-
1
-
-
33846140780
-
Antibody structure, instability, and formulation
-
DOI 10.1002/jps.20727
-
Wang W, Singh S, Zeng DL, King K, Nema S. Antibody structure, instability, and formulation. J Pharm Sci. 2007;96(1):1-26. (Pubitemid 46087335)
-
(2007)
Journal of Pharmaceutical Sciences
, vol.96
, Issue.1
, pp. 1-26
-
-
Wang, W.1
Singh, S.2
Zeng, D.L.3
King, K.4
Nema, S.5
-
2
-
-
33847683955
-
Quantitation of aggregate levels in a recombinant humanized monoclonal antibody formulation by size-exclusion chromatography, asymmetrical flow field flow fractionation, and sedimentation velocity
-
DOI 10.1002/jps.20760
-
Gabrielson JP, Brader ML, Pekar AH, Mathis KB, Winter G, Carpenter JF, et al. Quantitation of aggregate levels in a recombinant humanized monoclonal antibody formulation by size-exclusion chromatography, asymmetrical flow field flow fractionation, and sedimentation velocity. J Pharm Sci. 2007;96(2):268-79. (Pubitemid 46363558)
-
(2007)
Journal of Pharmaceutical Sciences
, vol.96
, Issue.2
, pp. 268-279
-
-
Gabrielson, J.P.1
Brader, M.L.2
Pekar, A.H.3
Mathis, K.B.4
Winter, G.5
Carpenter, J.F.6
Randolph, T.W.7
-
3
-
-
2642550862
-
Challenges in the development of high protein concentration formulations
-
DOI 10.1002/jps.20079
-
Shire SJ, Shahrokh Z, Liu J. Challenges in the development of high protein concentration formulations. J Pharm Sci. 2004;93(6):1390-402. (Pubitemid 38725014)
-
(2004)
Journal of Pharmaceutical Sciences
, vol.93
, Issue.6
, pp. 1390-1402
-
-
Shire, S.J.1
Shahrokh, Z.2
Liu, J.3
-
4
-
-
32644434554
-
Influence of aggregation on immunogenicity of recombinant human factor VIII in hemophilia A mice
-
DOI 10.1002/jps.20529
-
Purohit VS, Middaugh CR, Balasubramanian SV. Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice. J Pharm Sci. 2006;95(2):358-71. (Pubitemid 43241978)
-
(2006)
Journal of Pharmaceutical Sciences
, vol.95
, Issue.2
, pp. 358-371
-
-
Purohit, V.S.1
Middaugh, C.R.2
Balasubramanian, S.V.3
-
5
-
-
33748041958
-
Effects of protein aggregates: An Immunologic perspective
-
DOI 10.1208/aapsj080359, 59
-
Rosenberg AS. Effects of protein aggregates: an immunologic perspective. AAPS J. 2006;8(3):E501-507. (Pubitemid 44294011)
-
(2006)
AAPS Journal
, vol.8
, Issue.3
-
-
Rosenberg, A.S.1
-
6
-
-
0034076282
-
The thermal stability of immunoglobulin: Unfolding and aggregation of a multi-domain protein
-
Vermeer AW, Norde W. The thermal stability of immunoglobulin: unfolding and aggregation of a multi-domain protein. Biophys J. 2000;78(1):394-404. (Pubitemid 30207148)
-
(2000)
Biophysical Journal
, vol.78
, Issue.1
, pp. 394-404
-
-
Vermeer, A.W.P.1
Norde, W.2
-
7
-
-
77952684807
-
The use of native cation-exchange chromatography to study aggregationand phase separation of monoclonal antibodies
-
Chen S, Lau H, Brodsky Y, Kleemann GR, Latypov RF. The use of native cation-exchange chromatography to study aggregationand phase separation of monoclonal antibodies. Protein Sci. 2010;19(6):1191-204.
