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Volumn 500, Issue 2, 2007, Pages 311-321

Spatial relationship between synapse loss and β-amyloid deposition in Tg2576 mice

Author keywords

amyloid; Alzheimer's disease; Synapse; Synaptophysin; Tg2576 mice

Indexed keywords

BETA AMYLASE; SYNAPTOPHYSIN;

EID: 33845565678     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.21176     Document Type: Article
Times cited : (128)

References (73)
  • 1
    • 0026609559 scopus 로고
    • Alternative excitotoxic hypotheses
    • Albin RL, Greenamyre JT. 1992. Alternative excitotoxic hypotheses. Neurology 42:733-738.
    • (1992) Neurology , vol.42 , pp. 733-738
    • Albin, R.L.1    Greenamyre, J.T.2
  • 2
    • 0029064090 scopus 로고
    • Damage limited to the hippocampal region produces long-lasting memory impairment in monkeys
    • Alvarez P, Zola-Morgan S, Squire LR. 1995. Damage limited to the hippocampal region produces long-lasting memory impairment in monkeys. J Neurosci 15:3796-3807.
    • (1995) J Neurosci , vol.15 , pp. 3796-3807
    • Alvarez, P.1    Zola-Morgan, S.2    Squire, L.R.3
  • 4
    • 11144294809 scopus 로고    scopus 로고
    • Impaired Pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene
    • Barnes P, Good M. 2005. Impaired Pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene. Behav Brain Res 157:107-117.
    • (2005) Behav Brain Res , vol.157 , pp. 107-117
    • Barnes, P.1    Good, M.2
  • 5
    • 0026672363 scopus 로고
    • Early postnatal alcohol exposure acutely and permanently reduces the number of granule cells and mitral cells in the rat olfactory bulb: A stereological study
    • Bonthius DJ, Bonthius NE, Napper RM, West JR. 1992. Early postnatal alcohol exposure acutely and permanently reduces the number of granule cells and mitral cells in the rat olfactory bulb: a stereological study. J Comp Neurol 324:557-566.
    • (1992) J Comp Neurol , vol.324 , pp. 557-566
    • Bonthius, D.J.1    Bonthius, N.E.2    Napper, R.M.3    West, J.R.4
  • 6
    • 7444244454 scopus 로고    scopus 로고
    • Use of frozen sections to determine neuronal number in the murine hippocampus and neocortex using the optical disector and optical fractionator
    • Bonthius DJ, McKim R, Koele L, Harb H, Karacay B, Mahoney J, Pantazis NJ. 2004. Use of frozen sections to determine neuronal number in the murine hippocampus and neocortex using the optical disector and optical fractionator. Brain Res Brain Res Protoc 14:45-57.
    • (2004) Brain Res Brain Res Protoc , vol.14 , pp. 45-57
    • Bonthius, D.J.1    McKim, R.2    Koele, L.3    Harb, H.4    Karacay, B.5    Mahoney, J.6    Pantazis, N.J.7
  • 7
    • 5344246875 scopus 로고    scopus 로고
    • Entorhinal cortex lesions disrupt the relational organization of memory in monkeys
    • Buckmaster CA, Eichenbaum H, Amaral DG, Suzuki WA, Rapp PR. 2004. Entorhinal cortex lesions disrupt the relational organization of memory in monkeys. J Neurosci 24:9811-9825.
    • (2004) J Neurosci , vol.24 , pp. 9811-9825
    • Buckmaster, C.A.1    Eichenbaum, H.2    Amaral, D.G.3    Suzuki, W.A.4    Rapp, P.R.5
  • 11
    • 0030513943 scopus 로고    scopus 로고
    • Structural correlates of cognition in dementia: Quantification and assessment of synapse change
    • DeKosky ST, Scheff SW Styren SD. 1996. Structural correlates of cognition in dementia: quantification and assessment of synapse change. Neurodegeneration 5:417-421.
    • (1996) Neurodegeneration , vol.5 , pp. 417-421
    • DeKosky, S.T.1    Scheff, S.W.2    Styren, S.D.3
  • 13
    • 14944385354 scopus 로고    scopus 로고
    • Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors
    • Floden AM, Li S, Combs CK. 2005. Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors. J Neurosci 25:2566-2575.
