Huntington's disease and HDACi: Would sulpiride and valproate be of therapeutic value?

Medical Hypotheses

Volumn 69, Issue 4, 2007, Pages 964-965

  Tremolizzo, L ^a   Rodriguez Menendez, V ^a   DiFrancesco, J C ^a,b   Sala, G ^a   Galbussera, A ^a   Appollonio, I ^a   Ferrarese, C ^a,b  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b SCIENTIFIC INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMISULPRIDE; ANTICONVULSIVE AGENT; BENZAMIDE; HISTONE DEACETYLASE INHIBITOR; MOOD STABILIZER; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; NEUROLEPTIC AGENT; SULPIRIDE; VALPROIC ACID;

ADD ON THERAPY; CHROMATIN ASSEMBLY AND DISASSEMBLY; DEGENERATIVE DISEASE; DISEASE COURSE; DYSKINESIA; HUNTINGTON CHOREA; LETTER; MOTOR DYSFUNCTION; NEUROPROTECTION; PHENOTYPE; PRIORITY JOURNAL; PSYCHOSIS; SURVIVAL;

ANTICONVULSANTS; ANTIPSYCHOTIC AGENTS; HISTONE DEACETYLASES; HUMANS; HUNTINGTON DISEASE; MOTOR ACTIVITY; SULPIRIDE; VALPROIC ACID;

EID: 34547840258     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.02.025     Document Type: Letter

References (7)

1. Simonini M.V., Camargo L.M., Dong E., et al. The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases. Proc Natl Acad Sci USA 103 (2006) 1587-1592
2. Butler R., and Bates G.P. Histone deacetylase inhibitors as therapeutics for polyglutamine disorders. Nat Rev Neurosci 7 (2006) 784-796
3. Gardian G., Browne S.E., Choi D.K., et al. Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease. J Biol Chem 280 (2005) 556-563
4. Hockey E., Richon V.M., Woodman B., et al. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease. Proc Natl Acad Sci USA 100 (2003) 2041-2046
5. Bonelli R.M., and Wenning G.K. Pharmacological management of Huntington's disease: an evidence-based review. Curr Pharm Des 12 (2006) 2701-2720
6. Phiel C.J., Zhang F., Huang E.Y., Guenther M.G., Lazar M.A., and Klein P.S. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276 (2001) 36734-36741
7. Perucca E. Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs 16 (2002) 695-714