A novel sphingosine-1-phosphate receptor agonist KRP-203 attenuates rat autoimmune myocarditis

Biochemical and Biophysical Research Communications

Volumn 361, Issue 3, 2007, Pages 621-628

  Ogawa, Ryo ^a   Takahashi, Masafumi ^a   Hirose, Sho ichi ^a   Morimoto, Hajime ^a   Ise, Hirohiko ^a   Murakami, Takashi ^b   Yasue, Tokutaro ^c   Kuriyama, Kazuhiko ^c   Hongo, Minoru ^d   Kobayashi, Eiji ^b   Ikeda, Uichi ^a  

^a SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c KYORIN PHARMACEUTICAL CO LTD   (Japan)

^d SHINSHU UNIVERSITY   (Japan)

Author keywords

Cardiomyocyte; Cytokine; Inflammation; Lymphocyte

Indexed keywords

2 AMINO 2 [2 [4 (BENZYLOXYPHENYLTHIO) 2 CHLOROPHENYL]ETHYL] 1,3 PROPANEDIOL; IMMUNOMODULATING AGENT; KRP 203; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG;

AGONIST; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNE DISEASE; BODY WEIGHT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; FLOW CYTOMETRY; GRANULOCYTE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART WEIGHT; IMMUNOHISTOCHEMISTRY; MACROPHAGE ACTIVATION; MALE; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE;

ANIMALS; AUTOIMMUNE DISEASES; BODY WEIGHT; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEUKOCYTES; MALE; MYOCARDITIS; RATS; RATS, INBRED LEW; RECEPTORS, LYSOSPHINGOLIPID; SULFHYDRYL COMPOUNDS;

RATTUS;

EID: 34547756416     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.07.061     Document Type: Article

References (26)