    • (2005) J Neurosci , vol.25 , pp. 2566-2575
    • Floden, A.M.1    Li, S.2    Combs, C.K.3
  • 14
    • 0031673212 scopus 로고    scopus 로고
    • An overview of the etiology, diagnosis, and treatment of Alzheimer disease
    • Forsyth E, Ritzline PD. 1998. An overview of the etiology, diagnosis, and treatment of Alzheimer disease. Phys Ther 78:1325-1331.
    • (1998) Phys Ther , vol.78 , pp. 1325-1331
    • Forsyth, E.1    Ritzline, P.D.2
  • 16
    • 0030713391 scopus 로고    scopus 로고
    • Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys
    • Gazzaley AH, Thakker MM, Hof PR, Morrison JH. 1997. Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys. Neurobiol Aging 18:549-653.
    • (1997) Neurobiol Aging , vol.18 , pp. 549-653
    • Gazzaley, A.H.1    Thakker, M.M.2    Hof, P.R.3    Morrison, J.H.4
  • 18
    • 0042838303 scopus 로고    scopus 로고
    • Alzheimer's disease-affected brain: Presence of oligomeric a beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    • Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA, Klein WL, 2003. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci U S A 100:10417-10422.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10417-10422
    • Gong, Y.1    Chang, L.2    Viola, K.L.3    Lacor, P.N.4    Lambert, M.P.5    Finch, C.E.6    Krafft, G.A.7    Klein, W.L.8
  • 19
    • 84985280160 scopus 로고
    • The efficiency of systematic sampling in stereology and its prediction
    • Gundersen HJ, Jensen EB. 1987. The efficiency of systematic sampling in stereology and its prediction. J Microsc 147:229-263.
    • (1987) J Microsc , vol.147 , pp. 229-263
    • Gundersen, H.J.1    Jensen, E.B.2
  • 20
    • 0026569388 scopus 로고
    • An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease
    • Guntern R, Bouras C, Hof PR, Vallet PG. 1992. An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease. Experientia 48:8-10.
    • (1992) Experientia , vol.48 , pp. 8-10
    • Guntern, R.1    Bouras, C.2    Hof, P.R.3    Vallet, P.G.4
  • 21
    • 0025959301 scopus 로고
    • Transgene detection in unpurified mouse tail DNA by polymerase chain reaction
    • Hanley T, Merlie JP. 1991. Transgene detection in unpurified mouse tail DNA by polymerase chain reaction. Biotechniques 10:56.
    • (1991) Biotechniques , vol.10 , pp. 56
    • Hanley, T.1    Merlie, J.P.2
  • 22
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. 2002: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 24
    • 0031772223 scopus 로고    scopus 로고
    • Strain dependent and invariant features of transgenic mice expression Alzheimer amyloid precursor proteins
    • Hsiao K. 1998. Strain dependent and invariant features of transgenic mice expression Alzheimer amyloid precursor proteins. Prog Brain Res 117: 335-341.
    • (1998) Prog Brain Res , vol.117 , pp. 335-341
    • Hsiao, K.1
  • 25
    • 0035674312 scopus 로고    scopus 로고
    • Learning and memory in transgenic mice modeling Alzheimer's disease
    • Hsiao K. 2001. Learning and memory in transgenic mice modeling Alzheimer's disease. Learn Mem 8:301-308.
    • (2001) Learn Mem , vol.8 , pp. 301-308
    • Hsiao, K.1
  • 28
    • 3042693940 scopus 로고    scopus 로고
    • Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease
    • Hynd MR, Scott HL, Dodd PR. 2004. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease. Neurochem Int 45:583-595.
    • (2004) Neurochem Int , vol.45 , pp. 583-595
    • Hynd, M.R.1    Scott, H.L.2    Dodd, P.R.3
  • 29
    • 0030612033 scopus 로고    scopus 로고
    • APPsw transgenic mice develop age-related Ap deposits and neuropil abnormalities, but no neuronal loss in CA1
    • Irizarry M, McNamara M, Fedorchak K, Hsiao K, Hyman BT. 1997. APPsw transgenic mice develop age-related Ap deposits and neuropil abnormalities, but no neuronal loss in CA1. J Neuropathol Exp Neurol 56:965-973.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 965-973
    • Irizarry, M.1    McNamara, M.2    Fedorchak, K.3    Hsiao, K.4    Hyman, B.T.5
  • 30
    • 20444448593 scopus 로고    scopus 로고
    • Quantification of neurons expressing androgen receptor and volume estimation of the basolateral nuclear group of the canine amygdaloid body
    • Jacobs C, Van Den Broeck W, Simoens P. 2005. Quantification of neurons expressing androgen receptor and volume estimation of the basolateral nuclear group of the canine amygdaloid body. Brain Res Brain Res Protoc 15:92-104.
