Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: Consequences for mode of action in multiple sclerosis

Journal of Pharmacology and Experimental Therapeutics

Volumn 323, Issue 2, 2007, Pages 469-476

  Foster, Carolyn A ^a   Howard, Laurence M ^a   Schweitzer, Alain ^b   Persohn, Elke ^c   Hiestand, Peter C ^b   Balatoni, Balázs ^a,d   Reuschel, Roland ^a   Beerli, Christian ^b   Schwartz, Manuela ^a,e   Billich, Andreas ^a  

^a Novartis Institutes for BioMedical Research Vienna   (Austria)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Novartis Pharma AG   (Switzerland)

^d Novartis Hungary Healthcare   (Hungary)

^e Evangelisches Krankenhaus Vienna   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

FINGOLIMOD;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; DRUG PENETRATION; FEMALE; LOW DRUG DOSE; LYMPHOCYTE; MULTIPLE SCLEROSIS; MYELIN SHEATH; NEUROPROTECTION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; WHITE MATTER;

ADMINISTRATION, ORAL; ANIMALS; AUTORADIOGRAPHY; BRAIN; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE COUNT; MULTIPLE SCLEROSIS; PHOSPHORYLATION; PROPYLENE GLYCOLS; RATS; RATS, INBRED LEW; SPHINGOSINE;

EID: 35348970884     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.127183     Document Type: Article

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