Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 2, 2007, Pages

  Jagatheesan, Ganapathy ^a   Rajan, Sudarsan ^a   Petrashevskaya, Natalia ^a   Schwartz, Arnold ^a   Boivin, Greg ^a   Arteaga, Grace M ^b   Solaro, R John ^b   Liggett, Stephen B ^c   Wieczorek, David F ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium sensitivity; Contractile function; Genetically altered mice; Hypertrophy

Indexed keywords

CALCIUM; TROPOMYOSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; GENE MUTATION; HEART FUNCTION; MOUSE; MYOFILAMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MODIFICATION; SYSTOLIC DYSFUNCTION; TRANSGENIC MOUSE; TRANSGENICS;

ADRENERGIC BETA-AGONISTS; ANIMALS; CALCIUM; CARDIOMYOPATHY, HYPERTROPHIC, FAMILIAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENOTYPE; HEART RATE; ISOPROTERENOL; MICE; MICE, TRANSGENIC; MICROFILAMENTS; MUTATION; MYOCARDIAL CONTRACTION; MYOCARDIUM; PHENOTYPE; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SARCOMERES; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TROPOMYOSIN; VENTRICULAR PRESSURE;

EID: 34547856652     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01341.2006     Document Type: Article

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