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Volumn 90, Issue 4, 2010, Pages 498-510

Epigenetic regulation in the pathophysiology of Alzheimer's disease

Author keywords

Aging; Alzheimer's disease; Dementia; DNA methylation; Epigenetics; Gene environment interactions; Histone

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; HISTONE; HISTONE DEACETYLASE INHIBITOR;

EID: 77950866465     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2010.01.002     Document Type: Review
Times cited : (230)

References (165)
  • 2
    • 38649124003 scopus 로고    scopus 로고
    • Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
    • Abel T., Zukin R.S. Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Curr. Opin. Pharmacol. 2008, 8:57-64.
    • (2008) Curr. Opin. Pharmacol. , vol.8 , pp. 57-64
    • Abel, T.1    Zukin, R.S.2
  • 3
    • 33644875954 scopus 로고    scopus 로고
    • Neuronal protection by sirtuins in Alzheimer's disease
    • Anekonda T.S., Reddy P.H. Neuronal protection by sirtuins in Alzheimer's disease. J. Neurochem. 2006, 96:305-313.
    • (2006) J. Neurochem. , vol.96 , pp. 305-313
    • Anekonda, T.S.1    Reddy, P.H.2
  • 4
    • 24144475284 scopus 로고    scopus 로고
    • Reversing histone methylation
    • Bannister A.J., Kouzarides T. Reversing histone methylation. Nature 2005, 436:1103-1106.
    • (2005) Nature , vol.436 , pp. 1103-1106
    • Bannister, A.J.1    Kouzarides, T.2
  • 5
    • 69449086451 scopus 로고    scopus 로고
    • DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain
    • Barrachina M., Ferrer I. DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. J. Neuropathol. Exp. Neurol. 2009, 68:880-891.
    • (2009) J. Neuropathol. Exp. Neurol. , vol.68 , pp. 880-891
    • Barrachina, M.1    Ferrer, I.2
  • 6
    • 0037043838 scopus 로고    scopus 로고
    • Evidence for parent of origin effect in late-onset Alzheimer disease
    • Bassett S.S., Avramopoulos D., Fallin D. Evidence for parent of origin effect in late-onset Alzheimer disease. Am. J. Med. Genet. 2002, 114:679-686.
    • (2002) Am. J. Med. Genet. , vol.114 , pp. 679-686
    • Bassett, S.S.1    Avramopoulos, D.2    Fallin, D.3
  • 7
    • 58049089518 scopus 로고    scopus 로고
    • Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease
    • Belyaev N.D., Nalivaeva N.N., Makova N.Z., Turner A.J. Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease. EMBO Rep. 2009, 10:94-100.
    • (2009) EMBO Rep. , vol.10 , pp. 94-100
    • Belyaev, N.D.1    Nalivaeva, N.N.2    Makova, N.Z.3    Turner, A.J.4
  • 8
    • 0030893280 scopus 로고    scopus 로고
    • The role of heredity in late-onset Alzheimer disease and vascular dementia. A twin study
    • Bergem A.L., Engedal K., Kringlen E. The role of heredity in late-onset Alzheimer disease and vascular dementia. A twin study. Arch. Gen. Psychiatry 1997, 54:264-270.
    • (1997) Arch. Gen. Psychiatry , vol.54 , pp. 264-270
    • Bergem, A.L.1    Engedal, K.2    Kringlen, E.3
  • 9
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • Berger S.L. The complex language of chromatin regulation during transcription. Nature 2007, 447:407-412.
    • (2007) Nature , vol.447 , pp. 407-412
    • Berger, S.L.1
  • 10
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    • Bertram L., McQueen M.B., Mullin K., Blacker D., Tanzi R.E. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 2007, 39:17-23.
    • (2007) Nat. Genet. , vol.39 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3    Blacker, D.4    Tanzi, R.E.5
  • 11
    • 50249135503 scopus 로고    scopus 로고
    • Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
    • Bezprozvanny I., Mattson M.P. Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci. 2008, 31:454-463.
    • (2008) Trends Neurosci. , vol.31 , pp. 454-463
    • Bezprozvanny, I.1    Mattson, M.P.2
  • 12
    • 14544286348 scopus 로고    scopus 로고
    • Genetic factors in Alzheimer's disease
    • Bird T.D. Genetic factors in Alzheimer's disease. N. Engl. J. Med. 2005, 352:862-864.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 862-864
    • Bird, T.D.1
  • 13
    • 42149107502 scopus 로고    scopus 로고
    • Genetic aspects of Alzheimer disease
    • Bird T.D. Genetic aspects of Alzheimer disease. Genet. Med. 2008, 10:231-239.
    • (2008) Genet. Med. , vol.10 , pp. 231-239
    • Bird, T.D.1
  • 17
    • 0029113637 scopus 로고
    • Alzheimer's disease in the National Academy of Sciences-National Research Council Registry of Aging Twin Veterans. III. Detection of cases, longitudinal results, and observations on twin concordance
    • Breitner J.C., Welsh K.A., Gau B.A., McDonald W.M., Steffens D.C., Saunders A.M., Magruder K.M., Helms M.J., Plassman B.L., Folstein M.F., et al. Alzheimer's disease in the National Academy of Sciences-National Research Council Registry of Aging Twin Veterans. III. Detection of cases, longitudinal results, and observations on twin concordance. Arch. Neurol. 1995, 52:763-771.