-
(2010)
Protein Sci
, vol.19
, Issue.6
, pp. 1191-1204
-
-
Chen, S.1
Lau, H.2
Brodsky, Y.3
Kleemann, G.R.4
Latypov, R.F.5
-
8
-
-
68749118103
-
Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress
-
Hawe A, Kasper JC, Friess W, Jiskoot W. Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress. Eur J Pharm Sci. 2009;38(2):79-87.
-
(2009)
Eur J Pharm Sci
, vol.38
, Issue.2
, pp. 79-87
-
-
Hawe, A.1
Kasper, J.C.2
Friess, W.3
Jiskoot, W.4
-
9
-
-
55749113694
-
Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosity
-
Kanai S, Liu J, Patapoff TW, Shire SJ. Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosity. J Pharm Sci. 2008;97(10):4219-27.
-
(2008)
J Pharm Sci
, vol.97
, Issue.10
, pp. 4219-4227
-
-
Kanai, S.1
Liu, J.2
Patapoff, T.W.3
Shire, S.J.4
-
10
-
-
0032940238
-
Conformation, pH-induced conformational changes, and thermal unfolding of anti-p24 (HIV-1) monoclonal antibody CB4-1 and its Fab and Fc fragments
-
DOI 10.1016/S0167-4838(99)00046-1, PII S0167483899000461
-
Welfle K, Misselwitz R, Hausdorf G, Höhne W, Welfle H. Conformation, pH-induced conformational changes, and thermal unfolding of anti-p24 (HIV-1) monoclonal antibody CB4-1 and its Fab and Fc fragments. Biochim Biophys Acta. 1999;1431(1):120-31. (Pubitemid 29182728)
-
(1999)
Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology
, vol.1431
, Issue.1
, pp. 120-131
-
-
Welfle, K.1
Misselwitz, R.2
Hausdorf, G.3
Hohne, W.4
Welfle, H.5
-
11
-
-
68949122431
-
Elucidation of two major aggregation pathways in an IgG2 antibody
-
Van Buren N, Rehder D, Gadgil H, Matsumura M, Jacob J. Elucidation of two major aggregation pathways in an IgG2 antibody. J Pharm Sci. 2009;98(9):3013-30.
-
(2009)
J Pharm Sci
, vol.98
, Issue.9
, pp. 3013-3030
-
-
Van Buren, N.1
Rehder, D.2
Gadgil, H.3
Matsumura, M.4
Jacob, J.5
-
12
-
-
3042761213
-
Structure-immunogenicity relationships of therapeutic proteins
-
DOI 10.1023/B:PHAM.0000029275.41323.a6
-
Hermeling S, Crommelin DJA, Schellekens H, Jiskoot W. Structure-immunogenicity relationships of therapeutic proteins. Pharm Res. 2004;21(6):897-903. (Pubitemid 38870136)
-
(2004)
Pharmaceutical Research
, vol.21
, Issue.6
, pp. 897-903
-
-
Hermeling, S.1
Crommelin, D.J.A.2
Schellekens, H.3
Jiskoot, W.4
-
13
-
-
0008530768
-
Cold denaturation of staphylococcal nuclease
-
Griko YV, Privalov PL, Sturtevant JM, Venyaminov SYu. Cold denaturation of staphylococcal nuclease. Proc Natl Acad Sci USA. 1988;85(10):3343-7.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, Issue.10
, pp. 3343-3347
-
-
Griko, Y.V.1
Privalov, P.L.2
Sturtevant, J.M.3
Venyaminov, S.Yu.4
-
14
-
-
0030443567
-
Surface-induced denaturation of proteins during freezing and its inhibition by surfactants
-
DOI 10.1021/js960080y
-
Chang BS, Kendrick BS, Carpenter JF. Surface-induced denaturation of proteins during freezing and its inhibition by surfactants. J Pharm Sci. 1996;85(12):1325-30. (Pubitemid 27014188)
-
(1996)
Journal of Pharmaceutical Sciences
, vol.85
, Issue.12
, pp. 1325-1330
-
-
Chang, B.S.1
Kendrick, B.S.2
Carpenter, J.F.3
-
15
-
-
0028098067
-
