The physiological role of cardiac cytoskeleton and its alterations in heart failure

Biochimica et Biophysica Acta - Biomembranes

Volumn 1838, Issue 2, 2014, Pages 700-722

  Sequeira, Vasco ^a   Nijenkamp, Louise L A M ^a   Regan, Jessica A ^a,b   Van Der Velden, Jolanda ^a,c  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF ARIZONA   (United States)

^c ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

Author keywords

Cardiomyocyte; Costamere; Cytoskeleton; Heart failure

Indexed keywords

ACTIN; ALPHA ACTININ; ALPHA ACTININ ASSOCIATED LIM PROTEIN; BETA ADRENERGIC RECEPTOR; BINDING PROTEIN; CALCIUM ION; CONNECTIN; CONTRACTILE PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOSKELETON PROTEIN; DESMIN; ENIGMA PROTEIN; FILAMIN; FILAMIN ACTININ AND TELETHONIN BINDING PROTEIN; MEMBRANE PROTEIN; MYOMESIN; PROTEIN CAPZ; PROTEIN PDZ LIM; SCAFFOLD PROTEIN; TUBULIN; UNCLASSIFIED DRUG;

BIOMECHANICS; BIOSENSOR; CELL COMPONENT; CELL DAMAGE; CELL FUNCTION; CELL ULTRASTRUCTURE; COSTAMERE; CYTOSKELETON; DISEASE COURSE; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; GENE; GENE MUTATION; GENETIC DISORDER; HEART BEAT; HEART CONTRACTION; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE; HEART OUTPUT; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; MOLECULAR DYNAMICS; MYOCARDIAL DISEASE; MYOFILAMENT; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FAMILY; PROTEIN PROCESSING; REVIEW; SARCOMERE; SARCOMERE GENE; SIGNAL TRANSDUCTION;

CARDIOMYOCYTE; COSTAMERE; CYTOSKELETON; HEART FAILURE;

ANIMALS; CYTOSKELETON; HEART; HEART FAILURE; HUMANS; MUSCLE CONTRACTION;

EID: 84892173740     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2013.07.011     Document Type: Review

References (378)

1. AuthorsTask Force M, K. Dickstein, A. Cohen-Solal, G. Filippatos, J.J.V. McMurray, P. Ponikowski, P.A. Poole-Wilson, A. Strömberg, D.J. van Veldhuisen, D. Atar, A.W. Hoes, A. Keren, A. Mebazaa, M. Nieminen, S.G. Priori, K. Swedberg, Guidelines ESCCfP, A. Vahanian, J. Camm, R. De Caterina, V. Dean, K. Dickstein, G. Filippatos, C. Funck-Brentano, I. Hellemans, S.D. Kristensen, K. McGregor, U. Sechtem, S. Silber, M. Tendera, P. Widimsky, J.L. Zamorano, R. Document, M. Tendera, A. Auricchio, J. Bax, M. Böhm, U. Corrà, P. della Bella, P.M. Elliott, F. Follath, M. Gheorghiade, Y. Hasin, A. Hernborg, T. Jaarsma, M. Komajda, R. Kornowski, M. Piepoli, B. Prendergast, L. Tavazzi, J.-L. Vachiery, F.W.A. Verheugt, J.L. Zamorano, and F. Zannad ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM) Eur. Heart J. 29 2008 2388 2442
2. K.F. Fox, M.R. Cowie, D.A. Wood, A.J.S. Coats, J.S.R. Gibbs, S.R. Underwood, R.M. Turner, P.A. Poole-Wilson, S.W. Davies, and G.C. Sutton Coronary artery disease as the cause of incident heart failure in the population Eur. Heart J. 22 2001 228 236 (Pubitemid 32622473)
3. W.J. Paulus, and J.J.M. van Ballegoij Treatment of heart failure with normal ejection fraction: an inconvenient truth! J. Am. Coll. Cardiol. 55 2010 526 537
4. K. Chatterjee, and B. Massie Systolic and diastolic heart failure: differences and similarities J. Card. Fail. 13 2007 569 576 (Pubitemid 47362750)
5. D. Kitzman, W. Little, P. Brubaker, R. Anderson, W. Hundley, C. Marburger, B. Brosnihan, T. Morgan, and K. Stewart Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure JAMA 288 2002 2144 2150 (Pubitemid 35265382)
6. L. van Heerebeek, A. Borbély, H.W.M. Niessen, J.G.F. Bronzwaer, J. van der Velden, G.J.M. Stienen, W.A. Linke, G.J. Laarman, and W.J. Paulus Myocardial structure and function differ in systolic and diastolic heart failure Circulation 113 2006 1966 1973
7. A. Huxley Muscle structure and theories of contraction Prog. Biophys. Biophys. Chem. 7 1957 255 318
8. D.F. McKillop, and M.A. Geeves Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament Biophys. J. 65 1993 693 701 (Pubitemid 23263882)
9. W. Lehman, V. Hatch, V. Korman, M. Rosol, L. Thomas, R. Maytum, M.A. Geeves, J.E. Van Eyk, L.S. Tobacman, and R. Craig Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments J. Mol. Biol. 302 2000 593 606
10. S. Kostin, S. Hein, E. Arnon, D. Scholz, and J. Schaper The cytoskeleton and related proteins in the human failing heart Heart Fail. Rev. 5 2000 271 280
11. D. Frank, C. Kuhn, H. Katus, and N. Frey The sarcomeric Z-disc: a nodal point in signalling and disease J. Mol. Med. 84 2006 446 468 (Pubitemid 43801324)
12. P. Vibert, R. Craig, and W. Lehman Steric-model for activation of muscle thin filaments J. Mol. Biol. 266 1997 8 14 (Pubitemid 27170513)
13. P.P. de Tombe, R.D. Mateja, K. Tachampa, Y.A. Mou, G.P. Farman, and T.C. Irving Myofilament length dependent activation J. Mol. Cell. Cardiol. 48 2010 851 858
14. D.G. Allen, and J.C. Kentish The cellular basis of the length-tension relation in cardiac muscle J. Mol. Cell. Cardiol. 17 1985 821 840 (Pubitemid 16240155)
15. D.M. Bers Cardiac excitation-contraction coupling Nature 415 2002 198 205 (Pubitemid 34059525)
16. P.J. England Correlation between contraction and phosphorylation of the inhibitory subunit of troponin in perfused rat heart FEBS Lett. 50 1975 57 60
17. R.J. Solaro, A.J.G. Moir, and S.V. Perry Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart Nature 262 1976 615 617
18. M.S. Lim, and M.P. Walsh Phosphorylation of skeletal and cardiac muscle C-proteins by the catalytic subunit of cAMP-dependent protein kinase Biochem. Cell Biol. 64 1986 622 630 (Pubitemid 16023951)
19. M. Gautel, O. Zuffardi, A. Freiburg, and S. Labeit Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction? EMBO J. 14 1995 1952 1960
20. R. Yamasaki, Y. Wu, M. McNabb, M. Greaser, S. Labeit, and H. Granzier Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes Circ. Res. 90 2002 1181 1188 (Pubitemid 34786903)
21. O. Cazorla, S. Szilagyi, N. Vignier, G. Salazar, E. Kramer, G. Vassort, L. Carrier, and A. Lacampagne Length and protein kinase A modulations of myocytes in cardiac myosin binding protein C-deficient mice Cardiovasc. Res. 69 2006 370 380 (Pubitemid 43098793)
22. J.P. Konhilas, T.C. Irving, B.M. Wolska, E.E. Jweied, A.F. Martin, R.J. Solaro, and P.P. de Tombe Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing J. Physiol. 547 2003 951 961 (Pubitemid 36367375)
23. 2 +-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins Cardiovasc. Res. 57 2003 37 47 (Pubitemid 36009434)
24. J.E. Stelzer, J.R. Patel, and R.L. Moss Protein kinase A-mediated acceleration of the stretch activation response in murine skinned myocardium is eliminated by ablation of cMyBP-C Circ. Res. 99 2006 884 890 (Pubitemid 44556388)
25. P.J.M. Wijnker, D.B. Foster, A.L. Tsao, A.H. Frazier, C. dos Remedios, A.M. Murphy, G.J.M. Stienen, and J. van der Velden Impact of site-specific phosphorylation of the protein kinase A sites ser23 and ser24 of cardiac troponin in human cardiomyocytes Am. J. Physiol. 304 2013 H260 H268
26. N. Hamdani, V. Kooij, S. van Dijk, D. Merkus, W.J. Paulus, Cd. Remedios, D.J. Duncker, G.J.M. Stienen, and J. van der Velden Sarcomeric dysfunction in heart failure Cardiovasc. Res. 77 2008 649 658 (Pubitemid 351301859)
27. T. Schober, S. Huke, R. Venkataraman, O. Gryshchenko, D. Kryshtal, H.S. Hwang, F.J. Baudenbacher, and B.C. Knollmann Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia Circ. Res. 111 2012 170 179
28. S.J. van Dijk, E.R. Paalberends, A. Najafi, M. Michels, S. Sadayappan, L. Carrier, N.M. Boontje, D.W.D. Kuster, M. van Slegtenhorst, D. Dooijes, C. dos Remedios, F.J. ten Cate, G.J.M. Stienen, and J. van der Velden Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function Circ. Heart Fail. 5 2012 36 46
29. 2 + sensitivity increase J. Physiol. 575 2006 201 213 (Pubitemid 44178138)
30. 2 + as a result of phosphorylation of cardiac myosin-binding protein C J. Gen. Physiol. 136 2010 615 627
31. A. Borbély, I. Falcao-Pires, L. van Heerebeek, N. Hamdani, I. Édes, C. Gavina, A.F. Leite-Moreira, J.G.F. Bronzwaer, Z. Papp, J. van der Velden, G.J.M. Stienen, and W.J. Paulus Hypophosphorylation of the stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium Circ. Res. 104 2009 780 786
32. J. Tardiff Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes Heart Fail. Rev. 10 2005 237 248 (Pubitemid 43115833)
33. B.J. Maron, J.M. Gardin, J.M. Flack, S.S. Gidding, T.T. Kurosaki, and D.E. Bild Prevalence of hypertrophic cardiomyopathy in a general population of young adults: echocardiographic analysis of 4111 subjects in the CARDIA study Circulation 92 1995 785 789
34. S. Santos, V. Marques, M. Pires, L. Silveira, H. Oliveira, V. Lanca, D. Brito, H. Madeira, J.F. Esteves, A. Freitas, I. Carreira, I. Gaspar, C. Monteiro, and A. Fernandes High resolution melting: improvements in the genetic diagnosis of hypertrophic cardiomyopathy in a Portuguese cohort BMC Med. Genet. 13 13 2012
35. C.Y. Ho, C. Carlsen, J.J. Thune, O. Havndrup, H. Bundgaard, F. Farrohi, J. Rivero, A.L. Cirino, P.S. Andersen, M. Christiansen, B.J. Maron, E.J. Orav, and L. Køber Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathy Circ. Cardiovasc. Genet. 2 2009 314 321
36. T.R.I. Germans, M.J. Götte, M.D. Spreeuwenberg, P.A. Doevendans, Y.M. Pinto, R.J. van der Geest, J. van der Velden, A.A. Wilde, and A.C. van Rossum How do hypertrophic cardiomyopathy mutations affect myocardial function in carriers with normal wall thickness? Assessment with cardiovascular magnetic resonance J. Cardiovasc. Magn. Reson. 12 13 2010
37. 2 + sensitivity and diastolic dysfunction as early consequences of MYBPC3 mutation in heterozygous knock-in mice J. Mol. Cell. Cardiol. 52 2012 1299 1307
38. H. Watkins, W.J. McKenna, L. Thierfelder, H.J. Suk, R. Anan, A. O'Donoghue, P. Spirito, A. Matsumori, C.S. Moravec, J.G. Seidman, and C.E. Seidman Mutations in the genes for cardiac troponin T and α-tropomyosin in hypertrophic cardiomyopathy N. Engl. J. Med. 332 1995 1058 1065
39. J.K. Gwathmey, L. Copelas, R. MacKinnon, F.J. Schoen, M.D. Feldman, W. Grossman, and J.P. Morgan Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure Circulation 61 1987 70 76 (Pubitemid 17133480)
40. A.V. Gomes, and J.D. Potter Molecular and cellular aspects of troponin cardiomyopathies Ann. N. Y. Acad. Sci. 1015 2004 214 224 (Pubitemid 38879492)
