382605 scopus 로고    scopus 로고
    • Functional consequences of histone modifications
    • Iizuka, M.; Smith, M. M. Functional consequences of histone modifications. Curr. Opin. Genet. Dev. 2003, 13, 154-160.
    • (2003) Curr. Opin. Genet. Dev , vol.13 , pp. 154-160
    • Iizuka, M.1    Smith, M.M.2
  • 4
    • 0035231405 scopus 로고    scopus 로고
    • Regulation of the DNA methylation machinery and its role in cellular transformation
    • Szyf, M.; Detich, N. Regulation of the DNA methylation machinery and its role in cellular transformation. Prog. Nucleic Acid Res. Mol. Biol. 2001, 69, 47-79.
    • (2001) Prog. Nucleic Acid Res. Mol. Biol , vol.69 , pp. 47-79
    • Szyf, M.1    Detich, N.2
  • 5
    • 0035997356 scopus 로고    scopus 로고
    • ATP-dependent nucleosome remodeling
    • Becker, P. B.; Hörz, W. ATP-dependent nucleosome remodeling. Ann. Rev. Biochem. 2002, 71, 247-273.
    • (2002) Ann. Rev. Biochem , vol.71 , pp. 247-273
    • Becker, P.B.1    Hörz, W.2
  • 6
    • 0035986095 scopus 로고    scopus 로고
    • Dynamics of histone acetylation in vivo. A function for acetylation turnover?
    • Waterborg, J. H. Dynamics of histone acetylation in vivo. A function for acetylation turnover? Biochem. Cell Biol. 2002, 80, 363-378.
    • (2002) Biochem. Cell Biol , vol.80 , pp. 363-378
    • Waterborg, J.H.1
  • 7
    • 78651162036 scopus 로고
    • Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis
    • Allfrey, V. G.; Faulkner, R. M.; Minsky, A. E. Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis. Proc. Natl. Acad. Sci. USA 1966, 51, 786-794.
    • (1966) Proc. Natl. Acad. Sci. USA , vol.51 , pp. 786-794
    • Allfrey, V.G.1    Faulkner, R.M.2    Minsky, A.E.3
  • 8
    • 0034707037 scopus 로고    scopus 로고
    • Global histone acetylation and deacetylation in yeast
    • Vogelauer, M.; Wu, J.; Suka, N.; Grunstein, M. Global histone acetylation and deacetylation in yeast. Nature 2000, 408, 495-498.
    • (2000) Nature , vol.408 , pp. 495-498
    • Vogelauer, M.1    Wu, J.2    Suka, N.3    Grunstein, M.4
  • 9
    • 0036527775 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
    • Johnstone, R. W. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat. Rev. Drug Discov. 2002, 1, 287-299.
    • (2002) Nat. Rev. Drug Discov , vol.1 , pp. 287-299
    • Johnstone, R.W.1
  • 10
    • 0034508137 scopus 로고    scopus 로고
    • Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription
    • Kuo, M. H.; vom Baur, E.; Struhl, K.; Allis, C. D. Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription. Mol. Cell. 2000, 6, 1309-1320.
    • (2000) Mol. Cell , vol.6 , pp. 1309-1320
    • Kuo, M.H.1    vom Baur, E.2    Struhl, K.3    Allis, C.D.4
  • 11
    • 0035853455 scopus 로고    scopus 로고
    • Histone deacetylase complexes: Functional entities or molecular reservoirs
    • Khochbin, S.; Kao, H. Y. Histone deacetylase complexes: functional entities or molecular reservoirs. FEBS Lett. 2001, 494, 141-144.
    • (2001) FEBS Lett , vol.494 , pp. 141-144
    • Khochbin, S.1    Kao, H.Y.2
  • 15
    • 0033529565 scopus 로고    scopus 로고
    • Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
    • Kornberg, R. D.; Lorch, Y. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 1999, 98, 285-294.
    • (1999) Cell , vol.98 , pp. 285-294
    • Kornberg, R.D.1    Lorch, Y.2
  • 16
    • 0034707037 scopus 로고    scopus 로고
    • Global histone acetylation and deacetylation in yeast
    • Vogelauer, M.; Wu, J.; Suka, N.; Grunstein, M. Global histone acetylation and deacetylation in yeast. Nature 2000, 408, 495-498.
    • (2000) Nature , vol.408 , pp. 495-498
    • Vogelauer, M.1    Wu, J.2    Suka, N.3    Grunstein, M.4
  • 18
    • 33846261713 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors for cancer therapy
    • Kim, T. Y.; Bang, Y. J.; Robertson, K. D. Histone deacetylase inhibitors for cancer therapy. Epigenetics 2006, 1, 14-23.
    • (2006) Epigenetics , vol.1 , pp. 14-23
    • Kim, T.Y.1    Bang, Y.J.2    Robertson, K.D.3
  • 20
    • 34548748173 scopus 로고    scopus 로고
    • The pharmaceutical potential of histone deacetylase inhibitors
    • Elaut, G.; Rogiers, V.; Vanhaecke, T. The pharmaceutical potential of histone deacetylase inhibitors. Curr. Pharm. Des. 2007, 13, 2584-2620.
    • (2007) Curr. Pharm. Des , vol.13 , pp. 2584-2620
    • Elaut, G.1    Rogiers, V.2    Vanhaecke, T.3
  • 21
    • 0037303184 scopus 로고    scopus 로고
    • DNA demethylating agents and chromatin-remodelling drugs: Which, how and why?
    • Villar-Garea, A.; Esteller, M. DNA demethylating agents and chromatin-remodelling drugs: which, how and why? Curr. Drug Metab. 2003, 4, 11-31.
    • (2003) Curr. Drug Metab , vol.4 , pp. 11-31
    • Villar-Garea, A.1    Esteller, M.2
  • 23
    • 34249033131 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular and biological activity as a premise to clinical application
    • Santini, V.; Gozzini, A.; Ferrari, G. Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application. Curr. Drug Metab. 2007, 8, 383-393.