    • (1995) Arch. Neurol. , vol.52 , pp. 763-771
    • Breitner, J.C.1    Welsh, K.A.2    Gau, B.A.3    McDonald, W.M.4    Steffens, D.C.5    Saunders, A.M.6    Magruder, K.M.7    Helms, M.J.8    Plassman, B.L.9    Folstein, M.F.10
  • 19
    • 64749106321 scopus 로고    scopus 로고
    • Cancer: when restriction is good
    • Brunet A. Cancer: when restriction is good. Nature 2009, 458:713-714.
    • (2009) Nature , vol.458 , pp. 713-714
    • Brunet, A.1
  • 20
    • 67349270965 scopus 로고    scopus 로고
    • Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
    • Bu G. Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat. Rev. Neurosci. 2009, 10:333-344.
    • (2009) Nat. Rev. Neurosci. , vol.10 , pp. 333-344
    • Bu, G.1
  • 21
    • 61849157257 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Burns A., Iliffe S. Alzheimer's disease. BMJ 2009, 338:b158.
    • (2009) BMJ , vol.338
    • Burns, A.1    Iliffe, S.2
  • 22
    • 0035816661 scopus 로고    scopus 로고
    • A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
    • Cao X., Sudhof T.C. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 2001, 293:115-120.
    • (2001) Science , vol.293 , pp. 115-120
    • Cao, X.1    Sudhof, T.C.2
  • 23
    • 33747386882 scopus 로고    scopus 로고
    • The effect of S-adenosylmethionine on CNS gene expression studied by cDNA microarray analysis
    • Cavallaro R.A., Fuso A., D'Anselmi F., Seminara L., Scarpa S. The effect of S-adenosylmethionine on CNS gene expression studied by cDNA microarray analysis. J. Alzheimers Dis. 2006, 9:415-419.
    • (2006) J. Alzheimers Dis. , vol.9 , pp. 415-419
    • Cavallaro, R.A.1    Fuso, A.2    D'Anselmi, F.3    Seminara, L.4    Scarpa, S.5
  • 24
    • 67349190247 scopus 로고    scopus 로고
    • Linking DNA methylation and histone modification: patterns and paradigms
    • Cedar H., Bergman Y. Linking DNA methylation and histone modification: patterns and paradigms. Nat. Rev. Genet. 2009, 10:295-304.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 295-304
    • Cedar, H.1    Bergman, Y.2
  • 27
    • 56949102195 scopus 로고    scopus 로고
    • The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells
    • Chen K.L., Wang S.S., Yang Y.Y., Yuan R.Y., Chen R.M., Hu C.J. The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells. Biochem. Biophys. Res. Commun. 2009, 378:57-61.
    • (2009) Biochem. Biophys. Res. Commun. , vol.378 , pp. 57-61
    • Chen, K.L.1    Wang, S.S.2    Yang, Y.Y.3    Yuan, R.Y.4    Chen, R.M.5    Hu, C.J.6
  • 31
    • 3042857903 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Cummings J.L. Alzheimer's disease. N. Engl. J. Med. 2004, 351:56-67.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 56-67
    • Cummings, J.L.1
  • 32
    • 0034571152 scopus 로고    scopus 로고
    • DNA methylation, ageing and ribosomal genes activity
    • de Carvalho C.V., Payao S.L., Smith M.A. DNA methylation, ageing and ribosomal genes activity. Biogerontology 2000, 1:357-361.
    • (2000) Biogerontology , vol.1 , pp. 357-361
    • de Carvalho, C.V.1    Payao, S.L.2    Smith, M.A.3
  • 34
    • 0035002421 scopus 로고    scopus 로고
    • Neuropathology of Alzheimer's disease and other dementias
    • Dickson D.W. Neuropathology of Alzheimer's disease and other dementias. Clin. Geriatr. Med. 2001, 17:209-228.
    • (2001) Clin. Geriatr. Med. , vol.17 , pp. 209-228
    • Dickson, D.W.1
  • 35
    • 49549083278 scopus 로고    scopus 로고
    • Histone deacetylase 6 interacts with the microtubule-associated protein tau
    • Ding H., Dolan P.J., Johnson G.V. Histone deacetylase 6 interacts with the microtubule-associated protein tau. J. Neurochem. 2008, 106:2119-2130.
    • (2008) J. Neurochem. , vol.106 , pp. 2119-2130
    • Ding, H.1    Dolan, P.J.2    Johnson, G.V.3
  • 38
    • 0038747956 scopus 로고    scopus 로고
    • Relevance of DNA methylation in the management of cancer
    • Esteller M. Relevance of DNA methylation in the management of cancer. Lancet Oncol. 2003, 4:351-358.
    • (2003) Lancet Oncol. , vol.4 , pp. 351-358
    • Esteller, M.1
  • 40
    • 52649168263 scopus 로고    scopus 로고
    • Schizophrenia aetiology: do gene-environment interactions hold the key?
    • EU-GEI
    • EU-GEI Schizophrenia aetiology: do gene-environment interactions hold the key?. Schizophr. Res. 2008, 102:21-26.
    • (2008) Schizophr. Res. , vol.102 , pp. 21-26
  • 41
    • 2442684094 scopus 로고    scopus 로고
    • Cholesterol and APOE genotype interact to influence Alzheimer disease progression
    • Evans R.M., Hui S., Perkins A., Lahiri D.K., Poirier J., Farlow M.R. Cholesterol and APOE genotype interact to influence Alzheimer disease progression. Neurology 2004, 62:1869-1871.