41. P. Robinson, P.J. Griffiths, H. Watkins, and C.S. Redwood Dilated and hypertrophic cardiomyopathy mutations in troponin and α-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments Circ. Res. 101 2007 1266 1273 (Pubitemid 350294643)
42. L. Oberst, G. Zhao, J.T. Park, R. Brugada, L.H. Michael, M.L. Entman, R. Roberts, and A.J. Marian Dominant-negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice J. Clin. Invest. 102 1998 1498 1505 (Pubitemid 28492216)
43. J.C. Tardiff, T.E. Hewett, B.M. Palmer, C. Olsson, S.M. Factor, R.L. Moore, J. Robbins, and L.A. Leinwand Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy J. Clin. Invest. 104 1999 469 481 (Pubitemid 29534331)
44. T. Miller, D. Szczesna, P.R. Housmans, J. Zhao, F. de Freitas, A.V. Gomes, L. Culbreath, J. McCue, Y. Wang, Y. Xu, W.G.L. Kerrick, and J.D. Potter Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation J. Biol. Chem. 276 2001 3743 3755
45. S.J. van Dijk, D. Dooijes, C. dos Remedios, M. Michels, J.M.J. Lamers, S. Winegrad, S. Schlossarek, L. Carrier, F.J. ten Cate, G.J.M. Stienen, and J. van der Velden Cardiac myosin-binding protein C mutations and hypertrophic cardiomyopathy: haploinsufficiency, deranged phosphorylation and cardiomyocyte dysfunction Circulation 119 2009 1473 1483
46. 2 +-sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T Cardiovasc. Res. 97 2013 500 508
47. K. Freeman, C. Colon-Rivera, M.C. Olsson, R.L. Moore, H.D. Weinberger, I.L. Grupp, K.L. Vikstrom, G. Iaccarino, W.J. Koch, and L.A. Leinwand Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene Am. J. Physiol. 280 2001 H151 H159
48. R. Prabhakar, G.P. Boivin, I.L. Grupp, B. Hoit, G. Arteaga, J.R. Solaro, and D.F. Wieczorek A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice J. Mol. Cell. Cardiol. 33 2001 1815 1828 (Pubitemid 32977135)
49. A. Rapacciuolo, and H.A. Rockman Role of β-adrenoceptor desensitization in heart failure Cardiovasc. Drug Rev. 17 2000 384 394
50. M.R. Bristow, R. Ginsburg, W. Minobe, R.S. Cubicciotti, W.S. Sageman, K. Lurie, M.E. Billingham, D.C. Harrison, and E.B. Stinson Decreased catecholamine sensitivity and β-adrenergic-receptor density in failing human hearts N. Engl. J. Med. 307 1982 205 211 (Pubitemid 12079105)
51. 2-adrenoceptors in both atria and ventricles in severe congestive cardiomyopathy J. Cardiovasc. Pharmacol. 8 1986 1235 1242 (Pubitemid 17211590)
52. L. Choudhury, S. Guzzetti, D.C. Lefroy, P. Nihoyannopoulos, W.J. McKenna, C.M. Oakley, and P.G. Camici Myocardial β adrenoceptors and left ventricular function in hypertrophic cardiomyopathy Heart 75 1996 50 54 (Pubitemid 26058455)
53. H.A. Rockman, K.R. Chien, D.-J. Choi, G. Iaccarino, J.J. Hunter, J. Ross, R.J. Lefkowitz, and W.J. Koch Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice Proc. Natl. Acad. Sci. U. S. A. 95 1998 7000 7005 (Pubitemid 28278096)
54. C.A. Sumandea, M.L. Garcia-Cazarin, C.H. Bozio, G.A. Sievert, C.W. Balke, and M.P. Sumandea Cardiac Troponin T, a sarcomeric AKAP, tethers protein kinase A at the myofilaments J. Biol. Chem. 286 2011 530 541
55. J.J.C. Michel, and J.D. Scott AKAP mediated signal transduction Annu. Rev. Pharmacol. Toxicol. 42 2002 235 257 (Pubitemid 34160527)
56. R.H. Schwinger, M. Bohm, A. Koch, U. Schmidt, I. Morano, H.J. Eissner, P. Uberfuhr, B. Reichart, and E. Erdmann The failing human heart is unable to use the Frank-Starling mechanism Circ. Res. 74 1994 959 969 (Pubitemid 24121600)
57. R.M. Gill, B.D. Jones, A.K. Corbly, D.G. Ohad, G.D. Smith, G.E. Sandusky, M.E. Christe, J. Wang, and W. Shen Exhaustion of the Frank-Starling mechanism in conscious dogs with heart failure induced by chronic coronary microembolization Life Sci. 79 2006 536 544
58. K. Komamura, R.P. Shannon, T. Ihara, Y.T. Shen, I. Mirsky, S.P. Bishop, and S.F. Vatner Exhaustion of Frank-Starling mechanism in conscious dogs with heart failure Am. J. Physiol. 265 1993 H1119 H1131
59. C. Holubarsch, T. Ruf, D.J. Goldstein, R.C. Ashton, W. Nickl, B. Pieske, K. Pioch, J. Ludemann, S. Wiesner, G. Hasenfuss, H. Posival, H. Just, and D. Burkhoff Existence of the Frank-Starling mechanism in the failing human heart: investigations on the organ, tissue, and sarcomere levels Circulation 94 1996 683 689 (Pubitemid 26289222)
60. C.F. Vahl, T. Timek, A. Bonz, N. Kochsiek, H. Fuchs, L. Schaffer, M. Rosenberg, R. Dillmann, and S. Hagl Myocardial length-force relationship in end stage dilated cardiomyopathy and normal human myocardium: analysis of intact and skinned left ventricular trabeculae obtained during 11 heart transplantations Basic Res. Cardiol. 92 1997 261 270 (Pubitemid 27443300)
61. J. van der Velden, J.W. de Jong, V.J. Owen, P.B.J. Burton, and G.J.M. Stienen Effect of protein kinase A on calcium sensitivity of force and its sarcomere length dependence in human cardiomyocytes Cardiovasc. Res. 46 2000 487 495 (Pubitemid 30319334)
62. 2 +-ATPase mRNA expression and biphasic force-frequency relations in patients with hypertrophic cardiomyopathy Circulation 104 2001 658 663 (Pubitemid 32738519)
63. G. Jagatheesan, S. Rajan, N. Petrashevskaya, A. Schwartz, G. Boivin, G.M. Arteaga, R. John Solaro, S.B. Liggett, and D.F. Wieczorek Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis Am. J. Physiol. 293 2007 H949 H958
64. 2 + binding and myofilament contractility Physiol. Genet. 33 2008 257 266 (Pubitemid 351629533)
65. 2 + activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T Am. J. Physiol. 280 2001 H705 H713
66. S.J. Ford, R. Mamidi, J. Jimenez, J.C. Tardiff, and M. Chandra Effects of R92 mutations in mouse cardiac troponin T are influenced by changes in myosin heavy chain isoform J. Mol. Cell. Cardiol. 53 2012 542 551
67. S. Schaertl, S.S. Lehrer, and M.A. Geeves Separation and characterization of the two functional regions of troponin involved in muscle thin filament regulation Biochemistry 34 1995 15890 15894
68. K. Murakami, M. Stewart, K. Nozawa, K. Tomii, N. Kudou, N. Igarashi, Y. Shirakihara, S. Wakatsuki, T. Yasunaga, and T. Wakabayashi Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T Proc. Natl. Acad. Sci. U. S. A. 105 2008 7200 7205 (Pubitemid 351754455)
69. L.S. Tobacman, M. Nihli, C. Butters, M. Heller, V. Hatch, R. Craig, W. Lehman, and E. Homsher The troponin tail domain promotes a conformational state of the thin filament that suppresses myosin activity J. Biol. Chem. 277 2002 27636 27642 (Pubitemid 34966706)
70. 2 + affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I J. Biol. Chem. 281 2006 13471 13477 (Pubitemid 43855259)
71. J. Burhop, M. Rosol, R. Craig, L.S. Tobacman, and W. Lehman Effects of a cardiomyopathy-causing troponin T mutation on thin filament function and structure J. Biol. Chem. 276 2001 20788 20794
72. 2 +-regulated muscle relaxation at interaction sites of troponin with actin and tropomyosin J. Mol. Biol. 352 2005 178 201 (Pubitemid 41207448)
73. Harvard-Medical-School-Genetic-database Sarcomere protein gene mutation database Cardiogenomics Harvard Medical School database 2008
74. E.P. Manning, P.J. Guinto, and J.C. Tardiff Correlation of molecular and functional effects of mutations in cardiac troponin T linked to familial hypertrophic cardiomyopathy J. Biol. Chem. 287 2012 14515 14523
75. T. Palm, S. Graboski, S.E. Hitchcock-DeGregori, and N.J. Greenfield Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region Biophys. J. 81 2001 2827 2837 (Pubitemid 33020068)
76. E.P. Manning, J.C. Tardiff, and S.D. Schwartz Molecular effects of familial hypertrophic cardiomyopathy-related mutations in the TNT1 domain of cTnT J. Mol. Biol. 421 2012 54 66
77. I. Rayment, H.M. Holden, J.R. Sellers, L. Fananapazir, and N.D. Epstein Structural interpretation of the mutations in the β-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy Proc. Natl. Acad. Sci. U. S. A. 92 1995 3864 3868
78. G.P. Farman, D. Gore, E. Allen, K. Schoenfelt, T.C. Irving, and P.P. de Tombe Myosin head orientation: a structural determinant for the Frank-Starling relationship Am. J. Physiol. 300 2011 2155 2160
79. R. Coppini, C. Ferrantini, L. Yao, P. Fan, M. Del Lungo, F. Stillitano, L. Sartiani, B. Tosi, S. Suffredini, C. Tesi, M. Yacoub, I. Olivotto, L. Belardinelli, C. Poggesi, E. Cerbai, and A. Mugelli Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy Circulation 27 2013 575 584
80. J. Vigoreaux The muscle Z band: lessons in stress management J. Muscle Res. Cell Motil. 15 1994 237 255 (Pubitemid 24207447)
81. D. Frank, and N. Frey Cardiac Z-disc signaling network J. Biol. Chem. 286 2011 9897 9904
82. S. Hein, S. Kostin, A. Heling, Y. Maeno, and J. Schaper The role of the cytoskeleton in heart failure Cardiovasc. Res. 45 2000 273 278 (Pubitemid 30069492)
83. D. Selcen Myofibrillar myopathies Neuromuscul. Disord. 21 2011 161 171
84. D. Selcen Myofibrillar myopathies Neuromuscul. Disord. 21 2010 161 171
85. D. Selcen Myofibrillar myopathies Curr. Opin. Neurol. 23 2010 477 481
86. D. Selcen, M.B. Bromberg, S.S. Chin, and A.G. Engel Reducing bodies and myofibrillar myopathy features in FHL1 muscular dystrophy Neurology 77 2011 1951 1959
87. D. Selcen, and A.G. Engel Myofibrillar myopathies 3rd ed. Myology 2 2004 1187 1202
88. D. Li, T. Tapscoft, O. Gonzalez, P.E. Burch, M.A. Quiñones, W.A. Zoghbi, R. Hill, L.L. Bachinski, D.L. Mann, and R. Roberts Desmin mutation responsible for idiopathic dilated cardiomyopathy Circulation 100 1999 461 464 (Pubitemid 29360152)
89. N. Inagaki, T. Hayashi, T. Arimura, Y. Koga, M. Takahashi, H. Shibata, K. Teraoka, T. Chikamori, A. Yamashina, and A. Kimura αB-crystallin mutation in dilated cardiomyopathy Biochem. Biophys. Res. Commun. 342 2006 379 386
90. D. Fatkin, C. MacRae, T. Sasaki, M.R. Wolff, M. Porcu, M. Frenneaux, J. Atherton, H.J. Vidaillet, S. Spudich, U. De Girolami, J.G. Seidman, F. Muntoni, G. Müehle, W. Johnson, B. McDonough, and C.E. Seidman Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease N. Engl. J. Med. 341 1999 1715 1724