    • (2007) Curr. Drug Metab , vol.8 , pp. 383-393
    • Santini, V.1    Gozzini, A.2    Ferrari, G.3
  • 24
    • 0038676409 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase activity by butyrate
    • Davie, J. R. Inhibition of histone deacetylase activity by butyrate. J. Nutr. 2003, 133, 2485S-2493S.
    • (2003) J. Nutr , vol.133
    • Davie, J.R.1
  • 26
    • 0024996768 scopus 로고
    • Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
    • Yoshida, M.; Kijima, M.; Akita, M.; Beppu, T. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J. Biol. Chem. 1990, 265, 17174-17179.
    • (1990) J. Biol. Chem , vol.265 , pp. 17174-17179
    • Yoshida, M.1    Kijima, M.2    Akita, M.3    Beppu, T.4
  • 29
    • 0000032126 scopus 로고    scopus 로고
    • Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase
    • Kwon, H. J.; Owa, T., Hassig, C. A.; Shimada, J.; Schreiber, S. L. Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase. Proc. Natl. Acad. Sci. USA 1998, 95, 3356-3361.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3356-3361
    • Kwon, H.J.1    Owa, T.2    Hassig, C.A.3    Shimada, J.4    Schreiber, S.L.5
  • 30
    • 0034326799 scopus 로고    scopus 로고
    • Han, J. W.; Ahn, S. H.; Park, S. H.; Wang, S. Y.; Bae, G. U.; Seo, D. W.; Kwon, H. K.; Hong, S.; Lee, H. Y.; Leev, Y. W.; Lee, H. W. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 2000, 60, 6068-6074.
    • Han, J. W.; Ahn, S. H.; Park, S. H.; Wang, S. Y.; Bae, G. U.; Seo, D. W.; Kwon, H. K.; Hong, S.; Lee, H. Y.; Leev, Y. W.; Lee, H. W. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 2000, 60, 6068-6074.
  • 31
    • 0036401554 scopus 로고    scopus 로고
    • Pharmacological and therapeutic properties of valproate: A summary after 35 years of clinical experience
    • Perucca, E. Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs 2002, 16, 695-714.
    • (2002) CNS Drugs , vol.16 , pp. 695-714
    • Perucca, E.1
  • 32
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • Phiel, C. J.; Zhang, F.; Huang, E. Y.; Guenther, M. G.; Lazar, M. A.; Klein, P. S. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J. Biol. Chem. 2001, 276, 36734-36741.
    • (2001) J. Biol. Chem , vol.276 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5    Klein, P.S.6
  • 36
    • 3042576479 scopus 로고    scopus 로고
    • Valproic acid: An old drug newly discovered as inhibitor of histone deacetylases
    • Göttlicher, M. Valproic acid: an old drug newly discovered as inhibitor of histone deacetylases. Ann. Hematol. 2004, 83, 91-92.
    • (2004) Ann. Hematol , vol.83 , pp. 91-92
    • Göttlicher, M.1
  • 38
    • 0035837658 scopus 로고    scopus 로고
    • Paradoxical effects of trichostatin A: Inhibition of NF-Yassociated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA
    • Nair, A. R.; Boersma, L. J.; Schiltz, L.; Chaudhry, M. A.; Muschel, R. J. Paradoxical effects of trichostatin A: inhibition of NF-Yassociated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA. Cancer Lett. 2001, 166, 55-64.
    • (2001) Cancer Lett , vol.166 , pp. 55-64
    • Nair, A.R.1    Boersma, L.J.2    Schiltz, L.3    Chaudhry, M.A.4    Muschel, R.J.5
  • 40
    • 0042346416 scopus 로고    scopus 로고
    • Valproate induces replication- independent active DNA demethylation
    • Detich, N.; Bovenzi, V.; Szyf, M. Valproate induces replication- independent active DNA demethylation. J. Biol. Chem. 2003, 278, 27586-27592.
    • (2003) J. Biol. Chem , vol.278 , pp. 27586-27592
    • Detich, N.1    Bovenzi, V.2    Szyf, M.3
  • 41
    • 0001065199 scopus 로고
    • On the propyl derivatives and decomposition products of ethylacetoacetate
    • Burton, B. S. On the propyl derivatives and decomposition products of ethylacetoacetate. Am. Chem. J. 1882, 3, 385-395.
    • (1882) Am. Chem. J , vol.3 , pp. 385-395
    • Burton, B.S.1
  • 42
    • 73649173245 scopus 로고
    • Pharmacodynamic properties of N-dipropylacetic acid]
    • French
    • Meunier, H.; Carraz, G.; Neunier, Y.; Eymard, P.; Aimard, M. [Pharmacodynamic properties of N-dipropylacetic acid]. Therapie 1963, 18, 435-438. French.
    • (1963) Therapie , vol.18 , pp. 435-438
    • Meunier, H.1    Carraz, G.2    Neunier, Y.3    Eymard, P.4    Aimard, M.5
  • 43
    • 0037742375 scopus 로고    scopus 로고
    • Valproate: A reappraisal of its pharmacodynamic properties and mechanisms of action
    • Loscher, W. Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action. Prog. Neurobiol. 1999, 58, 31-59.
    • (1999) Prog. Neurobiol , vol.58 , pp. 31-59
    • Loscher, W.1
  • 45
    • 18044373043 scopus 로고    scopus 로고
    • Valproate in bipolar disorder: 2000 onwards
    • Bowden, C. L.; Singh, V. Valproate in bipolar disorder: 2000 onwards. Acta Psychiatr. Scand. 2005, 111, 13-20.
