Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model

PLoS ONE

Volumn 5, Issue 1, 2010, Pages

  Rai, Myriam ^a   Soragni, Elisabetta ^b   Chou, C James ^b,d   Barnes, Glenn ^c   Jones, Steve ^c   Rusche, James R ^c   Gottesfeld, Joel M ^b   Pandolfo, Massimo ^a  

^a ERASME HOSPITAL   (Belgium)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c REPLIGEN CORPORATION   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRATAXIN; HISTONE; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE INHIBITOR; MESSENGER RNA; N 1 (2 AMINOPHENYL) N 7 4 TOLYLHEPTANEDIAMIDE; N [6 (2 AMINO 4 FLUOROPHENYLAMINO) 6 OXOHEXYL] 4 METHYLBENZAMIDE; N [6 (2 AMINOPHENYLAMINO) 6 OXOHEXYL) 4 METHYLBENZAMIDE; PIMELIC DIPHENYLAMIDE; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SPECIFICITY; FRIEDREICH ATAXIA; LYMPHOCYTE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SPLEEN CELL; UPREGULATION;

ANIMALS; BASE SEQUENCE; DISEASE MODELS, ANIMAL; DNA PRIMERS; FRIEDREICH ATAXIA; HISTONE DEACETYLASE INHIBITORS; HUMANS; IRON-BINDING PROTEINS; MICE; MODELS, ANIMAL; PIMELIC ACIDS; POLYMERASE CHAIN REACTION; UP-REGULATION;

EID: 77952530173     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008825     Document Type: Article

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