-
1
-
-
3042857903
-
Alzheimer's disease
-
Cummings JL: Alzheimer's disease. N Engl J Med 2004, 351:56-67
-
(2004)
N Engl J Med
, vol.351
, pp. 56-67
-
-
Cummings, J.L.1
-
2
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe DJ: Alzheimer's disease is a synaptic failure. Science 2002 298:789-791
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
3
-
-
0036454496
-
Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease
-
Morrison JH, Hof PR: Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease. Prog Brain Res 2002, 136:467-486
-
(2002)
Prog Brain Res
, vol.136
, pp. 467-486
-
-
Morrison, J.H.1
Hof, P.R.2
-
4
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
5
-
-
0345276568
-
Synaptic pathology in Alzheimer's disease: A review of ultrastructural studies
-
Scheff SW, Price DA: Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies. Neurobiol Aging 2003, 24:1029-1046
-
(2003)
Neurobiol Aging
, vol.24
, pp. 1029-1046
-
-
Scheff, S.W.1
Price, D.A.2
-
6
-
-
0035433962
-
Alzheimer's disease and Abeta toxicity: From top to bottom
-
Small DH, Mok SS, Bornstein JC: Alzheimer's disease and Abeta toxicity: from top to bottom. Nat Rev Neurosci 2001, 2:595-598
-
(2001)
Nat Rev Neurosci
, vol.2
, pp. 595-598
-
-
Small, D.H.1
Mok, S.S.2
Bornstein, J.C.3
-
7
-
-
0023106967
-
A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease
-
Davies CA, Mann DM, Sumpter PQ, Yates PO: A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease. J Neurol Sci 1987, 78:151-164
-
(1987)
J Neurol Sci
, vol.78
, pp. 151-164
-
-
Davies, C.A.1
Mann, D.M.2
Sumpter, P.Q.3
Yates, P.O.4
-
8
-
-
4544322402
-
The aging brain: Morphomolecular senescence of cortical circuits
-
Hof PR, Morrison JH: The aging brain: morphomolecular senescence of cortical circuits. Trends Neurosci 2004, 27:607-613
-
(2004)
Trends Neurosci
, vol.27
, pp. 607-613
-
-
Hof, P.R.1
Morrison, J.H.2
-
9
-
-
0035933279
-
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice
-
Wirths O, Multhaup G, Czech C, Blanchard V, Moussaoui S, Tremp G, Pradier L, Beyreuther K, Bayer TA: Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci Lett 2001, 306:116-120
-
(2001)
Neurosci Lett
, vol.306
, pp. 116-120
-
-
Wirths, O.1
Multhaup, G.2
Czech, C.3
Blanchard, V.4
Moussaoui, S.5
Tremp, G.6
Pradier, L.7
Beyreuther, K.8
Bayer, T.A.9
-
10
-
-
0036019155
-
Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice
-
Wirths O, Multhaup G, Czech C, Feldmann N, Blanchard V, Tremp G, Beyreuther K, Pradier L, Bayer TA: Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice. Brain Pathol 2002, 12:275-286
-
(2002)
Brain Pathol
, vol.12
, pp. 275-286
-
-
Wirths, O.1
Multhaup, G.2
Czech, C.3
Feldmann, N.4
Blanchard, V.5
Tremp, G.6
Beyreuther, K.7
Pradier, L.8
Bayer, T.A.9
-
11
-
-
0344826476
-
Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice
-
Blanchard V, Moussaoui S, Czech C, Touchet N, Bonici B, Planche M, Canton T, Jedidi I, Gohin M, Wirths O, Bayer TA, Langui D, Duyckaerts C, Tremp G, Pradier L: Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice. Exp Neurol 2003, 184:247-263
-
(2003)
Exp Neurol
, vol.184
, pp. 247-263
-
-
Blanchard, V.1
Moussaoui, S.2
Czech, C.3
Touchet, N.4
Bonici, B.5
Planche, M.6
Canton, T.7
Jedidi, I.8
Gohin, M.9
Wirths, O.10
Bayer, T.A.11
Langui, D.12
Duyckaerts, C.13
Tremp, G.14
Pradier, L.15
-
12
-
-
12144288683
-
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
-
Schmitz C, Rutten BP, Pielen A, Schafer S, Wirths O, Tremp G, Czech C, Blanchard V, Multhaup G, Rezaie P, Korr H, Steinbusch HW, Pradier L, Bayer TA: Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am J Pathol 2004, 164:1495-1502
-
(2004)
Am J Pathol
, vol.164
, pp. 1495-1502
-
-