    • (2005) Acta Psychiatr. Scand , vol.111 , pp. 13-20
    • Bowden, C.L.1    Singh, V.2
  • 49
    • 34548176264 scopus 로고    scopus 로고
    • Valproic acid for the treatment of myeloid malignancies
    • Kuendgen, A.; Gattermann, N. Valproic acid for the treatment of myeloid malignancies. Cancer 2007, 110, 943-954.
    • (2007) Cancer , vol.110 , pp. 943-954
    • Kuendgen, A.1    Gattermann, N.2
  • 50
    • 34748877735 scopus 로고    scopus 로고
    • Inhibition of histone deacetylation: A strategy for tumor radiosensitization
    • Camphausen, K.; Tofilon, P. J. Inhibition of histone deacetylation: a strategy for tumor radiosensitization. J. Clin. Oncol. 2007, 25, 4051-4056.
    • (2007) J. Clin. Oncol , vol.25 , pp. 4051-4056
    • Camphausen, K.1    Tofilon, P.J.2
  • 51
    • 38449099535 scopus 로고    scopus 로고
    • The epigenetic modifier, valproic acid, enhances radiation sensitivity
    • Karagiannis, T. C.; Kn, H.; El-Osta, A. The epigenetic modifier, valproic acid, enhances radiation sensitivity. Epigenetics 2006, 1, 131-137.
    • (2006) Epigenetics , vol.1 , pp. 131-137
    • Karagiannis, T.C.1    Kn, H.2    El-Osta, A.3
  • 53
    • 35948965312 scopus 로고    scopus 로고
    • Valproic acid enhances tubulin acetylation and apoptotic activity of paclitaxel on anaplastic thyroid cancer cell lines
    • Catalano, M. G.; Poli, R.; Pugliese, M.; Fortunati, N.; Boccuzzi, G. Valproic acid enhances tubulin acetylation and apoptotic activity of paclitaxel on anaplastic thyroid cancer cell lines. Endocr. Relat. Cancer 2007, 14, 839-845.
    • (2007) Endocr. Relat. Cancer , vol.14 , pp. 839-845
    • Catalano, M.G.1    Poli, R.2    Pugliese, M.3    Fortunati, N.4    Boccuzzi, G.5
  • 54
    • 4444309863 scopus 로고    scopus 로고
    • Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid
    • Kuendgen, A.; Strupp, C.; Aivado, M.; Bernhardt, A.; Hildebrandt, B.; Haas, R.; Germing, U.; Gattermann, N. Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid. Blood 2004, 104, 1266-1269.
    • (2004) Blood , vol.104 , pp. 1266-1269
    • Kuendgen, A.1    Strupp, C.2    Aivado, M.3    Bernhardt, A.4    Hildebrandt, B.5    Haas, R.6    Germing, U.7    Gattermann, N.8
  • 55
    • 29144481615 scopus 로고    scopus 로고
    • Results of a phase 2 study of valproic acid alone or in combination with alltrans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukemia
    • Kuendgen, A.; Knipp, S.; Fox, F.; Strupp, C.; Hildebrandt, B.; Steidl, C.; Germing, U.; Haas, R.; Gattermann, N. Results of a phase 2 study of valproic acid alone or in combination with alltrans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukemia. Ann. Hematol. 2005, 84, 61-66.
    • (2005) Ann. Hematol , vol.84 , pp. 61-66
    • Kuendgen, A.1    Knipp, S.2    Fox, F.3    Strupp, C.4    Hildebrandt, B.5    Steidl, C.6    Germing, U.7    Haas, R.8    Gattermann, N.9
  • 56
    • 29744454120 scopus 로고    scopus 로고
    • The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia
    • Kuendgen, A.; Schmid, M.; Schlenk, R.; Knipp, S.; Hildebrandt, B.; Steidl, C.; Germing, U.; Haas, R.; Dohner, H.; Gattermann, N. The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia. Cancer 2006, 106, 112-119.
    • (2006) Cancer , vol.106 , pp. 112-119
    • Kuendgen, A.1    Schmid, M.2    Schlenk, R.3    Knipp, S.4    Hildebrandt, B.5    Steidl, C.6    Germing, U.7    Haas, R.8    Dohner, H.9    Gattermann, N.10
  • 57
    • 22544466164 scopus 로고    scopus 로고
    • Valproic acid and all-trans retinoic acid for the treatment of elderly patients with acute myeloid leukemia
    • Raffoux, E.; Chaibi, P.; Dombret, H.; Degos, L. Valproic acid and all-trans retinoic acid for the treatment of elderly patients with acute myeloid leukemia. Haematologica 2005, 90, 986-988.
    • (2005) Haematologica , vol.90 , pp. 986-988
    • Raffoux, E.1    Chaibi, P.2    Dombret, H.3    Degos, L.4
  • 59
    • 33748997409 scopus 로고    scopus 로고
    • Sequential valproic acid/alltrans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemia
    • Cimino, G.; Lo-Coco, F.; Fenu, S. Sequential valproic acid/alltrans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemia. Cancer Res. 2006, 66, 8903-8911.
    • (2006) Cancer Res , vol.66 , pp. 8903-8911
    • Cimino, G.1    Lo-Coco, F.2    Fenu, S.3
  • 62
    • 34548395116 scopus 로고    scopus 로고
    • Candelaria, M.; Gallardo-Rincón, D.; Arce, C.; Cetina, L.; Aguilar-Ponce, J. L.; Arrieta, O.; González-Fierro, A.; Chávez-Blanco, A.; de la Cruz-Hernández, E.; Camargo, M. F.; Trejo-Becerril, C.; Pérez-Cárdenas, E.; Pérez-Plasencia, C.; Taja-Chayeb, L.; Wegman-Ostrosky, T.; Revilla-Vazquez, A.; Dueñas-González, A. A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors. Ann. Oncol. 2007, 18, 1529-1538.