91. M. Vatta, B. Mohapatra, S. Jimenez, X. Sanchez, G. Faulkner, Z. Perles, G. Sinagra, J.-H. Lin, T.M. Vu, Q. Zhou, K.R. Bowles, A. Di Lenarda, L. Schimmenti, M. Fox, M.A. Chrisco, R.T. Murphy, W. McKenna, P. Elliott, N.E. Bowles, J. Chen, G. Valle, and J.A. Towbin Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction J. Am. Coll. Cardiol. 42 2003 2014 2027 (Pubitemid 37485581)
92. S. Arber, J.J. Hunter, J. Ross Jr., M. Hongo, G. Sansig, J. Borg, J.-C. Perriard, K.R. Chien, and P. Caroni MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure Cell 88 1997 393 403 (Pubitemid 27131381)
93. T.M. Olson, V.V. Michels, S.N. Thibodeau, Y.-S. Tai, and M.T. Keating Actin mutations in dilated cardiomyopathy, a heritable form of heart failure Science 280 1998 750 752 (Pubitemid 28243352)
94. K.R. Chien Genomic circuits and the integrative biology of cardiac diseases Nature 407 2000 227 232
95. M. Kamisago, S.D. Sharma, S.R. DePalma, S. Solomon, P. Sharma, B. McDonough, L. Smoot, M.P. Mullen, P.K. Woolf, E.D. Wigle, J.G. Seidman, J. Jarcho, L.R. Shapiro, and C.E. Seidman Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy N. Engl. J. Med. 343 2000 1688 1696
96. E.L. Burkett, and R.E. Hershberger Clinical and genetic issues in familial dilated cardiomyopathy J. Am. Coll. Cardiol. 45 2005 969 981 (Pubitemid 40432425)
97. R. Parvari, and A. Levitas The mutations associated with dilated cardiomyopathy Biochem. Res. Int. 2012 2012 12
98. D.S. Herman, L. Lam, M.R.G. Taylor, L. Wang, P. Teekakirikul, D. Christodoulou, L. Conner, S.R. DePalma, B. McDonough, E. Sparks, D.L. Teodorescu, A.L. Cirino, N.R. Banner, D.J. Pennell, S. Graw, M. Merlo, A. Di Lenarda, G. Sinagra, J.M. Bos, M.J. Ackerman, R.N. Mitchell, C.E. Murry, N.K. Lakdawala, C.Y. Ho, P.J.R. Barton, S.A. Cook, L. Mestroni, J.G. Seidman, and C.E. Seidman Truncations of titin causing dilated cardiomyopathy N. Engl. J. Med. 366 2012 619 628
99. M. Itoh-Satoh, T. Hayashi, H. Nishi, Y. Koga, T. Arimura, T. Koyanagi, M. Takahashi, S. Hohda, K. Ueda, T. Nouchi, M. Hiroe, F. Marumo, T. Imaizumi, M. Yasunami, and A. Kimura Titin mutations as the molecular basis for dilated cardiomyopathy Biochem. Biophys. Res. Commun. 291 2002 385 393 (Pubitemid 34694417)
100. B. Gerull, M. Gramlich, J. Atherton, M. McNabb, K. Trombitás, S. Sasse-Klaassen, J.G. Seidman, C. Seidman, H. Granzier, S. Labeit, M. Frenneaux, and L. Thierfelder Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy Nat. Genet. 30 2002 201 204
101. M. Taylor, S. Graw, G. Sinagra, C. Barnes, D. Slavov, F. Brun, B. Pinamonti, E.E. Salcedo, W. Sauer, S. Pyxaras, B. Anderson, B. Simon, J. Bogomolovas, S. Labeit, H. Granzier, and L. Mestroni Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy Circulation 124 2011 876 885
102. A.N. Chang, K. Harada, M.J. Ackerman, and J.D. Potter Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in α-tropomyosin J. Biol. Chem. 280 2005 34343 34349 (Pubitemid 41443160)
103. J. Staab, V. Ruppert, S. Pankuweit, and T. Meyer Polymorphisms in genes encoding nonsarcomeric proteins and their role in the pathogenesis of dilated cardiomyopathy Herz 37 2012 836 842
104. I. Banga, T. Erdos, M. Gerendás, F.H.M. Mommaerts, F.B. Straub, and A. Szent-Györgyi Myosin and muscular contraction Inst. Med. Chem. Univ. Szeged. 1 1941 1 71
105. F.B. Straub Actin Inst. Med. Chem. Univ. Szeged. 2 1942 1 15
106. J. Vandekerckhove, G. Bugaisky, and M. Buckingham Simultaneous expression of skeletal muscle and heart actin proteins in various striated muscle tissues and cells. A quantitative determination of the two actin isoforms J. Biol. Chem. 261 1986 1838 1843 (Pubitemid 17205023)
107. I. Papa, C. Astier, O. Kwiatek, F. Raynaud, C. Bonnal, M.-C. Lebart, C. Roustan, and Y. Benyamin Alpha actinin-CapZ, an anchoring complex for thin filaments in Z-line J. Muscle Res. Cell Motil. 20 1999 187 197 (Pubitemid 29290270)
108. A. Weber, C.R. Pennise, G.G. Babcock, and V.M. Fowler Tropomodulin caps the pointed ends of actin filaments J. Cell Biol. 127 1994 1627 1635 (Pubitemid 24380901)
109. S.W. Craig, and J.V. Pardo Gamma actin, spectrin, and intermediate filament proteins colocalize with vinculin at costameres, myofibril-to- sarcolemma attachment sites Cell Motil. 3 1983 449 462
110. J.V. Pardo, M.F. Pittenger, and S.W. Craig Subcellular sorting of isoactins: selective association of γ actin with skeletal muscle mitochondria Cell 32 1983 1093 1103 (Pubitemid 13033048)
111. I.N. Rybakova, K.J. Amann, and J.M. Ervasti A new model for the interaction of dystrophin with F-actin J. Cell Biol. 135 1996 661 672 (Pubitemid 26372923)
112. I.N. Rybakova, J.R. Patel, and J.M. Ervasti The dystrophin complex forms a mechanically strong link between the sarcolemma and costameric actin J. Cell Biol. 150 2000 1209 1214
113. K.W. Prins, D.A. Lowe, and J.M. Ervasti Skeletal muscle-specific ablation of γ(cyto)-actin does not exacerbate the mdx phenotype PLoS One 3 2008 e2419
114. D.H. Wachsstock, W.H. Schwartz, and T.D. Pollard Affinity of α-actinin for actin determines the structure and mechanical properties of actin filament gels Biophys. J. 65 1993 205 214 (Pubitemid 23206054)
115. A. van der Flier, and A. Sonnenberg Structural and functional aspects of filamins Biochim. Biophys. Acta 1538 2001 99 117 (Pubitemid 32402234)
116. T.M. Olson, T.P. Doan, N.Y. Kishimoto, F.G. Whitby, M.J. Ackerman, and L. Fananapazir Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy J. Mol. Cell. Cardiol. 32 2000 1687 1694
117. J. Mogensen, I.C. Klausen, A.K. Pedersen, H. Egeblad, P. Bross, T.A. Kruse, N. Gregersen, P.S. Hansen, U. Baandrup, and A.D. Borglum Alpha-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy J. Clin. Invest. 103 1999 R39 R43
118. A. Kumar, K. Crawford, L. Close, M. Madison, J. Lorenz, T. Doetschman, S. Pawlowski, J. Duffy, J. Neumann, J. Robbins, G.P. Boivin, B.A. O'Toole, and J.L. Lessard Rescue of cardiac α-actin-deficient mice by enteric smooth muscle γ-actin Proc. Natl. Acad. Sci. U. S. A. 94 1997 4406 4411
119. L. Rappaport, J.L. Samuel, K.W. Jeon, and M. Friedlander Microtubules in cardiac myocytes Int. Rev. Cytol. 113 1988 101 143 (Pubitemid 19051651)
120. H. Tsutsui, H. Tagawa, R.L. Kent, P.L. McCollam, K. Ishihara, M. Nagatsu, and G. Cooper Role of microtubules in contractile dysfunction of hypertrophied cardiocytes Circulation 90 1994 533 555 (Pubitemid 24203722)
121. H. Tsutsui, K. Ishihara, and G. Cooper Cytoskeletal role in the contractile dysfunction of hypertrophied myocardium Science 260 1993 682 687 (Pubitemid 23167592)
122. J. Eckel, and H. Reinauer Effects of microtubule-disrupting agents on insulin binding and degradation in isolated cardiocytes from adult rat Hoppe Seylers Z. Physiol. Chem. 7 1983 5
123. S.C. Watkins, J.L. Samuel, F. Marotte, B. Bertier-Savalle, and L. Rappaport Microtubules and desmin filaments during onset of heart hypertrophy in rat: a double immunoelectron microscope study Circ. Res. 60 1987 327 336 (Pubitemid 17094110)
124. E. White Mechanical modulation of cardiac microtubules Pflügers Arch. 462 2011 177 184
125. G. Cooper Cytoskeletal networks and the regulation of cardiac contractility: microtubules, hypertrophy, and cardiac dysfunction Am. J. Physiol. 291 2006 H1003 H1014
126. G. Cooper Cardiocyte cytoskeleton in hypertrophied myocardium Heart Fail. Rev. 5 2000 187 201
127. D.M. Eble, and F.G. Spinale Contractile and cytoskeletal content, structure, and mRNA levels with tachycardia-induced cardiomyopathy Am. J. Physiol. 268 1995 H2426 H2439
128. R. Stones, D. Benoist, M. Peckham, and E. White Microtubule proliferation in right ventricular myocytes of rats with monocrotaline-induced pulmonary hypertension J. Mol. Cell. Cardiol. 56 2012 91 96
129. A. Heling, R. Zimmermann, S. Kostin, Y. Maeno, S. Hein, B. Devaux, E. Bauer, Wolf-Peter Klövekorn, M. Schlepper, W. Schaper, and J. Schaper Increased expression of cytoskeletal, linkage, and extracellular proteins in failing human myocardium Circ. Res. 86 2000 846 853 (Pubitemid 30246981)
130. P.A. Watson, R. Hannan, L.L. Carl, and K.E. Giger Contractile activity and passive stretch regulate tubulin mRNA and protein content in cardiac myocytes Am. J. Physiol. 271 1996 C684 C689
131. X. Yutao, W. Geru, B. Xiaojun, G. Tao, and M. Aiqun Mechanical stretch-induced hypertrophy of neonatal rat ventricular myocytes is mediated by β1-integrin-microtubule signaling pathways Eur. J. Heart Fail. 8 2006 16 22 (Pubitemid 43012096)
132. C.S. Chung, and H.L. Granzier Contribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle J. Mol. Cell. Cardiol. 50 2011 731 739
133. H.L. Granzier, and T.C. Irving Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments Biophys. J. 68 1995 1027 1044
134. N.M.P. King, M. Methawasin, J. Nedrud, N. Harrell, C.S. Chung, M. Helmes, and H. Granzier Mouse intact cardiac myocyte mechanics: cross-bridge and titin-based stress in unactivated cells J. Gen. Physiol. 137 2011 81 91
135. K.W. Prins, J.L. Humston, A. Mehta, V. Tate, E. Ralston, and J.M. Ervasti Dystrophin is a microtubule-associated protein J. Cell Biol. 186 2009 363 369
136. D. Randazzo, E. Giacomello, S. Lorenzini, D. Rossi, E. Pierantozzi, B. Blaauw, C. Reggiani, S. Lange, A.K. Peter, J. Chen, and V. Sorrentino Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity J. Cell Biol. 200 2013 523 536
137. E. Lazarides, and B.D. Hubbard Immunological characterization of the
138. N. Laing, L. Goldfarb, M. Olivé, P. Vicart, and H.H. Goebel Intermediate filament diseases: desminopathy Adv. Exp. Med. Biol. 642 2008 131 164
139. L.G. Goldfarb, K.Y. Park, L. Cervenáková, S. Gorokhova, H.S. Lee, O. Vasconcelos, J.W. Nagle, C. Semino-Mora, K. Sivakumar, and M.C. Dalakas Missense mutations in desmin associated with familial cardiac and skeletal myopathy Nat. Genet. 19 1998 402 403 (Pubitemid 28357917)
140. B. Klauke, S. Kossmann, A. Gaertner, K. Brand, I. Stork, A. Brodehl, M. Dieding, V. Walhorn, D. Anselmetti, D. Gerdes, B. Bohms, U. Schulz, E. zu Knyphausen, M. Vorgerd, J. Gummert, and H. Milting De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy Hum. Mol. Genet. 19 2010 4595 4607
141. A. Lorenzon, G. Beffagna, B. Bauce, M. De Bortoli, I.E.A. Li Mura, M. Calore, E. Dazzo, C. Basso, A. Nava, G. Thiene, and A. Rampazzo Desmin mutations and arrhythmogenic right ventricular cardiomyopathy Am. J. Cardiol. 111 2013 400 405
