Effects of salts from the Hofmeister series on the conformational stability, aggregation propensity, and local flexibility of an IgG1 monoclonal antibody

Biochemistry

Volumn 52, Issue 19, 2013, Pages 3376-3389

  Majumdar, Ranajoy ^a   Manikwar, Prakash ^a,b   Hickey, John M ^a   Samra, Hardeep S ^b   Sathish, Hasige A ^b   Bishop, Steven M ^b   Middaugh, C Russell ^a   Volkin, David B ^a   Weis, David D ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b MEDIMMUNE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATE FORMATION; AGGREGATION PROPENSITY; AGGREGATION RATE; CONFORMATIONAL STABILITIES; CONFORMATIONAL TRANSITIONS; HOFMEISTER SERIES; LOCAL FLEXIBILITY; MONOCLONAL ANTIBODIES (MAB);

CHLORINE COMPOUNDS; DIFFERENTIAL SCANNING CALORIMETRY; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; NEGATIVE IONS; SULFUR COMPOUNDS;

CONFORMATIONS;

CHLORIDE; IMMUNOGLOBULIN G1 ANTIBODY; SULFATE; THIOCYANATE;

ARTICLE; CONFORMATIONAL TRANSITION; DIFFERENTIAL SCANNING CALORIMETRY; GEL PERMEATION CHROMATOGRAPHY; MASS SPECTROMETRY; MELTING POINT; PRIORITY JOURNAL; PROTEIN AGGREGATION; TEMPERATURE;

ANIONS; ANTIBODIES, MONOCLONAL; HUMANS; IMMUNOGLOBULIN G; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; SALTS; THERMODYNAMICS;

EID: 84877787093     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400232p     Document Type: Article

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