    • Candelaria, M.; Gallardo-Rincón, D.; Arce, C.; Cetina, L.; Aguilar-Ponce, J. L.; Arrieta, O.; González-Fierro, A.; Chávez-Blanco, A.; de la Cruz-Hernández, E.; Camargo, M. F.; Trejo-Becerril, C.; Pérez-Cárdenas, E.; Pérez-Plasencia, C.; Taja-Chayeb, L.; Wegman-Ostrosky, T.; Revilla-Vazquez, A.; Dueñas-González, A. A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors. Ann. Oncol. 2007, 18, 1529-1538.
  • 66
    • 38449122336 scopus 로고    scopus 로고
    • The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cells
    • Fedier, A.; Dedes, K. J.; Imesch, P.; Von Bueren, A. O.; Fink, D. The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cells. Int. J. Oncol. 2007, 31, 633-641.
    • (2007) Int. J. Oncol , vol.31 , pp. 633-641
    • Fedier, A.1    Dedes, K.J.2    Imesch, P.3    Von Bueren, A.O.4    Fink, D.5
  • 68
    • 0036158822 scopus 로고    scopus 로고
    • Chemotherapy-induced peripheral neuropathy
    • Quasthoff, S.; Hartung, H. P. Chemotherapy-induced peripheral neuropathy. J. Neurol. 2002, 249, 9-17.
    • (2002) J. Neurol , vol.249 , pp. 9-17
    • Quasthoff, S.1    Hartung, H.P.2
  • 69
    • 0033397107 scopus 로고    scopus 로고
    • Chemotherapeutic neuropathy
    • Windebank, A. J. Chemotherapeutic neuropathy. Curr. Opin. Neurol. 1999, 12, 565-571.
    • (1999) Curr. Opin. Neurol , vol.12 , pp. 565-571
    • Windebank, A.J.1
  • 70
    • 4644362706 scopus 로고    scopus 로고
    • Chemotherapy-induced peripheral neuropathy: Pathogenesis and emerging therapies
    • Ocean, A. J.; Vahdat, L. T. Chemotherapy-induced peripheral neuropathy: pathogenesis and emerging therapies. Support Care Cancer 2004, 12, 619-625.
    • (2004) Support Care Cancer , vol.12 , pp. 619-625
    • Ocean, A.J.1    Vahdat, L.T.2
  • 71
    • 0036796257 scopus 로고    scopus 로고
    • Recent advances in drug-induced neuropathies
    • Peltier, A. C.; Russell, J. W. Recent advances in drug-induced neuropathies. Curr. Opin. Neurol. 2002, 15, 633-638.
    • (2002) Curr. Opin. Neurol , vol.15 , pp. 633-638
    • Peltier, A.C.1    Russell, J.W.2
  • 72
    • 37049053957 scopus 로고
    • Inhibition of cell division in escherichia coli by electrolysis products from a platinum electrode
    • Rosenberg, B.; Vancamp, L.; Krigas, T. Inhibition of cell division in escherichia coli by electrolysis products from a platinum electrode. Nature 1965, 205, 698-699.
    • (1965) Nature , vol.205 , pp. 698-699
    • Rosenberg, B.1    Vancamp, L.2    Krigas, T.3
  • 73
    • 34547100275 scopus 로고    scopus 로고
    • The resurgence of platinum-based cancer chemotherapy
    • Kelland, L. The resurgence of platinum-based cancer chemotherapy. Nat. Rev. Cancer 2007, 7, 573-584.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 573-584
    • Kelland, L.1
  • 74
    • 8844232619 scopus 로고    scopus 로고
    • Chemotherapy-induced peripheral neurotoxicity
    • Cavaletti, G.; Marmiroli, P. Chemotherapy-induced peripheral neurotoxicity. Expert. Opin. Drug Saf. 2004, 3, 535-546.
    • (2004) Expert. Opin. Drug Saf , vol.3 , pp. 535-546
    • Cavaletti, G.1    Marmiroli, P.2
  • 75
    • 15944426735 scopus 로고    scopus 로고
    • Cisplatin preferentially binds to DNA in dorsal root ganglion neurons in vitro and in vivo: A potential mechanism for neurotoxicity
    • McDonald, E. S.; Randon, K. R.; Knight, A.; Windebank, A. J. Cisplatin preferentially binds to DNA in dorsal root ganglion neurons in vitro and in vivo: a potential mechanism for neurotoxicity. Neurobiol. Dis. 2005, 18, 305-313.
    • (2005) Neurobiol. Dis , vol.18 , pp. 305-313
    • McDonald, E.S.1    Randon, K.R.2    Knight, A.3    Windebank, A.J.4
  • 76
  • 77
    • 0025169939 scopus 로고
    • Cisplatin neurotoxicity
    • Mollman, J. E. Cisplatin neurotoxicity. N. Engl. J. Med. 1990, 322, 126-127.
    • (1990) N. Engl. J. Med , vol.322 , pp. 126-127
    • Mollman, J.E.1
  • 78
    • 0242582476 scopus 로고    scopus 로고
    • Theoretical study of cisplatin binding to purine bases: Why does cisplatin prefer guanine over adenine?
    • Baik, M. H.; Friesner, R. A.; Lippard, S. J. Theoretical study of cisplatin binding to purine bases: why does cisplatin prefer guanine over adenine? J. Am. Chem. Soc. 2003, 125, 14082-14092.
    • (2003) J. Am. Chem. Soc , vol.125 , pp. 14082-14092
    • Baik, M.H.1    Friesner, R.A.2    Lippard, S.J.3
  • 79
    • 0029585833 scopus 로고
    • Solution structure of a cisplatin-induced DNA interstrand crosslink
    • Huang, H.; Zhu, L.; Reid, B. R.; Drobny, G. P.; Hopkins, P. B. Solution structure of a cisplatin-induced DNA interstrand crosslink. Science 1995, 270, 1842-1845.