142. Y. Capetanaki, D.J. Milner, and G. Weitzer Desmin in muscle formation and maintenance: knockouts and consequences Cell Struct. Funct. 22 1997 103 116 (Pubitemid 27223251)
143. D.J. Milner, G. Weitzer, D. Tran, A. Bradley, and Y. Capetanaki Disruption of muscle architecture and myocardial degeneration in mice lacking desmin J. Cell Biol. 134 1996 1255 1270 (Pubitemid 26300170)
144. D.J. Milner, G.E. Taffet, X. Wang, T. Pham, T. Tamura, C. Hartley, M.A. Gerdes, and Y. Capetanaki The absence of desmin leads to cardiomyocyte hypertrophy and cardiac dilation with compromised systolic function J. Mol. Cell. Cardiol. 31 1999 2063 2076 (Pubitemid 29537605)
145. F. Bennardini, A. Wrzosek, and M. Chiesi Alpha B-crystallin in cardiac tissue. Association with actin and desmin filaments Circ. Res. 71 1992 288 294
146. K. Djabali, B. de Nechaud, F. Landon, and M.M. Portier AlphaB-crystallin interacts with intermediate filaments in response to stress J. Cell Sci. 110 1997 2759 2769 (Pubitemid 27499432)
147. P. Vicart, A. Caron, P. Guicheney, Z. Li, M.-C. Prévost, A. Faure, D. Chateau, F. Chapon, F. Tomé, and J.-M. Dupret A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy Nature 20 1998 92 95 (Pubitemid 28410353)
148. X. Wang, H. Osinska, R. Klevitsky, A.M. Gerdes, M. Nieman, J. Lorenz, T. Hewett, and J. Robbins Expression of R120G-αB-crystallin causes aberrant desmin and αB-crystallin aggregation and cardiomyopathy in mice Circ. Res. 89 2001 84 91 (Pubitemid 34135496)
149. B. Bullard, C. Ferguson, A. Minajeva, M.C. Leake, M. Gautel, D. Labeit, L. Ding, S. Labeit, J. Horwitz, K.R. Leonard, and W.A. Linke Association of the chaperone αB-crystallin with titin in heart muscle J. Biol. Chem. 279 2004 7917 7924 (Pubitemid 38294679)
150. N. Golenhofen, A. Arbeiter, R. Koob, and D. Drenckhahn Ischemia-induced association of the stress protein alpha B-crystallin with I-band portion of cardiac titin J. Mol. Cell. Cardiol. 34 2002 309 319 (Pubitemid 37162423)
151. A.K. Peter, H. Cheng, R.S. Ross, K.U. Knowlton, and J. Chen The costamere bridges sarcomeres to the sarcolemma in striated muscle Prog. Pediatr. Cardiol. 31 2011 83 88
152. K. Ralph, B. Buyandelger, and M. Lab The sarcomeric Z-disc and Z-discopathies J. Biomed. Biotechnol. 2011 2011 12
153. R.M. Robson, D.E. Goll, N. Arakawa, and M.H. Stromer Purification and properties of α-actinin from rabbit skeletal muscle Biochim. Biophys. Acta 200 1970 296 318
154. M. Mills, N. Yang, R. Weinberger, D.L. Vander Woude, A.H. Beggs, S. Easteal, and K. North Differential expression of the actin-binding proteins, α-actinin-2 and -3, in different species: implications for the evolution of functional redundancy Hum. Mol. Genet. 10 2001 1335 1346 (Pubitemid 32640662)
155. C. Chiu, R.D. Bagnall, J. Ingles, L. Yeates, M. Kennerson, J.A. Donald, M. Jormakka, J.M. Lind, and C. Semsarian Mutations in α-actinin-2 cause hypertrophic cardiomyopathy J. Am. Coll. Cardiol. 55 2010 1127 1135
156. B. Mohapatra, S. Jimenez, J.H. Lin, K.R. Bowles, K.J. Coveler, J.G. Marx, M.A. Chrisco, R.T. Murphy, P.R. Lurie, R.J. Schwartz, P.M. Elliott, M. Vatta, W. McKenna, J.A. Towbin, and N.E. Bowles Mutations in the muscle LIM protein and α-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis Mol. Genet. Metab. 80 2003 207 215 (Pubitemid 37272247)
157. M.D. Baron, M.D. Davison, P. Jones, and D.R. Critchley The structure and function of α-actinin Biochem. Soc. Trans. 15 1987 796 798
158. P. Salmikangas, O.-M. Mykkänenn, M. Grönholm, L. Heiska, J. Kere, and O. Carpén Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy Hum. Mol. Genet. 8 1999 1329 1336 (Pubitemid 29329003)
159. S. Lu, S.L. Carroll, A.H. Herrera, B. Ozanne, and R. Horowits New N-RAP-binding partners α-actinin, filamin and Krp1 detected by yeast two-hybrid screening: implications for myofibril assembly J. Cell Sci. 116 2003 2169 2178 (Pubitemid 36722363)
160. B.M. Jockusch, and G. Isenberg Interaction of α-actinin and vinculin with actin: opposite effects on filament network formation Proc. Natl. Acad. Sci. U. S. A. 75 1981 3005 3009
161. F.M. Pavalko, C.A. Otey, K.O. Simon, and K. Burridge Alpha-actinin: a direct link between actin and integrins Biochem. Soc. Trans. 19 1991 1065 1069
162. G. Faulkner, A. Pallavicini, E. Formentin, A. Comelli, C. Ievolella, S. Trevisan, G. Bortoletto, P. Scannapieco, M. Salamon, V. Mouly, G. Valle, and G. Lanfranchi ZASP: a new Z-band alternatively spliced PDZ-motif protein J. Cell Biol. 146 1999 465 475 (Pubitemid 29369781)
163. T. Klaavuniemi, A. Kelloniemi, and J. Ylänne The ZASP-like motif in actinin-associated LIM protein is required for interaction with the α-actinin rod and for targeting to the muscle Z-line J. Biol. Chem. 279 2004 26402 26410 (Pubitemid 38798792)
164. Q. Zhou, P. Ruiz-Lozano, M.E. Martone, and J. Chen Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to α-actinin-2 and protein kinase C J. Biol. Chem. 274 1999 19807 19813
165. P. Pomiès, T. Macalma, and M.C. Beckerle Purification and characterization of an α-actinin-binding PDZ-LIM protein that is up-regulated during muscle differentiation J. Biol. Chem. 274 1999 29242 29250
166. A.W. Crawford, J.W. Michelsen, and M.C. Beckerle An interaction between zyxin and α-actinin J. Cell Biol. 116 1992 1381 1393
167. R.A. Atkinson, C. Joseph, F. Dal Piaz, L. Birolo, G. Stier, P. Pucci, and A. Pastore Binding of α-actinin to titin: implications for Z-disk assembly Biochemistry 39 2000 5255 5264 (Pubitemid 30257063)
168. G. Faulkner, A. Pallavicini, A. Comelli, M. Salamon, G. Bortoletto, C. Ievolella, S. Trevisan, S. Kojić, F. Dalla Vecchia, P. Laveder, G. Valle, and G. Lanfranchi FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle J. Biol. Chem. 275 2000 41234 41242 (Pubitemid 32054956)
169. D.A. Schafer, C. Hug, and J.A. Cooper Inhibition of CapZ during myofibrillogenesis alters assembly of actin filaments J. Cell Biol. 128 1995 61 70
170. J.E. Caldwell, S.G. Heiss, V. Mermall, and J.A. Cooper Effects of CapZ, an actin-capping protein of muscle, on the polymerization of actin Biochemistry 28 1989 8506 8514 (Pubitemid 19269044)
171. D.A. Schafer, Y.O. Korshunova, T.A. Schroer, and J.A. Cooper Differential localization and sequence analysis of capping protein β-subunit isoforms of vertebrates J. Cell Biol. 127 1994 453 465
172. M.C. Hart, and J.A. Cooper Vertebrate isoforms of actin capping protein β have distinct functions in vivo J. Cell Biol. 147 1999 1287 1298 (Pubitemid 30012813)
173. V.E. Koteliansky, M.A. Glukhova, V.P. Shirinsky, V.R. Babaev, V.F. Kandalenko, V.S. Rukosuev, and V.N. Smirnov Identification of a filamin-like protein in chicken heart muscle FEBS Lett. 125 1981 44 48 (Pubitemid 11107832)
174. T.G. Thompson, Y.M. Chan, A.A. Hack, M. Brosius, M. Rajala, H.G. Lidov, E.M. McNally, S. Watkins, and L.M. Kunkel Filamin 2 (FLN2): a muscle-specific sarcoglycan interacting protein J. Cell Biol. 148 2000 115 126 (Pubitemid 30046786)
175. Y. Gontier, A. Taivainen, L. Fontao, A. Sonnenberg, A. van der Flier, O. Carpen, G. Faulkner, and L. Borradori The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins J. Cell Sci. 118 2005 3739 3749 (Pubitemid 41309420)
176. P.F.M. van der Ven, S. Wiesner, P. Salmikangas, D. Auerbach, M. Himmel, S. Kempa, K. Hayeß, D. Pacholsky, A. Taivainen, R. Schröder, O. Carpén, and D.O. Fürst Indications for a novel muscular dystrophy pathway: γ-filamin, the muscle-specific filamin isoform, interacts with myotilin J. Cell Biol. 151 2000 235 248
177. M. Vorgerd, P.F.M. van der Ven, V. Bruchertseifer, T. Löwe, R.A. Kley, R. Schröder, H. Lochmüller, M. Himmel, K. Koehler, D.O. Fürst, and A. Huebner A mutation in the dimerization domain of filamin C causes a novel type of autosomal dominant myofibrillar myopathy Am. J. Hum. Genet. 77 2005 297 304 (Pubitemid 41022711)
178. R.A. Kley, Y. Hellenbroich, P.F.M. van der Ven, D.O. Fürst, A. Huebner, V. Bruchertseifer, S.A. Peters, C.M. Heyer, J. Kirschner, R. Schröder, D. Fischer, K. Müller, K. Tolksdorf, K. Eger, A. Germing, T. Brodherr, C. Reum, M.C. Walter, H. Lochmüller, U.-P. Ketelsen, and M. Vorgerd Clinical and morphological phenotype of the filamin myopathy: a study of 31 German patients Brain 130 2007 3250 3264 (Pubitemid 350209082)
179. M.G. Price, D.R. Caprette, and R.H. Gomer Different temporal patterns of expression result in the same type, amount, and distribution of filamin (ABP) in cardiac and skeletal myofibrils Cell Motil. Cytoskeleton 27 1994 248 261 (Pubitemid 24108023)
180. P. Salmikangas, P.F.M. van der Ven, M. Lalowski, A. Taivainen, F. Zhao, H. Suila, R. Schröder, P. Lappalainen, D.O. Fürst, and O. Carpén Myotilin, the limb-girdle muscular dystrophy 1A (LGMD1A) protein, cross-links actin filaments and controls sarcomere assembly Hum. Mol. Genet. 12 2003 189 203 (Pubitemid 36124454)
181. M.A. Hauser, S.K. Horrigan, P. Salmikangas, U.M. Torian, K.D. Viles, R. Dancel, R.W. Tim, A. Taivainen, L. Bartoloni, J.M. Gilchrist, J.M. Stajich, P.C. Gaskell, J.R. Gilbert, J.M. Vance, M.A. Pericak-Vance, O. Carpen, C.A. Westbrook, and M.C. Speer Myotilin is mutated in limb girdle muscular dystrophy 1A Hum. Mol. Genet. 9 2000 2141 2147
182. D. Selcen, and A.G. Engel Mutations in myotilin cause myofibrillar myopathy Neurology 62 2004 1363 1371 (Pubitemid 38526050)
183. P. von Nandelstadh, M. Ismail, C. Gardin, H. Suila, I. Zara, A. Belgrano, G. Valle, O. Carpen, and G. Faulkner A class III PDZ binding motif in the myotilin and FATZ families binds Enigma family proteins: a common link for Z-disc myopathies Mol. Biol. Cell 29 2009 822 834
184. M. Zheng, H. Cheng, X. Li, J. Zhang, L. Cui, K. Ouyang, L. Han, T. Zhao, Y. Gu, N.D. Dalton, M.-L. Bang, K.L. Peterson, and J. Chen Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death Hum. Mol. Genet. 18 2009 701 713
185. M. Moza, L. Mologni, R. Trokovic, G. Faulkner, J. Partanen, and O. Carpén Targeted deletion of the muscular dystrophy gene myotilin does not perturb muscle structure or function in mice Mol. Cell. Biol. 27 2007 244 252 (Pubitemid 46013248)