    • (2004) Neurology , vol.62 , pp. 1869-1871
    • Evans, R.M.1    Hui, S.2    Perkins, A.3    Lahiri, D.K.4    Poirier, J.5    Farlow, M.R.6
  • 42
    • 0025806596 scopus 로고
    • Association of decreased paternal age and late-onset Alzheimer's disease. An example of genetic imprinting?
    • Farrer L.A., Cupples L.A., Connor L., Wolf P.A., Growdon J.H. Association of decreased paternal age and late-onset Alzheimer's disease. An example of genetic imprinting?. Arch. Neurol. 1991, 48:599-604.
    • (1991) Arch. Neurol. , vol.48 , pp. 599-604
    • Farrer, L.A.1    Cupples, L.A.2    Connor, L.3    Wolf, P.A.4    Growdon, J.H.5
  • 43
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between Apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
    • Farrer L.A., Cupples L.A., Haines J.L., Hyman B., Kukull W.A., Mayeux R., Myers R.H., Pericak-Vance M.A., Risch N., van Duijn C.M. Effects of age, sex, and ethnicity on the association between Apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 1997, 278:1349-1356.
    • (1997) JAMA , vol.278 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3    Hyman, B.4    Kukull, W.A.5    Mayeux, R.6    Myers, R.H.7    Pericak-Vance, M.A.8    Risch, N.9    van Duijn, C.M.10
  • 44
    • 85015069067 scopus 로고    scopus 로고
    • Controlling the double helix
    • Felsenfeld G., Groudine M. Controlling the double helix. Nature 2003, 421:448-453.
    • (2003) Nature , vol.421 , pp. 448-453
    • Felsenfeld, G.1    Groudine, M.2
  • 46
    • 34248523169 scopus 로고    scopus 로고
    • Recovery of learning and memory is associated with chromatin remodelling
    • Fischer A., Sananbenesi F., Wang X., Dobbin M., Tsai L.H. Recovery of learning and memory is associated with chromatin remodelling. Nature 2007, 447:178-182.
    • (2007) Nature , vol.447 , pp. 178-182
    • Fischer, A.1    Sananbenesi, F.2    Wang, X.3    Dobbin, M.4    Tsai, L.H.5
  • 48
    • 68149183508 scopus 로고    scopus 로고
    • Genetic and epigenetic regulation of aging
    • Fraga M.F. Genetic and epigenetic regulation of aging. Curr. Opin. Immunol. 2009, 21:446-453.
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 446-453
    • Fraga, M.F.1
  • 49
    • 34249683635 scopus 로고    scopus 로고
    • Cross-talk between aging and cancer: the epigenetic language
    • Fraga M.F., Agrelo R., Esteller M. Cross-talk between aging and cancer: the epigenetic language. Ann. N. Y. Acad. Sci. 2007, 1100:60-74.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1100 , pp. 60-74
    • Fraga, M.F.1    Agrelo, R.2    Esteller, M.3
  • 51
    • 34447625911 scopus 로고    scopus 로고
    • Epigenetics and aging: the targets and the marks
    • Fraga M.F., Esteller M. Epigenetics and aging: the targets and the marks. Trends Genet. 2007, 23:413-418.
    • (2007) Trends Genet. , vol.23 , pp. 413-418
    • Fraga, M.F.1    Esteller, M.2
  • 53
    • 77950861174 scopus 로고    scopus 로고
    • Epigenetic inheritance in mammals: evidence for the impact of adverse environmental effects
    • Franklin T.B., Mansuy I.M. Epigenetic inheritance in mammals: evidence for the impact of adverse environmental effects. Neurobiol. Dis. 2009.
    • (2009) Neurobiol. Dis.
    • Franklin, T.B.1    Mansuy, I.M.2
  • 55
    • 0037423186 scopus 로고    scopus 로고
    • The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
    • Fuks F., Hurd P.J., Wolf D., Nan X., Bird A.P., Kouzarides T. The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J. Biol. Chem. 2003, 278:4035-4040.
    • (2003) J. Biol. Chem. , vol.278 , pp. 4035-4040
    • Fuks, F.1    Hurd, P.J.2    Wolf, D.3    Nan, X.4    Bird, A.P.5    Kouzarides, T.6
  • 56
    • 34447642134 scopus 로고    scopus 로고
    • Gamma-secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells
    • Fuso A., Cavallaro R.A., Zampelli A., D'Anselmi F., Piscopo P., Confaloni A., Scarpa S. Gamma-secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells. J. Alzheimers Dis. 2007, 11:275-290.
    • (2007) J. Alzheimers Dis. , vol.11 , pp. 275-290
    • Fuso, A.1    Cavallaro, R.A.2    Zampelli, A.3    D'Anselmi, F.4    Piscopo, P.5    Confaloni, A.6    Scarpa, S.7
  • 58
    • 78649872779 scopus 로고    scopus 로고
    • and Scarpa, S. Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency. Neurobiology of Aging, in press, corrected proof.
    • Fuso, A., Nicolia, V., Pasqualato, A., Fiorenza, M. T., Cavallaro, R. A. and Scarpa, S. Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency. Neurobiology of Aging, in press, corrected proof.