    • (1995) Science , vol.270 , pp. 1842-1845
    • Huang, H.1    Zhu, L.2    Reid, B.R.3    Drobny, G.P.4    Hopkins, P.B.5
  • 81
    • 34548455064 scopus 로고    scopus 로고
    • Repair capacity for platinum-DNA adducts determines the severity of cisplatin-induced peripheral neuropathy
    • Dzagnidze, A.; Katsarava, Z.; Makhalova, J.; Liedert, B.; Yoon, M. S.; Kaube, H.; Limmroth, V.; Thomale, J. Repair capacity for platinum-DNA adducts determines the severity of cisplatin-induced peripheral neuropathy. J. Neurosci. 2007, 27, 9451-9457.
    • (2007) J. Neurosci , vol.27 , pp. 9451-9457
    • Dzagnidze, A.1    Katsarava, Z.2    Makhalova, J.3    Liedert, B.4    Yoon, M.S.5    Kaube, H.6    Limmroth, V.7    Thomale, J.8
  • 82
  • 83
    • 0024988359 scopus 로고
    • Activation of programmed cell death by anticancer agents: Cisplatin as a model system
    • Eastman, A. Activation of programmed cell death by anticancer agents: cisplatin as a model system. Cancer Cells 1990, 2, 275-280.
    • (1990) Cancer Cells , vol.2 , pp. 275-280
    • Eastman, A.1
  • 84
    • 0029125041 scopus 로고
    • An electrophysiological investigation of the effects of cisplatin and the protective actions of dexamethasone on cultured dorsal root ganglion neurons from neonatal rats
    • Scott, R. H.; Woods, A. J.; Lacey, M. J.; Fernando, D.; Crawford, J. H.; Andrews, P. L. An electrophysiological investigation of the effects of cisplatin and the protective actions of dexamethasone on cultured dorsal root ganglion neurons from neonatal rats. Naunyn Schmiedebergs Arch. Pharmacol. 1995, 352, 247-255.
    • (1995) Naunyn Schmiedebergs Arch. Pharmacol , vol.352 , pp. 247-255
    • Scott, R.H.1    Woods, A.J.2    Lacey, M.J.3    Fernando, D.4    Crawford, J.H.5    Andrews, P.L.6
  • 85
    • 0028829209 scopus 로고
    • An ultrastructural study of neuronal changes in dorsal root ganglia (DRG) of rats after chronic cisplatin administrations
    • Cece, R.; Petruccioli, M. G.; Cavaletti, G.; Barajon, I.; Tredici, G. An ultrastructural study of neuronal changes in dorsal root ganglia (DRG) of rats after chronic cisplatin administrations. Histol. Histopathol. 1995, 10, 837-845.
    • (1995) Histol. Histopathol , vol.10 , pp. 837-845
    • Cece, R.1    Petruccioli, M.G.2    Cavaletti, G.3    Barajon, I.4    Tredici, G.5
  • 86
    • 0026700476 scopus 로고
    • Morphometric study of the sensory neuron and peripheral nerve changes induced by chronic cisplatin (DDP) administration in rats
    • Cavaletti, G.; Tredici, G.; Marmiroli, P.; Petruccioli, M. G.; Barajon, I.; Fabbrica, D. Morphometric study of the sensory neuron and peripheral nerve changes induced by chronic cisplatin (DDP) administration in rats. Acta Neuropathol. (Berl). 1992, 84, 364-371.
    • (1992) Acta Neuropathol. (Berl) , vol.84 , pp. 364-371
    • Cavaletti, G.1    Tredici, G.2    Marmiroli, P.3    Petruccioli, M.G.4    Barajon, I.5    Fabbrica, D.6
  • 87
    • 0028102185 scopus 로고
    • Image analysis of neuritic regeneration by adult rat dorsal root ganglion neurons in culture: Quantification of the neurotoxicity of anticancer agents and of its prevention by nerve growth factor or basic fibroblast growth factor but not brain-derived neurotrophic factor or neurotrophin-3
    • Malgrange, B.; Delree, P.; Rigo, J. M.; Baron, H.; Moonen G.Image analysis of neuritic regeneration by adult rat dorsal root ganglion neurons in culture: quantification of the neurotoxicity of anticancer agents and of its prevention by nerve growth factor or basic fibroblast growth factor but not brain-derived neurotrophic factor or neurotrophin-3. J. Neurosci. Methods 1994, 53, 111-122.
    • (1994) J. Neurosci. Methods , vol.53 , pp. 111-122
    • Malgrange, B.1    Delree, P.2    Rigo, J.M.3    Baron, H.4    Moonen, G.5
  • 88
    • 0028292771 scopus 로고
    • Nerve growth factor prevents neurotoxic effects of cisplatin, vincristine and taxol, on adult rat sympathetic ganglion explants in vitro
    • Hayakawa, K.; Sobue, G.; Itoh, T.; Mitsuma, T. Nerve growth factor prevents neurotoxic effects of cisplatin, vincristine and taxol, on adult rat sympathetic ganglion explants in vitro. Life Sci. 1994, 55, 519-525.
    • (1994) Life Sci , vol.55 , pp. 519-525
    • Hayakawa, K.1    Sobue, G.2    Itoh, T.3    Mitsuma, T.4
  • 90
    • 0028933576 scopus 로고
    • Effect of nerve growth factor on peptide neurons in dorsal root ganglia after taxol or cisplatin treatment and in diabetic (db/db) mice
    • Schmidt, Y.; Unger, J. W.; Bartke, I.; Reiter, R. Effect of nerve growth factor on peptide neurons in dorsal root ganglia after taxol or cisplatin treatment and in diabetic (db/db) mice. Exp. Neurol. 1995, 132, 16-23.
