Complementary MS methods assist conformational characterization of antibodies with altered S-S bonding networks

Journal of the American Society for Mass Spectrometry

Volumn 24, Issue 6, 2013, Pages 835-845

  Jones, Lisa M ^a   Zhang, Hao ^a   Cui, Weidong ^a   Kumar, Sandeep ^b   Sperry, Justin B ^b   Carroll, James A ^b   Gross, Michael L ^a  

^a WASHINGTON UNIVERSITY   (United States)

^b PFIZER INC   (United States)

Author keywords

Antibody characterization; Antibody mutants; Fast photochemical oxidation of proteins (FPOP); IgG2; Ion mobility; Protein structure; Top down

Indexed keywords

IGG2; ION MOBILITY; PHOTOCHEMICAL OXIDATION; PROTEIN STRUCTURES; TOPDOWN;

COMPLEX NETWORKS; CONFORMATIONS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES;

PROTEINS;

IMMUNOGLOBULIN G2; MONOCLONAL ANTIBODY;

ARTICLE; CHEMICAL LABELING; COMPLEMENTARY MASS SPECTROMETRY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; DISULFIDE BOND; DRUG DETERMINATION; DRUG STRUCTURE; ION MOBILITY SPECTROMETRY; MASS SPECTROMETRY; MOLECULAR MODEL; PHOTOOXIDATION; PROTEIN FOOTPRINTING; SENSITIVITY ANALYSIS; STRUCTURAL HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; DISULFIDES; HUMANS; IMMUNOGLOBULIN G; ISOMERISM; MASS SPECTROMETRY; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OXIDATION-REDUCTION; RECOMBINANT PROTEINS;

EID: 84877741020     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-013-0582-4     Document Type: Article

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