    • Fuso, A.1    Nicolia, V.2    Pasqualato, A.3    Fiorenza, M.T.4    Cavallaro, R.A.5
  • 62
    • 33847047461 scopus 로고    scopus 로고
    • Epigenetics: a landscape takes shape
    • Goldberg A.D., Allis C.D., Bernstein E. Epigenetics: a landscape takes shape. Cell 2007, 128:635-638.
    • (2007) Cell , vol.128 , pp. 635-638
    • Goldberg, A.D.1    Allis, C.D.2    Bernstein, E.3
  • 64
    • 44649134044 scopus 로고    scopus 로고
    • Epigenetic codes in cognition and behaviour
    • Graff J., Mansuy I.M. Epigenetic codes in cognition and behaviour. Behav. Brain Res. 2008, 192:70-87.
    • (2008) Behav. Brain Res. , vol.192 , pp. 70-87
    • Graff, J.1    Mansuy, I.M.2
  • 65
    • 33748253471 scopus 로고    scopus 로고
    • Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease
    • Green K.N., Billings L.M., Roozendaal B., McGaugh J.L., LaFerla F.M. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J. Neurosci. 2006, 26:9047-9056.
    • (2006) J. Neurosci. , vol.26 , pp. 9047-9056
    • Green, K.N.1    Billings, L.M.2    Roozendaal, B.3    McGaugh, J.L.4    LaFerla, F.M.5
  • 66
    • 58149267462 scopus 로고    scopus 로고
    • Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau
    • Green K.N., Steffan J.S., Martinez-Coria H., Sun X., Schreiber S.S., Thompson L.M., LaFerla F.M. Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J. Neurosci. 2008, 28:11500-11510.
    • (2008) J. Neurosci. , vol.28 , pp. 11500-11510
    • Green, K.N.1    Steffan, J.S.2    Martinez-Coria, H.3    Sun, X.4    Schreiber, S.S.5    Thompson, L.M.6    LaFerla, F.M.7
  • 68
    • 33751113602 scopus 로고    scopus 로고
    • Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction
    • Haigis M.C., Guarente L.P. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev. 2006, 20:2913-2921.
    • (2006) Genes Dev. , vol.20 , pp. 2913-2921
    • Haigis, M.C.1    Guarente, L.P.2
  • 70
    • 67651180986 scopus 로고    scopus 로고
    • The amyloid hypothesis for Alzheimer's disease: a critical reappraisal
    • Hardy J. The amyloid hypothesis for Alzheimer's disease: a critical reappraisal. J. Neurochem. 2009, 110:1129-1134.
    • (2009) J. Neurochem. , vol.110 , pp. 1129-1134
    • Hardy, J.1
  • 72
    • 58849143335 scopus 로고    scopus 로고
    • Accumulated amyloid-beta peptide and hyperphosphorylated tau protein: relationship and links in Alzheimer's disease
    • Huang H.C., Jiang Z.F. Accumulated amyloid-beta peptide and hyperphosphorylated tau protein: relationship and links in Alzheimer's disease. J. Alzheimers Dis. 2009, 16:15-27.
    • (2009) J. Alzheimers Dis. , vol.16 , pp. 15-27
    • Huang, H.C.1    Jiang, Z.F.2
  • 73
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
    • Jaenisch R., Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 2003, 33(Suppl.):245-254.
    • (2003) Nat. Genet. , vol.33 , Issue.SUPPL. , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 74
    • 70350046301 scopus 로고    scopus 로고
    • Rethinking how DNA methylation patterns are maintained
    • Jones P.A., Liang G. Rethinking how DNA methylation patterns are maintained. Nat. Rev. Genet. 2009, 10:805-811.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 805-811
    • Jones, P.A.1    Liang, G.2
  • 75
    • 64749108996 scopus 로고    scopus 로고
    • Tumours with PI3K activation are resistant to dietary restriction
    • Kalaany N.Y., Sabatini D.M. Tumours with PI3K activation are resistant to dietary restriction. Nature 2009, 458:725-731.
    • (2009) Nature , vol.458 , pp. 725-731
    • Kalaany, N.Y.1    Sabatini, D.M.2
  • 78
    • 33847095134 scopus 로고    scopus 로고
    • Complex disease, gender and epigenetics
    • Kaminsky Z., Wang S.C., Petronis A. Complex disease, gender and epigenetics. Ann. Med. 2006, 38:530-544.
    • (2006) Ann. Med. , vol.38 , pp. 530-544
    • Kaminsky, Z.1    Wang, S.C.2    Petronis, A.3
  • 79
    • 1842778936 scopus 로고    scopus 로고
    • Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferases and cognitive function
    • Kennedy B.P., Bottiglieri T., Arning E., Ziegler M.G., Hansen L.A., Masliah E. Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferases and cognitive function. J. Neural Transm. 2004, 111:547-567.
    • (2004) J. Neural Transm. , vol.111 , pp. 547-567
    • Kennedy, B.P.1    Bottiglieri, T.2    Arning, E.3    Ziegler, M.G.4    Hansen, L.A.5    Masliah, E.6
  • 83
    • 34250819839 scopus 로고    scopus 로고
    • Intracellular amyloid-beta in Alzheimer's disease
    • LaFerla F.M., Green K.N., Oddo S. Intracellular amyloid-beta in Alzheimer's disease. Nat. Rev. Neurosci. 2007, 8:499-509.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 499-509
    • LaFerla, F.M.1    Green, K.N.2    Oddo, S.3
  • 85
    • 33846983823 scopus 로고    scopus 로고
    • How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the " LEARn" model (latent early-life associated regulation) may explain the triggering of AD
    • Lahiri D.K., Maloney B., Basha M.R., Ge Y.W., Zawia N.H. How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the " LEARn" model (latent early-life associated regulation) may explain the triggering of AD. Curr. Alzheimer Res. 2007, 4:219-228.