    • (1995) Exp. Neurol , vol.132 , pp. 16-23
    • Schmidt, Y.1    Unger, J.W.2    Bartke, I.3    Reiter, R.4
  • 91
    • 0034655960 scopus 로고    scopus 로고
    • ter Laak, M. P.; Hamers, F. P.; Kirk, C. J.; Gispen, W. H. rhGGF2 protects against cisplatin-induced neuropathy in the rat. J. Neurosci. Res. 2000, 60, 237-244.
    • ter Laak, M. P.; Hamers, F. P.; Kirk, C. J.; Gispen, W. H. rhGGF2 protects against cisplatin-induced neuropathy in the rat. J. Neurosci. Res. 2000, 60, 237-244.
  • 93
    • 0035660519 scopus 로고    scopus 로고
    • Alterations in cell cycle regulation underlie cisplatin induced apoptosis of dorsal root ganglion neurons in vivo
    • Fischer, S. J.; McDonald, E. S.; Gross, L.; Windebank, A. J. Alterations in cell cycle regulation underlie cisplatin induced apoptosis of dorsal root ganglion neurons in vivo. Neurobiol. Dis. 2001, 8, 1027-1035.
    • (2001) Neurobiol. Dis , vol.8 , pp. 1027-1035
    • Fischer, S.J.1    McDonald, E.S.2    Gross, L.3    Windebank, A.J.4
  • 94
    • 1042269461 scopus 로고    scopus 로고
    • Sodium valproate for painful diabetic neuropathy: A randomized double-blind placebo-controlled study
    • Kochar, D. K.; Rawat, N.; Agrawal, R. P.; Vyas, A.; Beniwal, R.; Kochar, S. K.; Garg, P. Sodium valproate for painful diabetic neuropathy: a randomized double-blind placebo-controlled study. QJM 2004, 97, 33-38.
    • (2004) QJM , vol.97 , pp. 33-38
    • Kochar, D.K.1    Rawat, N.2    Agrawal, R.P.3    Vyas, A.4    Beniwal, R.5    Kochar, S.K.6    Garg, P.7
  • 95
    • 0033663222 scopus 로고    scopus 로고
    • Anticonvulsants for neuropathic pain syndromes: Mechanisms of action and place in therapy
    • Tremont-Lukats, I. W.; Megeff, C.; Backonja, M. M. Anticonvulsants for neuropathic pain syndromes: mechanisms of action and place in therapy. Drugs 2000, 60, 1029-1052.
    • (2000) Drugs , vol.60 , pp. 1029-1052
    • Tremont-Lukats, I.W.1    Megeff, C.2    Backonja, M.M.3
  • 96
    • 0037728684 scopus 로고    scopus 로고
    • Valproic acid enhances axonal regeneration and recovery of motor function after sciatic nerve axotomy in adult rats
    • Cui, S. S.; Yang, C. P.; Bowen, R. C.; Bai, O.; Li, X. M.; Jiang, W.; Zhang, X. Valproic acid enhances axonal regeneration and recovery of motor function after sciatic nerve axotomy in adult rats. Brain Res. 2003, 975, 229-236.
    • (2003) Brain Res , vol.975 , pp. 229-236
    • Cui, S.S.1    Yang, C.P.2    Bowen, R.C.3    Bai, O.4    Li, X.M.5    Jiang, W.6    Zhang, X.7
  • 98
    • 75549094121 scopus 로고
    • Carnitine and its role in fatty acid metabolism
    • Fritz, I. B. Carnitine and its role in fatty acid metabolism. Adv. Lipid Res. 1963, 1, 285-334.
    • (1963) Adv. Lipid Res , vol.1 , pp. 285-334
    • Fritz, I.B.1
  • 99
    • 0025372395 scopus 로고
    • The role of carnitine in intracellular metabolism
    • Bremer, J. The role of carnitine in intracellular metabolism. J. Clin. Chem. Clin. Biochem. 1990, 28, 297-301.
    • (1990) J. Clin. Chem. Clin. Biochem , vol.28 , pp. 297-301
    • Bremer, J.1
  • 100
    • 0002188416 scopus 로고    scopus 로고
    • Acetyl-L-carnitine: Metabolism and applications in clinical practice
    • Furlong, J. H. Acetyl-L-carnitine: metabolism and applications in clinical practice. Alter. Med. Rev. 1996, 1, 85-93.
    • (1996) Alter. Med. Rev , vol.1 , pp. 85-93
    • Furlong, J.H.1
  • 101
    • 0037347231 scopus 로고    scopus 로고
    • Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease
    • Montgomery, S. A.; Thal, L. J.; Amrein, R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int. Clin. Psychopharmacol. 2003, 18, 61-71.
    • (2003) Int. Clin. Psychopharmacol , vol.18 , pp. 61-71
    • Montgomery, S.A.1    Thal, L.J.2    Amrein, R.3
  • 102
    • 33746468121 scopus 로고    scopus 로고
    • Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease
    • Abdul, H. M.; Calabrese, V.; Calvani, M.; Butterfield, D. A. Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. J. Neurosci. Res. 2006, 84, 398-408.
    • (2006) J. Neurosci. Res , vol.84 , pp. 398-408
    • Abdul, H.M.1    Calabrese, V.2    Calvani, M.3    Butterfield, D.A.4
  • 103
    • 0038681645 scopus 로고    scopus 로고
    • Effects of acetyl-L-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors
    • Bianchetti, A.; Rozzini, R.; Trabucchi, M. Effects of acetyl-L-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors. Curr. Med. Res. Opin. 2003, 19, 350-353.
    • (2003) Curr. Med. Res. Opin , vol.19 , pp. 350-353
    • Bianchetti, A.1    Rozzini, R.2    Trabucchi, M.3
  • 105
    • 43149121364 scopus 로고    scopus 로고
    • The protective effect of L-carnitine on ischemia-reperfusion heart
    • Xie, J.; Zeng, Q.; Wang, L. The protective effect of L-carnitine on ischemia-reperfusion heart. J. Huazhong Univ. Sci. Tech. Med. Sci. 2006, 26, 188-191.
