LIM proteins: Association with the actin cytoskeleton

Protoplasma

Volumn 219, Issue 1-2, 2002, Pages 1-12

  Khurana, T ^a   Khurana, B ^a   Noegel, A A ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Cysteine rich proteins; Dictyostelium discoideum; Enigma proteins; Focal adhesion; LIM kinases; Myogenesis

Indexed keywords

DICTYOSTELIUM; DICTYOSTELIUM DISCOIDEUM;

ACTIN; CARRIER PROTEIN; LIM KINASE; PDLIM7 PROTEIN, HUMAN; PROTEIN KINASE; SIGNAL PEPTIDE; ZINC FINGER PROTEIN;

ANIMAL; CHEMISTRY; CYTOSKELETON; FOCAL ADHESION; HUMAN; METABOLISM; MUSCLE DEVELOPMENT; PROTEIN BINDING; REVIEW;

ACTINS; ANIMALS; CARRIER PROTEINS; CYTOSKELETON; FOCAL ADHESIONS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUSCLE DEVELOPMENT; PROTEIN BINDING; PROTEIN KINASES; ZINC FINGERS;

EID: 0036008284     PISSN: 0033183X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007090200000     Document Type: Review

References (115)

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7. Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells
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14. Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin
15. Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1: Localization of SLIM1 at focal adhesions and the isoform slimmer in the nucleus of myoblasts and cytoplasm of myotubes suggests distinct roles in the cytoskeleton and in nuclear-cytoplasmic communication
16. The VAV family of signal transduction molecules
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18. Protein-protein interaction of FHL2, a LIM domain protein preferentially expressed in human heart, with hCDC47
19. The Dictyostelium LIM domaincontaining protein LIM2 is essential for proper chemotaxis and morphogenesis
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22. PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL
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24. Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain
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26. The LIM/double zinc-finger motif functions as a protein dimerization domain
27. The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of betaI-spectrin
28. LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition
29. Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11
30. Mapping of a human LIM protein (CLP) to human chromosome 11p15.1 by fluorescence in situ hybridization
31. Characterization of a human cardiac gene which encodes for a LIM domain protein and is developmentally expressed in myocardial development
32. Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: Building a functional insulin minienhancer complex
33. The PDZ domain of the LIM protein enigma binds to beta-tropomyosin
34. Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP
35. Purification of a vasodilator-regulated phosphoprotein from human platelets
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37. Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton
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39. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans
40. Structure and function of LIM domains
41. Profilin promotes barbedend actin filament assembly without lowering the critical concentration
42. Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain
43. Expression of ril, a novel LIM domain gene, is down-regulated in Hras-transformed cells and restored in phenotypic revertants
44. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD
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47. Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2
48. Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells
49. Protein-protein interaction of zinc finger LIM domains with protein kinase C
50. The amino-terminal part of ActA is critical for the actin-based motility of Listeria monocytogenes: The central proline-rich region acts as a stimulator
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54. Characterization of a brain-specific nuclear LIM domain protein (FHL1B) which is an alternatively spliced variant of FHL1
55. Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport
56. Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats
57. Translocation of a human focal adhesion LIM-only protein, FHL2, during myofibrillogenesis and identification of LIM2 as the principal determinants of FHL2 focal adhesion localization
58. Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET)
59. Leupaxin is a novel LIM domain protein that forms a complex with PYK2
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61. Focal adhesion as a signal transduction organelle
62. Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression
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64. Mutational analysis of the metal sites in an LIM domain
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68. The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle
69. The developmental regulation of a novel muscle LIM-protein
70. FHL2, a novel tissue-specific coactivator of the androgen receptor
71. The N-terminal LIM domain negatively regulates the kinase activity of LIM-kinase 1
72. ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain
73. Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion
74. Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: A potential mechanism for communication between sites of cell adhesion and the nucleus
75. Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs
76. Parvin, a 42 kDa focal adhesion protein, related to the (alpha)-actinin superfamily
77. Vinculin
78. Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP
79. LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity
80. CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin
81. DdLIM is a cytoskeleton-associated protein involved in the protrusion of lamellipodia in Dictyostelium
82. A new LIM protein containing an autoepitope homologous to "senescent cell antigen"
83. The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts
84. The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins
85. Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein)
86. An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment
87. Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein
88. Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src
89. Zyxin and cCRP: Two interactive LIM domain proteins associated with the cytoskeleton
90. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL
91. pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk
92. The LIM domain is a modular protein-binding interface
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94. Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin
95. LIM-kinase1
96. Two muscle-specific LIM proteins in Drosophila
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98. LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein
99. Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways
100. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells
101. Paxillin and focal adhesion signalling
102. Transmembrane molecular assemblies in cell-extracellular matrix interactions
103. Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: Identification of a vinculin and pp125Fak-binding region
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107. mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans
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109. The cloning, genomic organization and expression of the focal contact protein paxillin in Drosophila
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111. Specificity of LIM domain interactions with receptor tyrosine kinases
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113. A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction
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115. Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C