186. C.T. Pappas, K.T. Bliss, A. Zieseniss, and C.C. Gregorio The Nebulin family: an actin support group Trends Cell Biol. 21 2011 29 37
187. K. Wang, and J. Wright Architecture of the sarcomere matrix of skeletal muscle: immunoelectron microscopic evidence that suggests a set of parallel inextensible nebulin filaments anchored at the Z line J. Cell Biol. 107 1988 2199 2212 (Pubitemid 19015099)
188. S. Labeit, T. Gibson, A. Lakey, K. Leonard, M. Zeviani, P. Knight, J. Wardale, and J. Trinick Evidence that nebulin is a protein-ruler in muscle thin filaments FEBS Lett. 282 1991 313 316
189. M.-L. Bang, X. Li, R. Littlefield, S. Bremner, A. Thor, K.U. Knowlton, R.L. Lieber, and J. Chen Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle J. Cell Biol. 173 2006 905 916
190. C.A. Ottenheijm, H. Granzier, and S. Labeit The sarcomeric protein nebulin: another multifunctional giant in charge of muscle strength optimization Front. Physiol. 3 2012 37
191. K. Pelin, P. Hilpelä, K. Donner, C. Sewry, P.A. Akkari, S.D. Wilton, D. Wattanasirichaigoon, M.-L. Bang, T. Centner, F. Hanefeld, S. Odent, M. Fardeau, J.A. Urtizberea, F. Muntoni, V. Dubowitz, A.H. Beggs, N.G. Laing, S. Labeit, A. de la Chapelle, and C. Wallgren-Pettersson Mutations in the nebulin gene associated with autosomal recessive nemaline myopathy Proc. Natl. Acad. Sci. U. S. A. 96 1999 2305 2310 (Pubitemid 29117910)
192. D. Sanoudou, and A.H. Beggs Clinical and genetic heterogeneity in nemaline myopathy - a disease of skeletal muscle thin filaments Trends Mol. Med. 7 2001 362 368 (Pubitemid 32735022)
193. C.L. Moncman, and K. Wang Nebulette: a 107 kD nebulin-like protein in cardiac muscle Cell Motil. Cytoskeleton 32 1995 205 225
194. C. Moncman, and K. Wang Architecture of the thin filament-Z-line junction: lessons from nebulette and nebulin homologies J. Muscle Res. Cell Motil. 21 2000 153 169 (Pubitemid 30612265)
195. C.L. Moncman, and K. Wang Targeted disruption of nebulette protein expression alters cardiac myofibril assembly and function Exp. Cell Res. 273 2002 204 218 (Pubitemid 34920671)
196. K. Wang, M. Knipfer, Q.-Q. Huang, A. van Heerden, L.C.-L. Hsu, G. Gutierrez, X.-L. Quian, and H. Stedman Human skeletal muscle nebulin sequence encodes a blueprint for thin filament architecture. Sequence motifs and affinity profiles of tandem repeats and terminal SH J. Biol. Chem. 271 1996 4304 4314
197. O. Ogut, M.M. Hossain, and J.-P. Jin Interactions between nebulin-like motifs and thin filament regulatory proteins J. Biol. Chem. 278 2003 3089 3097 (Pubitemid 36801218)
198. J.R. Bonzo, A.A. Norris, M. Esham, and C.L. Moncman The nebulette repeat domain is necessary for proper maintenance of tropomyosin with the cardiac sarcomere Exp. Cell Res. 314 2008 3519 3530
199. M.-L. Bang, C. Gregorio, and S. Labeit Molecular dissection of the interaction of desmin with the C-terminal region of nebulin J. Struct. Biol. 137 2002 119 127 (Pubitemid 35430427)
200. C.L. Moncman, and K. Wang Functional dissection of nebulette demonstrates actin binding of nebulin-like repeats and Z-line targeting of SH3 and linker domains Cell Motil. Cytoskeleton 44 1999 1 22 (Pubitemid 29416508)
201. C.C. Witt, C. Burkart, D. Labeit, M. McNabb, Y. Wu, H. Granzier, and S. Labeit Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo EMBO J. 25 2006 3843 3855 (Pubitemid 44300270)
202. M.-L. Bang, R.E. Mudry, A.S. McElhinny, K. Trombitás, A.J. Geach, R. Yamasaki, H. Sorimachi, H. Granzier, C.C. Gregorio, and S. Labeit Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies J. Cell Biol. 153 2001 413 428
203. B. Li, L. Zhuang, and B. Trueb Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1 J. Biol. Chem. 279 2004 20401 20410 (Pubitemid 38623487)
204. K. Ma, and K. Wang Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin FEBS Lett. 532 2002 273 278 (Pubitemid 35441360)
205. W.B. Holmes, and C.L. Moncman Nebulette interacts with filamin C Cell Motil. Cytoskeleton 65 2008 130 142 (Pubitemid 351272974)
206. E. Purevjav, J. Varela, M. Morgado, D.L. Kearney, H. Li, M.D. Taylor, T. Arimura, C.L. Moncman, W. McKenna, R.T. Murphy, S. Labeit, M. Vatta, N.E. Bowles, A. Kimura, A.M. Boriek, and J.A. Towbin Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis J. Am. Coll. Cardiol. 56 2010 1493 1502
207. M. Esham, K. Bryan, J. Milnes, W.B. Holmes, and C.L. Moncman Expression of nebulette during early cardiac development Cell Motil. Cytoskeleton 64 2007 258 273 (Pubitemid 46452035)
208. G. Luo, J.Q. Zhang, T.-P. Nguyen, A.H. Herrera, B. Paterson, and R. Horowits Complete cDNA sequence and tissue localization of N-RAP, a novel nebulin-related protein of striated muscle Cell Motil. Cytoskeleton 38 1997 75 90 (Pubitemid 27383301)
209. A. Dhume, S. Lu, and R. Horowits Targeted disruption of N-RAP gene function by RNA interference: a role for N-RAP in myofibril organization Cell Motil. Cytoskeleton 63 2006 493 511 (Pubitemid 44162638)
210. V. Schreiber, R. Masson, J. Linares, M.-G. Mattei, C. Tomasetto, and M.-C. Rio Chromosomal assignment and expression pattern of the murine Lasp-1 gene Gene 207 1998 171 175 (Pubitemid 28085347)
211. A. Zieseniss, A.G. Terasaki, and C.C. Gregorio Lasp-2 expression, localization, and ligand interactions: a new Z-disc scaffolding protein Cell Motil. Cytoskeleton 65 2008 59 72
212. J.V. Pardo, J.D. Siliciano, and S.W. Craig A vinculin-containing cortical lattice in skeletal muscle: transverse lattice elements ("costameres" ) mark sites of attachment between myofibrils and sarcolemma Proc. Natl. Acad. Sci. U. S. A. 80 1983 1008 1012 (Pubitemid 13118076)
213. S.F. Street Lateral transmission of tension in frog myofibers: a myofibrillar network and transverse cytoskeletal connections are possible transmitters J. Cell. Physiol. 114 1983 346 364 (Pubitemid 13161556)
214. B.A. Danowski, K. Imanaka-Yoshida, J.M. Sanger, and J.W. Sanger Costameres are sites of force transmission to the substratum in adult rat cardiomyocytes J. Cell Biol. 118 1992 1411 1420
215. R.J. Bloch, and H. Gonzalez-Serratos Lateral force transmission across costameres in skeletal muscle Exerc. Sport Sci. Rev. 31 2003 6
216. M. Hoshijima Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures Am. J. Physiol. 290 2006 H1313 H1325
217. B. Russell, M.W. Curtis, Y.E. Koshman, and A.M. Samarel Mechanical stress-induced sarcomere assembly for cardiac muscle growth in length and width J. Mol. Cell. Cardiol. 48 2010 817 823
218. J.M. Ervasti, and K.P. Campbell Dystrophin-associated glycoproteins: their possible roles in the pathogenesis of Duchenne muscular dystrophy Mol. Cell Biol. Hum. Dis. Ser. 3 1993 139 166
219. J.A. Towbin, J.F. Hejtmancik, P. Brink, B. Gelb, X.M. Zhu, J.S. Chamberlain, E.R. McCabe, and M. Swift X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus Circulation 87 1993 1854 1865 (Pubitemid 23165627)
220. A.H. Beggs Dystrophinopathy, the expanding phenotype: dystrophin abnormalities in X-linked dilated cardiomyopathy Circulation 95 1997 2344 2347 (Pubitemid 27224725)
221. R.M. Grady, H. Teng, M.C. Nichol, J.C. Cunningham, R.S. Wilkinson, and J.R. Sanes Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy Cell 90 1997 729 738 (Pubitemid 27357964)
222. C. Badorff, G.H. Lee, B.J. Lamphear, M.E. Martone, K.P. Campbell, R.E. Rhoads, and K.U. Knowlton Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy Nat. Med. 5 1999 320 326 (Pubitemid 29124369)
223. K.H. Holt, L.E. Lim, V. Straub, D.P. Venzke, F. Duclos, R.D. Anderson, B.L. Davidson, and K.P. Campbell Functional rescue of the sarcoglycan complex in the BIO 14.6 hamster using δ-sarcoglycan gene transfer Mol. Cell 1 1998 841 848 (Pubitemid 128379068)
224. E.M. McNally, D. Duggan, J. Rafael Gorospe, C.G. Bönnemann, M. Fanin, E. Pegoraro, H.G.W. Lidov, S. Noguchi, E. Ozawa, R.S. Finkel, R.P. Cruse, C. Angelini, L.M. Kunkel, and E.P. Hoffman Mutations that disrupt the carboxyl-terminus of γ-sarcoglycan cause muscular dystrophy Hum. Mol. Genet. 5 1996 1841 1847 (Pubitemid 26372422)
225. A.A. Hack, C.T. Ly, F. Jiang, C.J. Clendenin, K.S. Sigrist, R.L. Wollmann, and E.M. McNally Gamma-sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin J. Cell Biol. 142 1998 1279 1287 (Pubitemid 28429109)
226. R.O. Hynes Integrins: bidirectional, allosteric signaling machines Cell 110 2002 673 687 (Pubitemid 35283958)
227. L. Hemmings, D.J. Rees, V. Ohanian, S.J. Bolton, A.P. Gilmore, B. Patel, H. Priddle, J.E. Trevithick, R.O. Hynes, and D.R. Critchley Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site J. Cell Sci. 109 1996 2715 2726 (Pubitemid 26388356)
228. W.H. Goldmann, Z. Guttenberg, S. Kaufmann, D. Hess, R.M. Ezzell, and G. Isenberg Examining F-actin interaction with intact talin and talin head and tail fragment using static and dynamic light scattering Eur. J. Biochem. 250 1997 447 450 (Pubitemid 28012687)
229. A.P. Gilmore, and K. Burridge Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate Nature 381 1996 531 535 (Pubitemid 26170933)
230. A.E. Zemljic-Harpf, S. Ponrartana, R.T. Avalos, M.C. Jordan, K.P. Roos, N.D. Dalton, V.Q. Phan, E.D. Adamson, and R.S. Ross Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy Am. J. Pathol. 165 2004 1033 1044 (Pubitemid 39129308)
231. T.M. Olson, S. Illenberger, N.Y. Kishimoto, S. Huttelmaier, M.T. Keating, and B.M. Jockusch Metavinculin mutations alter actin interaction in dilated cardiomyopathy Circulation 105 2002 431 437 (Pubitemid 34141698)
232. M. Maeda, E. Holder, B. Lowes, S. Valent, and R.D. Bies Dilated cardiomyopathy associated with deficiency of the cytoskeletal protein metavinculin Circulation 95 1997 17 20 (Pubitemid 27029936)
233. R.K. Harston, and D. Kuppuswamy Integrins are the necessary links to hypertrophic growth in cardiomyocytes J. Signal Trans. 2011 2011 8
234. T. Matsushita, M. Oyamada, K. Fujimoto, Y. Yasuda, S. Masuda, Y. Wada, T. Oka, and T. Takamatsu Remodeling of cell-cell and cell-extracellular matrix interactions at the border zone of rat myocardial infarcts Circ. Res. 85 1999 1046 1055
235. L. Terracio, K. Rubin, D. Gullberg, E. Balog, W. Carver, R. Jyring, and T.K. Borg Expression of collagen binding integrins during cardiac development and hypertrophy Circ. Res. 68 1991 734 744