Effect of mannitol crystallinity on the stabilization of enzymes during freeze-drying
-
Izutsu K, Yoshioka S, Terao T. Effect of mannitol crystallinity on the stabilization of enzymes during freeze-drying. Chem Pharm Bull. 1994;42(1):5-8. (Pubitemid 24067499)
-
(1994)
Chemical and Pharmaceutical Bulletin
, vol.42
, Issue.1
, pp. 5-8
-
-
Izutsu, K.-I.1
Yoshioka, S.2
Terao, T.3
-
16
-
-
0024316909
-
Salt precipitation during the freeze-concentration of phosphate buffer solutions
-
DOI 10.1016/0301-4622(89)80066-3
-
Murase N, Franks F. Salt precipitation during the freeze-concentration of phosphate buffer solutions. Biophys Chem. 1989;34(3):293-300. (Pubitemid 20007779)
-
(1989)
Biophysical Chemistry
, vol.34
, Issue.3
, pp. 293-300
-
-
Murase, N.1
Franks, F.2
-
17
-
-
0031018084
-
Probing the non-covalent structure of proteins by amide hydrogen exchange and mass spectrometry
-
DOI 10.1002/(SICI)1096-9888(199702)32:2<135::AID-JMS486>3.0.CO;2-M
-
Smith DL, Deng Y, Zhang Z. Probing the non-covalent structure of proteins by amide hydrogen exchange and mass spectrometry. J Mass Spectrom. 1997;32(2):135-46. (Pubitemid 27087380)
-
(1997)
Journal of Mass Spectrometry
, vol.32
, Issue.2
, pp. 135-146
-
-
Smith, D.L.1
Deng, Y.2
Zhang, Z.3
-
18
-
-
33749838193
-
Hydrogen/deuterium exchange mass spectrometry-a window into amyloid structure
-
Kheterpal I, Wetzel R. Hydrogen/deuterium exchange mass spectrometry-a window into amyloid structure. Acc Chem Res. 2006;39(9):584-93.
-
(2006)
Acc Chem Res
, vol.39
, Issue.9
, pp. 584-593
-
-
Kheterpal, I.1
Wetzel, R.2
-
19
-
-
38749137344
-
Pharmaceutical applications of isoelectric focusing on microchip with imaged UV detection
-
Vlcková M, Kalman F, Schwarz MA. Pharmaceutical applications of isoelectric focusing on microchip with imaged UV detection. J Chromatogr A. 2008;1181(1-2):145-52.
-
(2008)
J Chromatogr A
, vol.1181
, Issue.1-2
, pp. 145-152
-
-
Vlcková, M.1
Kalman, F.2
Schwarz, M.A.3
-
20
-
-
64649105762
-
Accelerating molecular dynamic simulation on graphics processing units
-
Friedrichs MS, Eastman P, Vaidyanathan V, Houston M, Legrand S, Beberg AL, et al. Accelerating molecular dynamic simulation on graphics processing units. J Comput Chem. 2009;30(6):864-72.
-
(2009)
J Comput Chem
, vol.30
, Issue.6
, pp. 864-872
-
-
Friedrichs, M.S.1
Eastman, P.2
Vaidyanathan, V.3
Houston, M.4
Legrand, S.5
Beberg, A.L.6
-
21
-
-
33748518255
-
Comparison of multiple amber force fields and development of improved protein backbone parameters
-
DOI 10.1002/prot.21123
-
Hornak V, Abel R, Okur A, Strockbine B, Roitberg A, Simmerling C. Comparison of multiple Amber force fields and development of improved protein backbone parameters. Proteins. 2006;65(3):712-25. (Pubitemid 44583220)
-
(2006)
Proteins: Structure, Function and Genetics
, vol.65
, Issue.3
, pp. 712-725
-
-
Hornak, V.1
Abel, R.2
Okur, A.3
Strockbine, B.4
Roitberg, A.5
Simmerling, C.6
-
22
-
-
0033654297
-
Generalized born models of macromolecular solvation effects
-
Bashford D, Case DA. Generalized born models of macromolecular solvation effects. Annu Rev Phys Chem. 2000;51:129-52.
