Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo

Circulation

Volumn 124, Issue 25, 2011, Pages 2882-2891

  Bishu, Kalkidan ^a   Hamdani, Nazha ^b   Mohammed, Selma F ^a   Kruger, Martina ^b   Ohtani, Tomohito ^a   Ogut, Ozgur ^a   Brozovich, Frank V ^a   Burnett, John C ^a   Linke, Wolfgang A ^b   Redfield, Margaret M ^a  

^a MAYO CLINIC   (United States)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

brain; Cyclic GMP dependent protein kinases; Heart failure, diastolic; Natriuretic peptide; Sildenafil

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; CONNECTIN; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN 2; PHOSPHOLAMBAN; SILDENAFIL; TROPONIN I; TROPONIN T;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; DOG; DRUG EFFECT; HEART BEAT; HEART DILATATION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE CELL; HYPERTENSION; IN VIVO STUDY; LEFT VENTRICULAR DIASTOLIC DISTENSIBILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW;

AGE FACTORS; AGING; ANIMALS; BIOPSY; COMPLIANCE; CYCLIC GMP; DIASTOLE; DOGS; HYPERTENSION; MUSCLE PROTEINS; MYOCYTES, CARDIAC; NATRIURETIC PEPTIDE, BRAIN; PHOSPHORYLATION; PIPERAZINES; PROTEIN KINASES; PURINES; SARCOMERES; SULFONES; VASODILATOR AGENTS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 84155163078     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.048520     Document Type: Review

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