HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3

Journal of Clinical Investigation

Volumn 113, Issue 4, 2004, Pages 569-581

  Nofer, Jerzy Roch ^a   Van Der Giet, Markus ^b   Tölle, Markus ^b   Wolinska, Iza ^a   Von Wnuck Lipinski, Karin ^a   Baba, Hideo A ^c   Tietge, Uwe J ^b   Gödecke, Axel ^d   Ishii, Isao ^e   Kleuser, Burkhard ^f   Schäfers, Michael ^a   Fobker, Manfred ^a   Zidek, Walter ^b   Assmann, Gerd ^a   Chun, Jerold ^g   Levkau, Bodo ^a,c  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^f FREIE UNIVERSITÄT BERLIN   (Germany)

^g SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HIGH DENSITY LIPOPROTEIN; LYSOPHOSPHOLIPID; LYSOPHOSPHOLIPID RECEPTOR S1P3; NITRIC OXIDE; PROTEIN KINASE B; SPHINGOSINE 1 PHOSPHATE; SPHINGOSYLPHOSPHORYLCHOLINE; SULFOGALACTOSYLSPHINGOSINE; UNCLASSIFIED DRUG; AKT1 PROTEIN, HUMAN; AKT1 PROTEIN, RAT; CALCIUM; ENZYME INHIBITOR; G PROTEIN COUPLED RECEPTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; LYSOPHOSPHOLIPID RECEPTOR; NITRIC OXIDE SYNTHASE; NOS3 PROTEIN, HUMAN; NOS3 PROTEIN, MOUSE; NOS3 PROTEIN, RAT; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE;

AORTA; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL TONE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MEAN ARTERIAL PRESSURE; PRIORITY JOURNAL; RECEPTOR BINDING; VASODILATATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; FEMALE; GENETICS; HISTOLOGY; IN VITRO STUDY; MALE; METABOLISM; MOUSE; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY; RAT; VASCULAR ENDOTHELIUM; WISTAR KYOTO RAT; WISTAR RAT;

ANIMALS; AORTA; CALCIUM; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; HUMANS; LIPOPROTEINS, HDL; LYSOPHOSPHOLIPIDS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, INBRED WKY; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOPHOSPHOLIPID; VASODILATION;

EID: 11144356028     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200418004     Document Type: Article

References (54)

