Second generation S1P pathway modulators: Research strategies and clinical developments

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1841, Issue 5, 2014, Pages 745-758

  Bigaud, Marc ^a   Guerini, Danilo ^a   Billich, Andreas ^a   Bassilana, Frederic ^a   Brinkmann, Volker ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Fingolimod; Immunomodulator; S1P modulator; S1P1

Indexed keywords

2 AMINO 2 [2 [4 (3 BENZYLOXYPHENYLTHIO) 2 CHLOROPHENYL]ETHYL] 1,3 PROPANEDIOL; BIOLOGICAL MARKER; CS 0777; ENZYME INHIBITOR; FINGOLIMOD; GSK 2018682; IMMUNOSUPPRESSIVE AGENT; LIPOPROTEIN RECEPTOR; ONO 4641; PONESIMOD; RECEPTOR SUBTYPE; RPC 1063; SIPONIMOD; SPHINGOMAB; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTHRITIS; ASTROCYTE; ASTROCYTOSIS; BLOOD BRAIN BARRIER; BLOOD PRESSURE; BRAIN ATROPHY; CLINICAL TRIAL; CLINICAL TRIAL (TOPIC); DRUG BINDING; DRUG RECEPTOR BINDING; ENDOTHELIUM; HEART RATE; HOMEOSTASIS; HUMAN; INFLAMMATION; LYMPHOCYTE; MODULATION; MULTIPLE SCLEROSIS; NERVE CELL; NERVE CONDUCTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECURRENT DISEASE; REMYELINIZATION; REVIEW; T LYMPHOCYTE; VASCULAR ENDOTHELIUM;

ANIMALIA;

FINGOLIMOD; IMMUNOMODULATOR; S1P MODULATOR; S1P1;

BIOMEDICAL RESEARCH; CLINICAL MEDICINE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYSOPHOSPHOLIPIDS; PROPYLENE GLYCOLS; RECEPTORS, LYSOSPHINGOLIPID; RESEARCH DESIGN; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 84897954440     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2013.11.001     Document Type: Review

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