-
(2000)
Annu Rev Phys Chem
, vol.51
, pp. 129-152
-
-
Bashford, D.1
Case, D.A.2
-
23
-
-
33646940952
-
Numerical-integration of cartesian equations of motion of a system with constraints-molecular-dynamics of N-alkanes
-
Ryckaert J-P, Ciccotti G, Berendsen HJC. Numerical-integration of cartesian equations of motion of a system with constraints-molecular-dynamics of N-alkanes. J Comput Phys. 1977;23:327-41.
-
(1977)
J Comput Phys
, vol.23
, pp. 327-341
-
-
Ryckaert, J.-P.1
Ciccotti, G.2
Berendsen, H.J.C.3
-
24
-
-
67650683480
-
Aggregation-prone motifs in human immunoglobulin G
-
Chennamsetty N, Helk B, Voynov V, Kayser V, Trout BL. Aggregation-prone motifs in human immunoglobulin G. J Mol Biol. 2009;391(2):404-13.
-
(2009)
J Mol Biol
, vol.391
, Issue.2
, pp. 404-413
-
-
Chennamsetty, N.1
Helk, B.2
Voynov, V.3
Kayser, V.4
Trout, B.L.5
-
25
-
-
67749111952
-
Design of therapeutic proteins with enhanced stability
-
Chennamsetty N, Voynov V, Kayser V, Helk B, Trout BL. Design of therapeutic proteins with enhanced stability. Proc Natl Acad Sci USA. 2009;106(29):11937-42.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.29
, pp. 11937-11942
-
-
Chennamsetty, N.1
Voynov, V.2
Kayser, V.3
Helk, B.4
Trout, B.L.5
-
26
-
-
0036639910
-
Parameter optimized surfaces (POPS): Analysis of key interactions and conformational changes in the ribosome
-
Fraternali F, Cavallo L. Parameter optimized surfaces (POPS): analysis of key interactions and conformational changes in the ribosome. Nucleic Acids Res. 2002;30(13):2950-60. (Pubitemid 34790204)
-
(2002)
Nucleic Acids Research
, vol.30
, Issue.13
, pp. 2950-2960
-
-
Fraternali, F.1
Cavallo, L.2
-
27
-
-
0344784400
-
Construction and characterization of an NaCl-sensitive mutant of Halomonas elongata impaired in ectoine biosynthesis
-
DOI 10.1016/S0378-1097(98)00086-X, PII S037810979800086X
-
Göller K, Ofer A, Galinski EA. Construction and characterization of an NaCl-sensitive mutant of Halomonas elongata impaired in ectoine biosynthesis. FEMS Microbiol Lett. 1998;161(2):293-300. (Pubitemid 28179434)
-
(1998)
FEMS Microbiology Letters
, vol.161
, Issue.2
, pp. 293-300
-
-
Goller, K.1
Ofer, A.2
Galinski, E.A.3
-
28
-
-
79955620192
-
A new approach to explore the impact of freeze-thaw cycling on protein structure: Hydrogen/deuterium exchange mass spectrometry (HX-MS)
-
Zhang A, Qi W, Singh SK, Fernandez EJ. A new approach to explore the impact of freeze-thaw cycling on protein structure: hydrogen/deuterium exchange mass spectrometry (HX-MS). Pharm Res. 2011;28(5):1179-93.
-
(2011)
Pharm Res
, vol.28
, Issue.5
, pp. 1179-1193
-
-
Zhang, A.1
Qi, W.2
Singh, S.K.3
Fernandez, E.J.4
-
29
-
-
0030043206
-
Proteins in frozen solutions: Evidence of ice-induced partial unfolding
-
Strambini GB, Gabellieri E. Proteins in frozen solutions: evidence of ice-induced partial unfolding. Biophys J. 1996;70(2):971-6. (Pubitemid 26028311)
-
(1996)
Biophysical Journal
, vol.70
, Issue.2 I
, pp. 971-976
-
-
Strambini, G.B.1
Gabellieri, E.2
-
30
-
-
43249105327
-
Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies
-
Ionescu RM, Vlasak J, Price C, Kirchmeier M. Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies. J Pharm Sci. 2008;97(4):1414-26.