Schmitz, C.1
Rutten, B.P.2
Pielen, A.3
Schafer, S.4
Wirths, O.5
Tremp, G.6
Czech, C.7
Blanchard, V.8
Multhaup, G.9
Rezaie, P.10
Korr, H.11
Steinbusch, H.W.12
Pradier, L.13
Bayer, T.A.14
-
13
-
-
1642368934
-
Building a more perfect beast: aPP transgenic mice with neuronal loss
-
Dickson DW: Building a more perfect beast: aPP transgenic mice with neuronal loss. Am J Pathol 2004, 164:1143-1146
-
(2004)
Am J Pathol
, vol.164
, pp. 1143-1146
-
-
Dickson, D.W.1
-
14
-
-
7244236841
-
A modified beta-amyloid hypothesis: Intraneuronal accumulation of the beta-amyloid peptide - The first step of a fatal cascade
-
Wirths O, Multhaup G, Bayer TA: A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptidev - the first step of a fatal cascade. J Neurochem 2004, 91:513-520
-
(2004)
J Neurochem
, vol.91
, pp. 513-520
-
-
Wirths, O.1
Multhaup, G.2
Bayer, T.A.3
-
15
-
-
0033793772
-
Synaptic numbers in striatum and cortex of aged rats following perinatal asphyxia: A stereologic and behavioral correlative analysis
-
Van de Berg WDJ, Blokland A, Schmitz C, Cuello AC, Steinbusch HWM, Blanco CE: Synaptic numbers in striatum and cortex of aged rats following perinatal asphyxia: a stereologic and behavioral correlative analysis. J Chem Neuroanat 2000, 20:71-82
-
(2000)
J Chem Neuroanat
, vol.20
, pp. 71-82
-
-
Van De Berg, W.D.J.1
Blokland, A.2
Schmitz, C.3
Cuello, A.C.4
Steinbusch, H.W.M.5
Blanco, C.E.6
-
16
-
-
0344405773
-
No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment
-
Rutten BP, Wirths O, Van de Berg WD, Lichtenthaler SF, Vehoff J, Steinbusch HW, Korr H, Beyreuther K, Multhaup G, Bayer TA, Schmitz C: No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment. Neurobiol Dis 2003, 12:110-120
-
(2003)
Neurobiol Dis
, vol.12
, pp. 110-120
-
-
Rutten, B.P.1
Wirths, O.2
Van De Berg, W.D.3
Lichtenthaler, S.F.4
Vehoff, J.5
Steinbusch, H.W.6
Korr, H.7
Beyreuther, K.8
Multhaup, G.9
Bayer, T.A.10
Schmitz, C.11
-
17
-
-
0024364877
-
Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease
-
Masliah E, Terry RD, DeTeresa RM, Hansen LA: Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease. Neurosci Lett 1989, 103:234-239
-
(1989)
Neurosci Lett
, vol.103
, pp. 234-239
-
-
Masliah, E.1
Terry, R.D.2
DeTeresa, R.M.3
Hansen, L.A.4
-
18
-
-
0031937121
-
Synaptic numbers across cortical laminae and cognitive performance of the rat during ageing
-
Wong TP, Campbell PM, Ribeiro-da-Silva A, Cuello AC: Synaptic numbers across cortical laminae and cognitive performance of the rat during ageing. Neuroscience 1998, 84:403-412
-
(1998)
Neuroscience
, vol.84
, pp. 403-412
-
-
Wong, T.P.1
Campbell, P.M.2
Ribeiro-da-Silva, A.3
Cuello, A.C.4
-
19
-
-
0034279244
-
Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats
-
Smith TD, Adams MM, Gallagher M, Morrison JH, Rapp PR: Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats. J Neurosci 2000, 20:6587-6593
-
(2000)
J Neurosci
, vol.20
, pp. 6587-6593
-
-
Smith, T.D.1
Adams, M.M.2
Gallagher, M.3
Morrison, J.H.4
Rapp, P.R.5
-
20
-
-
0034213718
-
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
-
Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L: High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 2000, 20:4050-4058
-
(2000)
J Neurosci
, vol.20
, pp. 4050-4058
-
-
Mucke, L.1
Masliah, E.2
Yu, G.Q.3
Mallory, M.4
Rockenstein, E.M.5
Tatsuno, G.6
Hu, K.7
Kholodenko, D.8
Johnson-Wood, K.9
McConlogue, L.10
-
21
-
-
0036468268
-
Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: Correlations with cognitive impairment
-
King DL, Arendash GW: Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairment. Brain Res 2002, 926:58-68
-
(2002)
Brain Res
, vol.926
, pp. 58-68
-
-
King, D.L.1
