Conformational analysis of therapeutic proteins by hydroxyl radical protein footprinting

AAPS Journal

Volumn 14, Issue 2, 2012, Pages 206-217

  Watson, Caroline ^a   Sharp, Joshua S ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Biosimilars; Hydroxyl radical protein footprinting; Mass spectrometry; Protein conformation; Therapeutic proteins

Indexed keywords

AMINO ACID; HYDROXYL RADICAL; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ERYTHROPOIETIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG CONFORMATION; DRUG FORMULATION; DRUG STABILITY; EXPIRATION DATE; HEAT TREATMENT; HYDROXYL RADICAL PROTEIN FOOTPRINTING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FOOTPRINTING; TANDEM MASS SPECTROMETRY;

ANIMALS; CATTLE; CHROMATOGRAPHY, LIQUID; GRANULOCYTE COLONY-STIMULATING FACTOR; HYDROXYL RADICAL; MASS SPECTROMETRY; PROTEIN CONFORMATION; PROTEIN FOOTPRINTING; RECOMBINANT PROTEINS;

EID: 84860758736     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-012-9336-7     Document Type: Article

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