-
(2008)
J Pharm Sci
, vol.97
, Issue.4
, pp. 1414-1426
-
-
Ionescu, R.M.1
Vlasak, J.2
Price, C.3
Kirchmeier, M.4
-
31
-
-
77953655331
-
Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies
-
Wang X, Das TK, Singh SK, Kumar S. Potential aggregation prone regions in biotherapeutics: a survey of commercial monoclonal antibodies. MAbs. 2009;1(3):254-67.
-
(2009)
MAbs
, vol.1
, Issue.3
, pp. 254-267
-
-
Wang, X.1
Das, T.K.2
Singh, S.K.3
Kumar, S.4
-
32
-
-
5044235541
-
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins
-
DOI 10.1038/nbt1012
-
Fernandez-Escamilla A-M, Rousseau F, Schymkowitz J, Serrano L. Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins. Nat Biotechnol. 2004;22(10):1302-6. (Pubitemid 39336784)
-
(2004)
Nature Biotechnology
, vol.22
, Issue.10
, pp. 1302-1306
-
-
Fernandez-Escamilla, A.-M.1
Rousseau, F.2
Schymkowitz, J.3
Serrano, L.4
-
34
-
-
34250793865
-
Consensus prediction of amyloidogenic determinants in amyloid fibril-forming proteins
-
DOI 10.1016/j.ijbiomac.2007.03.008, PII S0141813007001018
-
Hamodrakas SJ, Liappa C, Iconomidou VA. Consensus prediction of amyloidogenic determinants in amyloid fibril-forming proteins. Int J Biol Macromol. 2007;41(3):295-300. (Pubitemid 46990531)
-
(2007)
International Journal of Biological Macromolecules
, vol.41
, Issue.3
, pp. 295-300
-
-
Hamodrakas, S.J.1
Liappa, C.2
Iconomidou, V.A.3
-
36
-
-
34548756136
-
Identification of amyloid fibril-forming segments based on structure and residue-based statistical potential
-
DOI 10.1093/bioinformatics/btm325
-
Zhang Z, Chen H, Lai L. Identification of amyloid fibril-forming segments based on structure and residue-based statistical potential. Bioinformatics. 2007;23(17):2218-25. (Pubitemid 47423858)
-
(2007)
Bioinformatics
, vol.23
, Issue.17
, pp. 2218-2225
-
-
Zhang, Z.1
Chen, H.2
Lai, L.3
-
37
-
-
64849114588
-
Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry
-
Houde D, Arndt J, Domeier W, Berkowitz S, Engen JR. Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry. Anal Chem. 2009;81(7):2644-51.
-
(2009)
Anal Chem
, vol.81
, Issue.7
, pp. 2644-2651
-
-
Houde, D.1
Arndt, J.2
Domeier, W.3
Berkowitz, S.4
Engen, J.R.5
-
38
-
-
77953171768
-
Stability of protein pharmaceuticals: An update
-
Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Stability of protein pharmaceuticals: an update. Pharm Res. 2010;27(4):544-75.
-
(2010)
Pharm Res
, vol.27
, Issue.4
, pp. 544-575
-
-
Manning, M.C.1
Chou, D.K.2
Murphy, B.M.3
Payne, R.W.4
Katayama, D.S.5
-
39
-
-
33847416982
-
A broad range of Fab stabilities within a host of therapeutic IgGs
-
DOI 10.1016/j.bbrc.2007.02.042, PII S0006291X07002975
-
Garber E, Demarest SJ. A broad range of Fab stabilities within a host of therapeutic IgGs. Biochem. Biophys Res Commun. 2007;355(3):751-7. (Pubitemid 46343718)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.355
, Issue.3
, pp. 751-757
-
-
Garber, E.1
Demarest, S.J.2
|