Arendash, G.W.2
-
22
-
-
0033430087
-
Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion
-
Borchardt T, Camakaris J, Cappai R, Masters CL, Beyreuther K, Multhaup G: Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion. Biochem J 1999, 344:461-467
-
(1999)
Biochem J
, vol.344
, pp. 461-467
-
-
Borchardt, T.1
Camakaris, J.2
Cappai, R.3
Masters, C.L.4
Beyreuther, K.5
Multhaup, G.6
-
23
-
-
1542273213
-
Two-photon microscopy for imaging of the (atherosclerotic) vascular wall: A proof of concept study
-
van Zandvoort M, Engels W, Douma K, Beckers L, Oude Egbrink M, Daemen M, Slaaf DW: Two-photon microscopy for imaging of the (atherosclerotic) vascular wall: a proof of concept study. J Vasc Res 2004, 41:54-63
-
(2004)
J Vasc Res
, vol.41
, pp. 54-63
-
-
Van Zandvoort, M.1
Engels, W.2
Douma, K.3
Beckers, L.4
Oude Egbrink, M.5
Daemen, M.6
Slaaf, D.W.7
-
25
-
-
84985280160
-
The efficiency of systematic sampling in stereology and its prediction
-
Gundersen HJ, Jensen EB: The efficiency of systematic sampling in stereology and its prediction. J Microsc 1987, 147:229-263
-
(1987)
J Microsc
, vol.147
, pp. 229-263
-
-
Gundersen, H.J.1
Jensen, E.B.2
-
26
-
-
11844300345
-
Design-based stereology in neuroscience
-
Schmitz C, Hof PR: Design-based stereology in neuroscience. Neuroscience 2004, 130:813-831
-
(2004)
Neuroscience
, vol.130
, pp. 813-831
-
-
Schmitz, C.1
Hof, P.R.2
-
27
-
-
0017119312
-
Precise and general conditions for the validity of a comprehensive set of stereological fundamental formulae
-
Miles RE, Davy PJ: Precise and general conditions for the validity of a comprehensive set of stereological fundamental formulae. J Microsc 1976, 107:211-226
-
(1976)
J Microsc
, vol.107
, pp. 211-226
-
-
Miles, R.E.1
Davy, P.J.2
-
28
-
-
0025002019
-
Alzheimer patients and Down patients: Abnormal presynaptic terminals are related to cerebral preamyloid deposits
-
Bugiani O, Giaccone G, Verga L, Polio B, Ghetti B, Frangione B, Tagliavini F: Alzheimer patients and Down patients: abnormal presynaptic terminals are related to cerebral preamyloid deposits. Neurosci Lett 1990, 119:56-59
-
(1990)
Neurosci Lett
, vol.119
, pp. 56-59
-
-
Bugiani, O.1
Giaccone, G.2
Verga, L.3
Polio, B.4
Ghetti, B.5
Frangione, B.6
Tagliavini, F.7
-
29
-
-
7044220336
-
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
-
Tsai J, Grutzendler J, Duff K, Gan WB: Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat Neurosci 2004, 7:1181-1183
-
(2004)
Nat Neurosci
, vol.7
, pp. 1181-1183
-
-
Tsai, J.1
Grutzendler, J.2
Duff, K.3
Gan, W.B.4
-
30
-
-
2342653632
-
Alzheimer pathology disorganizes cortico-cortical circuitry: Direct evidence from a transgenic animal model
-
Delatour B, Blanchard V, Pradier L, Duyckaerts C: Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model. Neurobiol Dis 2004, 16:41-47
-
(2004)
Neurobiol Dis
, vol.16
, pp. 41-47
-
-
Delatour, B.1
Blanchard, V.2
Pradier, L.3
Duyckaerts, C.4
-
31
-
-
0037450356
-
PDAPP; YFP double transgenic mice: A tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures
-
Brendza RP, O'Brien C, Simmons K, McKeel DW, Bales KR, Paul SM, Olney JW, Sanes JR, Holtzman DM: PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures. J Comp Neurol 2003, 456:375-383
-
(2003)
J Comp Neurol
, vol.456
, pp. 375-383
-
-
Brendza, R.P.1
O'Brien, C.2
Simmons, K.3
McKeel, D.W.4
Bales, K.R.5
Paul, S.M.6
Olney, J.W.7
Sanes, J.R.8
Holtzman, D.M.9
-
32
-
-
0035889404
-
Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42)
-
Rockenstein E, Mallory M, Mante M, Sisk A, Masliaha E: Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42). J Neurosci Res 2001, 66:573-582
-
(2001)
J Neurosci Res
, vol.66
, pp. 573-582
