Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors

Analytical Biochemistry

Volumn 434, Issue 2, 2013, Pages 247-253

  Billich, Andreas ^a   Beerli, Christian ^a   Bergmann, Reinhard ^a   Bruns, Christian ^a   Loetscher, Erika ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Cellular assay; Lyase; Sphingosine 1 phosphate

Indexed keywords

ALKANOLAMINES; CELL CULTURE; ENZYME INHIBITION; LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY; SPHINGOSINES;

CELLULAR ASSAYS; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC MS/MS); LYASE; RELATIVE POTENCIES; SHORT INTERFERING RNA (SIRNA); SPHINGOSINE; SPHINGOSINE-1-PHOSPHATE LYASE; THERAPEUTIC INTERVENTION;

CELLS;

LX 2931; LYASE; LYASE INHIBITOR; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL CULTURE; CELL DENSITY; CELL LINE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; ENZYME DEGRADATION; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; INCUBATION TIME; LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

EID: 84873381957     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2012.11.026     Document Type: Article

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