    • (2007) Curr. Alzheimer Res. , vol.4 , pp. 219-228
    • Lahiri, D.K.1    Maloney, B.2    Basha, M.R.3    Ge, Y.W.4    Zawia, N.H.5
  • 86
    • 70350432817 scopus 로고    scopus 로고
    • The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases
    • Lahiri D.K., Maloney B., Zawia N.H. The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases. Mol. Psychiatry 2009, 14:992-1003.
    • (2009) Mol. Psychiatry , vol.14 , pp. 992-1003
    • Lahiri, D.K.1    Maloney, B.2    Zawia, N.H.3
  • 87
    • 2542441462 scopus 로고    scopus 로고
    • Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease
    • Lahiri D.K., Sambamurti K., Bennett D.A. Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease. Neurobiol. Aging 2004, 25:651-660.
    • (2004) Neurobiol. Aging , vol.25 , pp. 651-660
    • Lahiri, D.K.1    Sambamurti, K.2    Bennett, D.A.3
  • 88
    • 56049100240 scopus 로고    scopus 로고
    • Early-life events may trigger biochemical pathways for Alzheimer's disease: the " LEARn" model
    • Lahiri D.K., Zawia N.H., Greig N.H., Sambamurti K., Maloney B. Early-life events may trigger biochemical pathways for Alzheimer's disease: the " LEARn" model. Biogerontology 2008, 9:375-379.
    • (2008) Biogerontology , vol.9 , pp. 375-379
    • Lahiri, D.K.1    Zawia, N.H.2    Greig, N.H.3    Sambamurti, K.4    Maloney, B.5
  • 91
    • 66249144685 scopus 로고    scopus 로고
    • Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins
    • Law I.K., Liu L., Xu A., Lam K.S., Vanhoutte P.M., Che C.M., Leung P.T., Wang Y. Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins. Proteomics 2009, 9:2444-2456.
    • (2009) Proteomics , vol.9 , pp. 2444-2456
    • Law, I.K.1    Liu, L.2    Xu, A.3    Lam, K.S.4    Vanhoutte, P.M.5    Che, C.M.6    Leung, P.T.7    Wang, Y.8
  • 92
    • 67650809239 scopus 로고    scopus 로고
    • S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters
    • Lin H.C., Hsieh H.M., Chen Y.H., Hu M.L. S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters. Neurotoxicology 2009, 30:622-627.
    • (2009) Neurotoxicology , vol.30 , pp. 622-627
    • Lin, H.C.1    Hsieh, H.M.2    Chen, Y.H.3    Hu, M.L.4
  • 93
    • 77950864455 scopus 로고    scopus 로고
    • Epigenetic changes related to beta-amyloid-implications for Alzheimer's disease
    • Lithner C.U., Hernandez C.M., Nordberg A., Sweatt J.D. Epigenetic changes related to beta-amyloid-implications for Alzheimer's disease. Alzheimer's Demen. 2009, 5:P304-P1304.
    • (2009) Alzheimer's Demen. , vol.5
    • Lithner, C.U.1    Hernandez, C.M.2    Nordberg, A.3    Sweatt, J.D.4
  • 94
    • 44449134663 scopus 로고    scopus 로고
    • Gene-environment interactions and epigenetic basis of human diseases
    • Liu L., Li Y., Tollefsbol T.O. Gene-environment interactions and epigenetic basis of human diseases. Curr. Issues Mol. Biol. 2008, 10:25-36.
    • (2008) Curr. Issues Mol. Biol. , vol.10 , pp. 25-36
    • Liu, L.1    Li, Y.2    Tollefsbol, T.O.3
  • 96
    • 1842411320 scopus 로고    scopus 로고
    • Crystal structure of the nucleosome core particle at 2.8A resolution
    • Luger K., Mader A.W., Richmond R.K., Sargent D.F., Richmond T.J. Crystal structure of the nucleosome core particle at 2.8A resolution. Nature 1997, 389:251-260.
    • (1997) Nature , vol.389 , pp. 251-260
    • Luger, K.1    Mader, A.W.2    Richmond, R.K.3    Sargent, D.F.4    Richmond, T.J.5
  • 98
    • 33645808672 scopus 로고    scopus 로고
    • Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease
    • Mahley R.W., Weisgraber K.H., Huang Y. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:5644-5651.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 5644-5651
    • Mahley, R.W.1    Weisgraber, K.H.2    Huang, Y.3
  • 99
    • 31144475537 scopus 로고    scopus 로고
    • In the cerebral cortex of female and male mice, amyloid precursor protein (APP) promoter methylation is higher in females and differentially regulated by sex steroids
    • Mani S.T., Thakur M.K. In the cerebral cortex of female and male mice, amyloid precursor protein (APP) promoter methylation is higher in females and differentially regulated by sex steroids. Brain Res. 2006, 1067:43-47.
    • (2006) Brain Res. , vol.1067 , pp. 43-47
    • Mani, S.T.1    Thakur, M.K.2
  • 101
    • 68949096744 scopus 로고    scopus 로고
    • Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease
    • Mastroeni D., McKee A., Grover A., Rogers J., Coleman P.D. Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS One 2009, 4:e6617.