-
-
Rockenstein, E.1
Mallory, M.2
Mante, M.3
Sisk, A.4
Masliaha, E.5
-
33
-
-
0033872024
-
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss
-
Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DM, Hyman BT, Iwatsubo T: Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. Am J Pathol 2000, 157:331-339
-
(2000)
Am J Pathol
, vol.157
, pp. 331-339
-
-
Takeuchi, A.1
Irizarry, M.C.2
Duff, K.3
Saido, T.C.4
Hsiao Ashe, K.5
Hasegawa, M.6
Mann, D.M.7
Hyman, B.T.8
Iwatsubo, T.9
-
34
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
-
Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Burki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B: Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA 1997, 94:13287-13292
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
Wiederhold, K.H.4
Mistl, C.5
Rothacher, S.6
Ledermann, B.7
Burki, K.8
Frey, P.9
Paganetti, P.A.10
Waridel, C.11
Calhoun, M.E.12
Jucker, M.13
Probst, A.14
Staufenbiel, M.15
Sommer, B.16
-
35
-
-
1642578930
-
Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1
-
Boutajangout A, Authelet M, Blanchard V, Touchet N, Tremp G, Pradier L, Brion JP: Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1. Neurobiol Dis 2004, 15:47-60
-
(2004)
Neurobiol Dis
, vol.15
, pp. 47-60
-
-
Boutajangout, A.1
Authelet, M.2
Blanchard, V.3
Touchet, N.4
Tremp, G.5
Pradier, L.6
Brion, J.P.7
-
36
-
-
0033215972
-
Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice
-
Phinney AL, Deller T, Stalder M, Calhoun ME, Frotscher M, Sommer B, Staufenbiel M, Jucker M: Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice. J Neurosci 1999, 19:8552-8559
-
(1999)
J Neurosci
, vol.19
, pp. 8552-8559
-
-
Phinney, A.L.1
Deller, T.2
Stalder, M.3
Calhoun, M.E.4
Frotscher, M.5
Sommer, B.6
Staufenbiel, M.7
Jucker, M.8
-
37
-
-
0037111837
-
Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice
-
Lazarov O, Lee M, Peterson DA, Sisodia SS: Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. J Neurosci 2002, 22:9785-9793
-
(2002)
J Neurosci
, vol.22
, pp. 9785-9793
-
-
Lazarov, O.1
Lee, M.2
Peterson, D.A.3
Sisodia, S.S.4
-
38
-
-
0141957935
-
Alzheimer's disease proteins in cerebellar and hippocampal synapses during postnatal development and aging of the rat
-
Ribaut-Barassin C, Dupont JL, Haeberle AM, Bombarde G, Huber G, Moussaoui S, Mariani J, Bailly Y: Alzheimer's disease proteins in cerebellar and hippocampal synapses during postnatal development and aging of the rat. Neuroscience 2003, 120:405-423
-
(2003)
Neuroscience
, vol.120
, pp. 405-423
-
-
Ribaut-Barassin, C.1
Dupont, J.L.2
Haeberle, A.M.3
Bombarde, G.4
Huber, G.5
Moussaoui, S.6
Mariani, J.7
Bailly, Y.8
-
39
-
-
0033133484
-
No loss of synaptic proteins in the hippocampus of aged, behaviorally impaired rats
-
Nicolle MM, Gallagher M, McKinney M: No loss of synaptic proteins in the hippocampus of aged, behaviorally impaired rats. Neurobiol Aging 1999, 20:343-348
-
(1999)
Neurobiol Aging
, vol.20
, pp. 343-348
-
-
Nicolle, M.M.1
Gallagher, M.2
McKinney, M.3
-
40
-
-
0032459615
-
Hippocampal neuron and synaptophysin-positive bouton number in aging C57BL/6 mice
-
Calhoun ME, Kurth D, Phinney AL, Long JM, Hengemihle J, Mouton PR, Ingram DK, Jucker M: Hippocampal neuron and synaptophysin-positive bouton number in aging C57BL/6 mice. Neurobiol Aging 1998, 19:599-606
-
(1998)
Neurobiol Aging
, vol.19
, pp. 599-606
-
-
Calhoun, M.E.1
Kurth, D.2
Phinney, A.L.3
Long, J.M.4
Hengemihle, J.5
Mouton, P.R.6
Ingram, D.K.7
Jucker, M.8
-
41
-
-
0029924264
-
Neurotrophic and neuroprotective effects of hAPP in transgenic mice
-
Mucke L, Abraham CR, Masliah E: Neurotrophic and neuroprotective effects of hAPP in transgenic mice. Ann NY Acad Sci 1996, 777:82-88