    • (2006) J. Huazhong Univ. Sci. Tech. Med. Sci , vol.26 , pp. 188-191
    • Xie, J.1    Zeng, Q.2    Wang, L.3
  • 106
    • 0025010733 scopus 로고    scopus 로고
    • Tempesta, E.; Troncon, R.; Janiri, L.; Colusso, L.; Riscica, P.; Saraceni, G.; Gesmundo, E.; Calvani, M.; Benedetti, N.; Pola, P. Role of acetyl-L-carnitine in the treatment of cognitive deficit in chronic alcoholism. Int. J. Clin. Pharmacol. Res. 1990, 10, 101-107.
    • Tempesta, E.; Troncon, R.; Janiri, L.; Colusso, L.; Riscica, P.; Saraceni, G.; Gesmundo, E.; Calvani, M.; Benedetti, N.; Pola, P. Role of acetyl-L-carnitine in the treatment of cognitive deficit in chronic alcoholism. Int. J. Clin. Pharmacol. Res. 1990, 10, 101-107.
  • 107
    • 0037965156 scopus 로고    scopus 로고
    • Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term randomized, double-blind, placebo-controlled study
    • De Grandis, D.; Minardi, C. Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term randomized, double-blind, placebo-controlled study. Drugs R.D. 2002, 3, 223-231.
    • (2002) Drugs R.D , vol.3 , pp. 223-231
    • De Grandis, D.1    Minardi, C.2
  • 108
    • 35348863733 scopus 로고    scopus 로고
    • Acetyl-L-carnitine in diabetic polyneuropathy: Experimental and clinical data
    • Sima, A. A. Acetyl-L-carnitine in diabetic polyneuropathy: experimental and clinical data. CNS Drugs 2007, 21, 13-23.
    • (2007) CNS Drugs , vol.21 , pp. 13-23
    • Sima, A.A.1
  • 109
    • 34247873189 scopus 로고    scopus 로고
    • ALCAR Study Group. A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection
    • Youle, M.; Osio, M.; ALCAR Study Group. A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. HIV Med. 2007, 8, 241-250.
    • (2007) HIV Med , vol.8 , pp. 241-250
    • Youle, M.1    Osio, M.2
  • 110
    • 33644772837 scopus 로고    scopus 로고
    • Long-term effect of acetyl-L-carnitine for antiretroviral toxic neuropathy
    • Herzmann, C.; Johnson, M. A.; Youle, M. Long-term effect of acetyl-L-carnitine for antiretroviral toxic neuropathy. HIV Clin. Trials 2005, 6, 344-350.
    • (2005) HIV Clin. Trials , vol.6 , pp. 344-350
    • Herzmann, C.1    Johnson, M.A.2    Youle, M.3
  • 111
    • 33644783056 scopus 로고    scopus 로고
    • Acetyl-l-carnitine in the treatment of painful antiretroviral toxic neuropathy in human immunodeficiency virus patients: An open label study
    • Osio, M.; Muscia, F.; Zampini, L.; Nascimbene, C.; Mailland, E.; Cargnel, A.; Mariani, C. Acetyl-l-carnitine in the treatment of painful antiretroviral toxic neuropathy in human immunodeficiency virus patients: an open label study. J. Peripher. Nerv. Syst. 2006, 11, 72-76.
    • (2006) J. Peripher. Nerv. Syst , vol.11 , pp. 72-76
    • Osio, M.1    Muscia, F.2    Zampini, L.3    Nascimbene, C.4    Mailland, E.5    Cargnel, A.6    Mariani, C.7
  • 112
    • 11844273799 scopus 로고    scopus 로고
    • Acetyl-L-Carnitine Study Group. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic dia betic neuropathy: An analysis of two randomized placebo-controlled trials
    • Sima, A. A.; Calvani, M.; Mehra, M.; Amato, A.; Acetyl-L-Carnitine Study Group. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic dia betic neuropathy: an analysis of two randomized placebo-controlled trials. Diabetes Care 2005, 28, 89-94.
    • (2005) Diabetes Care , vol.28 , pp. 89-94
    • Sima, A.A.1    Calvani, M.2    Mehra, M.3    Amato, A.4
  • 115
    • 33644980892 scopus 로고    scopus 로고
    • Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy
    • Flatters, S. J.; Xiao, W. H.; Bennett, G. J. Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy. Neurosci. Lett. 2006, 397, 219-223.
    • (2006) Neurosci. Lett , vol.397 , pp. 219-223
    • Flatters, S.J.1    Xiao, W.H.2    Bennett, G.J.3
  • 116
    • 35348914748 scopus 로고    scopus 로고
    • Acetyl-L-carnitine treatment of chemotherapy/induced peripheral neuropathy: A short review
    • De Grandis, D. Acetyl-L-carnitine treatment of chemotherapy/induced peripheral neuropathy: a short review. CNS Drugs 2007, 21, 39-43.
    • (2007) CNS Drugs , vol.21 , pp. 39-43
    • De Grandis, D.1
  • 117
    • 35348878570 scopus 로고    scopus 로고
    • Acetyl-L-carnitine in neuropathic pain: Experimental data
    • Chiechio, S.; Copani, A.; Gereau, R. W. 4th; Nicoletti, F. Acetyl-L-carnitine in neuropathic pain: experimental data. CNS Drugs 2007, 21, 31-38.
    • (2007) CNS Drugs , vol.21 , pp. 31-38
    • Chiechio, S.1    Copani, A.2    Gereau 4th, R.W.3    Nicoletti, F.4
  • 118
    • 33845927528 scopus 로고    scopus 로고
    • Peripheral neuropathy: Pathogenic mechanisms and alternative therapies
    • Head, K. A. Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern. Med. Rev. 2006, 11, 294-329.
