Conformational analysis of recombinant monoclonal antibodies with hydrogen/deuterium exchange mass spectrometry

Methods in Molecular Biology

Volumn 988, Issue , 2013, Pages 269-289

  Houde, Damian ^a   Engen, John R ^b  

^a BIOGEN   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Antibody; Conformation; Deuterium; Hydrogen exchange; Immunoglobin; Protein structure

Indexed keywords

BUFFER; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ARTICLE; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN MODIFICATION; PURIFICATION; STORAGE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; METHODOLOGY; MOLECULAR WEIGHT; STANDARD; TANDEM MASS SPECTROMETRY;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, LIQUID; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; IMMUNOGLOBULIN G; MOLECULAR WEIGHT; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; REFERENCE STANDARDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84877763599     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-327-5_17     Document Type: Article

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