-
(1996)
Ann NY Acad Sci
, vol.777
, pp. 82-88
-
-
Mucke, L.1
Abraham, C.R.2
Masliah, E.3
-
42
-
-
0027970897
-
Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice
-
Mucke L, Masliah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Forss-Petter S, Pietropaolo M, Mallory M, Abraham CR: Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice. Brain Res 1994, 666:151-167
-
(1994)
Brain Res
, vol.666
, pp. 151-167
-
-
Mucke, L.1
Masliah, E.2
Johnson, W.B.3
Ruppe, M.D.4
Alford, M.5
Rockenstein, E.M.6
Forss-Petter, S.7
Pietropaolo, M.8
Mallory, M.9
Abraham, C.R.10
-
43
-
-
0001216824
-
Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes
-
Wong TP, Debeir T, Duff K, Cuello AC: Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes. J Neurosci 1999, 19:2706-2716
-
(1999)
J Neurosci
, vol.19
, pp. 2706-2716
-
-
Wong, T.P.1
Debeir, T.2
Duff, K.3
Cuello, A.C.4
-
44
-
-
0034107615
-
Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice
-
Dodart JC, Mathis C, Saura J, Bales KR, Paul SM, Ungerer A: Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice. Neurobiol Dis 2000, 7:71-85
-
(2000)
Neurobiol Dis
, vol.7
, pp. 71-85
-
-
Dodart, J.C.1
Mathis, C.2
Saura, J.3
Bales, K.R.4
Paul, S.M.5
Ungerer, A.6
-
45
-
-
5744242532
-
Presenilins in memory, Alzheimer's disease, and therapy
-
Marjaux E, Hartmann D, De Strooper B: Presenilins in memory, Alzheimer's disease, and therapy. Neuron 2004, 42:189-192
-
(2004)
Neuron
, vol.42
, pp. 189-192
-
-
Marjaux, E.1
Hartmann, D.2
De Strooper, B.3
-
46
-
-
16044366039
-
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
-
Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin S: Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 1996, 383:710-713
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.N.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
47
-
-
3142512452
-
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration
-
Koo EH, Kopan R: Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nat Med 2004, 10:326-533
-
(2004)
Nat Med
, vol.10
, pp. 326-533
-
-
Koo, E.H.1
Kopan, R.2
-
48
-
-
0036049185
-
Presenilins and APP in neuritic and synaptic plasticity: Implications for the pathogenesis of Alzheimer's disease
-
Chan SL, Furukawa K, Mattson MP: Presenilins and APP in neuritic and synaptic plasticity: implications for the pathogenesis of Alzheimer's disease. Neuromolecular Med 2002, 2:167-196
-
(2002)
Neuromolecular Med
, vol.2
, pp. 167-196
-
-
Chan, S.L.1
Furukawa, K.2
Mattson, M.P.3
-
49
-
-
0042536471
-
Neuronal and glial calcium signaling in Alzheimer's disease
-
Mattson MP, Chan SL: Neuronal and glial calcium signaling in Alzheimer's disease. Cell Calcium 2003, 34:385-397
-
(2003)
Cell Calcium
, vol.34
, pp. 385-397
-
-
Mattson, M.P.1
Chan, S.L.2
-
50
-
-
0037462753
-
Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein
-
Herms J, Schneider I, Dewachter I, Caluwaerts N, Kretzschmar H, Van Leuven F: Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein. J Biol Chem 2003, 278:2484-2489
-
(2003)
J Biol Chem
, vol.278
, pp. 2484-2489
-
-
Herms, J.1
Schneider, I.2
Dewachter, I.3
Caluwaerts, N.4
Kretzschmar, H.5
Van Leuven, F.6
-
51
-
-
0035478721
-
Structural complexity and functional diversity of endoplasmic reticulum Ca(2+) stores
-
Blaustein MP, Golovina VA: Structural complexity and functional diversity of endoplasmic reticulum Ca(2+) stores. Trends Neurosci 2001, 24:602-608
-
(2001)
Trends Neurosci
, vol.24
, pp. 602-608
-
-
Blaustein, M.P.1
Golovina, V.A.2
-
52
-
-
0141987911
-
Flow cytometric analysis of mitochondria from CA1 and CA3 regions of rat hippocampus reveals differences in permeability transition pore activation
-
