A new approach to explore the impact of freeze-thaw cycling on protein structure: Hydrogen/deuterium exchange mass spectrometry (HX-MS)

Pharmaceutical Research

Volumn 28, Issue 5, 2011, Pages 1179-1193

  Zhang, Aming ^a   Qi, Wei ^a,b   Singh, Satish K ^c   Fernandez, Erik J ^a  

^a University of Virginia   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c PFIZER INC   (United States)

Author keywords

aggregation; freeze thaw; hydrogen deuterium exchange; lactate dehydrogenase; structural denaturation

Indexed keywords

LACTATE DEHYDROGENASE;

ALGORITHM; ARTICLE; DEUTERIUM HYDROGEN EXCHANGE; FREEZE THAWING; HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN DENATURATION; PROTEIN STRUCTURE; SEPARATION TECHNIQUE;

ANIMALS; DEUTERIUM; DEUTERIUM EXCHANGE MEASUREMENT; FREEZING; HYDROGEN; L-LACTATE DEHYDROGENASE; MASS SPECTROMETRY; PROTEIN CONFORMATION; RABBITS;

EID: 79955620192     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0383-z     Document Type: Article

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