Mass spectrometric analysis of intact human monoclonal antibody aggregates fractionated by size-exclusion chromatography

Pharmaceutical Research

Volumn 27, Issue 10, 2010, Pages 2197-2204

  Kükrer, Başak ^a   Filipe, Vasco ^a   Van Duijn, Esther ^b   Kasper, Piotr T ^a,c   Vreeken, Rob J ^a,c   Heck, Albert J R ^b   Jiskoot, Wim ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c NETHERLANDS METABOLOMICS CENTRE   (Netherlands)

Author keywords

HP SEC; IgG1; monoclonal antibody; native ESI TOF mass spectrometry; protein aggregation

Indexed keywords

AMMONIUM ACETATE; DIMER; IMMUNOGLOBULIN; IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; MONOMER; TETRAMER;

ARTICLE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FRACTIONATION; GEL PERMEATION CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; TIME OF FLIGHT MASS SPECTROMETRY;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, GEL; DRUG STABILITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FRACTIONATION, FIELD FLOW; HUMANS; IMMUNOGLOBULIN G; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 77957333488     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0224-5     Document Type: Article

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