Mattiasson G, Friberg H, Hansson M, Elmer E, Wieloch T: Flow cytometric analysis of mitochondria from CA1 and CA3 regions of rat hippocampus reveals differences in permeability transition pore activation. J Neurochem 2003, 87:532-544
-
(2003)
J Neurochem
, vol.87
, pp. 532-544
-
-
Mattiasson, G.1
Friberg, H.2
Hansson, M.3
Elmer, E.4
Wieloch, T.5
-
53
-
-
0036014989
-
Oxidative stress in synaptosomal proteins from mutant presenilin-1 knock-in mice: Implications for familial Alzheimer's disease
-
LaFontaine MA, Mattson MP, Butterfield DA: Oxidative stress in synaptosomal proteins from mutant presenilin-1 knock-in mice: implications for familial Alzheimer's disease. Neurochem Res 2002, 27:417-421
-
(2002)
Neurochem Res
, vol.27
, pp. 417-421
-
-
LaFontaine, M.A.1
Mattson, M.P.2
Butterfield, D.A.3
-
54
-
-
0032972922
-
Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice
-
Begley JG, Duan W, Chan S, Duff K, Mattson MP: Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. J Neurochem 1999, 72:1030-1039
-
(1999)
J Neurochem
, vol.72
, pp. 1030-1039
-
-
Begley, J.G.1
Duan, W.2
Chan, S.3
Duff, K.4
Mattson, M.P.5
-
55
-
-
0038118207
-
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
-
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J: Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci 2003, 23:4499-4508
-
(2003)
J Neurosci
, vol.23
, pp. 4499-4508
-
-
Pigino, G.1
Morfini, G.2
Pelsman, A.3
Mattson, M.P.4
Brady, S.T.5
Busciglio, J.6
-
56
-
-
0036469290
-
Glycogen synthase kinase-3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility
-
Morfini G, Szebenyi G, Elluru R, Ratner N, Brady ST: Glycogen synthase kinase-3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. EMBO J 2002, 21:281-293
-
(2002)
EMBO J
, vol.21
, pp. 281-293
-
-
Morfini, G.1
Szebenyi, G.2
Elluru, R.3
Ratner, N.4
Brady, S.T.5
-
57
-
-
0036234543
-
NFAT signaling: Choreographing the social lives of cells
-
Crabtree GR, Olson EN: NFAT signaling: choreographing the social lives of cells. Cell 2002, 109:367-379
-
(2002)
Cell
, vol.109
, pp. 367-379
-
-
Crabtree, G.R.1
Olson, E.N.2
-
58
-
-
0037146553
-
Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage
-
Kim DY, Ingano LA, Kovacs DM: Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage. J Biol Chem 2002, 277:49976-49981
-
(2002)
J Biol Chem
, vol.277
, pp. 49976-49981
-
-
Kim, D.Y.1
Ingano, L.A.2
Kovacs, D.M.3
-
59
-
-
0033401526
-
Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts
-
Georgakopoulos A, Marambaud P, Efthimiopoulos S, Shioi J, Cui W, Li HC, Schutte M, Gordon R, Holstein GR, Martinelli G, Mehta P, Friedrich VL Jr, Robakis NK: Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Mol Cell 1999, 4:893-902
-
(1999)
Mol Cell
, vol.4
, pp. 893-902
-
-
Georgakopoulos, A.1
Marambaud, P.2
Efthimiopoulos, S.3
Shioi, J.4
Cui, W.5
Li, H.C.6
Schutte, M.7
Gordon, R.8
Holstein, G.R.9
Martinelli, G.10
Mehta, P.11
Friedrich Jr., V.L.12
Robakis, N.K.13
-
60
-
-
4043052896
-
Identification of the role of presenilins beyond Alzheimer's disease
-
Thinakaran G, Parent AT: Identification of the role of presenilins beyond Alzheimer's disease. Pharmacol Res 2004, 50:411-418
-
(2004)
Pharmacol Res
, vol.50
, pp. 411-418
-
-
Thinakaran, G.1
Parent, A.T.2
-
61
-
-
2942653014
-
Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis
-
Wang R, Dineley KT, Sweatt JD, Zheng H: Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis. Neuroscience 2004, 126:305-312
-
(2004)
Neuroscience
, vol.126
, pp. 305-312
-
-
Wang, R.1
Dineley, K.T.2
Sweatt, J.D.3
Zheng, H.4
-
62
-
-
0033637232
-
Familial Alzheimer's disease presenilin-1 mutants potentiate cell cycle arrest
-