    • (2009) PLoS One , vol.4
    • Mastroeni, D.1    McKee, A.2    Grover, A.3    Rogers, J.4    Coleman, P.D.5
  • 103
    • 34347346105 scopus 로고    scopus 로고
    • Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health
    • Meaney M.J., Szyf M., Seckl J.R. Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. Trends Mol. Med. 2007, 13:269-277.
    • (2007) Trends Mol. Med. , vol.13 , pp. 269-277
    • Meaney, M.J.1    Szyf, M.2    Seckl, J.R.3
  • 104
    • 57049151436 scopus 로고    scopus 로고
    • Epigenetic principles and mechanisms underlying nervous system functions in health and disease
    • Mehler M.F. Epigenetic principles and mechanisms underlying nervous system functions in health and disease. Prog. Neurobiol. 2008, 86:305-341.
    • (2008) Prog. Neurobiol. , vol.86 , pp. 305-341
    • Mehler, M.F.1
  • 105
    • 58149506264 scopus 로고    scopus 로고
    • Depression in the prodromal phase of Alzheimer disease and the reverse causal hypothesis
    • Modrego P.J. Depression in the prodromal phase of Alzheimer disease and the reverse causal hypothesis. Arch. Gen. Psychiatry 2009, 66:107.
    • (2009) Arch. Gen. Psychiatry , vol.66 , pp. 107
    • Modrego, P.J.1
  • 106
    • 4043179916 scopus 로고    scopus 로고
    • Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study
    • Modrego P.J., Ferrandez J. Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study. Arch. Neurol. 2004, 61:1290-1293.
    • (2004) Arch. Neurol. , vol.61 , pp. 1290-1293
    • Modrego, P.J.1    Ferrandez, J.2
  • 107
    • 18344396274 scopus 로고    scopus 로고
    • Strategy for investigating interactions between measured genes and measured environments
    • Moffitt T.E., Caspi A., Rutter M. Strategy for investigating interactions between measured genes and measured environments. Arch. Gen. Psychiatry 2005, 62:473-481.
    • (2005) Arch. Gen. Psychiatry , vol.62 , pp. 473-481
    • Moffitt, T.E.1    Caspi, A.2    Rutter, M.3
  • 108
    • 0036150827 scopus 로고    scopus 로고
    • Alzheimer's disease-do tauists and baptists finally shake hands?
    • Mudher A., Lovestone S. Alzheimer's disease-do tauists and baptists finally shake hands?. Trends Neurosci. 2002, 25:22-26.
    • (2002) Trends Neurosci. , vol.25 , pp. 22-26
    • Mudher, A.1    Lovestone, S.2
  • 112
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • Nan X., Ng H.H., Johnson C.A., Laherty C.D., Turner B.M., Eisenman R.N., Bird A. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 1998, 393:386-389.
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6    Bird, A.7
  • 115
    • 45449114804 scopus 로고    scopus 로고
    • The colorful history of active DNA demethylation
    • Ooi S.K., Bestor T.H. The colorful history of active DNA demethylation. Cell 2008, 133:1145-1148.
    • (2008) Cell , vol.133 , pp. 1145-1148
    • Ooi, S.K.1    Bestor, T.H.2
  • 118
    • 33745752370 scopus 로고    scopus 로고
    • Epigenetics and twins: three variations on the theme
    • Petronis A. Epigenetics and twins: three variations on the theme. Trends Genet. 2006, 22:347-350.
    • (2006) Trends Genet. , vol.22 , pp. 347-350
    • Petronis, A.1
  • 119
    • 58149339917 scopus 로고    scopus 로고
    • Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity
    • Pfister J.A., Ma C., Morrison B.E., D'Mello S.R. Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity. PLoS ONE 2008, 3:e4090.
    • (2008) PLoS ONE , vol.3
    • Pfister, J.A.1    Ma, C.2    Morrison, B.E.3    D'Mello, S.R.4
  • 120
    • 34247473478 scopus 로고    scopus 로고
    • The epigenetic basis of twin discordance in age-related diseases
    • Poulsen P., Esteller M., Vaag A., Fraga M.F. The epigenetic basis of twin discordance in age-related diseases. Pediatr. Res. 2007, 61:38R-42R.
    • (2007) Pediatr. Res. , vol.61
    • Poulsen, P.1    Esteller, M.2    Vaag, A.3    Fraga, M.F.4
  • 124
    • 70349763297 scopus 로고    scopus 로고
    • Epigenetics, genomic mutations and cognitive function
    • Reichenberg A., Mill J., MacCabe J.H. Epigenetics, genomic mutations and cognitive function. Cogn. Neuropsychiatry 2009, 14:377-390.
    • (2009) Cogn. Neuropsychiatry , vol.14 , pp. 377-390
    • Reichenberg, A.1    Mill, J.2    MacCabe, J.H.3
  • 125
    • 0037992395 scopus 로고    scopus 로고
    • The structure of DNA in the nucleosome core
    • Richmond T.J., Davey C.A. The structure of DNA in the nucleosome core. Nature 2003, 423:145-150.
    • (2003) Nature , vol.423 , pp. 145-150
    • Richmond, T.J.1    Davey, C.A.2
  • 127
    • 0347624644 scopus 로고    scopus 로고
    • Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration
    • Rouaux C., Jokic N., Mbebi C., Boutillier S., Loeffler J.P., Boutillier A.L. Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration. EMBO J. 2003, 22:6537-6549.
