Intrathecal 5-azacytidine inhibits global DNA methylation and methyl- CpG-binding protein 2 expression and alleviates neuropathic pain in rats following chronic constriction injury

Brain Research

Volumn 1418, Issue , 2011, Pages 64-69

  Wang, Ying ^a   Liu, Chang ^a   Guo, Qu Lian ^a   Yan, Jian Qin ^a   Zhu, Xiao Yan ^a   Huang, Chang Sheng ^a   Zou, Wang Yuan ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

5 azacytidine; Chronic constriction injury; DNA methylation; Methyl CpG binding protein 2; Neuropathic pain

Indexed keywords

AZACITIDINE; METHYL CPG BINDING PROTEIN 2;

ALLODYNIA; ANIMAL EXPERIMENT; ARTICLE; CHRONIC CONSTRICTION INJURY; CONTROLLED STUDY; DNA METHYLATION; DRUG INHIBITION; ENZYME REPRESSION; HYPERALGESIA; MALE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD; SPINAL CORD INJURY; SPINAL CORD SURGERY; SPRAGUE DAWLEY RAT;

ANALYSIS OF VARIANCE; ANIMALS; AZACITIDINE; CHRONIC DISEASE; CONSTRICTION, PATHOLOGIC; DISEASE MODELS, ANIMAL; DNA METHYLATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FUNCTIONAL LATERALITY; GENE EXPRESSION REGULATION; INJECTIONS, SPINAL; MALE; METHYL-CPG-BINDING PROTEIN 2; NEURALGIA; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIME FACTORS;

RATTUS; VERTEBRATA;

EID: 80053385022     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.08.040     Document Type: Article

References (36)

