DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models

Journal of Nutritional Biochemistry

Volumn 22, Issue 3, 2011, Pages 242-251

  Fuso, Andrea ^a   Nicolia, Vincenzina ^a   Cavallaro, Rosaria A ^a   Scarpa, Sigfrido ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Alzheimer's Disease; B vitamin deficiency; DNA demethylase; DNA methylation; One carbon metabolism; S adenosylmethionine

Indexed keywords

DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; PRESENILIN 1; S ADENOSYLMETHIONINE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBON METABOLISM; DNA METHYLATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; VITAMIN DEFICIENCY;

ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; ANIMALS; CARBON; CELL LINE; DISEASE MODELS, ANIMAL; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA-BINDING PROTEINS; EPIGENOMICS; FEMALE; FOLIC ACID; HUMANS; MALE; METHYLATION; MICE; MICE, 129 STRAIN; MICE, TRANSGENIC; S-ADENOSYLMETHIONINE; VITAMIN B 12; VITAMIN B 6; VITAMIN B COMPLEX; VITAMIN B DEFICIENCY;

MUS;

EID: 79951677959     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2010.01.010     Document Type: Article

References (46)

1. Liu L., Li Y., Tollefsbol T.O. Gene-environment interactions and epigenetic basis of human diseases. Curr Issues Mol Biol 2008, 10:25-36.
2. Pogribny I.P., Beland F.A. DNA hypomethylation in the origin ad pathogenesis of human diseases. Cell Mol Life Sci 2009, [in press]. 10.1007/s00018-0090015-5.
3. Fuso A., Seminara L., Cavallaro R.A., D'Anselmi F., Scarpa S. Homocysteine/S-adenosylmethionine cycle alterations unbalance DNA methylation status with consequent up-regulation of beta-amyloid production. Mol Cell Neurosci 2005, 28:195-204.
4. Fuso A., Cavallaro R.A., Zampelli A., D'Anselmi F., Piscopo P., Confaloni A., et al. γ-secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells. J Alz Dis 2007, 11:275-290.
5. Fuso A., Nicolia V., Cavallaro R.A., Ricceri L., D'Anselmi F., Coluccia P., et al. B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice. Mol Cell Neurosci 2008, 37:731-746.
6. Fuso A., Nicolia V., Pasqualato A., Fiorenza M.T., Cavallaro R.A., Scarpa S. Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency. Neurobiol Aging 2009, [in press]. 10.1016/j.neurobiolaging.2009.02.013.
7. Ladd-Acosta C., Pevsner J., Sabunciyan S., Yolken R.H., Webster M.J., Dinkins T., et al. DNA methylation signatures within the human brain. Am J Hum Genet 2007, 81:1304-1315.
8. Siegmund K.D., Connor C.M., Campan M., Long T.I., Weisenberger D.J., Biniszkiewicz D., et al. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS ONE 2007, 2:e895.
9. Bjornsson H.T., Sigurdsson M.I., Fallin M.D., Irizarry R.A., Aspelund T., Cui H., et al. Intra-individual change over time in DNA methylation with familial clustering. J Am Med Ass 2008, 299:2877-2883.
10. Wang S.C., Oelze B., Schumacher A. Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS ONE 2008, 3:e2698.
11. Liu L., van Groen T., Kadish I., Tollefsbol T.O. DNA methylation impacts on learning and memory in aging. Neurobiol Aging 2009, 30:549-560.
12. Mastroeni D., Grover A., Delvaux E., Whiteside C., Coleman P.D., Rogers J. Epigenetic changes in Alzheimer's disease: decrements in DNA methylation. Neurobiol Aging 2009, [in press]. 10.1016/j.neurobiolaging.2008.12.005.
13. Chiang P.K., Gordon R.K., Tal J., Zeng G.C., Doctor B.P., Pardhasaradhi K., et al. S-adenosylmethionine and methylation. FASEB J 1996, 10:471-480.
14. Medina M.A., Urdiales J.L., Amores-Sanchez M.I. Roles of homocysteine in cell metabolism: old and new function. Eur J Biochem 2001, 268:3871-3882.
15. Quadri P., Fragiacomo C., Pezzati R., Zanda E., Forloni G., Tettamanti M., et al. Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr 2004, 80:114-122.
16. Malaguarnera M., Ferri R., Bella R., Alagona G., Carnemolla A., Pennisi G. Homocysteine, vitamin B12 and folate in vascular dementia and in Alzheimer disease. Clin Chem Lab Med 2004, 42:1032-1035.
17. Kado D.M., Karlamangla A.S., Huang M.H., Troen A., Rowe J.V., Selhub J., et al. Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur studies of successful aging. Am J Med 2005, 118:161-167.
18. Hermann A., Gowher H., Jeltsch A. Biochemistry and biology of mammalian DNA methyltransferases. Cell Mol Life Sci 2004, 61:2571-2587.
19. McGowan P.O., Meaney M.J., Szyf M. Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Res 2008, 1237:12-24.