    • (2006) Altern. Med. Rev , vol.11 , pp. 294-329
    • Head, K.A.1
  • 119
    • 18944404875 scopus 로고    scopus 로고
    • A pilot study on the effect of acetyl-L-carnitine in paclitaxel- and cisplatin-induced peripheral neuropathy
    • Maestri, A.; De Pasquale Ceratti, A.; Cundari, S.; Zanna, C.; Cortesi, E.; Crino, L. A pilot study on the effect of acetyl-L-carnitine in paclitaxel- and cisplatin-induced peripheral neuropathy. Tumori 2005, 91, 135-138.
    • (2005) Tumori , vol.91 , pp. 135-138
    • Maestri, A.1    De Pasquale Ceratti, A.2    Cundari, S.3    Zanna, C.4    Cortesi, E.5    Crino, L.6
  • 120
    • 18844398832 scopus 로고    scopus 로고
    • Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments
    • Tabolacci, E.; Pietrobono, R.; Moscato, U.; Oostra, B. A.; Chiurazzi, P.; Neri, G. Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments. Eur. J. Hum. Genet. 2005, 13, 641-648.
    • (2005) Eur. J. Hum. Genet , vol.13 , pp. 641-648
    • Tabolacci, E.1    Pietrobono, R.2    Moscato, U.3    Oostra, B.A.4    Chiurazzi, P.5    Neri, G.6
  • 121
    • 0037411794 scopus 로고    scopus 로고
    • Effect of PPF and ALCAR on the induction of NGF- and p75-mRNA and on APP processing in Tg257 brain
    • Chauhan, N. B.; Siegel, G. J. Effect of PPF and ALCAR on the induction of NGF- and p75-mRNA and on APP processing in Tg257 brain. Neurochem. Int. 2003, 43, 225-233.
    • (2003) Neurochem. Int , vol.43 , pp. 225-233
    • Chauhan, N.B.1    Siegel, G.J.2
  • 122
    • 0028175075 scopus 로고
    • Acetyl-L-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats
    • Taglialatela, G.; Navarra, D.; Cruciani, R.; Ramacci, M. T.; Alema, G. S.; Angelucci, L. Acetyl-L-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats. Exp. Gerontol. 1994, 29, 55-66.
    • (1994) Exp. Gerontol , vol.29 , pp. 55-66
    • Taglialatela, G.1    Navarra, D.2    Cruciani, R.3    Ramacci, M.T.4    Alema, G.S.5    Angelucci, L.6
  • 123
    • 33751120697 scopus 로고    scopus 로고
    • Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain
    • Faraco, G.; Pancani, T.; Formentini, L.; Mascagni, P.; Fossati, G.; Leoni, F.; Moroni, F.; Chiarugi, A. Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain. Mol. Pharmacol. 2006, 70, 1876-1884.
    • (2006) Mol. Pharmacol , vol.70 , pp. 1876-1884
    • Faraco, G.1    Pancani, T.2    Formentini, L.3    Mascagni, P.4    Fossati, G.5    Leoni, F.6    Moroni, F.7    Chiarugi, A.8
  • 124
    • 34248530339 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: Multiple mechanisms of action
    • Kim, H. J.; Rowe, M.; Ren, M.; Hong, J. S.; Chen, P. S.; Chuang, D. M. Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J. Pharmacol. Exp. Ther. 2007, 321, 892-901.
    • (2007) J. Pharmacol. Exp. Ther , vol.321 , pp. 892-901
    • Kim, H.J.1    Rowe, M.2    Ren, M.3    Hong, J.S.4    Chen, P.S.5    Chuang, D.M.6
  • 125
    • 8344270103 scopus 로고    scopus 로고
    • Valproate is neuroprotective against malonate toxicity in rat striatum: An association with augmentation of high-affinity glutamate uptake
    • Morland, C.; Boldingh, K. A.; Iversen, E. G.; Hassel, B. Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake. J. Cereb. Blood Flow Metab. 2004, 24, 1226-1234.
    • (2004) J. Cereb. Blood Flow Metab , vol.24 , pp. 1226-1234
    • Morland, C.1    Boldingh, K.A.2    Iversen, E.G.3    Hassel, B.4
  • 127
    • 33748450288 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: A novel therapeutic approach to Huntington's disease (complex mechanism of neuronal death)
    • Sadri-Vakili, G.; Cha, J. H. Histone deacetylase inhibitors: a novel therapeutic approach to Huntington's disease (complex mechanism of neuronal death). Curr. Alzheimer Res. 2006, 3, 403-408.
    • (2006) Curr. Alzheimer Res , vol.3 , pp. 403-408
    • Sadri-Vakili, G.1    Cha, J.H.2
  • 129
    • 33748928786 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors as therapeutics for polyglutamine disorders
    • Butler, R.; Bates, G. P. Histone deacetylase inhibitors as therapeutics for polyglutamine disorders. Nat. Rev. Neurosci. 2006, 7, 784-796.
    • (2006) Nat. Rev. Neurosci , vol.7 , pp. 784-796
    • Butler, R.1    Bates, G.P.2
  • 133
    • 34250612194 scopus 로고    scopus 로고
    • Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model
    • Rouaux, C.; Panteleeva, I.; René, F.; Gonzalez de Aguilar, J. L.; Echaniz-Laguna, A.; Dupuis, L.; Menger, Y.; Boutillier, A. L.; Loeffler, J. P. Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model. J. Neurosci. 2007, 27, 5535-5545.
    • (2007) J. Neurosci , vol.27 , pp. 5535-5545
    • Rouaux, C.1    Panteleeva, I.2    René, F.3    Gonzalez de Aguilar, J.L.4    Echaniz-Laguna, A.5    Dupuis, L.6    Menger, Y.7    Boutillier, A.L.8    Loeffler, J.P.9


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