236. C.D. Willey, S. Balasubramanian, M.C. Rodríguez Rosas, R.S. Ross, and D. Kuppuswamy Focal complex formation in adult cardiomyocytes is accompanied by the activation of β3 integrin and c-Src J. Mol. Cell. Cardiol. 35 2003 671 683 (Pubitemid 36677451)
237. E. Ogawa, Y. Saito, M. Harada, S. Kamitani, K. Kuwahara, Y. Miyamoto, M. Ishikawa, I. Hamanaka, N. Kajiyama, N. Takahashi, O. Nakagawa, I. Masuda, I. Kishimoto, and K. Nakao Outside-in signalling of fibronectin stimulates cardiomyocyte hypertrophy in cultured neonatal rat ventricular myocytes J. Mol. Cell. Cardiol. 32 2000 765 776 (Pubitemid 30658914)
238. R.S. Ross, C. Pham, S.Y. Shai, J.I. Goldhaber, C. Fenczik, C.C. Glembotski, M.H. Ginsberg, and J.C. Loftus β1 integrins participate in the hypertrophic response of rat ventricular myocytes Circ. Res. 82 1998 1160 1172 (Pubitemid 28311124)
239. J. Schaper, R. Froede, S. Hein, A. Buck, H. Hashizume, B. Speiser, A. Friedl, and N. Bleese Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy Circulation 83 1991 504 514
240. M.M. Parast, and C.A. Otey Characterization of palladin, a novel protein localized to stress fibers and cell adhesions J. Cell Biol. 150 2000 643 656
241. C.A. Otey, A. Rachlin, M. Moza, D. Arneman, O. Carpen, and W.J. Kwang The palladin/myotilin/myopalladin family of actin-associated scaffolds Int. Rev. Cytol. 246 2005 31 58 (Pubitemid 41825796)
242. R. Jeyaseelan, C. Poizat, R.K. Baker, S. Abdishoo, L.B. Isterabadi, G.E. Lyons, and L. Kedes A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes J. Biol. Chem. 272 1997 22800 22808 (Pubitemid 27386100)
243. L. Duboscq-Bidot, P. Xu, P. Charron, N. Neyroud, G. Dilanian, A. Millaire, V. Bors, M. Komajda, and E. Villard Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy Cardiovasc. Res. 77 2008 118 125 (Pubitemid 351195145)
244. T. Meyer, V. Ruppert, S. Ackermann, A. Richter, A. Perrot, S.R. Sperling, M.G. Posch, B. Maisch, and S. Pankuweit Novel mutations in the sarcomeric protein myopalladin in patients with dilated cardiomyopathy Eur. J. Hum. Genet. 7 2012
245. E. Purevjav, T. Arimura, S. Augustin, A.-C. Huby, K. Takagi, S. Nunoda, D.L. Kearney, M.D. Taylor, F. Terasaki, J.M. Bos, S.R. Ommen, H. Shibata, M. Takahashi, M. Itoh-Satoh, W.J. McKenna, R.T. Murphy, S. Labeit, Y. Yamanaka, N. Machida, J.-E. Park, P.M.A. Alexander, R.G. Weintraub, Y. Kitaura, M.J. Ackerman, A. Kimura, and J.A. Towbin Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations Hum. Mol. Genet. 21 2012 2039 2053
246. N. Frey, J.A. Richardson, and E.N. Olson Calsarcins, a novel family of sarcomeric calcineurin-binding proteins Proc. Natl. Acad. Sci. U. S. A. 97 2000 14632 14637 (Pubitemid 32016627)
247. F. Takada, D.L.V. Woude, H.-Q. Tong, T.G. Thompson, S.C. Watkins, L.M. Kunkel, and A.H. Beggs Myozenin: an α-actinin- and γ-filamin-binding protein of skeletal muscle Z lines Proc. Natl. Acad. Sci. U. S. A. 98 2001 1595 1600 (Pubitemid 32165544)
248. N. Frey, and E.N. Olson Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins J. Biol. Chem. 277 2002 13998 14004 (Pubitemid 34968008)
249. J.D. Molkentin Calcineurin and beyond: cardiac hypertrophic signaling Circ. Res. 87 2000 731 738
250. B.J. Wilkins, and J.D. Molkentin Calcineurin and cardiac hypertrophy: where have we been? where are we going? J. Physiol. 541 2002 1 8 (Pubitemid 35203232)
251. N. Frey, T. Barrientos, J.M. Shelton, D. Frank, H. Rütten, D. Gehring, C. Kuhn, M. Lutz, B. Rothermel, R. Bassel-Duby, J.A. Richardson, H.A. Katus, J.A. Hill, and E.N. Olson Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress Nat. Med. 10 2004 1336 1343 (Pubitemid 40022715)
252. A. Osio, L. Tan, S.N. Chen, R. Lombardi, S.F. Nagueh, S. Shete, R. Roberts, J.T. Willerson, and A.J. Marian Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy Circ. Res. 100 2007 766 768 (Pubitemid 46555681)
253. M.G. Posch, L. Thiemann, P. Tomasov, J. Veselka, N. Cardim, M. Garcia-Castro, E. Coto, A. Perrot, C. Geier, R. Dietz, W. Haverkamp, and C. Ozcelik Sequence analysis of myozenin 2 in 438 European patients with familial hypertrophic cardiomyopathy Med. Sci. Monit. 14 2008 CR372 CR374
254. A.Y. Hung, and M. Sheng PDZ domains: structural modules for protein complex assembly J. Biol. Chem. 277 2002 5699 5702 (Pubitemid 34968344)
255. G.N. Gill The enigma of LIM domains Structure 3 1995 1285 1289 (Pubitemid 3010765)
256. A.J.W. te Velthuis, and C.P. Bagowski PDZ and LIM domain-encoding genes: molecular interactions and their role in development Sci. World J. 7 2007 1470 1492 (Pubitemid 47435428)
257. M. Zheng, H. Cheng, I. Banerjee, and J. Chen ALP/Enigma PDZ-LIM domain proteins in the heart J. Mol. Cell Biol. 2 2010 96 102
258. M. Kotaka, S.-M. Ngai, M. Garcia-Barcelo, S.K.W. Tsui, K.-P. Fung, C.-Y. Lee, and M.M.Y. Waye Characterization of the human 36-kDa carboxyl terminal LIM domain protein (hCLIM1) J. Cell. Biochem. 72 1999 279 285 (Pubitemid 29021941)
259. M. Kotaka, S. Kostin, S.-m. Ngai, K.-k. Chan, Y.-m. Lau, S.M.Y. Lee, H.-y. Li, E.K.O. Ng, J. Schaper, S.K.W. Tsui, K.-p. Fung, C.-y. Lee, and M.M.Y. Waye Interaction of hCLIM1, an enigma family protein, with α-actinin 2 J. Cell. Biochem. 78 2000 558 565 (Pubitemid 30623492)
260. H. Xia, S.T. Winokur, W.-L. Kuo, M.R. Altherr, and D.S. Bredt Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifs J. Cell Biol. 139 1997 507 515 (Pubitemid 27459321)
261. M. Pashmforoush, P. Pomiès, K. Peterson, S. Kubalak, J.J. Ross, A. Hefti, U. Aebi, M. Beckerle, and K. Chien Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy Nat. Med. 5 2001 591 597 (Pubitemid 32448327)
262. J.E. Nieset, A.R. Redfield, F. Jin, K.A. Knudsen, K.R. Johnson, and M.J. Wheelock Characterization of the interactions of α-catenin with α-actinin and β-catenin/plakoglobin J. Cell Sci. 110 1997 1013 1022 (Pubitemid 27216121)
263. L. Masuelli, R. Bei, P. Sacchetti, I. Scappaticci, P. Francalanci, L. Albonici, A. Coletti, C. Palumbo, M. Minieri, R. Fiaccavento, F. Carotenuto, C. Fantini, L. Carosella, A. Modesti, and P. Di Nardo β-catenin accumulates in intercalated disks of hypertrophic cardiomyopathic hearts Cardiovasc. Res. 60 2003 376 387 (Pubitemid 37412371)
264. I. Lorenzen-Schmidt, A. McCulloch, and J. Omens Deficiency of actinin-associated LIM protein alters regional right ventricular function and hypertrophic remodeling Ann. Biomed. Eng. 33 2005 888 896 (Pubitemid 40997675)
265. R.Y. Wu, and G.N. Gill LIM domain recognition of a tyrosine-containing tight turn J. Biol. Chem. 269 1994 25085 25090 (Pubitemid 24311779)
266. T. Khurana, B. Khurana, and A.A. Noegel LIM proteins: association with the actin cytoskeleton Protoplasma 219 2002 1 12 (Pubitemid 34166167)
267. Romain Barrès, T. Gonzalez, Y.L. Marchand-Brustel, and J.-F. Tanti The interaction between the adaptor protein APS and Enigma is involved in actin organisation Exp. Cell Res. 308 2005 334 344
268. P.M. Guy, D.A. Kenny, and G.N. Gill The PDZ domain of the LIM protein Enigma binds to β-tropomyosin Mol. Biol. Cell 10 1999 1973 1984 (Pubitemid 29272644)
269. Kuroda Si, C. Tokunaga, Y. Kiyohara, O. Higuchi, H. Konishi, K. Mizuno, G.N. Gill, and U. Kikkawa Protein-protein interaction of zinc finger LIM domains with protein kinase C J. Biol. Chem. 271 1996 31029 31032 (Pubitemid 26408538)
270. N. Nakagawa, M. Hoshijima, M. Oyasu, N. Saito, K. Tanizawa, and Si Kuroda ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain Biochem. Biophys. Res. Commun. 272 2000 505 512 (Pubitemid 30444647)
271. N. Niederländer, N.A. Fayein, C. Auffray, and P. Pomiès Characterization of a new human isoform of the enigma homolog family specifically expressed in skeletal muscle Biochem. Biophys. Res. Commun. 325 2004 1304 1311 (Pubitemid 39535905)
272. A.D. Maturana, S. Wälchli, M. Iwata, S. Ryser, J. Van Lint, M. Hoshijima, W. Schlegel, Y. Ikeda, K. Tanizawa, and Si Kuroda Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel Cardiovasc. Res. 78 2008 458 465 (Pubitemid 351769773)
273. T. Yamazaki, S. Wälchli, T. Fujita, S. Ryser, M. Hoshijima, W. Schlegel, Si Kuroda, and A.D. Maturana Splice variants of Enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy Cardiovasc. Res. 86 2010 374 382
274. A.-M. Lompré Enigma in cardiac hypertrophy Cardiovasc. Res. 86 2010 349 350
275. H. Cheng, K. Kimura, A.K. Peter, L. Cui, K. Ouyang, T. Shen, Y. Liu, Y. Gu, N.D. Dalton, S.M. Evans, K.U. Knowlton, K.L. Peterson, and J. Chen Loss of enigma homolog protein results in dilated cardiomyopathy Circ. Res. 107 2010 348 356
276. R. Passier, J.A. Richardson, and E.N. Olson Oracle, a novel PDZ-LIM domain protein expressed in heart and skeletal muscle Mech. Dev. 92 2000 277 284 (Pubitemid 30155922)
277. Q. Zhou, P.-H. Chu, C. Huang, C.-F. Cheng, M.E. Martone, G. Knoll, G.D. Shelton, S. Evans, and J. Chen Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy J. Cell Biol. 155 2001 605 612 (Pubitemid 34289318)
278. T. Arimura, T. Hayashi, H. Terada, S.-Y. Lee, Q. Zhou, M. Takahashi, K. Ueda, T. Nouchi, S. Hohda, M. Shibutani, M. Hirose, J. Chen, J.-E. Park, M. Yasunami, H. Hayashi, and A. Kimura A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C J. Biol. Chem. 279 2004 6746 6752 (Pubitemid 38248815)
279. J.L. Theis, J.M. Bos, V.B. Bartleson, M.L. Will, J. Binder, M. Vatta, J.A. Towbin, B.J. Gersh, S.R. Ommen, and M.J. Ackerman Echocardiographic- determined septal morphology in Z-disc hypertrophic cardiomyopathy Biochem. Biophys. Res. Commun. 351 2006 896 902 (Pubitemid 44715870)
280. D. Selcen, and A.G. Engel Mutations in ZASP define a novel form of muscular dystrophy in humans Ann. Neurol. 57 2005 269 276 (Pubitemid 40179865)
281. D. Mochly-Rosen, G. Wu, H. Hahn, H. Osinska, T. Liron, J.N. Lorenz, A. Yatani, J. Robbins, and G.W. Dorn Cardiotrophic effects of protein kinase Cε: analysis by in vivo modulation of PKCε translocation Circ. Res. 86 2000 1173 1179 (Pubitemid 30396044)
282. Y. Takeishi, P. Ping, R. Bolli, D.L. Kirkpatrick, B.D. Hoit, and R.A. Walsh Transgenic overexpression of constitutively active protein kinase Cε causes concentric cardiac hypertrophy Circ. Res. 86 2000 1218 1223 (Pubitemid 30436661)
