Efficacy of mycophenolic acid combined with KRP-203, a novel immunomodulator, in a rat heart transplantation model

Journal of Heart and Lung Transplantation

Volumn 25, Issue 3, 2006, Pages 302-309

  Suzuki, Chihiro ^a   Takahashi, Masafumi ^a,b   Morimoto, Hajime ^a   Izawa, Atsushi ^a   Ise, Hirohiko ^a   Fujishiro, Jun ^b   Murakami, Takashi ^b   Ishiyama, Junichi ^c   Nakada, Akihiro ^c   Nakayama, Jun ^a   Shimada, Kazuyuki ^b   Ikeda, Uichi ^a   Kobayashi, Eiji ^b  

^a SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIN 1; IMMUNOMODULATING AGENT; INTERLEUKIN 8; KRP 203; MONOCYTE CHEMOTACTIC PROTEIN 1; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; SPHINGOSINE 1 PHOSPHATE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLEEDING; CARDIAC GRAFT REJECTION; CELL INFILTRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG TOLERABILITY; GRAFT SURVIVAL; HEART MUSCLE FIBROSIS; HEART MUSCLE NECROSIS; HEART TRANSPLANTATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; MACROPHAGE; MALE; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECIPIENT; SURVIVAL; T LYMPHOCYTE;

ANIMALS; BLOOD CELLS; CELL MOVEMENT; DRUG THERAPY, COMBINATION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE AGENTS; MACROPHAGES; MALE; MYCOPHENOLIC ACID; RATS; SULFHYDRYL COMPOUNDS; T-LYMPHOCYTES;

EID: 33344462470     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2005.09.021     Document Type: Article

References (37)

