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Analytical Chemistry

Volumn 83, Issue 22, 2011, Pages 8501-8508

Revealing a positive charge patch on a recombinant monoclonal antibody by chemical labeling and mass spectrometry

(6) Zhang, Liangyi a Lilyestrom, Wayne b Li, Charlene a Scherer, Thomas b Van Reis, Robert c Zhang, Boyan a

a Protein Analytical Chemistry (United States)

b Pharmaceutical Development (United States)

c GENENTECH INC (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CHROMATOGRAPHY; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; POSITIVE IONS;

AMINO ACID COMPOSITIONS; ANALYTICAL CHARACTERIZATION; ARGININE RESIDUE; CATION EXCHANGE CHROMATOGRAPHY; CATION EXCHANGE RESINS; CHARGE HETEROGENEITY; CHEMICAL LABELING; COMPARATIVE STUDIES; FC REGION; FOOTPRINTING; PEPTIDE MAPPING; POSITIVE CHARGES; POSITIVELY CHARGED; PURIFICATION PROCESS; REACTION DYNAMICS; RECOMBINANT MONOCLONAL ANTIBODY; RETENTION TIME; SELECTIVE LABELING; THERAPEUTIC MONOCLONAL ANTIBODIES; VARIABLE DOMAIN;

POLYPEPTIDES;

EID: 81255175613 PISSN: 00032700 EISSN: None Source Type: Journal
DOI: 10.1021/ac2016129 Document Type: Article

Times cited : (25)

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