20. Fatemi M., Hermann A., Pradhan S., Jeltsch A. The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA. J Mol Biol 2001, 309:1189-1199.
21. Hsieh C.L. In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b. Mol Cell Biol 1999, 19:8211-8218.
22. Ramsahoye B.H., Biniszkiewicz D., Lyko F., Clark V., Bird A.P., Jaenisch R. Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci USA 2000, 97:5237-5342.
23. Gowher H., Jeltsch A. Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG sites. J Mol Biol 2001, 309:1201-1208.
24. Suetake I., Miyazaki J., Murakami C., Takeshima H., Tajima S. Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b. J Biochem 2003, 133:737-744.
25. Zhu B., Zheng Y., Hess D., Angliker H., Schwarz S., Siegmann M., et al. 5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex. Proc Natl Acad Sci USA 2000, 97:5135-5139.
26. Barreto G., Schäfer A., Marhold J., Stach D., Swaminathan S.K., Handa V., et al. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 2007, 445:671-675.
27. Brown S.E., Suderman M.J., Hallett M., Szyf M. DNA demethylation induced by the methyl-CpG-binding domain protein MBD3. Gene 2008, 420:99-106.
28. Métivier R., Gallais R., Tiffoche C., Le Péron C., Jurkowska R.Z., Carmouche R.P., et al. Cyclical DNA methylation of a transcriptionally active promoter. Nature 2008, 452:45-50.
29. Bhattacharya S.K., Ramchandani S., Cervoni N., Szyf M. A mammalian protein with specific demethylase activity for mCpG DNA. Nature 1999, 397:579-583.
30. Cervoni N., Bhattacharya S., Szyf M. DNA demethylase is a processive enzyme. J Biol Chem 1999, 274:8363-8366.
31. Detich N., Hamm S., Just G., Knox J.D., Szyf M. The methyl donor S-adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-adenosylmethionine. J Biol Chem 2003, 278:20812-20820.
32. Kangaspeska S., Stride B., Métivier R., Polycarpou-Schwarz M., Ibberson D., Carmouche R.P., et al. Transient cyclical methylation of promoter DNA. Nature 2008, 452:112-115.
33. Levenson J.M., Roth T.L., Lubin F.D., Miller C.A., Huang I.C., Desai P., et al. Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus. J Biol Chem 2006, 281:15763-15773.
34. Murgatroyd C., Patchev A.V., Wu Y., Micale V., Bockmühl Y., Fischer D., et al. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci 2009, 12:1559-1566.
35. Szyf M. Epigenetics, DNA methylation, and chromatin modifying drugs. Annu Rev Pharmacol Toxicol 2009, 49:243-263.
36. Girault I., Lerebours F., Amarir S., Tozlu S., Tubiana-Hulin M., Lidereau R., et al. Expression analysis of estrogen receptor alpha coregulators in breast carcinoma: evidence that NCOR1 expression is predictive of the response to tamoxifen. Clin Cancer Res 2003, 9:1259-1266.
37. Kanai Y., Ushijima S., Nakanishi Y., Hirohashi S. Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers. Biochem Biophys Res Commun 1999, 264:962-966.
38. La Salle S., Mertineit C., Taketo T., Moens P.B., Bestor T.H., Trasler J.M. Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells. Dev Biol 2004, 268:403-415.
39. Di Giaimo R., Russo G.M.R., Bevilacqua M.A., Iovine B., Del Gaudio R., Geraci G., et al. The expression of de novo DNA methylase DNMT3b, of the methyl-CpG binding protein MBD2 and of 5-MCDG glycosylase shows two waves of induction during CaCO-2 cell differentiation. Gene 2005, 351:73-81.
40. Patra S.K., Patra A., Zhao H., Dahiya R. DNA methyltransferase and demethylase in human prostate cancer. Mol Carcinog 2002, 33:163-171.
41. Szyf M., Bhattacharya S.K. Measuring DNA demethylase activity in vitro. Methods Mol Biol 2002, 200:155-161.
42. Jamaluddin M.S., Chen I., Yang F., Jiang X., Jan M., Liu X., et al. Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. Blood 2007, 110:3648-3655.
43. Ghoshal K., Li X., Datta J., Bai S., Pogribny I., Pogribny M., et al. A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. J Nutr 2006, 136:1522-1527.
44. Jost J.P., Oakeley E.J., Zhu B., Benjamin D., Thiry S., Siegmann M., et al. 5-methylcytosine DNA glycosylase participates in the genome-wide loss of DNA methylation occurring during mouse myoblast differentiation. Nucleic Acids Res 2001, 29:4452-4461.
45. Jin S.G., Guo C., Pfeifer G.P. GADD45A does not promote DNA demethylation. Plos Genet 2008, 4:e1000013.
46. Engel N., Tront J.S., Erinle T., Nguyen N., Latham K.E., Sapienza C., et al. Conserved DNA methylation in Gadd45a(-/-) mice. Epigenetics 2009, 4:98-99.