Pharmacokinetic/pharmacodynamic modelling of 2-acetyl-4(5)- tetrahydroxybutyl imidazole-induced peripheral lymphocyte sequestration through increasing lymphoid sphingosine 1-phosphate

Xenobiotica

Volumn 40, Issue 5, 2010, Pages 350-356

  Yu, X Q ^a   Kramer, J ^a   Moran, L ^a   O'Neill, E ^a   Nouraldeen, A ^a   Oravecz, T ^a   Wilson, A G E ^a  

^a LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

2 acetyl 4(5) tetrahydroxybutyl imidazole (THI); Lymphopenia; Pharmacokinetic pharmacodynamic (PK PD) modelling; Signal transduction; Sphingosine 1 phosphate (S1P)

Indexed keywords

2 ACETYL 4 (1,2,3,4 TETRAHYDROXYBUTYL)IMIDAZOLE; SPHINGOSINE 1 PHOSPHATE; 2-ACETYL-4(5)-TETRAHYDROXYBUTYLIMIDAZOLE; IMIDAZOLE DERIVATIVE; LYSOPHOSPHOLIPID; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EXPOSURE; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; LYMPHOID ORGAN; MALE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PHARMACODYNAMICS; RAT; SIGNAL TRANSDUCTION; SIMULATION; ANALOGS AND DERIVATIVES; ANIMAL; BIOLOGICAL MODEL; BLOOD; COMPUTER SIMULATION; DRUG EFFECTS; LYMPHOCYTE; METABOLISM; MOUSE; ORAL DRUG ADMINISTRATION; SPLEEN; SPRAGUE DAWLEY RAT; TIME;

ADMINISTRATION, ORAL; ANIMALS; COMPUTER SIMULATION; IMIDAZOLES; LYMPHOCYTES; LYSOPHOSPHOLIPIDS; MALE; MICE; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOSINE; SPLEEN; TIME FACTORS;

RATTUS; RODENTIA;

EID: 77950814703     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498251003611376     Document Type: Article

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