Blocking S1P interaction with S1P 1 receptor by a novel competitive S1P 1-selective antagonist inhibits angiogenesis

Biochemical and Biophysical Research Communications

Volumn 419, Issue 4, 2012, Pages 754-760

  Fujii, Yasuyuki ^a   Ueda, Yasuji ^a   Ohtake, Hidenori ^a   Ono, Naoya ^a   Takayama, Tetsuo ^a   Nakazawa, Kiyoshi ^a   Igarashi, Yasuyuki ^b   Goitsuka, Ryo ^c  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Angiogenesis; Antagonist; Sphingosine 1 phosphate; Type 1 S1P receptor; Vascular endothelial growth factor

Indexed keywords

ANGIOGENESIS INHIBITOR; FIBROBLAST GROWTH FACTOR 2; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR TYPE 1; TASP 0277308; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; EMBRYO DEVELOPMENT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; UMBILICAL VEIN ENDOTHELIAL CELL;

CELL LINE, TUMOR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LYSOPHOSPHOLIPIDS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; SULFONES; TRIAZOLES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84858750845     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.02.096     Document Type: Article

References (28)

1. Carmeliet P., Jain R.K. Angiogenesis in cancer and other diseases. Nature 2000, 407:249-257.
2. Carmeliet P., De Smet F., Loges S., Mazzone M. Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way. Nat. Rev. Clin. Oncol. 2009, 6:315-326.
3. Azam F., Mehta S., Harris A.L. Mechanisms of resistance to antiangiogenesis therapy. Eur J. Cancer. 2010, 46:1323-1332.
4. Hla T. Signaling and biological actions of sphingosine 1-phosphate. Pharmacol. Res. 2003, 47:401-407.
5. Hla T. Physiological and pathological actions of sphingosine 1-phosphate. Semin. Cell Dev. Biol.. 2004, 15:513-520.
6. Kono M., Mi Y., Liu Y., Sasaki T., Allende M.L., Wu Y.P., Yamashita T., Proia R.L. The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J. Biol. Chem. 2004, 279:29367-29373.
7. Pyne S., Pyne N. Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors. Pharmacol. Ther. 2000, 88:115-131.
8. Takuwa Y., Okamoto Y., Yoshioka K., Takuwa N. Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system. Biochim. Biophys. Acta 2008, 1781:483-488.
9. Visentin B., Vekich J.A., Sibbald B.J., Cavalli A.L., Moreno K.M., Matteo R.G., Garland W.A., Lu Y., Yu S., Hall H.S., Kundra V., Mills G.B., Sabbadini R.A. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell 2006, 9:225-238.
10. Chae S.S., Paik J.H., Furneaux H., Hla T. Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J. Clin. Invest. 2004, 114:1082-1089.
11. Igarashi J., Erwin P.A., Dantas A.P., Chen H., Michel T. VEGF induces S1P1 receptors in endothelial cells: implications for cross-talk between sphingolipid and growth factor receptors. Proc. Natl. Acad. Sci. U S A. 2003, 100:10664-10669.
12. Chae S.S., Paik J.H., Allende M.L., Proia R.L., Hla T. Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. Dev. Biol. 2004, 268:441-447.
13. Milstien S., Spiegel S. Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics. Cancer Cell 2006, 9:148-150.
14. Sabbadini R.A. Targeting sphingosine-1-phosphate for cancer therapy. Br. J. Cancer. 2006, 95:1131-1135.
15. Fujii Y., Hirayama T., Ohtake H., Ono N., Inoue T., Sakurai T., Takayama T., Matsumoto K., Tsukahara N., Hidano S., Harima N., Nakazawa K., Igarashi Y., Goitsuka R. Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities. J. Immunol. 2012, 188:206-215.
16. Davis M.D., Clemens J.J., Macdonald T.L., Lynch K.R. Sphingosine 1-phosphate analogs as receptor antagonists. J. Biol. Chem. 2005, 280:9833-9841.
17. Kennedy P.C., Zhu R., Huang T., Tomsig J.L., Mathews T.P., David M., Peyruchaud O., Macdonald T.L., Lynch K.R. Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. J. Pharmacol. Exp. Ther. 2011, 338:879-889.
18. Sanna M.G., Wang S.K., Gonzalez-Cabrera P.J., Don A., Marsolais D., Matheu M.P., Wei S.H., Parker I., Jo E., Cheng W.C., Cahalan M.D., Wong C.H., Rosen H. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat. Chem. Biol. 2006, 2:434-441.
19. Foss F.W., Snyder A.H., Davis M.D., Rouse M., Okusa M.D., Lynch K.R., Macdonald T.L. Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg. Med. Chem. 2007, 15:663-677.
20. Yonesu K., Kawase Y., Inoue T., Takagi N., Tsuchida J., Takuwa Y., Kumakura S., Nara F. Involvement of sphingosine-1-phosphate and S1P(1) in angiogenesis: analyses using a new S1P(1) antagonist of non-sphingosine-1-phosphate analog. Biochem. Pharmacol. 2008.
21. Yonesu K., Nakamura T., Mizuno Y., Suzuki C., Nagayama T., Satoh S., Nara F. A novel sphingosine-1-phosphate receptor 1 antagonist prevents the proliferation and relaxation of vascular endothelial cells by sphingosine-1-phosphate. Biol. Pharm. Bull. 2010, 33:1500-1505.
22. LaMontagne K., Littlewood-Evans A., Schnell C., O'Reilly T., Wyder L., Sanchez T., Probst B., Butler J., Wood A., Liau G., Billy E., Theuer A., Hla T., Wood J. Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res. 2006, 66:221-231.
23. Lee O.H., Kim Y.M., Lee Y.M., Moon E.J., Lee D.J., Kim J.H., Kim K.W., Kwon Y.G. Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 1999, 264:743-750.
24. Oikawa T., Sasaki M., Inose M., Shimamura M., Kuboki H., Hirano S., Kumagai H., Ishizuka M., Takeuchi T. Effects of cytogenin, a novel microbial product, on embryonic and tumor cell-induced angiogenic responses in vivo. Anticancer Res. 1997, 17:1881-1886.
25. Funahashi Y., Wakabayashi T., Semba T., Sonoda J., Kitoh K., Yoshimatsu K. Establishment of a quantitative mouse dorsal air sac model and its application to evaluate a new angiogenesis inhibitor. Oncol Res. 1999, 11:319-329.
26. Alvarez S.E., Milstien S., Spiegel S. Autocrine and paracrine roles of sphingosine-1-phosphate. Trends Endocrinol. Metab. 2007, 18:300-307.
27. Heo K., Park K.A., Kim Y.H., Kim S.H., Oh Y.S., Kim I.H., Ryu S.H., Suh P.G. Sphingosine 1-phosphate induces vascular endothelial growth factor expression in endothelial cells. BMB Rep. 2009, 42:685-690.
28. Bergelin N., Lof C., Balthasar S., Kalhori V., Tornquist K. S1P1 and VEGFR-2 form a signaling complex with extracellularly regulated kinase 1/2 and protein kinase C-alpha regulating ML-1 thyroid carcinoma cell migration. Endocrinology 2010, 151:2994-3005.