Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry

Protein Science

Volumn 19, Issue 4, 2010, Pages 826-835

  Burkitt, William ^a   Domann, Paula ^a   O'Connor, Gavin ^a  

^a LGC   (United Kingdom)

Author keywords

Hydrogen exchange; Mass spectrometry; Monoclonal antibody; Oxidation and structural analysis

Indexed keywords

GLYCAN; METHIONINE; METHIONINE SULFOXIDE; MONOCLONAL ANTIBODY;

ARTICLE; CHEMICAL MODIFICATION; DEUTERIUM HYDROGEN EXCHANGE; DISULFIDE BOND; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; DEUTERIUM; DEUTERIUM EXCHANGE MEASUREMENT; HYDROGEN; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; PROTEIN CONFORMATION;

EID: 77950236865     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.362     Document Type: Article

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