A neurochemical basis for an epigenetic vision of psychiatric disorders (1994-2009)

Pharmacological Research

Volumn 64, Issue 4, 2011, Pages 344-349

  Guidotti, Alessandro ^a   Grayson, Dennis R ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Antipsychotics; Bipolar Disorder; Epigenetics; GABA; Reelin; Schizophrenia

Indexed keywords

CLOZAPINE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; GLUTAMATE DECARBOXYLASE 67; HALOPERIDOL; HISTONE DEACETYLASE INHIBITOR; OLANZAPINE; QUETIAPINE; REELIN; RISPERIDONE; VALPROIC ACID;

BIPOLAR DISORDER; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA METHYLATION; DOWN REGULATION; DYNAMICS; EPIGENETICS; GABAERGIC TRANSMISSION; GENE OVEREXPRESSION; GENETIC REGULATION; HUMAN; MENTAL DISEASE; MENTAL FUNCTION; NEUROCHEMISTRY; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; SCHIZOPHRENIA;

ANIMALS; ANTIPSYCHOTIC AGENTS; EPIGENESIS, GENETIC; GAMMA-AMINOBUTYRIC ACID; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; MENTAL DISORDERS; NEUROCHEMISTRY;

EID: 80052964607     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.05.026     Document Type: Review

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98. B. Kadriu, A. Guidotti, E. Costa, J. Auta, and Imidazenil a non-sedating anticonvulsant benzodiazepine is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage Toxicology 256 2009 164 174
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101. G. Pinna, E. Costa, and A. Guidotti SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake Curr Opin Pharmacol 9 2009 24 30
102. A. Zhubi, M. Veldic, N.V. Puri, B. Kadriu, H. Caruncho, and I. Loza An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes Schizophr Res 111 2009 115 122
103. E. Dong, D.R. Grayson, A. Guidotti, and E. Costa Antipsychotic subtypes can be characterized by differences in their ability to modify GABAergic promoter methylation Epigenomics 1 2009 201 211
104. J. Auta, B. Kadriu, P. Giusti, E. Costa, and A. Guidotti Anticonvulsant, anxiolytic, and non-sedating actions of imidazenil and other imidazo-benzodiazepine carboxamide derivatives Pharmacol Biochem Behav 95 2010 383 389
105. P. Tueting, M. Davis John, M. Veldic, F. Pibiri, B. Kadriu, and A. Guidotti l-methionine decreases dendritic spine density in mouse frontal cortex [Spine density downregulation by l-methionine] Neuroreport 21 2010 543 548
106. E. Maloku, I.R. Covelo, I. Hanbauer, A. Guidotti, B. Kadriu, and Q. Hu Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression Proc Natl Acad Sci USA 1079 2010 4407 4411
107. R.C. Smith, A. Zhubi, E. Maloku, H. Sershen, A. Lajtha, and J.M. Davis Varenicline treatment decreases DNMT1 mRNA expression in lymphocytes of schizophrenic patients who are cigarette smokers Schizophr Res 1191-1193 2010 269 270
108. E. Dong, Y. Chen, D.P. Gavin, D.R. Grayson, and A. Guidotti Valproate induces DNA demethylation in nuclear extracts from adult mouse brain Epigenetics 5 2010 1 6
109. B. Kadriu, A. Guidotti, E. Costa, J.M. Davis, and J. Auta Acute imidazenil treatment after the onset of DFP-induced seizure is more effective and longer lasting than midazolam at preventing seizure activity and brain neuropathology Toxic Sci 120 2011 136 145
110. A. Guidotti, J. Auta, Y. Chen, J.M. Davis, E. Dong, and D.P. Gavin Epigenetic GABAergic targets in schizophrenia and bipolar disorder Neuropharmacology November (11) 2010 Epub ahead of print
111. 2 nicotinic acetylcholine receptor agonists target epigenetic mechanisms in cortical GABAergic neurons. Neuropsychopharmacology, in press (online publication March 2, 2011).