1. Toborek, M., and Kaiser, S. 1999. Endothelial cell functions. Relationship to atherogenesis. Basic Res. Cardiol. 94:295-314.
2. Loscalzo, J. 2001. Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ. Res. 88:756-762.
3. Cohen, R.A. 1995. The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease. Prog. Cardiovasc. Dis. 38:105-128.
4. Harrison, D.G., and Ohara, Y. 1995. Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: implications for impaired vasomotion. Am. J. Cardiol. 75:75B-81B.
5. Candipan, R.C., Wang, B.Y., Buitrago, R., Tsao, P.S., and Cooke, J.P. 1996. Regression or progression. Dependency on vascular nitric oxide. Arterioscler. Thromb. Vasc. Biol. 16:44-50.
6. Nofer, J.R., et al. 2002. HDL and arteriosclerosis: beyond reverse cholesterol transport. Atherosclerosis. 161:1-16.
7. Yuhanna, I.S., et al. 2001. High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. Nat. Med. 7:853-857.
8. Mineo, C., Yuhanna, I.S., Quon, M.J., and Shaul, P.W. 2003. High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases. J. Biol. Chem. 278:9142-9149.
9. Lodge, P.A., Haisch, C.E., and Thomas, F.T. 1992. A simple method of vascular endothelial cell isolation. Transplant. Proc. 24:2816-2817.
10. Havel, R.J., Eder, H., and Bragdon, J. 1955. The distribution and chemical composition of ultracentrifugally isolated lipoproteins from human plasma. J. Clin. Invest. 34:1345-1353.
11. Nofer, J.R., et al. 2001. Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysophospholipids. J. Biol. Chem. 276:34480-34485.
12. Sugimoto, K., Fujii, S., Takemasa, T., and Yamashita, K. 2000. Detection of intracellular nitric oxide using a combination of aldehyde fixatives with 4,5-diaminofluorescein diacetate. Histochem. Cell Biol. 113:341-347.
13. Ishii, I., et al. 2001. Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LPB3/EDG-3. J. Biol. Chem. 276:33697-33704.
14. Ishii, I., et al. 2002. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3. J. Biol. Chem. 277:25152-25159.
15. Tepel, M., et al. 1997. Diadenosine polyphosphates' action on calcium and vessel contraction. Am. J. Hypertens. 10:1404-1410.
16. Schluter, H., et al. 1994. Diadenosine phosphates and the physiological control of blood pressure. Nature. 367:186-188.
17. Ruwisch, L., Schafer-Korting, M., and Kleuser, B. 2001. An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials. Naunyn Schmiedebergs Arch. Pharmacol. 363:358-363.
18. Nofer, J.R., et al. 2000. Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux. Biochemistry. 39:15199-15207.
19. Dimmeler, S., et al. 1999. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 399:601-605.
20. Fulton, D., et al. 1999. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 399:597-601.
21. Igarashi J., Bernier, S.G., and Michel, T. 2001. Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase: differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. J. Biol. Chem. 276:12420-12426.
22. Tanimoto, T., Jin, Z.G., and Berk, B.C. 2002. Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). J. Biol. Chem. 277:42997-43001.
23. Dantas, A.P., Igarashi, J., and Michel, T. 2003. Sphingosine 1-phosphate and control of vascular tone. Am. J. Physiol. 284:H2045-H2052.
24. Li, X.A., et al. 2002. High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner. J. Biol. Chem. 277:11058-11063.
25. Honda, H.M., et al. 1999. High-density lipoprotein increases intracellular calcium levels by releasing calcium from internal stores in human endothelial cells. Atherosclerosis. 143:299-306.
26. Kimura, T., et al. 2001. Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. J. Biol. Chem. 276:31780-31785.
27. Morales-Ruiz, M., et al. 2001. Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. J. Biol. Chem. 276:19672-19677.
28. Levade, T., et al. 2001. Sphingolipid mediators in cardiovascular cell biology and pathology. Circ. Res. 89:957-968.
29. Yang, A.H., Ishii, I., and Chun, J. 2002. In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice. Biochim. Biophys. Acta. 1582:197-203.
30. Fukushima, N., Ishii, I., Contos, J.J.A., Weiner, J.A., and Chun, J. 2001. Lysophospholipid receptors. Ann. Rev. Pharmacol. Toxicol. 41:507-534.
31. Chun, J., et al. 2002. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol. Rev. 54:265-269.
32. O'Connell, B.J., and Genest, J., Jr. 2001. High-density lipoproteins and endothelial function. Circulation. 104:1978-1983.
33. Spieker, L.E., et al. 2002. High-density lipoprotein restores endothelial function in hypercholesterolemic men. Circulation. 105:1399-1402.
34. Fleisher, L.N., Tall, A.R., Witte, L.D., Miller, R.W., and Cannon, P.J. 1982. Stimulation of arterial endothelial cell prostacyclin synthesis by high density lipoproteins. J. Biol. Chem. 257:6653-6655.
35. Boo, Y.C., et al. 2002. Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1177 by Akt-independent mechanisms: role of protein kinase A. J. Biol. Chem. 277:3388-3396.
36. Zachary, I., and Gliki, G. 2001. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc. Res. 49:568-581.
37. Haynes, M.P., et al. 2000. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ. Res. 87:677-682.
38. Michell, B.J., et al. 1999. The Akt kinase signals directly to endothelial nitric oxide synthase. Curr. Biol. 9:845-848.
39. Xu, Y. 2002. Sphingosylphosphorylcholine and lysophosphatidyl-choline: G protein-coupled receptors and receptor-mediated signal transduction. Biochim. Biophys. Acta. 1582:81-88.
40. Lee, M.J., et al. 1999. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell. 99:301-312.
41. McGiffert, C., Contos, J.J., Friedman, B., and Chun, J. 2002. Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis. FEBS Lett. 531:103-108.
42. Zhang, G., Contos, J.J.A., Weiner, J.A., Fukushima, N., and Chun, J. 1999. Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene. 227:89-99.
43. Meyer zu Heringdorf, D., Himmel, H.M., and Jakobs, K.H. 2002. Sphingosylphosphorylcholine-biological functions and mechanisms of action. Biochim. Biophys. Acta. 1582:178-189.
44. Ishii, I., Fukushima, N., Ye, X., and Chun, J. 2004. Lysophospholipid receptors: signaling and biology. Ann. Rev. Biochem. In press.
45. Banno, Y., et al. 2003. Involvement of phospholipase D in insulin-like growth factor-1-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells. Biochem. J. 369:363-368.
46. Kwon, Y.G., et al. 2001. Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production. J. Biol. Chem. 276:10627-10633.
47. Ishii, I., et al. 2002. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J. Biol. Chem. 277:25152-25159.
48. Salomone S., et al. 2003. S1P(3) receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate. Eur. J. Pharmacol. 469:125-134.
49. Ohmori, T., et al. 2003. Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. Cardiovasc. Res. 58:170-177.
50. Gong, M., et al. 2003. HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI-dependent manner. J. Clin. Invest. 111:1579-1587. doi:10.1172/JCI200316777.
51. Haynes, M.P., et al. 2003. Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen. J. Biol. Chem. 278:2118-2123.
52. Wyckoff, M.H., et al. 2001. Plasma membrane estrogen receptors are coupled to endotheLial nitric-oxide synthase through Galpha(i). J. Biol. Chem. 276:27071-27076.
53. Chambliss, K.L., and Shaul, P.W. 2002. Estrogen modulation of endothelial nitric oxide synthase. Endocr. Rev. 23:665-686.
54. Tamama, K., and Okajima, F. 2002. Sphingosine 1-phosphate signaling in atherosclerosis and vascular biology. Curr. Opin. Lipidol. 13:489-495.