Characterization of IgG1 Conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry

Analytical Chemistry

Volumn 81, Issue 7, 2009, Pages 2644-2651

  Houde, Damian ^a,b   Arndt, Joseph ^a   Domeier, Wayne ^a   Berkowitz, Steven ^a   Engen, John R ^b  

^a BIOGEN   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL TOOLS; BIO-PHARMACEUTICAL INDUSTRIES; BIOPHARMACEUTICALS; CHROMATOGRAPHIC METHODS; CONFORMATIONAL BEHAVIORS; CONFORMATIONAL CHANGES; CONFORMATIONAL DYNAMICS; DEGLYCOSYLATION; FC REGIONS; FC-RECEPTORS; GLYCOSYLATED; HIGH SENSITIVITIES; HIGHER-ORDER STRUCTURES; HYDROGEN/DEUTERIUM EXCHANGES; IDENTIFICATION ALGORITHMS; PROCESSING STEPS; PROTEIN CONFORMATIONS; PROTEIN FUNCTIONS;

AMINES; ANTIBODIES; DATA PROCESSING; DEUTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; SPECTRUM ANALYSIS;

CONFORMATIONS;

DEUTERIUM; FC RECEPTOR; HYDROGEN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; PEPTIDE;

ALGORITHM; ARTICLE; CHEMICAL LABELING; CHROMATOGRAPHY; CONTROLLED STUDY; DEGLYCOSYLATION; DEUTERIUM HYDROGEN EXCHANGE; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MOLECULE; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN GLYCOSYLATION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM EXCHANGE MEASUREMENT; GLYCOSYLATION; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPSIN A; PROTEIN CONFORMATION; RECEPTORS, FC; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 64849114588     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac802575y     Document Type: Article

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