Resolving disulfide structural isoforms of IgG2 monoclonal antibodies by ion mobility mass spectrometry

Analytical Chemistry

Volumn 82, Issue 16, 2010, Pages 6751-6755

  Bagal, Dhanashri ^a   Valliere Douglass, John F ^b   Balland, Alain ^b   Schnier, Paul D ^a  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY THERAPEUTICS; DISULFIDE BONDING; DISULFIDE BONDS; GASPHASE; HIGHER-ORDER STRUCTURE; HUMAN DISEASE; ION MOBILITY-MASS SPECTROMETRY; ISOFORMS; RECOMBINANT MONOCLONAL ANTIBODY; THERAPEUTIC AGENTS;

MASS SPECTROMETRY; SURFACE PLASMON RESONANCE;

MONOCLONAL ANTIBODIES;

DISULFIDE; IMMUNOGLOBULIN G; ISOPROTEIN; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ARTICLE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; GAS; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METABOLISM; METHODOLOGY; MUTATION;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISULFIDES; GASES; HUMANS; IMMUNOGLOBULIN G; MUTATION; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 77955606264     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac1013139     Document Type: Article

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