1. H. Eisen, H. Ross Optimizing the immunosuppressive regimen in heart transplantation J Heart Lung Transplant 23 2004 S207 S213
2. H. Azuma, N.L. Tilney Chronic graft rejection Curr Opin Immunol 6 1994 770 776
3. J.L. Hillebrands, J. Rozing Chronic transplant dysfunction and transplant arteriosclerosis new insights into underlying mechanisms Expert Rev Mol Med 2003 2003 1 23
4. S.M. Stepkowski Molecular targets for existing and novel immunosuppressive drugs Expert Rev Mol Med 2000 2000 1 23
5. A.J. Olyaei, A.M. de Mattos, W.M. Bennett Nephrotoxicity of immunosuppressive drugs new insight and preventive strategies Curr Opin Crit Care 7 2001 384 389
6. W.M. Bennett, A. DeMattos, M.M. Meyer, T. Andoh, J.M. Barry Chronic cyclosporine nephropathy the Achilles' heel of immunosuppressive therapy Kidney Int 50 1996 1089 1100
7. M. Sander, R.G. Victor Hypertension after cardiac transplantation pathophysiology and management Curr Opin Nephrol Hypertens 4 1995 443 451
8. R. Moore, D. Hernandez, H. Valantine Calcineurin inhibitors and post-transplant hyperlipidaemias Drug Saf 24 2001 755 766
9. H. Shimizu, M. Takahashi, T. Kaneko KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts Circulation 111 2005 222 229
10. M. Takahashi, H. Shimizu, T. Murakami A novel immunomodulator KRP-203 combined with cyclosporine prolonged graft survival and abrogated transplant vasculopathy in rat heart allografts Transplant Proc 37 2005 143 145
11. T.S. Mele, P.F. Halloran The use of mycophenolate mofetil in transplant recipients Immunopharmacology 47 2000 215 245
12. European Mycophenolate Mofetil Cooperative Study Group Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection Lancet 345 1995 1321 1325
13. A.A. Hollander, J.L. van Saase, A.M. Kootte Beneficial effects of conversion from cyclosporin to azathioprine after kidney transplantation Lancet 345 1995 610 614
14. D. Xiu, H. Uchida, H. To Simplified method of heterotopic rat heart transplantation using the cuff technique application to sublethal dose protocol of methotrexate on allograft survival Microsurgery 21 2001 16 21
15. V. Brinkmann, M.D. Davis, C.E. Heise The immune modulator FTY720 targets sphingosine 1-phosphate receptors J Biol Chem 277 2002 21453 21457
16. A. Yamaguchi, D.N. Miniati, K. Hirata, E.G. Hoyt, R.C. Robbins Ex vivo blockade of endothelin-1 inhibits graft coronary artery disease in a rodent cardiac allograft model J Heart Lung Transplant 21 2002 417 424
17. M.S. Simonson, W.H. Herman, A. Robinson, J. Schulak, D.E. Hricik Inhibition of endothelin-converting enzyme attenuates transplant vasculopathy and rejection in rat cardiac allografts Transplantation 67 1999 1542 1547
18. R.K. Sihvola, V.P. Pulkkinen, P.K. Koskinen, K.B. Lemstrom Crosstalk of endothelin-1 and platelet-derived growth factor in cardiac allograft arteriosclerosis JAMA 39 2002 710 717
19. D.M. Little, L.D. Haynes, T. Alam, J.G. Geraghty, H.W. Sollinger, D.A. Hullett Does transforming growth factor beta 1 play a role in the pathogenesis of chronic allograft rejection? Transpl Int 12 1999 393 401
20. P.J. Lijnen, V.V. Petrov, R.H. Fagard Induction of cardiac fibrosis by transforming growth factor-beta(1) Mol Genet Metab 71 2000 418 435
21. M.E. Russell Macrophages and transplant arteriosclerosis known and novel molecules J Heart Lung Transplant 14 1995 S111 S115
22. M.H. Kown, C.L. Jahncke, M.A. Lijkwan The use of (99m) technetium-labeled MCP-1 to assess graft coronary artery disease in rat cardiac allografts J Heart Lung Transplant 21 2002 1009 1015
23. F. Joucher, G.M. Mazmanian, M. German-Fattal E-selectin early overexpression induced by allogeneic activation in isolated mouse lung Transplantation 78 2004 1283 1289
24. H. Shimizu, M. Takahashi, S. Takeda Mycophenolate mofetil prevents transplant arteriosclerosis by direct inhibition of vascular smooth muscle cell proliferation Transplantation 77 2004 1661 1667
25. H. Shimizu, M. Takahashi, S. Takeda Conversion from cyclosporine A to mycophenolate mofetil protects recipient kidney and prevents intimal hyperplasia in rat aortic allografts Transpl Immunol 13 2004 219 227
26. I.A. Hauser, L. Renders, H.H. Radeke, R.B. Sterzel, M. Goppelt-Struebe Mycophenolate mofetil inhibits rat and human mesangial cell proliferation by guanosine depletion Nephrol Dial Transplant 14 1999 58 63
27. J.I. Moon, Y.S. Kim, M.S. Kim Effect of cyclosporine, mycophenolic acid, and rapamycin on the proliferation of rat aortic vascular smooth muscle cells in vitro study Transplant Proc 32 2000 2026 2027
28. U. Heemann, H. Azuma, P. Hamar, C. Schmid, N. Tilney, T. Philipp Mycophenolate mofetil inhibits lymphocyte binding and the upregulation of adhesion molecules in acute rejection of rat kidney allografts Transpl Immunol 4 1996 64 67
29. M.L. Rose, J. Smith, G. Dureau, A. Keogh, J. Kobashigowa Mycophenolate mofetil decreases antibody production after cardiac transplantation J Heart Lung Transplant 21 2002 282 285
30. H.J. Eisen, J. Kobashigawa, A. Keogh Three-year results of a randomized, double-blind, controlled trial of mycophenolate mofetil versus azathioprine in cardiac transplant recipients J Heart Lung Transplant 24 2005 517 525
31. J. Klupp, T. van Gelder, C. Dambrin Sustained suppression of peripheral blood immune functions by treatment with mycophenolate mofetil correlates with reduced severity of cardiac allograft rejection J Heart Lung Transplant 23 2004 334 351
32. S. Takeda, M. Takahashi, Y. Sado Prevention of glomerular crescent formation in glomerulonephritis by mycophenolate mofetil in rats Nephrol Dial Transplant 19 2004 2228 2236
33. S. Takeda, M. Takahashi, E. Kusano, E. Kobayashi Mycophenolate mofetil prevents development of urinary protein in autoimmune nephritis Kidney Int 64 2003 365 366
34. B.J. McVerry, J.G. Garcia In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate mechanistic insights Cell Signal 17 2005 131 139
35. N. Picard, T. Cresteil, A. Premaud, P. Marquet Characterization of a phase 1 metabolite of mycophenolic acid produced by CYP3A4/5 Ther Drug Monit 26 2004 600 608
36. K. Budde, R.L. Schmouder, R. Brunkhorst First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients J Am Soc Nephrol 13 2002 1073 1083
37. M.G. Sanna, J. Liao, E. Jo Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate J Biol Chem 279 2004 13839 13848