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Volumn 27, Issue 1, 2006, Pages 67-77

The Arctic Alzheimer mutation facilitates early intraneuronal Aβ aggregation and senile plaque formation in transgenic mice

Author keywords

Alzheimer's disease; Amyloid peptide; Amyloid deposition; Intraneuronal; Transgenic mice

Indexed keywords

AMYLOID BETA PROTEIN;

EID: 27744512118     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2004.12.007     Document Type: Article
Times cited : (214)

References (45)
  • 1
    • 0023838532 scopus 로고
    • Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
    • C.R. Abraham, D.J. Selkoe, and H. Potter Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease Cell 52 1988 487 501
    • (1988) Cell , vol.52 , pp. 487-501
    • Abraham, C.R.1    Selkoe, D.J.2    Potter, H.3
  • 2
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • P.V. Arriagada, J.H. Growdon, E.T. Hedley-Whyte, and B.T. Hyman Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease Neurology 42 1992 631 639
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arriagada, P.V.1    Growdon, J.H.2    Hedley-Whyte, E.T.3    Hyman, B.T.4
  • 3
    • 0037452779 scopus 로고    scopus 로고
    • Epitope and isotype specificities of antibodies to beta-amyloid peptide for protection against Alzheimer's disease-like neuropathology
    • F. Bard, R. Barbour, C. Cannon, R. Carretto, M. Fox, and D. Games Epitope and isotype specificities of antibodies to beta-amyloid peptide for protection against Alzheimer's disease-like neuropathology Proc Natl Acad Sci USA 100 2003 2023 2028
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2023-2028
    • Bard, F.1    Barbour, R.2    Cannon, C.3    Carretto, R.4    Fox, M.5    Games, D.6
  • 4
    • 0344826476 scopus 로고    scopus 로고
    • Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice
    • V. Blanchard, S. Moussaoui, C. Czech, N. Touchet, B. Bonici, and M. Planche Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice Exp Neurol 184 2003 247 263
    • (2003) Exp Neurol , vol.184 , pp. 247-263
    • Blanchard, V.1    Moussaoui, S.2    Czech, C.3    Touchet, N.4    Bonici, B.5    Planche, M.6
  • 5
    • 4644276796 scopus 로고    scopus 로고
    • Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model
    • C. Casas, N. Sergeant, J.M. Itier, V. Blanchard, O. Wirths, and N. van der Kolk Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model Am J Pathol 165 2004 1289 1300
    • (2004) Am J Pathol , vol.165 , pp. 1289-1300
    • Casas, C.1    Sergeant, N.2    Itier, J.M.3    Blanchard, V.4    Wirths, O.5    Van Der Kolk, N.6
  • 6
    • 9144272296 scopus 로고    scopus 로고
    • Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation
    • I.H. Cheng, J.J. Palop, L.A. Esposito, N. Bien-Ly, F. Yan, and L. Mucke Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation Nat Med 10 2004 1190 1192
    • (2004) Nat Med , vol.10 , pp. 1190-1192
    • Cheng, I.H.1    Palop, J.J.2    Esposito, L.A.3    Bien-Ly, N.4    Yan, F.5    Mucke, L.6
  • 7
    • 0035120525 scopus 로고    scopus 로고
    • Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
    • M.R. D'Andrea, R.G. Nagele, H.Y. Wang, P.A. Peterson, and D.H. Lee Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease Histopathology 38 2001 120 134
    • (2001) Histopathology , vol.38 , pp. 120-134
    • D'Andrea, M.R.1    Nagele, R.G.2    Wang, H.Y.3    Peterson, P.A.4    Lee, D.H.5
  • 8
    • 2442594971 scopus 로고    scopus 로고
    • Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor
    • J. Davis, F. Xu, R. Deane, G. Romanov, M.L. Previti, and K. Zeigler Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor J Biol Chem 279 2004 20296 20306
    • (2004) J Biol Chem , vol.279 , pp. 20296-20306
    • Davis, J.1    Xu, F.2    Deane, R.3    Romanov, G.4    Previti, M.L.5    Zeigler, K.6
  • 9
    • 0036083396 scopus 로고    scopus 로고
    • The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
    • M.H. Glickman, and A. Ciechanover The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction Physiol Rev 82 2002 373 428
    • (2002) Physiol Rev , vol.82 , pp. 373-428
    • Glickman, M.H.1    Ciechanover, A.2
  • 10
    • 0036175608 scopus 로고    scopus 로고
    • Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1 + APP mouse
    • M.N. Gordon, L.A. Holcomb, P.T. Jantzen, G. DiCarlo, D. Wilcock, and K.W. Boyett Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1 + APP mouse Exp Neurol 173 2002 183 195