Janicki SM, Stabler SM, Monteiro MJ: Familial Alzheimer's disease presenilin-1 mutants potentiate cell cycle arrest. Neurobiol Aging 2000, 21:829-836
-
(2000)
Neurobiol Aging
, vol.21
, pp. 829-836
-
-
Janicki, S.M.1
Stabler, S.M.2
Monteiro, M.J.3
-
63
-
-
21244460664
-
Age-related early hippocampal neuron loss in a novel transgenic/knock-in mouse model of AD
-
Van der Kolk N, van de Steeg E, Rutten BPF, Wirths O, Blanchard V, Itier J, Tremp G, Steinbusch HWM, Pradier L, Bayer TA, Schmitz C: Age-related early hippocampal neuron loss in a novel transgenic/knock-in mouse model of AD. Soc Neurosci Abstr 2004, 338:4
-
(2004)
Soc Neurosci Abstr
, vol.338
, pp. 4
-
-
Van Der Kolk, N.1
Van De Steeg, E.2
Rutten, B.P.F.3
Wirths, O.4
Blanchard, V.5
Itier, J.6
Tremp, G.7
Steinbusch, H.W.M.8
Pradier, L.9
Bayer, T.A.10
Schmitz, C.11
-
64
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
-
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM: Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular-Abeta and synaptic dysfunction. Neuron 2003, 39:409-421
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
LaFerla, F.M.10
-
65
-
-
0032888131
-
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
-
Lue LF, Kuo YM, Roher AE, Brachova L, Shen Y, Sue L, Beach T, Kurth JH, Rydel RE, Rogers J: Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 1999, 155:853-862
-
(1999)
Am J Pathol
, vol.155
, pp. 853-862
-
-
Lue, L.F.1
Kuo, Y.M.2
Roher, A.E.3
Brachova, L.4
Shen, Y.5
Sue, L.6
Beach, T.7
Kurth, J.H.8
Rydel, R.E.9
Rogers, J.10
-
66
-
-
5344277556
-
Deciphering the molecular basis of memory failure in Alzheimer's disease
-
Walsh DM, Selkoe DJ: Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 2004, 44:181-193
-
(2004)
Neuron
, vol.44
, pp. 181-193
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
67
-
-
0037884977
-
Synaptic plasticity in animal models of early Alzheimer's disease
-
Rowan MJ, Klyubin I, Cullen WK, Anwyl R: Synaptic plasticity in animal models of early Alzheimer's disease. Philos Trans R Soc Lond B Biol Sci 2003, 358:821-828
-
(2003)
Philos Trans R Soc Lond B Biol Sci
, vol.358
, pp. 821-828
-
-
Rowan, M.J.1
Klyubin, I.2
Cullen, W.K.3
Anwyl, R.4
-
68
-
-
0035297712
-
Targeting small Abeta oligomers: The solution to an Alzheimer's disease conundrum?
-
Klein WL, Krafft GA, Finch CE: Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? Trends Neurosci 2001, 24:219-224
-
(2001)
Trends Neurosci
, vol.24
, pp. 219-224
-
-
Klein, W.L.1
Krafft, G.A.2
Finch, C.E.3
-
69
-
-
2342486529
-
Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: Digital morphometric analyses
-
Wu CC, Chawla F, Games D, Rydel RE, Freedman S, Schenk D, Young WG, Morrison JH, Bloom FE: Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses. Proc Natl Acad Sci USA 2004, 101:7141-7146
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 7141-7146
-
-
Wu, C.C.1
Chawla, F.2
Games, D.3
Rydel, R.E.4
Freedman, S.5
Schenk, D.6
Young, W.G.7
Morrison, J.H.8
Bloom, F.E.9
-
70
-
-
4644276796
-
Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model
-
Casas C, Sergeant N, Itier JM, Blanchard V, Wirths O, van der Kolk N, Vingtdeux V, van de Steeg E, Ret G, Canton T, Drobecq H, Clark A, Bonici B, Delacourte A, Benavides J, Schmitz C, Tremp G, Bayer TA, Benoit P, Pradier L: Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am J Pathol 2004, 165:1289-1300
-
(2004)
Am J Pathol
, vol.165
, pp. 1289-1300
-
-
Casas, C.1
Sergeant, N.2
Itier, J.M.3
Blanchard, V.4
Wirths, O.5
Van Der Kolk, N.6
Vingtdeux, V.7
Van De Steeg, E.8
Ret, G.9
Canton, T.10
Drobecq, H.11
Clark, A.12
Bonici, B.13
Delacourte, A.14
Benavides, J.15
Schmitz, C.16
Tremp, G.17
Bayer, T.A.18
Benoit, P.19
Pradier, L.20
more..