    • (2005) Brain Res Brain Res Protoc , vol.15 , pp. 92-104
    • Jacobs, C.1    Van Den Broeck, W.2    Simoens, P.3
  • 32
    • 0034721678 scopus 로고    scopus 로고
    • Signal-processing machines at the postsynaptic density
    • Kennedy MB. 2000. Signal-processing machines at the postsynaptic density. Science 290:750-754.
    • (2000) Science , vol.290 , pp. 750-754
    • Kennedy, M.B.1
  • 33
    • 0036468268 scopus 로고    scopus 로고
    • Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: Correlations with cognitive impairment
    • King DL, Arendash GW. 2002. Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairment. Brain Res 926:58-68.
    • (2002) Brain Res , vol.926 , pp. 58-68
    • King, D.L.1    Arendash, G.W.2
  • 34
    • 0026583442 scopus 로고
    • Normal anatomy and neurophysiology of the hippocampal formation
    • Knowles WD. 1992. Normal anatomy and neurophysiology of the hippocampal formation. J Clin Neurophysiol 9:252-263.
    • (1992) J Clin Neurophysiol , vol.9 , pp. 252-263
    • Knowles, W.D.1
  • 35
    • 0031593784 scopus 로고    scopus 로고
    • Abeta associated neuropil changes: Correlation with neuronal loss and dementia
    • Knowles RB, Gomez-Isla T, Hyman BT. 1998. Abeta associated neuropil changes: correlation with neuronal loss and dementia. J Neuropathol Exp Neurol 57:1122-1130.
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 1122-1130
    • Knowles, R.B.1    Gomez-Isla, T.2    Hyman, B.T.3
  • 36
    • 11844300395 scopus 로고    scopus 로고
    • Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain
    • Kokubo H, Kayed R, Glabe CG, Yamaguchi H. 2005. Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain. Brain Res 1031: 222-228.
    • (2005) Brain Res , vol.1031 , pp. 222-228
    • Kokubo, H.1    Kayed, R.2    Glabe, C.G.3    Yamaguchi, H.4
  • 38
    • 0043095312 scopus 로고    scopus 로고
    • Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype
    • Lanz TA, Carter DB, Merchant KM. 2003. Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype. Neurobiol Dis 13:246-253.
    • (2003) Neurobiol Dis , vol.13 , pp. 246-253
    • Lanz, T.A.1    Carter, D.B.2    Merchant, K.M.3
  • 40
    • 0034861742 scopus 로고    scopus 로고
    • Inhibitory synapse cover on the somata of excitatory neurons in macaque monkey visual cortex
    • Lund JS, Griffiths S, Rumberger A, Levitt JB. 2001. Inhibitory synapse cover on the somata of excitatory neurons in macaque monkey visual cortex. Cereb Cortex 11:783-795.
    • (2001) Cereb Cortex , vol.11 , pp. 783-795
    • Lund, J.S.1    Griffiths, S.2    Rumberger, A.3    Levitt, J.B.4
  • 41
    • 0030779677 scopus 로고    scopus 로고
    • Cellular actions of beta-amyloid precursor protein and its soluble fibrillogenic derivatives
    • Mattson MP. 1997. Cellular actions of beta-amyloid precursor protein and its soluble fibrillogenic derivatives. Physiol Rev 77:1081-1132.
    • (1997) Physiol Rev , vol.77 , pp. 1081-1132
    • Mattson, M.P.1
  • 42
    • 0037444553 scopus 로고    scopus 로고
    • In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy
    • McLellan ME, Kajdasz ST, Hyman BT, Bacskai BJ. 2003. In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy. J Neurosci 23:2212-2217.