    • (2003) EMBO J. , vol.22 , pp. 6537-6549
    • Rouaux, C.1    Jokic, N.2    Mbebi, C.3    Boutillier, S.4    Loeffler, J.P.5    Boutillier, A.L.6
  • 128
    • 73949103869 scopus 로고    scopus 로고
    • Epigenetic mediation of environmental influences in major psychotic disorders
    • Rutten B.P., Mill J. Epigenetic mediation of environmental influences in major psychotic disorders. Schizophr. Bull. 2009, 35:1045-1056.
    • (2009) Schizophr. Bull. , vol.35 , pp. 1045-1056
    • Rutten, B.P.1    Mill, J.2
  • 129
    • 77950865150 scopus 로고    scopus 로고
    • P3-260: epigenetic modification in a monozygotic twin with Alzheimer's disease
    • Ryu H., Barrup M., Kowall N.W., McKee A.C. P3-260: epigenetic modification in a monozygotic twin with Alzheimer's disease. Alzheimer's Demen. 2008, 4:T598-T1598.
    • (2008) Alzheimer's Demen. , vol.4
    • Ryu, H.1    Barrup, M.2    Kowall, N.W.3    McKee, A.C.4
  • 130
    • 33748331132 scopus 로고    scopus 로고
    • Progressive loss of SIRT1 with cell cycle withdrawal
    • Sasaki T., Maier B., Bartke A., Scrable H. Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell 2006, 5:413-422.
    • (2006) Aging Cell , vol.5 , pp. 413-422
    • Sasaki, T.1    Maier, B.2    Bartke, A.3    Scrable, H.4
  • 132
    • 33747449599 scopus 로고    scopus 로고
    • Gene silencing through methylation: an epigenetic intervention on Alzheimer disease
    • Scarpa S., Cavallaro R.A., D'Anselmi F., Fuso A. Gene silencing through methylation: an epigenetic intervention on Alzheimer disease. J. Alzheimers Dis. 2006, 9:407-414.
    • (2006) J. Alzheimers Dis. , vol.9 , pp. 407-414
    • Scarpa, S.1    Cavallaro, R.A.2    D'Anselmi, F.3    Fuso, A.4
  • 133
    • 0037464488 scopus 로고    scopus 로고
    • Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?
    • Scarpa S., Fuso A., D'Anselmi F., Cavallaro R.A. Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?. FEBS Lett. 2003, 541:145-148.
    • (2003) FEBS Lett. , vol.541 , pp. 145-148
    • Scarpa, S.1    Fuso, A.2    D'Anselmi, F.3    Cavallaro, R.A.4
  • 134
    • 33748095194 scopus 로고    scopus 로고
    • Epigenetics of complex diseases: from general theory to laboratory experiments
    • Schumacher A., Petronis A. Epigenetics of complex diseases: from general theory to laboratory experiments. Curr. Top. Microbiol. Immunol. 2006, 310:81-115.
    • (2006) Curr. Top. Microbiol. Immunol. , vol.310 , pp. 81-115
    • Schumacher, A.1    Petronis, A.2
  • 135
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 2001, 81:741-766.
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 136
    • 7944233158 scopus 로고    scopus 로고
    • Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases
    • Selkoe D.J. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat. Cell Biol. 2004, 6:1054-1061.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 1054-1061
    • Selkoe, D.J.1
  • 141
    • 56349119351 scopus 로고    scopus 로고
    • Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis
    • Small S.A., Duff K. Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron 2008, 60:534-542.
    • (2008) Neuron , vol.60 , pp. 534-542
    • Small, S.A.1    Duff, K.2
  • 143
    • 33746845341 scopus 로고    scopus 로고
    • One-carbon metabolism in psychiatric illness
    • Sugden C. One-carbon metabolism in psychiatric illness. Nutr. Res. Rev. 2006, 19:117-136.
    • (2006) Nutr. Res. Rev. , vol.19 , pp. 117-136
    • Sugden, C.1
  • 144
    • 34248549732 scopus 로고    scopus 로고
    • Behavioural neuroscience: down memory lane
    • Sweatt J.D. Behavioural neuroscience: down memory lane. Nature 2007, 447:151-152.
    • (2007) Nature , vol.447 , pp. 151-152
    • Sweatt, J.D.1
  • 146
    • 34447324675 scopus 로고    scopus 로고
    • Maternal care, the epigenome and phenotypic differences in behavior
    • Szyf M., Weaver I., Meaney M. Maternal care, the epigenome and phenotypic differences in behavior. Reprod. Toxicol. 2007, 24:9-19.
    • (2007) Reprod. Toxicol. , vol.24 , pp. 9-19
    • Szyf, M.1    Weaver, I.2    Meaney, M.3
  • 147
    • 4444276735 scopus 로고    scopus 로고
    • Clearance of Alzheimer's Abeta peptide: the many roads to perdition
    • Tanzi R.E., Moir R.D., Wagner S.L. Clearance of Alzheimer's Abeta peptide: the many roads to perdition. Neuron 2004, 43:605-608.
    • (2004) Neuron , vol.43 , pp. 605-608
    • Tanzi, R.E.1    Moir, R.D.2    Wagner, S.L.3
  • 148
    • 0033052929 scopus 로고    scopus 로고
    • Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex
    • Tohgi H., Utsugisawa K., Nagane Y., Yoshimura M., Genda Y., Ukitsu M. Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex. Brain Res. Mol. Brain Res. 1999, 70:288-292.