-
71
-
-
1842732209
-
Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain
-
Takahashi RH, Almeida CG, Kearney PF, Yu F, Lin MT, Milner TA, Gouras GK: Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain. J Neurosci 2004, 24:3592-3599
-
(2004)
J Neurosci
, vol.24
, pp. 3592-3599
-
-
Takahashi, R.H.1
Almeida, C.G.2
Kearney, P.F.3
Yu, F.4
Lin, M.T.5
Milner, T.A.6
Gouras, G.K.7
-
72
-
-
0006300658
-
Microglia, amyloid and dementia in Alzheimer's disease: A correlative study
-
Arends YM, Duyckaerts C, Rozemuller JM, Eikelenboom P, Hauw JJ: Microglia, amyloid and dementia in Alzheimer's disease: a correlative study. Neurobiol Aging 2000, 21:39-47
-
(2000)
Neurobiol Aging
, vol.21
, pp. 39-47
-
-
Arends, Y.M.1
Duyckaerts, C.2
Rozemuller, J.M.3
Eikelenboom, P.4
Hauw, J.J.5
-
73
-
-
0035845283
-
In-vivo measurement of microglia in dementia
-
Cagnin A, Brooks DJ, Kennedy AM, Gunn RN, Myers R, Turkheimer FE, Jones T, Banati RB: In-vivo measurement of microglia in dementia. Lancet 2000, 358:461-467
-
(2000)
Lancet
, vol.358
, pp. 461-467
-
-
Cagnin, A.1
Brooks, D.J.2
Kennedy, A.M.3
Gunn, R.N.4
Myers, R.5
Turkheimer, F.E.6
Jones, T.7
Banati, R.B.8
-
74
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
-
Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS: Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 1996, 17:1005-1013
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
75
-
-
16944365745
-
Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins
-
Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ: Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J Biol Chem 1997, 272:7977-7982
-
(1997)
J Biol Chem
, vol.272
, pp. 7977-7982
-
-
Xia, W.1
Zhang, J.2
Kholodenko, D.3
Citron, M.4
Podlisny, M.B.5
Teplow, D.B.6
Haass, C.7
Seubert, P.8
Koo, E.H.9
Selkoe, D.J.10
-
76
-
-
0036548070
-
gamma-Secretase, Notch, Abeta and Alzheimer's disease: Where do the presenilins fit in?
-
Sisodia SS, St George-Hyslop PH: gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat Rev Neurosci 2002, 3:281-290
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 281-290
-
-
Sisodia, S.S.1
St George-Hyslop, P.H.2
-
77
-
-
0028801680
-
Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease
-
Heinonen O, Soininen H, Sorvari H, Kosunen O, Paljarvi L, Koivisto E, Riekkinen PJ Sr: Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease. Neuroscience 1995, 64:375-384
-
(1995)
Neuroscience
, vol.64
, pp. 375-384
-
-
Heinonen, O.1
Soininen, H.2
Sorvari, H.3
Kosunen, O.4
Paljarvi, L.5
Koivisto, E.6
Riekkinen Sr., P.J.7
-
78
-
-
0028989895
-
Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease
-
Callahan LM, Coleman PD: Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease. Neurobiol Aging 1995, 16:311-314
-
(1995)
Neurobiol Aging
, vol.16
, pp. 311-314
-
-
Callahan, L.M.1
Coleman, P.D.2
-
79
-
-
0033025080
-
Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles
-
Callahan LM, Vaules WA, Coleman PD: Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles. J Neuropathol Exp Neural 1999, 58:275-287
-
(1999)
J Neuropathol Exp Neural
, vol.58
, pp. 275-287
-
-
Callahan, L.M.1
Vaules, W.A.2
Coleman, P.D.3
-
80
-
-
0036098423
-
Progressive reduction of synaptophysin message in single neurons in Alzheimer disease
-
Callahan LM, Vaules WA, Coleman PD: Progressive reduction of synaptophysin message in single neurons in Alzheimer disease. J Neuropathol Exp Neurol 2002, 61:384-395
-
(2002)
J Neuropathol Exp Neurol
, vol.61
, pp. 384-395
-
-
Callahan, L.M.1
Vaules, W.A.2
Coleman, P.D.3
-
81
-
-
0036955813
-
Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation
-
Kril JJ, Patel S, Harding AJ, Halliday GM: Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation. Acta Neuropathol 2002, 103:370-376
-
(2002)
Acta Neuropathol
, vol.103
, pp. 370-376
-
-
Kril, J.J.1
Patel, S.2
Harding, A.J.3
Halliday, G.M.4
-
82
-
-
0025863618
-
Neuropathological staging of Alzheimer-related changes
-
Braak H, Braak E: Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 1991, 82:239-259
-
(1991)
Acta Neuropathol
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
|