Conformational characterization of the charge variants of a human IgG1 monoclonal antibody using H/D exchange mass spectrometry

mAbs

Volumn 5, Issue 1, 2013, Pages 114-125

  Tang, Liangjie ^a   Sundaram, Shanmuuga ^a   Zhang, Jingming ^a   Carlson, Ping ^a   Matathia, Alice ^a   Parekh, Babita ^a   Zhou, Qinwei ^a   Hsieh, Ming Ching ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Charge heterogeneity; Folding unfolding stability; Hydrogen deuterium exchange mass spectrometry; IgG1; Ion exchange chromatography; Monoclonal antibody (mAb); Protein conformation

Indexed keywords

AMIDE; DEUTERIUM; HYDROGEN; IGG1 MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; PROTON; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DENATURATION; DRUG CONFORMATION; HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY; HYDROGEN DEUTERIUM EXCHANGE TIME COURSE; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN UNFOLDING; SUPREX TECHNIQUE;

ANTIBODIES, MONOCLONAL; DEUTERIUM; HUMANS; HYDROGEN; IMMUNOGLOBULIN G; MASS SPECTROMETRY; MODELS, MOLECULAR; PEPTIDE MAPPING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN UNFOLDING;

EID: 84872845314     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.22695     Document Type: Article

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