283. J.A. Johnson, M.O. Gray, C.-H. Chen, and D. Mochly-Rosen A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function J. Biol. Chem. 271 1996 24962 24966 (Pubitemid 26333253)
284. I. Sadler, A.W. Crawford, J.W. Michelsen, and M.C. Beckerle Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton J. Cell Biol. 119 1992 1573 1587
285. S. Arber, G. Halder, and P. Caroni Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation Cell 79 1994 221 231 (Pubitemid 24324913)
286. H.A. Louis, J.D. Pino, K.L. Schmeichel, P. Pomiès, and M.C. Beckerle Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression J. Biol. Chem. 272 1997 27484 27491 (Pubitemid 27452719)
287. Y.P. Yu, and J.-H. Luo Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin J. Cancer Res. 66 2006 7414 7419 (Pubitemid 44289193)
288. D.A. Nix, J. Fradelizi, S. Bockholt, B. Menichi, D. Louvard, E. Friederich, and M.C. Beckerle Targeting of zyxin to sites of actin membrane interaction and to the nucleus J. Biol. Chem. 276 2001 34759 34767
289. D.A. Nix, and M.C. Beckerle Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus J. Cell Biol. 138 1997 1139 1147 (Pubitemid 27386462)
290. T. Kato, J. Muraski, Y. Chen, Y. Tsujita, J. Wall, C.C. Glembotski, E. Schaefer, M. Beckerle, and M.A. Sussman Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt J. Clin. Invest. 115 2005 2716 2730 (Pubitemid 41434399)
291. D.S. Burley, P. Ferdinandy, and G.F. Baxter Cyclic GMP and protein kinase-G in myocardial ischaemia-reperfusion: opportunities and obstacles for survival signaling Br. J. Pharmacol. 152 2007 855 869 (Pubitemid 350100488)
292. K. Gehmlich, E. Ehler, A. Perrot, D.O. Fürst, and C. Geier "MLP: a stress sensor goes nuclear" by Sylvia Gunkel, Jörg Heineke, Denise Hilfiker-Kleiner, Ralph Knöll, J Mol Cell Cardiol. 2009;47(4):423-5 J. Mol. Cell. Cardiol. 48 2010 424 425
293. K. Gehmlich, C. Geier, K.J. Osterziel, P.F.M. Ven, and D.O. Fürst Decreased interactions of mutant muscle LIM protein (MLP) with N-RAP and α-actinin and their implication for hypertrophic cardiomyopathy Cell Tissue Res. 317 2004 129 136 (Pubitemid 39070612)
294. R. Knöll, M. Hoshijima, H.M. Hoffman, V. Person, I. Lorenzen-Schmidt, M.-L. Bang, T. Hayashi, N. Shiga, H. Yasukawa, W. Schaper, W. McKenna, M. Yokoyama, N.J. Schork, J.H. Omens, A.D. McCulloch, A. Kimura, C.C. Gregorio, W. Poller, J. Schaper, H.P. Schultheiss, and K.R. Chien The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy Cell 111 2002 943 955 (Pubitemid 36044687)
295. R. Postel, P. Vakeel, J. Topczewski, R. Knöll, and J. Bakkers Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex Dev. Biol. 318 2008 92 101
296. J. Heineke, H. Ruetten, C. Willenbockel, S.C. Gross, M. Naguib, A. Schaefer, T. Kempf, D. Hilfiker-Kleiner, P. Caroni, T. Kraft, R.A. Kaiser, J.D. Molkentin, H. Drexler, and K.C. Wollert Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc Proc. Natl. Acad. Sci. U. S. A. 102 2005 1655 1660 (Pubitemid 40209223)
297. Y. Kong, M.J. Flick, A.J. Kudla, and S.F. Konieczny Muscle LIM protein promotes myogenesis by enhancing the activity of myoD Mol. Cell. Biol. 17 1997 4750 4760 (Pubitemid 27318150)
298. M.J. Flick, and S.F. Konieczny The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of β-spectrin J. Cell Sci. 113 2000 1553 1564 (Pubitemid 30312504)
299. E. Ehler, R. Horowits, C. Zuppinger, R.L. Price, E. Perriard, M. Leu, P. Caroni, M. Sussman, H.M. Eppenberger, and J.-C. Perriard Alterations at the intercalated disk associated with the absence of muscle LIM protein J. Cell Biol. 153 2001 763 772 (Pubitemid 34286108)
300. S.Y. Boateng, R.J. Belin, D.L. Geenen, K.B. Margulies, J.L. Martin, M. Hoshijima, P.P. de Tombe, and B. Russell Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein Am. J. Physiol. 292 2007 H259 H269
301. C. Geier, K. Gehmlich, E. Ehler, S. Hassfeld, A. Perrot, K. Hayess, N. Cardim, K. Wenzel, B. Erdmann, F. Krackhardt, M.G. Posch, A. Bublak, H. Nägele, T. Scheffold, R. Dietz, K.R. Chien, S. Spuler, D.O. Fürst, P. Nürnberg, and C. Özcelik Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy Hum. Mol. Genet. 17 2008 2753 2765
302. K. Gehmlich, C. Geier, H. Milting, D. Fürst, and E. Ehler Back to square one: what do we know about the functions of Muscle LIM Protein in the heart? J. Muscle Res. Cell Motil. 29 2008 155 158
303. O. Zolk, P. Caroni, and M. Böhm Decreased expression of the cardiac LIM domain protein MLP in chronic human heart failure Circulation 101 2000 2674 2677 (Pubitemid 30390568)
304. K. Wang, J. McClure, and A. Tu Titin: major myofibrillar components of striated muscle Proc. Natl. Acad. Sci. U. S. A. 76 1979 3698 3702 (Pubitemid 9246443)
305. K. Maruyama, S. Matsubara, R. Natori, Y. Nonomura, S. Kimura, K. Ohashi, F. Murakami, S. Handa, and G. Eguchi Connectin, an elastic protein of muscle. Characterization and function J. Biochem. 82 1977 317 337 (Pubitemid 8168500)
306. D.O. Fürst, M. Osborn, R. Nave, and K. Weber The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line J. Cell Biol. 106 1988 1563 1572
307. K. Maruyama, T. Yoshioka, H. Higuchi, K. Ohashi, S. Kimura, and R. Natori Connectin filaments link thick filaments and Z lines in frog skeletal muscle as revealed by immunoelectron microscopy J. Cell Biol. 101 1985 2167 2172 (Pubitemid 16169946)
308. C.C. Gregorio, K. Trombitás, T. Centner, B. Kolmerer, G. Stier, K. Kunke, K. Suzuki, F. Obermayr, B. Herrmann, H. Granzier, H. Sorimachi, and S. Labeit The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity J. Cell Biol. 143 1998 1013 1027 (Pubitemid 28547400)
309. A. Mues, P.F.M. van der Ven, P. Young, D.O. Fürst, and M. Gautel Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin FEBS Lett. 428 1998 111 114 (Pubitemid 28266840)
310. O. Mayans, P.F.M. van der Ven, M. Wilm, A. Mues, P. Young, D.O. Furst, M. Wilmanns, and M. Gautel Structural basis for activation of the titin kinase domain during myofibrillogenesis Nature 395 1998 863 869 (Pubitemid 28503420)
311. K. Trombitás, M.L. Greaser, and G.H. Pollack Interaction between titin and thin filaments in intact cardiac muscle J. Muscle Res. Cell Motil. 18 1997 345 351 (Pubitemid 27216444)
312. H. Ohtsuka, H. Yajima, K. Maruyama, and S. Kimura Binding of the N-terminal 63 kDa portion of connectin/titin to α-actinin as revealed by the yeast two-hybrid system FEBS Lett. 401 1997 65 67 (Pubitemid 27051259)
313. H. Sorimachi, A. Freiburg, B. Kolmerer, S. Ishiura, G. Stier, C.C. Gregorio, D. Labeit, W.A. Linke, K. Suzuki, and S. Labeit Tissue-specific expression and α-actinin binding properties of the Z-disc titin: implications for the nature of vertebrate Z-discs J. Mol. Biol. 270 1997 688 695 (Pubitemid 27332059)
314. M. Gautel, D. Goulding, B. Bullard, K. Weber, and D.O. Furst The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers J. Cell Sci. 109 1996 2747 2754 (Pubitemid 26388359)
315. S. Labeit, and B. Kolmerer Titins: giant proteins in charge of muscle ultrastructure and elasticity Science 270 1995 293 296
316. M.E. Zoghbi, J.L. Woodhead, R.L. Moss, and R.W. Craig Three-dimensional structure of vertebrate cardiac muscle myosin filaments Proc. Natl. Acad. Sci. U. S. A. 105 2008 2386 2390 (Pubitemid 351520523)
317. A. Freiburg, and M. Gautel A molecular map of the interactions between titin and myosin-binding protein C. Implications for sarcomeric assembly in familial hypertrophic cardiomyopathy Eur. J. Biochem. 235 1996 317 323
318. M. Helmes, and H. Granzier Cardiomyocyte stretch-sensing 2011 OUP Oxford
319. W.A. Linke Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction Cardiovasc. Res. 77 2008 637 648 (Pubitemid 351301882)
320. N. Fukuda, Y. Wu, P. Nair, and H.L. Granzier Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner J. Gen. Physiol. 125 2005 257 271 (Pubitemid 40388308)
321. M. Krüger, and W. Linke Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension J. Muscle Res. Cell Motil. 27 2006 435 444 (Pubitemid 44325622)
322. M. Krüger, S. Kötter, A. Grützner, P. Lang, C. Andresen, M.M. Redfield, E. Butt, C.G. dos Remedios, and W.A. Linke Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs Circ. Res. 104 2009 87 94
323. C. Hidalgo, B. Hudson, J. Bogomolovas, Y. Zhu, B. Anderson, M. Greaser, S. Labeit, and H. Granzier PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness Circ. Res. 105 2009 631 638
324. B.D. Hudson, C.G. Hidalgo, M. Gotthardt, and H.L. Granzier Excision of titin's cardiac PEVK spring element abolishes PKCα-induced increases in myocardial stiffness J. Mol. Cell. Cardiol. 48 2010 972 978
325. A. Borbély, J. van der Velden, Z. Papp, J.G.F. Bronzwaer, I. Edes, G.J.M. Stienen, and W.J. Paulus Cardiomyocyte stiffness in diastolic heart failure Circulation 111 2005 774 781 (Pubitemid 40250638)
326. L. van Heerebeek, C. Franssen, N. Hamdani, F. Verheugt, G. Somsen, and W. Paulus Molecular and cellular basis for diastolic dysfunction Curr. Heart Fail. Rep. 9 2012 293 302
327. K. Bishu, N. Hamdani, S.F. Mohammed, M. Kruger, T. Ohtani, O. Ogut, F.V. Brozovich, J.C. Burnett, W.A. Linke, and M.M. Redfield Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo Circulation 124 2011 2882 2891
328. N. Hamdani, K.G. Bishu, M. von Frieling-Salewsky, M.M. Redfield, and W.A. Linke Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction Cardiovasc. Res. 97 2013 464 471
329. 2 +)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements J. Mol. Cell. Cardiol. 54 2013 90 97
330. 2 +/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation Circ. Res. 112 2013 664 674
331. M.-L. Bang, T. Centner, F. Fornoff, A.J. Geach, M. Gotthardt, M. McNabb, C.C. Witt, D. Labeit, C.C. Gregorio, H. Granzier, and S. Labeit The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system Circ. Res. 89 2001 1065 1072 (Pubitemid 34640875)
332. S. Lahmers, Y. Wu, D.R. Call, S. Labeit, and H. Granzier Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium Circ. Res. 94 2004 505 513 (Pubitemid 38326286)
333. O. Cazorla, A. Freiburg, M. Helmes, T. Centner, M. McNabb, Y. Wu, K. Trombitas, S. Labeit, and H. Granzier Differential expression of cardiac titin isoforms and modulation of cellular stiffness Circ. Res. 86 2000 59 67 (Pubitemid 30044169)
