Discrimination Among IgG1-κ Monoclonal Antibodies Produced by Two Cell Lines Using Charge State Distributions in nanoESI-TOF Mass Spectra

Journal of the American Society for Mass Spectrometry

Volumn 20, Issue 6, 2009, Pages 1030-1036

  Zamani, Leila ^a   Lindholm, Jessica ^a   Ilag, Leopold L ^a   Jacobsson, Sven P ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM ACETATES; CELL LINES; CENTRAL COMPOSITES; CHARGE STATE DISTRIBUTIONS; DATA SETS; DE SOLVATIONS; EXPERIMENTAL CONDITIONS; EXPERIMENTAL DESIGNS; EXPERIMENTAL PARAMETERS; FISHER LINEAR DISCRIMINANT ANALYSIS; GAS-FLOW RATES; INSTRUMENTAL SETTINGS; MASS SPECTRUM; NANO-ESI; ORGANIC MODIFIERS; PRODUCTION SYSTEMS;

AMMONIUM COMPOUNDS; CELL CULTURE; DISCRIMINANT ANALYSIS; FACE RECOGNITION; MASS SPECTROMETERS; MASS SPECTROMETRY; METHANOL; MONOCLONAL ANTIBODIES; PH EFFECTS; PRODUCTION ENGINEERING; PROTEINS;

PRINCIPAL COMPONENT ANALYSIS;

AMMONIUM ACETATE; BUFFER; IMMUNOGLOBULIN G1; METHANOL; MONOCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; CELL LINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISCRIMINANT ANALYSIS; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; FLOW RATE; GAS FLOW; HUMAN; HUMAN CELL; NONHUMAN; PH; PRINCIPAL COMPONENT ANALYSIS; PROTEIN ANALYSIS; TEMPERATURE;

ACETATES; ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA-CHAINS; LINEAR MODELS; METHANOL; MICE; MODELS, IMMUNOLOGICAL; PRINCIPAL COMPONENT ANALYSIS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TEMPERATURE;

EID: 65549096754     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2009.01.008     Document Type: Article

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