Discovery of BAF312 (Siponimod), a potent and selective S1P receptor modulator

ACS Medicinal Chemistry Letters

Volumn 4, Issue 3, 2013, Pages 333-337

  Pan, Shifeng ^a   Gray, Nathanael S ^a   Gao, Wenqi ^a   Mi, Yuan ^a   Fan, Yi ^a   Wang, Xing ^a   Tuntland, Tove ^a   Che, Jianwei ^a   Lefebvre, Sophie ^a   Chen, Yu ^a   Chu, Alan ^a   Hinterding, Klaus ^b   Gardin, Anne ^b   End, Peter ^b   Heining, Peter ^b   Bruns, Christian ^b   Cooke, Nigel G ^b   Nuesslein Hildesheim, Barbara ^b  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

lymphocytes; S1P receptor; S1P1 agonist

Indexed keywords

FINGOLIMOD; SIPONIMOD;

AEROBIC METABOLISM; ARTICLE; DRUG BINDING SITE; DRUG BIOAVAILABILITY; DRUG EXCRETION; DRUG METABOLISM; HALF LIFE TIME; HEART REPOLARIZATION; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LIVER MICROSOME; LYMPHOCYTE COUNT; MOLECULAR MODEL; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION; URINARY EXCRETION;

EID: 84875200649     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300396r     Document Type: Article

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