    • (2003) J Neurosci , vol.23 , pp. 2212-2217
    • McLellan, M.E.1    Kajdasz, S.T.2    Hyman, B.T.3    Bacskai, B.J.4
  • 45
    • 0036166948 scopus 로고    scopus 로고
    • The mRNA of the NR1 subtype of glutamate receptor in Alzheimer's disease
    • Panegyres PK, Zafiris-Toufexis K, Kakulas BA. 2002. The mRNA of the NR1 subtype of glutamate receptor in Alzheimer's disease. J Neural Transm 109:77-89.
    • (2002) J Neural Transm , vol.109 , pp. 77-89
    • Panegyres, P.K.1    Zafiris-Toufexis, K.2    Kakulas, B.A.3
  • 46
    • 0022558388 scopus 로고
    • New perspectives on Alzheimer's disease
    • Price D. 1986. New perspectives on Alzheimer's disease. Annu Rev Neurosci 9:489-512.
    • (1986) Annu Rev Neurosci , vol.9 , pp. 489-512
    • Price, D.1
  • 47
    • 0032989712 scopus 로고    scopus 로고
    • Tangles and plaques in nondemented aging and preclinical Alzheimer's disease
    • Price JL, Morris JC. 1999. Tangles and plaques in nondemented aging and preclinical Alzheimer's disease. Ann Neurol 45:358-368.
    • (1999) Ann Neurol , vol.45 , pp. 358-368
    • Price, J.L.1    Morris, J.C.2
  • 48
  • 49
    • 0032926449 scopus 로고    scopus 로고
    • No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice
    • Phinney AL, Calhoun ME, Wolfer DP, Lipp HP, Zheng H, Jucker M. 1999. No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice. Neuroscience 90:1207-1216.
    • (1999) Neuroscience , vol.90 , pp. 1207-1216
    • Phinney, A.L.1    Calhoun, M.E.2    Wolfer, D.P.3    Lipp, H.P.4    Zheng, H.5    Jucker, M.6
  • 51
    • 30644475475 scopus 로고    scopus 로고
    • Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses
    • Roselli F, Tirard M, Lu J, Hutzler P, Lamberti P, Livrea P, Morabito M, Almeida OF. 2005. Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses. J Neurosci 30:11061-11070.
    • (2005) J Neurosci , vol.30 , pp. 11061-11070
    • Roselli, F.1    Tirard, M.2    Lu, J.3    Hutzler, P.4    Lamberti, P.5    Livrea, P.6    Morabito, M.7    Almeida, O.F.8
  • 52
    • 21244480573 scopus 로고    scopus 로고
    • Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice
    • Rutten BP, Van der Kolk NM, Schafer S, van Zandvoort MA, Bayer TA, Steinbusch HW, Schmitz C. 2005. Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice. Am J Pathol 167:161-173.
    • (2005) Am J Pathol , vol.167 , pp. 161-173
    • Rutten, B.P.1    Van Der Kolk, N.M.2    Schafer, S.3    Van Zandvoort, M.A.4    Bayer, T.A.5    Steinbusch, H.W.6    Schmitz, C.7
  • 53
    • 0029793008 scopus 로고    scopus 로고
    • Quantitative assessment of synaptic density in the outer molecular layer of the hippocampal dentate gyrus in Alzheimer's disease
    • Scheff SW, Sparks DL, Price DA. 1996. Quantitative assessment of synaptic density in the outer molecular layer of the hippocampal dentate gyrus in Alzheimer's disease. Dementia 7:226-232.
    • (1996) Dementia , vol.7 , pp. 226-232
    • Scheff, S.W.1    Sparks, D.L.2    Price, D.A.3
  • 54
    • 0025753852 scopus 로고
    • Alzheimer's disease. In the beginning
    • Selkoe DJ. 1991. Alzheimer's disease. In the beginning. Neuron 6:487-498.
    • (1991) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.J.1
  • 56
    • 23444448170 scopus 로고    scopus 로고
    • Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
    • Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, Bacskai BJ, Hyman BT. 2005. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci 25:7278-7287.