1. S. Aizawa, N. Sensui, and Y. Yamamuro Induction of cholinergic differentiation by 5-azacytidine in NG108-15 neuronal cells Neuroreport 20 2009 157 160
2. S. Akbarian, R.Z. Chen, J. Gribnau, T.P. Rasmussen, H. Fong, R. Jaenisch, and E.G. Jones Expression pattern of the Rett syndrome gene MeCP2 in primate prefrontal cortex Neurobiol. Dis. 8 2001 784 791 (Pubitemid 33055595)
3. R.E. Amir, I.B. Van den Veyver, M. Wan, C.Q. Tran, U. Francke, and H.Y. Zoghbi Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 Nat. Genet. 23 1999 185 188 (Pubitemid 29455390)
4. S. Bauer, and P.H. Patterson The cell cycle-apoptosis connection revisited in the adult brain J. Cell Biol. 171 2005 641 650 (Pubitemid 41668723)
5. G.J. Bennett, and Y.K. Xie A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man Pain 33 1988 87 107
6. G. Cruccu, P. Anand, N. Attal, L. Garcia-Larrea, M. Haanpaa, E. Jorum, J. Serra, and T.S. Jensen EFNS guidelines on neuropathic pain assessment Eur. J. Neurol. 11 2004 153 162 (Pubitemid 38373032)
7. A. Doehring, G. Geisslinger, and J. Lotsch Epigenetics in pain and analgesia: an imminent research field Eur. J. Pain 15 2011 11 16
8. J. Downs, S.M. Geranton, A. Bebbington, P. Jacoby, N. Bahi-Buisson, D. Ravine, and H. Leonard Linking MECP2 and pain sensitivity: the example of Rett syndrome Am. J. Med. Genet. A 152A 2010 1197 1205
9. R.H. Dworkin, M. Backonja, M.C. Rowbotham, R.R. Allen, C.R. Argoff, G.J. Bennett, M.C. Bushnell, J.T. Farrar, B.S. Galer, J.A. Haythornthwaite, D.J. Hewitt, J.D. Loeser, M.B. Max, M. Saltarelli, K.E. Schmader, C. Stein, D. Thompson, D.C. Turk, M.S. Wallace, L.R. Watkins, and S.M. Weinstein Advances in neuropathic pain - diagnosis, mechanisms, and treatment recommendations Arch. Neurol. 60 2003 1524 1534 (Pubitemid 37443116)
10. S.M. Geranton, C. Morenilla-Palao, and S.P. Hunt A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states J. Neurosci. 27 2007 6163 6173 (Pubitemid 46890014)
11. S.M. Geranton, V. Fratto, K.K. Tochiki, and S.P. Hunt Descending serotonergic controls regulate inflammation-induced induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn Mol. Pain 4 2008
12. K. Ghoshal, and S.M. Bai DNA methyltransferases as targets for cancer therapy Drugs Today 43 2007 395 422 (Pubitemid 47234771)
13. J. Guz, M. Foksinski, and R. Olinski Mechanism of DNA methylation and demethylation-its role in control of genes expression Postepy Biochem. 56 2010 7 15
14. N.D. Halim, C.S. Weickert, B.W. McClintock, D.R. Weinberger, and B.K. Lipska Effects of chronic haloperidol and clozapine treatment on neurogenesis in the adult rat hippocampus Neuropsychopharmacology 29 2004 1063 1069 (Pubitemid 38670044)
15. R. Holliday, and T. Ho DNA methylation and epigenetic inheritance Methods 27 2002 179 183 (Pubitemid 34757131)
16. R. Jaenisch, and A. Bird Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals Nat. Genet. 33 2003 245 254 (Pubitemid 36278835)
17. W. Jin, J.J. Lee, M.S. Kim, B.H. Son, Y.K. Cho, and H.P. Kim DNA methylation-dependent regulation of TrkA, TrkB, and TrkC genes in human hepatocellular carcinoma Biochem. Biophys. Res. Commun. 406 2011 89 95
18. N. Kishi, and J.D. Macklis MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions Mol. Cell. Neurosci. 27 2004 306 321 (Pubitemid 39433843)
19. H. Korr, and B. Schultze Unscheduled DNA-synthesis in various types of cells of the mouse-brain in vivo Exp. Brain Res. 74 1989 573 578 (Pubitemid 19065680)
20. C.Y. Kuan, A.J. Schloemer, A.G. Lu, K.A. Burns, W.L. Weng, M.T. Williams, K.I. Strauss, C.V. Vorhees, R.A. Flavell, R.J. Davis, F.R. Sharp, and P. Rakic Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain J. Neurosci. 24 2004 10763 10772 (Pubitemid 39557651)
21. J.D. Lewis, R.R. Meehan, W.J. Henzel, I. Maurerfogy, P. Jeppesen, F. Klein, and A. Bird Purification, sequence, and cellular-localization of a novel chromosomal protein that binds to methylated DNA Cell 69 1992 905 914
22. Y. Luo, Y. Li, Y. Su, H. Yin, N. Hu, S. Wang, and Q. Lu Abnormal DNA methylation in T cells from patients with subacute cutaneous lupus erythematosus Br. J. Dermatol. 159 2008 827 833
23. G. Moalem, and D.J. Tracey Immune and inflammatory mechanisms in neuropathic pain Brain Res. Rev. 51 2006 240 264 (Pubitemid 43902971)
24. Y. Oishi, Y. Uezono, N. Yanagihara, F. Izumi, T. Nakamura, and K. Suzuki Transmural compression-induced proliferation and DNA synthesis through activation of a tyrosine kinase pathway in rat astrocytoma RCR-1 cells Brain Res. 781 1998 159 166 (Pubitemid 28082858)
25. Y. Oki, and J.-P.J. Issa Review: recent clinical trials in epigenetic therapy Rev. Recent Clin. Trials 1 2006 169 182
26. J. Scholz, and C.J. Woolf The neuropathic pain triad: neurons, immune cells and glia Nat. Neurosci. 10 2007 1361 1368 (Pubitemid 350014681)
27. G. Sciandrello, F. Caradonna, and G. Barbata The DNA methylation inhibitor 5-azacytidine modulates 6-thioguanine toxicity in mammalian cells Toxicol. Lett. 142 2003 29 35 (Pubitemid 36369211)
28. M.D. Shahbazian, B. Antalffy, D.L. Armstrong, and H.Y. Zoghbi Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation Hum. Mol. Genet. 11 2002 115 124 (Pubitemid 34157003)
29. R.P. Sharma, N. Tun, and D.R. Grayson Depolarization induces downregulation of DNMT1 and DNMT3a in primary cortical cultures Epigenetics 3 2008 74 80
30. R. Shechter, Y. Ziv, and M. Schwartz New GABAergic Interneurons supported by myelin-specific T cells are formed in intact adult spinal cord Stem Cells 25 2007 2277 2282 (Pubitemid 47480486)
31. D.E. Stephanopoulos, J.C. Kappes, and D.I. Bernstein Enhanced in vitro reactivation of herpes-simplex virus type-2 from latently infected guinea-pig neural tissues by 5-azacytidine J. Gen. Virol. 69 1988 1079 1083
32. K. Tikoo, I.Y. Ali, J. Gupta, and C. Gupta 5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats Toxicol. Lett. 191 2009 158 166
33. M. Vessal, A. Aycock, M.T. Garton, M. Ciferri, and C. Darian-Smith Adult neurogenesis in primate and rodent spinal cord: comparing a cervical dorsal rhizotomy with a dorsal column transection Eur. J. Neurosci. 26 2007 2777 2794 (Pubitemid 350115503)
34. Y. Wang, X.A. Zhang, Q.L. Guo, W.Y. Zou, C.S. Huang, and J.Q. Yan Cyclooxygenase inhibitors suppress the expression of P2X(3) receptors in the DRG and attenuate hyperalgesia following chronic constriction injury in rats Neurosci. Lett. 478 2010 77 81
35. F. Xu, T. Li, and B. Zhang An improved method for protecting and fixing the lumbar catheters placed in the spinal subarachnoid space of rats J. Neurosci. Methods 183 2009 114 118
36. Y. Ziv, and M. Schwartz Orchestrating brain-cell renewal: the role of immune cells in adult neurogenesis in health and disease Trends Mol. Med. 14 2008 471 478