334. I. Makarenko, C.A. Opitz, M.C. Leake, C. Neagoe, M. Kulke, J.K. Gwathmey, F. del Monte, R.J. Hajjar, and W.A. Linke Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts Circ. Res. 95 2004 708 716 (Pubitemid 39331931)
335. S.F. Nagueh, G. Shah, Y. Wu, G. Torre-Amione, N.M.P. King, S. Lahmers, C.C. Witt, K. Becker, S. Labeit, and H.L. Granzier Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy Circulation 110 2004 155 162 (Pubitemid 38924583)
336. C. Neagoe, M. Kulke, F. del Monte, J.K. Gwathmey, P.P. de Tombe, R.J. Hajjar, and W.A. Linke Titin isoform switch in ischemic human heart disease Circulation 106 2002 1333 1341 (Pubitemid 35013035)
337. O. Cazorla, G. Vassort, D. Garnier, and J.-Y. Le Guennec Length modulation of active force in tat cardiac myocytes: is titin the sensor? J. Mol. Cell. Cardiol. 31 1999 1215 1227 (Pubitemid 29276619)
338. O. Cazorla, Y. Wu, T.C. Irving, and H. Granzier Titin-based modulation of calcium sensitivity of active tension in mouse skinned cardiac myocytes Circ. Res. 88 2001 1028 1035 (Pubitemid 34137115)
339. N. Fukuda, Y. Wu, G. Farman, T.C. Irving, and H. Granzier Titin isoform variance and length dependence of activation in skinned bovine cardiac muscle J. Physiol. 553 2003 147 154 (Pubitemid 37483923)
340. R.D. Mateja, M.L. Greaser, and P.P. de Tombe Impact of titin isoform on length dependent activation and cross-bridge cycling kinetics in rat skeletal muscle Biochim. Biophys. Acta 1833 2012 804 811
341. M.L. Greaser, C.M. Warren, K. Esbona, W. Guo, Y. Duan, A.M. Parrish, P.R. Krzesinski, H.S. Norman, S. Dunning, D.P. Fitzsimons, and R.L. Moss Mutation that dramatically alters rat titin isoform expression and cardiomyocyte passive tension J. Mol. Cell. Cardiol. 44 2008 983 991
342. M.M. LeWinter, and H. Granzier Cardiac titin: a multifunctional giant Circulation 121 2010 2137 2145
343. S.Y. Boateng, S.E. Senyo, L. Qi, P.H. Goldspink, and B. Russell Myocyte remodeling in response to hypertrophic stimuli requires nucleocytoplasmic shuttling of muscle LIM protein J. Mol. Cell. Cardiol. 47 2009 426 435
344. J.R. Wilding, C.A. Lygate, K.E. Davies, S. Neubauer, and K. Clarke MLP accumulation and remodelling in the infarcted rat heart Eur. J. Heart Fail. 8 2006 343 346 (Pubitemid 43832163)
345. J.D. Molkentin, J.-R. Lu, C.L. Antos, B. Markham, J. Richardson, J. Robbins, S.R. Grant, and E.N. Olson A calcineurin-dependent transcriptional pathway for cardiac hypertrophy Cell 93 1998 215 228 (Pubitemid 28180855)
346. R. Knöll, W.A. Linke, P. Zou, S. Miočic, S. Kostin, B. Buyandelger, C.-H. Ku, S. Neef, M. Bug, K. Schäfer, G. Knöll, L.E. Felkin, J. Wessels, K. Toischer, F. Hagn, H. Kessler, M. Didié, T. Quentin, L.S. Maier, N. Teucher, B. Unsöld, A. Schmidt, E.J. Birks, S. Gunkel, P. Lang, H. Granzier, W.-H. Zimmermann, L.J. Field, G. Faulkner, M. Dobbelstein, P.J.R. Barton, M. Sattler, M. Wilmanns, and K.R. Chien Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart Circ. Res. 109 2011 758 769
347. M. Ibrahim, U. Siedlecka, B. Buyandelger, M. Harada, C. Rao, A. Moshkov, A. Bhargava, M. Schneider, M.H. Yacoub, J. Gorelik, R. Knöll, and C.M. Terracciano A critical role for telethonin in regulating t-tubule structure and function in the mammalian heart Hum. Mol. Genet. 22 2013 372 383
348. T. Hayashi, T. Arimura, M. Itoh-Satoh, K. Ueda, S. Hohda, N. Inagaki, M. Takahashi, H. Hori, M. Yasunami, H. Nishi, Y. Koga, H. Nakamura, M. Matsuzaki, B.Y. Choi, S.W. Bae, C.W. You, K.H. Han, J.E. Park, R. Knöll, M. Hoshijima, K.R. Chien, and A. Kimura Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy J. Am. Coll. Cardiol. 44 2004 2192 2201 (Pubitemid 39576040)
349. S. Lange, D. Auerbach, P. McLoughlin, E. Perriard, B.W. Schäfer, J.-C. Perriard, and E. Ehler Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2 J. Cell Sci. 115 2002 4925 4936 (Pubitemid 36054644)
350. F. Sheikh, A. Raskin, P.-H. Chu, S. Lange, A.A. Domenighetti, M. Zheng, X. Liang, T. Zhang, T. Yajima, Y. Gu, N.D. Dalton, S.K. Mahata, G.W. Dorn, J. Heller-Brown, K.L. Peterson, J.H. Omens, A.D. McCulloch, and J. Chen An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice J. Clin. Invest. 118 2008 3870 3880
351. H.L. Granzier, M.H. Radke, J. Peng, D. Westermann, O.L. Nelson, K. Rost, N.M.P. King, Q. Yu, C. Tschöpe, M. McNabb, D.F. Larson, S. Labeit, and M. Gotthardt Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction Circ. Res. 105 2009 557 564
352. M.H. Radke, J. Peng, Y. Wu, M. McNabb, O.L. Nelson, H. Granzier, and M. Gotthardt Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy Proc. Natl. Acad. Sci. U. S. A. 104 2007 3444 3449 (Pubitemid 46364178)
353. A. Raskin, S. Lange, K. Banares, R.C. Lyon, A. Zieseniss, L.K. Lee, K.G. Yamazaki, H.L. Granzier, C.C. Gregorio, A.D. McCulloch, J.H. Omens, and F. Sheikh A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics J. Biol. Chem. 287 2012 29273 29284
354. I. Agarkova, and J.-C. Perriard The M-band: an elastic web that crosslinks thick filaments in the center of the sarcomere Trends Cell Biol. 15 2005 477 485 (Pubitemid 41253467)
355. I. Agarkova, E. Ehler, S. Lange, R. Schoenauer, and J.C. Perriard M-band: a safeguard for sarcomere stability? J. Muscle Res. Cell Motil. 24 2003 191 203 (Pubitemid 37323621)
356. H.M. Eppenberger, J.C. Perriard, U.B. Rosenberg, and E.E. Strehler The Mr 165,000 M-protein myomesin: a specific protein of cross-striated muscle cells J. Cell Biol. 89 1981 185 193 (Pubitemid 11081440)
357. T. Masaki, and O. Takaiti M-Protein J. Biochem. 75 1974 367 380
358. R. Schoenauer, M. Emmert, A. Felley, E. Ehler, C. Brokopp, B. Weber, M. Nemir, G. Faggian, T. Pedrazzini, V. Falk, S. Hoerstrup, and I. Agarkova EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy Basic Res. Cardiol. 106 2011 233 247
359. R. Schoenauer, S. Lange, A. Hirschy, E. Ehler, J.-C. Perriard, and I. Agarkova Myomesin 3, a novel structural component of the M-band in striated muscle J. Mol. Biol. 376 2008 338 351
360. W.M.J. Obermann, M. Gautel, K. Weber, and D.O. Furst Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin EMBO J. 16 1997 211 220 (Pubitemid 27049379)
361. W.M. Obermann, M. Gautel, F. Steiner, P.F. van der Ven, K. Weber, and D.O. Furst The structure of the sarcomeric M band: localization of defined domains of myomesin, M-protein, and the 250-kD carboxy-terminal region of titin by immunoelectron microscopy J. Cell Biol. 134 1996 1441 1453 (Pubitemid 26318017)
362. W.M.J. Obermann, P.F.M. van der Ven, F. Steiner, K. Weber, and D.O. Fürst Mapping of a myosin-binding domain and a regulatory phosphorylation site in M-protein, a structural protein of the sarcomeric M band Mol. Biol. Cell 9 1998 829 840 (Pubitemid 28173636)
363. S. Lange, M. Himmel, D. Auerbach, I. Agarkova, K. Hayess, D.O. Fürst, J.C. Perriard, and E. Ehler Dimerisation of myomesin: implications for the structure of the sarcomeric M-band J. Mol. Biol. 345 2005 289 298 (Pubitemid 39574851)
364. R. Siegert, A. Perrot, S. Keller, J. Behlke, A. Michalewska- Włudarczyk, A. Wycisk, M. Tendera, I. Morano, and C. Ozcelik A myomesin mutation associated with hypertrophic cardiomyopathy deteriorates dimerisation properties Biochem. Biophys. Res. Commun. 405 2011 473 479
365. R. Schoenauer, P. Bertoncini, G. Machaidze, U. Aebi, J.C. Perriard, M. Hegner, and I. Agarkova Myomesin is a molecular spring with adaptable elasticity J. Mol. Biol. 349 2005 367 379 (Pubitemid 40693755)
366. T. Hornemann, S. Kempa, M. Himmel, K. Hayess, D.O. Fürst, and T. Wallimann Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein J. Mol. Biol. 332 2003 877 887 (Pubitemid 37101374)
367. T. Wallimann, M. Wyss, D. Brdiczka, K. Nicolay, and H.M. Eppenberger Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis Biochem. J. 281 1992 21 40
368. 1 integrin receptor J. Biol. Chem. 279 2004 28641 28652 (Pubitemid 38900147)
369. R.D. Will, M. Eden, S. Just, A. Hansen, A. Eder, D. Frank, C. Kuhn, T.S. Seeger, U. Oehl, S. Wiemann, B. Korn, M. Koegl, W. Rottbauer, T. Eschenhagen, H.A. Katus, and N. Frey Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing Circ. Res. 107 2010 1253 1264
370. A. Fukuzawa, S. Lange, M. Holt, A. Vihola, V. Carmignac, A. Ferreiro, B. Udd, and M. Gautel Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band J. Cell Sci. 121 2008 1841 1851 (Pubitemid 351943377)
371. P. Bagnato, V. Barone, E. Giacomello, D. Rossi, and V. Sorrentino Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles J. Cell Biol. 160 2003 245 253 (Pubitemid 36254958)
372. A. Kontrogianni-Konstantopoulos, D.H. Catino, J.C. Strong, S. Sutter, A.B. Borisov, D.W. Pumplin, M.W. Russell, and R.J. Bloch Obscurin modulates the assembly and organization of sarcomeres and the sarcoplasmic reticulum FASEB J. 20 2006 2102 2111
373. S. Lange, K. Ouyang, G. Meyer, L. Cui, H. Cheng, R.L. Lieber, and J. Chen Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum J. Cell Sci. 122 2009 2640 2650
374. G. Ayalon, J.Q. Davis, P.B. Scotland, and V. Bennett An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan Cell 135 2008 1189 1200
375. S.-Y. Shai, A.E. Harpf, C.J. Babbitt, M.C. Jordan, M.C. Fishbein, J. Chen, M. Omura, T.A. Leil, K.D. Becker, M. Jiang, D.J. Smith, S.R. Cherry, J.C. Loftus, and R.S. Ross Cardiac myocyte-specific excision of the β1 integrin gene results in myocardial fibrosis and cardiac failure Circ. Res. 90 2002 458 464 (Pubitemid 34633916)
376. W. Cheng, B. Li, J. Kajstura, P. Li, M. Wolin, E. Sonnenblick, T. Hintze, G. Olivetti, and P. Anversa Stretch-induced programmed myocyte cell death J. Clin. Invest. 96 1995 2247 2259
377. B. Crozatier, M. Ashraf, D. Franklin, J. Ross Jr., L. Nimmo, and D. McKown Sarcomere length in experimental myocardial infarction: evidence for sarcomere overstretch in dyskinetic ventricular regions J. Mol. Cell. Cardiol. 9 1977 785 797 (Pubitemid 8196080)
378. S.M. Factor, M. Flomenbaum, M.-J. Zhao, C. Eng, and T.F. Robinson The effects of acutely increased ventricular cavity pressure on intrinsic myocardial connective tissue J. Am. Coll. Cardiol. 12 1988 1582 1589