    • (2005) J Neurosci , vol.25 , pp. 7278-7287
    • Spires, T.L.1    Meyer-Luehmann, M.2    Stern, E.A.3    McLean, P.J.4    Skoch, J.5    Nguyen, P.T.6    Bacskai, B.J.7    Hyman, B.T.8
  • 58
    • 0032527597 scopus 로고    scopus 로고
    • Selective deposition of amyloid-β protein in the entorhinal-dentate projection of a transgenic mouse model of Alzheimer's disease
    • Su Y, Ni B. 1998. Selective deposition of amyloid-β protein in the entorhinal-dentate projection of a transgenic mouse model of Alzheimer's disease. J Neurosci Res 53:177-186.
    • (1998) J Neurosci Res , vol.53 , pp. 177-186
    • Su, Y.1    Ni, B.2
  • 59
    • 1842732209 scopus 로고    scopus 로고
    • Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain
    • Takahashi RH, Almeida CG, Kearney PF, Yu F, Lin MT, Milner TA, Gouras GK. 2004. Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain. J Neurosci 24:3592-3599.
    • (2004) J Neurosci , vol.24 , pp. 3592-3599
    • Takahashi, R.H.1    Almeida, C.G.2    Kearney, P.F.3    Yu, F.4    Lin, M.T.5    Milner, T.A.6    Gouras, G.K.7
  • 60
    • 0033872024 scopus 로고    scopus 로고
    • Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss
    • Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DM, Hyman BT, Iwatsubo T. 2000. Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. Am J Pathol 157:331-339.
    • (2000) Am J Pathol , vol.157 , pp. 331-339
    • Takeuchi, A.1    Irizarry, M.C.2    Duff, K.3    Saido, T.C.4    Hsiao Ashe, K.5    Hasegawa, M.6    Mann, D.M.7    Hyman, B.T.8    Iwatsubo, T.9
  • 62
    • 33645505550 scopus 로고    scopus 로고
    • Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: A potent role for trimers
    • Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. 2006. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol 572:477-492.
    • (2006) J Physiol , vol.572 , pp. 477-492
    • Townsend, M.1    Shankar, G.M.2    Mehta, T.3    Walsh, D.M.4    Selkoe, D.J.5
  • 63
    • 7044220336 scopus 로고    scopus 로고
    • Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
    • Tsai J, Grutzendler J, Duff K, Gan WB. 2004. Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat Neurosci 7:1181-1183.
    • (2004) Nat Neurosci , vol.7 , pp. 1181-1183
    • Tsai, J.1    Grutzendler, J.2    Duff, K.3    Gan, W.B.4
  • 64
    • 19344374239 scopus 로고    scopus 로고
    • Beta-Amyloid peptides impair PKC-dependent functions of metabotropic glutamate receptors in prefrontal cortical neurons
    • Tyszkiewicz JP, Yan Z. 2005. beta-Amyloid peptides impair PKC-dependent functions of metabotropic glutamate receptors in prefrontal cortical neurons. J Neurophysiol 93:3102-3111.
    • (2005) J Neurophysiol , vol.93 , pp. 3102-3111
    • Tyszkiewicz, J.P.1    Yan, Z.2
  • 68
    • 0023756223 scopus 로고
    • Antibodies against GABA and glutamate label neurons with morphologically distinct synaptic vesicles in the locust central nervous system
    • Watson AH. 1988. Antibodies against GABA and glutamate label neurons with morphologically distinct synaptic vesicles in the locust central nervous system. Neuroscience 26:33-44.
    • (1988) Neuroscience , vol.26 , pp. 33-44
    • Watson, A.H.1
  • 70
    • 0025327731 scopus 로고
    • Unbiased stereological estimation of the number of neurons in the human hippocampus
    • West MJ, Gundersen HJ. 1990. Unbiased stereological estimation of the number of neurons in the human hippocampus. J Comp Neurol 296:1-22.
    • (1990) J Comp Neurol , vol.296 , pp. 1-22
    • West, M.J.1    Gundersen, H.J.2
  • 71
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
    • West MJ, Slomianka L, Gundersen HJ. 1991. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231:482-497.
    • (1991) Anat Rec , vol.231 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.3
  • 72
    • 0022391791 scopus 로고
    • Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles
    • Wiedenmann B, Franke WW. 1985. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell 41:1017-1028.
    • (1985) Cell , vol.41 , pp. 1017-1028
    • Wiedenmann, B.1    Franke, W.W.2


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