    • (2002) Exp Neurol , vol.173 , pp. 183-195
    • Gordon, M.N.1    Holcomb, L.A.2    Jantzen, P.T.3    Dicarlo, G.4    Wilcock, D.5    Boyett, K.W.6
  • 12
    • 0034745017 scopus 로고    scopus 로고
    • Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome
    • K.A. Gyure, R. Durham, W.F. Stewart, J.E. Smialek, and J.C. Troncoso Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome Arch Pathol Lab Med 125 2001 489 492
    • (2001) Arch Pathol Lab Med , vol.125 , pp. 489-492
    • Gyure, K.A.1    Durham, R.2    Stewart, W.F.3    Smialek, J.E.4    Troncoso, J.C.5
  • 13
    • 0037975676 scopus 로고    scopus 로고
    • Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta
    • M. Hoshi, M. Sato, S. Matsumoto, A. Noguchi, K. Yasutake, and N. Yoshida Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta Proc Natl Acad Sci USA 100 2003 6370 6375
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6370-6375
    • Hoshi, M.1    Sato, M.2    Matsumoto, S.3    Noguchi, A.4    Yasutake, K.5    Yoshida, N.6
  • 14
    • 0028169925 scopus 로고
    • Visualization of a beta 42(43) and a beta 40 in senile plaques with end-specific a beta monoclonals: Evidence that an initially deposited species is a beta 42(43)
    • T. Iwatsubo, A. Odaka, N. Suzuki, H. Mizusawa, N. Nukina, and Y. Ihara Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43) Neuron 13 1994 45 53
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 15
    • 0027195933 scopus 로고
    • Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
    • J.T. Jarrett, and Lansbury P.T.Jr. Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell 73 1993 1055 1058
    • (1993) Cell , vol.73 , pp. 1055-1058
    • Jarrett, J.T.1    Lansbury, P.T.Jr.2
  • 16
    • 0031020909 scopus 로고    scopus 로고
    • Amyloid precursor protein processing and a beta42 deposition in a transgenic mouse model of Alzheimer disease
    • K. Johnson-Wood, M. Lee, R. Motter, K. Hu, G. Gordon, and R. Barbour Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease Proc Natl Acad Sci USA 94 1997 1550 1555
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1550-1555
    • Johnson-Wood, K.1    Lee, M.2    Motter, R.3    Hu, K.4    Gordon, G.5    Barbour, R.6
  • 17
    • 0026733343 scopus 로고
    • Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region
    • K. Kamino, H.T. Orr, H. Payami, E.M. Wijsman, M.E. Alonso, and S.M. Pulst Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region Am J Hum Genet 51 1992 998 1014
    • (1992) Am J Hum Genet , vol.51 , pp. 998-1014
    • Kamino, K.1    Orr, H.T.2    Payami, H.3    Wijsman, E.M.4    Alonso, M.E.5    Pulst, S.M.6
  • 18
    • 0034657130 scopus 로고    scopus 로고
    • Evidence for seeding of beta-amyloid by intracerebral infusion of Alzheimer brain extracts in beta-amyloid precursor protein-transgenic mice
    • M.D. Kane, W.J. Lipinski, M.J. Callahan, F. Bian, R.A. Durham, and R.D. Schwarz Evidence for seeding of beta-amyloid by intracerebral infusion of Alzheimer brain extracts in beta-amyloid precursor protein-transgenic mice J Neurosci 20 2000 3606 3611
    • (2000) J Neurosci , vol.20 , pp. 3606-3611
    • Kane, M.D.1    Lipinski, W.J.2    Callahan, M.J.3    Bian, F.4    Durham, R.A.5    Schwarz, R.D.6
  • 19
    • 11544279355 scopus 로고    scopus 로고
    • Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
    • M.P. Lambert, A.K. Barlow, B.A. Chromy, C. Edwards, R. Freed, and M. Liosatos Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins Proc Natl Acad Sci USA 95 1998 6448 6453
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6448-6453
    • Lambert, M.P.1    Barlow, A.K.2    Chromy, B.A.3    Edwards, C.4    Freed, R.5    Liosatos, M.6
  • 21
    • 9044229145 scopus 로고    scopus 로고
    • On the nucleation and growth of amyloid beta-protein fibrils: Detection of nuclei and quantitation of rate constants
    • A. Lomakin, D.S. Chung, G.B. Benedek, D.A. Kirschner, and D.B. Teplow On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants Proc Natl Acad Sci USA 93 1996 1125 1129
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1125-1129
    • Lomakin, A.1    Chung, D.S.2    Benedek, G.B.3    Kirschner, D.A.4    Teplow, D.B.5
  • 22
    • 16944366420 scopus 로고    scopus 로고
    • Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation
    • A. Luthi, H. Van der Putten, F.M. Botteri, I.M. Mansuy, M. Meins, and U. Frey Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation J Neurosci 17 1997 4688 4699
    • (1997) J Neurosci , vol.17 , pp. 4688-4699
    • Luthi, A.1    Van Der Putten, H.2    Botteri, F.M.3    Mansuy, I.M.4    Meins, M.5    Frey, U.6
  • 23
    • 0022156464 scopus 로고
    • Neuronal origin of a cerebral amyloid: Neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels
    • C.L. Masters, G. Multhaup, G. Simms, J. Pottgiesser, R.N. Martins, and K. Beyreuther Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels EMBO J 4 1985 2757 2763
    • (1985) EMBO J , vol.4 , pp. 2757-2763
    • Masters, C.L.1    Multhaup, G.2    Simms, G.3    Pottgiesser, J.4    Martins, R.N.5    Beyreuther, K.6
  • 24
    • 0032590054 scopus 로고    scopus 로고
    • Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
    • C.A. McLean, R.A. Cherny, F.W. Fraser, S.J. Fuller, M.J. Smith, and K. Beyreuther Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease Ann Neurol 46 1999 860 866
    • (1999) Ann Neurol , vol.46 , pp. 860-866
    • McLean, C.A.1    Cherny, R.A.2    Fraser, F.W.3    Fuller, S.J.4    Smith, M.J.5    Beyreuther, K.6
  • 26
    • 0026907151 scopus 로고
    • A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
    • M. Mullan, F. Crawford, K. Axelman, H. Houlden, L. Lilius, and B. Winblad A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid Nat Genet 1 1992 345 347
    • (1992) Nat Genet , vol.1 , pp. 345-347
    • Mullan, M.1    Crawford, F.2    Axelman, K.3    Houlden, H.4    Lilius, L.5    Winblad, B.6
  • 27
    • 0242580170 scopus 로고    scopus 로고
    • Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: Implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease
    • K. Murakami, K. Irie, A. Morimoto, H. Ohigashi, M. Shindo, and M. Nagao Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease J Biol Chem 278 2003 46179 46187
    • (2003) J Biol Chem , vol.278 , pp. 46179-46187
    • Murakami, K.1    Irie, K.2    Morimoto, A.3    Ohigashi, H.4    Shindo, M.5    Nagao, M.6
  • 28
    • 0025971426 scopus 로고
    • Apolipoprotein e immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
    • Y. Namba, M. Tomonaga, H. Kawasaki, E. Otomo, and K. Ikeda Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease Brain Res 541 1991 163 166
    • (1991) Brain Res , vol.541 , pp. 163-166
    • Namba, Y.1    Tomonaga, M.2    Kawasaki, H.3    Otomo, E.4    Ikeda, K.5
  • 29
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • J. Näslund, V. Haroutunian, R. Mohs, K.L. Davis, P. Davies, and P. Greengard Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline J Am Med Assoc 283 2000 1571 1577
    • (2000) J Am Med Assoc , vol.283 , pp. 1571-1577
    • Näslund, J.1    Haroutunian, V.2    Mohs, R.3    Davis, K.L.4    Davies, P.5    Greengard, P.6
  • 31
    • 0035282790 scopus 로고    scopus 로고
    • Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease
    • L.N. Nilsson, K.R. Bales, G. DiCarlo, M.N. Gordon, D. Morgan, and S.M. Paul Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease J Neurosci 21 2001 1444 1451
    • (2001) J Neurosci , vol.21 , pp. 1444-1451
    • Nilsson, L.N.1    Bales, K.R.2    Dicarlo, G.3    Gordon, M.N.4    Morgan, D.5    Paul, S.M.6
  • 32
    • 4043104729 scopus 로고    scopus 로고
    • Cognitive impariment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation
    • Nilsson LNG, G.W. Arendash, R.E. Leighty, D.A. Costa, M.A. Low, and M.F. Garcia Cognitive impariment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation Neurobiol Aging 25 2004 1153 1167
    • (2004) Neurobiol Aging , vol.25 , pp. 1153-1167
    • Lng, N.1    Arendash, G.W.2    Leighty, R.E.3    Costa, D.A.4    Low, M.A.5    Garcia, M.F.6
  • 33
    • 4043167747 scopus 로고    scopus 로고
    • Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • S. Oddo, L. Billings, J.P. Kesslak, D.H. Cribbs, and F.M. LaFerla Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome Neuron 43 2004 321 332
    • (2004) Neuron , vol.43 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    Laferla, F.M.5
  • 34
    • 10744230663 scopus 로고    scopus 로고
    • The human amyloid-beta precursor protein 770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates
    • A.E. Roher, T.A. Kokjohn, C. Esh, N. Weiss, J. Childress, and W. Kalback The human amyloid-beta precursor protein 770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates J Biol Chem 279 2004 5829 5836
    • (2004) J Biol Chem , vol.279 , pp. 5829-5836
    • Roher, A.E.1    Kokjohn, T.A.2    Esh, C.3    Weiss, N.4    Childress, J.5    Kalback, W.6
  • 35
    • 0031781642 scopus 로고    scopus 로고
    • Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture
    • D.M. Skovronsky, R.W. Doms, and V.M. Lee Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture J Cell Biol 141 1998 1031 1039
    • (1998) J Cell Biol , vol.141 , pp. 1031-1039
    • Skovronsky, D.M.1    Doms, R.W.2    Lee, V.M.3
  • 37
    • 1842732209 scopus 로고    scopus 로고
    • Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain
    • R.H. Takahashi, C.G. Almeida, P.F. Kearney, F. Yu, M.T. Lin, and T.A. Milner Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain J Neurosci 24 2004 3592 3599
    • (2004) J Neurosci , vol.24 , pp. 3592-3599
    • Takahashi, R.H.1    Almeida, C.G.2    Kearney, P.F.3    Yu, F.4    Lin, M.T.5    Milner, T.A.6
  • 38
    • 0036827031 scopus 로고    scopus 로고
    • Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology
    • R.H. Takahashi, T.A. Milner, F. Li, E.E. Nam, M.A. Edgar, and H. Yamaguchi Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology Am J Pathol 161 2002 1869 1879
    • (2002) Am J Pathol , vol.161 , pp. 1869-1879
    • Takahashi, R.H.1    Milner, T.A.2    Li, F.3    Nam, E.E.4    Edgar, M.A.5    Yamaguchi, H.6
  • 39
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • R.D. Terry, E. Masliah, D.P. Salmon, N. Butters, R. DeTeresa, and R. Hill Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment Ann Neurol 30 1991 572 580
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    Deteresa, R.5    Hill, R.6
  • 40
    • 0033520461 scopus 로고    scopus 로고
    • Amyloid beta-protein fibrillogenesis: Structure and biological activity of protofibrillar intermediates
    • D.M. Walsh, D.M. Hartley, Y. Kusumoto, Y. Fezoui, M.M. Condron, and A. Lomakin Amyloid beta-protein fibrillogenesis Structure and biological activity of protofibrillar intermediates J Biol Chem 274 1999 25945 25952
    • (1999) J Biol Chem , vol.274 , pp. 25945-25952
    • Walsh, D.M.1    Hartley, D.M.2    Kusumoto, Y.3    Fezoui, Y.4    Condron, M.M.5    Lomakin, A.6
  • 41
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • D.M. Walsh, I. Klyubin, J.V. Fadeeva, W.K. Cullen, R. Anwyl, and M.S. Wolfe Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo Nature 416 2002 535 539
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6
  • 42
    • 0030799122 scopus 로고    scopus 로고
    • Amyloid beta-protein fibrillogenesis: Detection of a protofibrillar intermediate
    • D.M. Walsh, A. Lomakin, G.B. Benedek, M.M. Condron, and D.B. Teplow Amyloid beta-protein fibrillogenesis Detection of a protofibrillar intermediate J Biol Chem 272 1997 22364 22372
    • (1997) J Biol Chem , vol.272 , pp. 22364-22372
    • Walsh, D.M.1    Lomakin, A.2    Benedek, G.B.3    Condron, M.M.4    Teplow, D.B.5
  • 43
    • 0027361386 scopus 로고
    • Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides
    • A.M. Wertkin, R.S. Turner, S.J. Pleasure, T.E. Golde, S.G. Younkin, and J.Q. Trojanowski Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides Proc Natl Acad Sci USA 90 1993 9513 9517
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9513-9517
    • Wertkin, A.M.1    Turner, R.S.2    Pleasure, S.J.3    Golde, T.E.4    Younkin, S.G.5    Trojanowski, J.Q.6
  • 44
    • 0036019155 scopus 로고    scopus 로고
    • Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice
    • O. Wirths, G. Multhaup, C. Czech, N. Feldmann, V. Blanchard, and G. Tremp Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice Brain Pathol 12 2002 275 286
    • (2002) Brain Pathol , vol.12 , pp. 275-286
    • Wirths, O.1    Multhaup, G.2    Czech, C.3    Feldmann, N.4    Blanchard, V.5    Tremp, G.6
  • 45
    • 0034744296 scopus 로고    scopus 로고
    • TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice
    • T. Wyss-Coray, C. Lin, F. Yan, G.Q. Yu, M. Rohde, and L. McConlogue TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice Nat Med 7 2001 612 618
    • (2001) Nat Med , vol.7 , pp. 612-618
    • Wyss-Coray, T.1    Lin, C.2    Yan, F.3    Yu, G.Q.4    Rohde, M.5    McConlogue, L.6


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