Amyloid β oligomers (Aβ1-42 globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents

Journal of Neuroscience

Volumn 28, Issue 4, 2008, Pages 788-797

  Nimmrich, Volker ^a   Grimm, Christiane ^b   Draguhn, Andreas ^b   Barghorn, Stefan ^a   Lehmann, Alexander ^b   Schoemaker, Hans ^a   Hillen, Heinz ^a   Gross, Gerhard ^a   Ebert, Ulrich ^a   Bruehl, Claus ^b  

^a ABBOTT GMBH AND CO KG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

A globulomer; A oligomers; Alzheimer's disease; Amyloid; Hippocampal neurons; P Q type calcium channel

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM; ROSCOVITINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CELL DISRUPTION; GABAERGIC SYSTEM; MOLECULAR MECHANICS; NERVE CELL PLASTICITY; NONHUMAN; PATHOLOGY; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; SYNAPTIC POTENTIAL; SYNAPTIC TRANSMISSION;

AMYLOID BETA-PROTEIN; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, P-TYPE; CALCIUM CHANNELS, Q-TYPE; CELLS, CULTURED; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HIPPOCAMPUS; NEURAL INHIBITION; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; SYNAPTIC TRANSMISSION;

EID: 38549141544     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4771-07.2008     Document Type: Article

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