    • (1999) Brain Res. Mol. Brain Res. , vol.70 , pp. 288-292
    • Tohgi, H.1    Utsugisawa, K.2    Nagane, Y.3    Yoshimura, M.4    Genda, Y.5    Ukitsu, M.6
  • 149
    • 0032716797 scopus 로고    scopus 로고
    • The methylation status of cytosines in a tau gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex
    • Tohgi H., Utsugisawa K., Nagane Y., Yoshimura M., Ukitsu M., Genda Y. The methylation status of cytosines in a tau gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex. Neurosci. Lett. 1999, 275:89-92.
    • (1999) Neurosci. Lett. , vol.275 , pp. 89-92
    • Tohgi, H.1    Utsugisawa, K.2    Nagane, Y.3    Yoshimura, M.4    Ukitsu, M.5    Genda, Y.6
  • 151
    • 69949099211 scopus 로고    scopus 로고
    • Gene-environment-wide interaction studies in psychiatry
    • van Os J., Rutten B.P. Gene-environment-wide interaction studies in psychiatry. Am. J. Psychiatry 2009, 166:964-966.
    • (2009) Am. J. Psychiatry , vol.166 , pp. 964-966
    • van Os, J.1    Rutten, B.P.2
  • 152
    • 54249166128 scopus 로고    scopus 로고
    • Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions
    • van Os J., Rutten B.P., Poulton R. Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophr. Bull. 2008, 34:1066-1082.
    • (2008) Schizophr. Bull. , vol.34 , pp. 1066-1082
    • van Os, J.1    Rutten, B.P.2    Poulton, R.3
  • 153
    • 49949108971 scopus 로고    scopus 로고
    • Age-specific epigenetic drift in late-onset Alzheimer's disease
    • Wang S.C., Oelze B., Schumacher A. Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS ONE 2008, 3:e2698.
    • (2008) PLoS ONE , vol.3
    • Wang, S.C.1    Oelze, B.2    Schumacher, A.3
  • 154
    • 34249700597 scopus 로고    scopus 로고
    • Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: let's call the whole thing off
    • Weaver I.C. Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: let's call the whole thing off. Epigenetics 2007, 2:22-28.
    • (2007) Epigenetics , vol.2 , pp. 22-28
    • Weaver, I.C.1
  • 156
    • 0029440466 scopus 로고
    • Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient
    • West R.L., Lee J.M., Maroun L.E. Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient. J. Mol. Neurosci. 1995, 6:141-146.
    • (1995) J. Mol. Neurosci. , vol.6 , pp. 141-146
    • West, R.L.1    Lee, J.M.2    Maroun, L.E.3
  • 158
    • 0020638422 scopus 로고
    • DNA methylation decreases in aging but not in immortal cells
    • Wilson V.L., Jones P.A. DNA methylation decreases in aging but not in immortal cells. Science 1983, 220:1055-1057.
    • (1983) Science , vol.220 , pp. 1055-1057
    • Wilson, V.L.1    Jones, P.A.2
  • 159
    • 0023664725 scopus 로고
    • Genomic 5-methyldeoxycytidine decreases with age
    • Wilson V.L., Smith R.A., Ma S., Cutler R.G. Genomic 5-methyldeoxycytidine decreases with age. J. Biol. Chem. 1987, 262:9948-9951.
    • (1987) J. Biol. Chem. , vol.262 , pp. 9948-9951
    • Wilson, V.L.1    Smith, R.A.2    Ma, S.3    Cutler, R.G.4
  • 160
    • 38149024924 scopus 로고    scopus 로고
    • Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD
    • Wu J., Basha M.R., Brock B., Cox D.P., Cardozo-Pelaez F., McPherson C.A., Harry J., Rice D.C., Maloney B., Chen D., Lahiri D.K., Zawia N.H. Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. J. Neurosci. 2008, 28:3-9.
    • (2008) J. Neurosci. , vol.28 , pp. 3-9
    • Wu, J.1    Basha, M.R.2    Brock, B.3    Cox, D.P.4    Cardozo-Pelaez, F.5    McPherson, C.A.6    Harry, J.7    Rice, D.C.8    Maloney, B.9    Chen, D.10    Lahiri, D.K.11    Zawia, N.H.12
  • 162
    • 0025219026 scopus 로고
    • Genomic organization of the human amyloid beta-protein precursor gene
    • Yoshikai S., Sasaki H., Doh-ura K., Furuya H., Sakaki Y. Genomic organization of the human amyloid beta-protein precursor gene. Gene 1990, 87:257-263.
    • (1990) Gene , vol.87 , pp. 257-263
    • Yoshikai, S.1    Sasaki, H.2    Doh-ura, K.3    Furuya, H.4    Sakaki, Y.5
  • 164
    • 36148948982 scopus 로고    scopus 로고
    • Global hypomethylation defines a sub-population of reactive microglia/macrophages in experimental traumatic brain injury
    • Zhang Z.Y., Zhang Z., Fauser U., Schluesener H.J. Global hypomethylation defines a sub-population of reactive microglia/macrophages in experimental traumatic brain injury. Neurosci. Lett. 2007, 429:1-6.
    • (2007) Neurosci. Lett. , vol.429 , pp. 1-6
    • Zhang, Z.Y.1    Zhang, Z.2    Fauser, U.3    Schluesener, H.J.4


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