1. Moloney E.D., Egan J.J., Kelly P., Wood A.E., and Cooper Jr. L.T. Transplantation for myocarditis: a controversy revisited. J. Heart Lung Transplant. 24 (2005) 1103-1110
2. Mason J.W. Myocarditis and dilated cardiomyopathy: an inflammatory link. Cardiovasc. Res. 60 (2003) 5-10
3. Caforio A.L., Mahon N.J., Tona F., and McKenna W.J. Circulating cardiac autoantibodies in dilated cardiomyopathy and myocarditis: pathogenetic and clinical significance. Eur. J. Heart Fail. 4 (2002) 411-417
4. Caforio A.L., Stewart J.T., Bonifacio E., Burke M., Davies M.J., McKenna W.J., and Bottazzo G.F. Inappropriate major histocompatibility complex expression on cardiac tissue in dilated cardiomyopathy. Relevance for autoimmunity?. J. Autoimmun. 3 (1990) 187-200
5. Kodama M., Okura Y., Aizawa Y., and Izumi T. Animal Models of Autoimmune Myocarditis. Myocarditis: From Bench to Bedside (2003), Human Press, Totowa, New Jersey pp. 197-214
6. Kamiyoshi Y., Takahashi M., Yokoseki O., Yazaki Y., Hirose S., Morimoto H., Watanabe N., Kinoshita O., Hongo M., and Ikeda U. Mycophenolate mofetil prevents the development of experimental autoimmune myocarditis. J. Mol. Cell Cardiol. 39 (2005) 467-477
7. Shimizu H., Takahashi M., Kaneko T., Murakami T., Hakamata Y., Kudou S., Kishi T., Fukuchi K., Iwanami S., Kuriyama K., Yasue T., Enosawa S., Matsumoto K., Takeyoshi I., Morishita Y., and Kobayashi E. KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts. Circulation 111 (2005) 222-229
8. Takahashi M., Shimizu H., Murakami T., Enosawa S., Suzuki C., Takeno Y., Hakamata Y., Kudou S., Izawa S., Yasue T., and Kobayashi E. A novel immunomodulator KRP-203 combined with cyclosporine prolonged graft survival and abrogated transplant vasculopathy in rat heart allografts. Transplant. Proc. 37 (2005) 143-145
9. Fujishiro J., Kudou S., Iwai S., Takahashi M., Hakamata Y., Kinoshita M., Iwanami S., Izawa S., Yasue T., Hashizume K., Murakami T., and Kobayashi E. Use of sphingosine-1-phosphate 1 receptor agonist, KRP-203, in combination with a subtherapeutic dose of cyclosporine A for rat renal transplantation. Transplantation 82 (2006) 804-812
10. Suzuki C., Takahashi M., Morimoto H., Izawa A., Ise H., Fujishiro J., Murakami T., Ishiyama J., Nakada A., Nakayama J., Shimada K., Ikeda U., and Kobayashi E. Efficacy of mycophenolic acid combined with KRP-203, a novel immunomodulator, in a rat heart transplantation model. J. Heart Lung Transplant. 25 (2006) 302-309
11. Kaneko T., Murakami T., Kawana H., Takahashi M., Yasue T., and Kobayashi E. Sphingosine-1-phosphate receptor agonists suppress concanavalin A-induced hepatic injury in mice. Biochem. Biophys. Res. Commun. 345 (2006) 85-92
12. Hirose S., Takahashi M., Ogawa R., Morimoto H., Izawa A., Sato H., Ise H., Hongo M., and Ikeda U. Erythropoietin attenuates the development of experimental autoimmune myocarditis. Cardiovasc. Drugs Ther. 21 (2007) 17-27
13. Suzuki C., Takahashi M., Morimoto H., Izawa A., Ise H., Hongo M., Hoshikawa Y., Ito T., Miyashita H., Kobayashi E., Shimada K., and Ikeda U. Mycophenolate mofetil attenuates pulmonary arterial hypertension in rats. Biochem. Biophys. Res. Commun. 349 (2006) 781-788
14. Morimoto H., Takahashi M., Izawa A., Ise H., Hongo M., Kolattukudy P.E., and Ikeda U. Cardiac overexpression of monocyte chemoattractant protein-1 in transgenic mice prevents cardiac dysfunction and remodeling after myocardial infarction. Circ. Res. 99 (2006) 891-899
15. Shiba Y., Takahashi M., Yoshioka T., Yajima N., Morimoto H., Izawa A., Ise H., Hatake K., Motoyoshi K., and Ikeda U. M-CSF accelerates neointimal formation in the early phase after vascular injury in mice: the critical role of the SDF-1-CXCR4 system. Arterioscler. Thromb. Vasc. Biol. 27 (2007) 283-289
16. Binah O. Cytotoxic lymphocytes and cardiac electrophysiology. J. Mol. Cell Cardiol. 34 (2002) 1147-1161
17. Matsumori A., Yamada T., Suzuki H., Matoba Y., and Sasayama S. Increased circulating cytokines in patients with myocarditis and cardiomyopathy. Br. Heart J. 72 (1994) 561-566
18. Yamada T., Matsumori A., and Sasayama S. Therapeutic effect of anti-tumor necrosis factor-alpha antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus. Circulation 89 (1994) 846-851
19. Kitabayashi H., Isobe M., Watanabe N., Suzuki J., Yazaki Y., and Sekiguchi M. FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. J. Cardiovasc. Pharmacol. 35 (2000) 410-416
20. Matloubian M., Lo C.G., Cinamon G., Lesneski M.J., Xu Y., Brinkmann V., Allende M.L., Proia R.L., and Cyster J.G. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427 (2004) 355-360
21. Lo C.G., Xu Y., Proia R.L., and Cyster J.G. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J. Exp. Med. 201 (2005) 291-301
22. Allende M.L., Dreier J.L., Mandala S., and Proia R.L. Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J. Biol. Chem. 279 (2004) 15396-15401
23. Brinkmann V., Davis M.D., Heise C.E., Albert R., Cottens S., Hof R., Bruns C., Prieschl E., Baumruker T., Hiestand P., Foster C.A., Zollinger M., and Lynch K.R. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem. 277 (2002) 21453-21457
24. Sanna M.G., Liao J., Jo E., Alfonso C., Ahn M.Y., Peterson M.S., Webb B., Lefebvre S., Chun J., Gray N., and Rosen H. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J. Biol. Chem. 279 (2004) 13839-13848
25. Hanawa H., Kodama M., Zhang S., Izumi T., and Shibata A. An immunosuppressant compound, FK-506, prevents the progression of autoimmune myocarditis in rats. Clin. Immunol. Immunopathol. 62 (1992) 321-326
26. Zhang S., Kodama M., Hanawa H., Izumi T., Shibata A., and Masani F. Effects of cyclosporine prednisolone and aspirin on rat autoimmune giant cell myocarditis. J. Am. Coll. Cardiol. 21 (1993) 1254-1260